20. GENERAL PHARMACOLOGY (МIII-ОФАР) STUDY PROGRAM DEPARTMENT COURSE TITLE / CODE COURSE STATUS INTEGRATED STUDIES IN MEDICINE DEPARTMENT OF PHARMACOLOGY, TOXICOLOGY AND CLINICAL PHARMACOLOGY GENERAL PHARMACOLOGY COMPULSORY Condition: MEDICAL BIOCHEMISTRY AND CHEMISTRY; PHYSIOLOGY (exam) Year of study Winter semester (hours/week) III Summer semester (hours/week) Lecture Practice Lecture Practice 0 0 3 1 Teaching methods Colloquia Seminars 2 ECTS Credits 4,5 Lectures, Practical work AIM Medical students are acquainted with basic biologic mechanisms of drugs and their effects on organ systems Knowledge GOAL Skills Student should know why, how and when to apply particular drug, general information on drug metabolism in the body, site and mechanism of its action, interactions and side effects of drugs. Student must be able to describe the effects, therapeutic indications and application of drugs used in treatment of microbial diseases. Practical classes deal with practical pharmacotherapeutical problems and recipes. Student must know to: • to properly fill a prescription (magistral drugs, officinal drugs, ready-made drugs) and to explain it; • to use drug register books; • to fill the registration form / report on unwanted effects of the drug. Theoretical classes SADRŽAJ PREDMETA History of Pharmacology. The drug and the poison. Mode of application. Dosage of drugs. Doses. Therapeutic index and therapeutic scope of the drug. Movement of the drug in the body. Biomembrane penetration. Reabsorption and distribution of drugs. Excretion of drugs. Drug metabolism. Induction and enzyme inhibition. Factors affecting the metabolism of drugs. Pharmacokinetic models. Pharmacokinetic parameters. Drug action. Sites of action. Mechanisms of action. Receptors. G-protein. Interactions of drugs. Synergism and antagonism. Applying drugs in particular circumstances (children, elderly, pathological condition, pregnancy, breastfeeding). Pharmacogenetics Adverse effects of drugs. Addiction. Toxicology. Poisons. Drug poisoning. Disinfection and antisepsis. Antimicrobial agents. Antimycotic, antiviral and antiparasitic drugs Practical classes Drug classification. Putting drugs on the market. Names of drugs. Pharmacopoeia. Drug prescription scheme. Magistral and generic formulas. Ready-made drugs. Drugs in solid form. Drugs in liquid form. Semi-solid forms of drugs. Inhalation. Bandage material. Antimicrobial drug prescription. 1. 2. 3. 4. Compulsory 5. RECOMMENDED LITERATURE 6. 1. 2. 3. Optional 4. 5. Varagić V, Milošević M. FARMAKOLOGIJA. Elit Medica, Beograd (2004., 2005., 2006. ili 2007.) Sabo A, Tomić Z, Stanulović M. ANTIBAKTERIJSKI LEKOVI. A.D.Š. Kultura, Bački Petrovac, 2001. Vasović V, Mikov M, Đaković-Švajcer K. ODABRANA POGLAVLjA IZ TOKSIKOLOGIJE. Štamparija Borac, Kula, 2003. Đaković-Švajcer K and sar. TEST-PITANjA IZ FARMAKOLOGIJE and TOKSIKOLOGIJE. Medicinski fakultet Novi Sad, 2001. Popović J, Sabo A, Mikov M. PRIRUČNIK IZ FARMAKOLOGIJE, TOKSIKOLOGIJE and KLINIČKE FARMAKOLOGIJE-OPŠTI DEO. Nova prosveta, 1992. Mikov M, Popović J, Sabo A. PRIRUČNIK IZ FARMAKOLOGIJE, TOKSIKOLOGIJE and KLINIČKE FARMAKOLOGIJE-SPECIJALNI DEO. Nova prosveta, 1992. Rang HP, Dale MM, Ritter JM, Moore PK. FARMAKOLOGIJA. Data Status, Beograd, 2005. Joksović D. AKUTNA TROVANjA LEKOVIMA. Rivel, Beograd, 1999. Popović J. MATEMATIČKI PRINCIPI U FARMAKOKINETICI, KOMPARTMANSKOJ ANALIZI and BIOFARMACIJI. Medicinski fakultet Novi Sad, 1999. Stanojević Z, Bukumirić Z, Bulajić S. FARMAKOGRAFIJA ZA STUDENTE MEDICINE. Alfagraf, Petrovaradin, 2007. LEKOVI U PROMETU, OrtoMedics, Novi Sad, 2007 (i starija izdanja) Student’s activity assessment (points) Pre-exam activities Lecture Practice Colloquium 20 2h20 Total Final exam Essay Other Pismeni Oral 10 30 100 Teaching staff Techn. 1 1. 2. 3. 4. 5. 6. Teaching Ass. Lecturer 3 Prof dr Kornelija Đaković-Švajcer Prof. dr Ana Sabo Prof. dr Momir Mikov Prof. dr Jovan Popović Prof. dr Zdenko Tomić Doc. dr Velibor Vasović Assist.Prof. 3 7. 8. 9. 10. 11. Assoc.Prof. Full-time Prof. 4 Doc. dr Aleksandar Rašković Teaching Ass. mr Isidora Samojlik Teaching Ass. mr Olga Horvat Teaching Ass. mr Saša Vukmirović Techn. demonstrator Boris Milijašević, dr Head of the Department Prof. dr Ana Sabo. s.r. Scient. Res.