LEKOVI KOJI SE MOGU DAVATI BOLESNICIMA OBOLELIM OD AKUTNE
INTERMITENTNE PORFIRIJE
BOLESTI I TEGOBE
KATEGORIJA LEKA
Specifično lečenje
VRSTA LEKA
Ugljeni hidrati
Hematin (HEMODONIN,
NORMOSANG, PANHEMATIN)
Propranolol (INDERAL)
Folna kis. (FOLAN)
Bolovi
Analgetici
Acetilsaliclna kiselina
(ASPIRIN, ACETISAL,
ANDOL, MIDOL i dr.)
Morfin
Petidin (DOLANTIN)
Stomačne tegobe
Antiulkusni lekovi
Cimetidin (BELOMET)
Metoklopramid (KLOMETOL,
REGLAN, VENTROMET)
Antiemetici
Hlorpromazin (LARGACTIL)
Opstipacija
Neostigmin (PROSTIGMIN)
Antihipertenzivi,antiaritmi
ci i koronarni dilatatori
Diltiazem (CORTIAZEM RET)
Prazosin (VASOFLEX)
Diazoksid (HYPERSTAT)
Labetalol (LAMITOL)
Na-nitroprusid
Rezerpin
Propranolol (INDERAL)
Metoprolol (PRESOLOL)
Prokainamid (NOVOCAMID)
Verapamil (VEPAMIL, ISOPTIN)
Kardiotonici
Digitalis (DILACOR)
Diuretici
Furosemid (LASIX)
Tiazidi (hidrohlortiazid - MONOZID)
Triamteren (TIAREN)
Bumetanid (YURINEX)
Cirkulatorni poremećaji
Naftidrofuril (DUSODRIL)
Nicergolin (ADAVIN)
Drugo
Atropin
Antipsihotici
Hlorpromazin (LARGACTIL)
Promazin (PRAZINE)
Bolesti srca i cirkulacije
Neuroze i psihoze
www.belimantil.info
Levopromazin (NOZINAN)
Haloperidol (HALDOL)
Bolesti nervnog sistema
Infekcije
Anestezija
Antidepresivi
Amitriptilin (AMYZOL)
Meprotilin (MAPROTILIN)
Klomipramin (ANAFRANIL)
Imipramin (EUPRAMIN)
Sedativi i hipnotici
Bromazepam (BROMAZEPAM,
LEXILLIUM)
Midazolam (FLORMIDAL)
Oksazepam (ADUMBRAN)
Lorazepam (LORSILAN,LORAM)
Hlordiazepoksid (LIBRIUM)
Flunitrazepam (BENZOSAN)
Hloral hidrat
Psihostimulansi
Piracetam (OIKAMID)
Antikonvulzivi
Klonazepam (RIVOTRIL)
Midazolam (FLORMIDAL)
Parkinsonova bolest
Triheksifenidil (ARTANE,
HEXIFEN)
Antibiotici
Penicilini (Amoksicilin -SINACILIN,
AMOKSICILIN, ampicilini PENTREXYL, pivampicilinDANCILIN, i dr.)
Cefalosporini (ALFACET,
PALITREX, LONGACEPH,
TOLYCAR)
Aminoglikozidi (GARAMYCIN,
netilmicin-NETROMYCIN)
Rifampicin (RIFAMOR)
Uroantiseptici
Oksolinska kis. (OKSAREN)
Virostatici
Aciklovir (ACIKLOVIR, ZOVIRAX)
Antimikotici
Flucitozin (ANCOTIL)
Opšti anestetici
Fentanil (FENTANIL)
Droperidol
(DEHYDROBENZPEIDOL)
Etar
Azot oksidul
Lokalni anestetici
Tetrakain (GINGICAIN)
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Prokain (PROCAINI
HYDROCHLORIDUM)
Miorelaksansi
Sukcinilholin (MIDARINE)
Pankuronjum(PAVULON, MIOLAX)
Tubokurarin (TUBARINE)
Šećerna bolest
Antidijabetici
Insulini
Bolesti štitne žlezde
Antitireotici
Propiltiouracil
Reumatske bolesti
Antireumatici
Acetilsalicilna kis.
Flurbiprofen (FLUGALIN)
Indometacin (INDOMETACIN)
Naproksen (NAPROXEN)
Tiaprofenska kis. (TURGANIL)
Diklofenak (DIKLOFEN)
Ketoprofen (KETONAL)
Oksifenbutazon (TANDERIL)
Piroksikam (REMOXICAM)
Sulindak (KLINORIL)
Alergijske reakcije
Antihistaminici
Difenhidramin (DIMIDRIL)
Prometazin (PHENERGAN)
Očne bolesti
Glaukom
Acetazolamid (DIAMOX)
Hormonska oboljenja
Hormoni
ACTH
Kortikosteroidi
Kateholamini
Glukagon (GLUCAGON)
Tiroksin (TIVORAL, VOBENOL)
Bolesti disajnih oragana
Antitusici
Kodein (CODEINI PHOSPHAS)
Bolesti krvi
Antikoagulansi
Heparin
Dikumarol
Antiagregacioni
Aceilsalicilna kis.
Dipridamol (PERSANTIN)
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DRUGI DOZVOLJNI LEKOVI KOJI NISU REGISTROVANI U NAŠOJ ZEMLJI
Alimemazin
Amfotericin Br
Buflomedil
Butakain
Dekshlorfeniramin
Estazolam
Etibenzatropin
Fenoperidin
Glafenin
Gvanetidin
Gvanfacin
Heptaminol
Mekvitazin
Metopimazin
Nefopam
Nifluminska kiselina
Organon
Oksibuprokain
Parapenzolat
Perheksilin
www.belimantil.info
Pipotiazin
Propanidid
Propoksifen
Proksimetakalne
Na-oksibat (hidroksibutirat)
Tienilična kiselina
Traneksemična kiselina
Trinitrin
Triandomicin
LEKOVI KOJI SU KONTRAINDIKOVANI KOD OBOLELIH OD PORFIRIJE
Alkohol
Kaptopril (KATOPIL, ZORKAPTIL), antihipertenziv
Alkuronium (ALLOFERIN), miorelaksans
Karbamazepin (MAZEPIN, KARBAPIN),antiepileptik
Alfadlolon-Alfeksalon
Karisoprodol
Alopurinol (ALOPURINOL, ZYLORIC), giht
Ketamin (RALATEK), opšti anestetik
Alfakalne
Kinin
Alprazolam (XANAX), sedativ
Klobazam (ODIPAM), sedativ
Amidopirin
Klometacin
Amineptin
Klometiazol (HEMINEVRIN), sedativ
Amjodaron (AMIODARON, CORDARONE)
Klomifen (KLOMIFEN), ovarijalni stimulator
Klonidin (CATAPRESSAN), antihipertenziv
Androgeni
Astemizol (ASTEMISAN, HISTAZOL), antihist. Klotiazepam
Lidokain (LIDOKAIN-HLORID, XYLOCAIN)
Barbiturati
Basden
Loksapin
Bepridil
Mefenaminska kiselina
Bromokriptin (BROMERGON, PARLODEL)
Mefenezin
Bupivakain (VEXELIT), lokalni anestetik
Mepivakain
Dekstromoramid
Meprobamat (MEPROBAMAT), sedativ
Dekstropropoksifen
Metildopa (ALDOMET), antihipertenziv
Diazepam (BENSEDIN, APAURIN), sedativ
Metilergometrin , uterostiptik
Dizopiramid (KORAPEIS), antiaritmik
Metiprilon
Enfluran
Metronidazol (ORVAGYL, EFLORAN),
Ergotamin i derivati (ERGOTAN, DITAMIN)
Minaserin (MIANSAN), antidepresiv
Eritromicin (ERITROMICIN), antibiotik
Mikonazol (DAKTARIN), antimikotik
Etamsilat (DICYNONE), opšti hemostiptik
Nalidiksna kiselina (BAKTOGRAM), uroantisept
Etidokain
Nifedipin (NIFECARD, NIFELAT, CORDIPIN),
Etomidat (HYPNOMIDATE), opšti anestetik
tenziv
Fenacetin
Nitrazepam (NITRAM), sedativ
Fenazon (COSAVIL, PYRA-RECTIOLE)
Noramidopirin
Fenoksibenzamin
Estroprogestativi
Fenilbutazon (PHENILBUTAZON),antireumatik Estrogeni
Fenofibrat (FENOFIBRAT, KATALIP)
Paracetamol (FEBRICET, PARACET),
Floktafenin
Pargilin
Flumekvin
Pentazocin (FORTRAL), opijatni analgetik
Flunarizin
Pentoksifilin (TRENTAL), vazoaktivni lek
Glutetimid
Pipebuzon
Grizeofulvin (GRISEOFULVIN M), antimikotik
Pipemidna kiselina (PIPEM, PIPEGAL),
Halotan, opšti anestetik
Prilokain
Heksapropimat
Primidon (MAJSOLIN), antiepileptik
Probenecid
Hidantoini
Hidralazin
Progabid
Hidroksizin (ATARAX), sedativ
Progesteroni
Hloramfenikol (CHLORAMPHENICOL), antibiotikPropofol (DISOPRIVAN), opšti anestetik
Hlormezanon
Pirazinamid (PYRAZINAMID), antiepileptik,
Hlorohin (CHLOROCHIN), antimalarik
Pirokain
Hlorazepat (TRANEX), sedativ
Ranitidin (RANISAN, RANITAL), antiulkusik
Inhibitori MAO
Spironolakton (ALDACTONE), diuretik
Izoniazid (ISONIAZID), tuberkulostatik
Sukcinamidi
www.belimantil.info
Sulfonamidi
Sulfinpirazon
Sulpirid (SULPIRID), antipsihotik
Sulfoprid
Tamoksifen (TAMOFEN), ovarijalni stimulator,
Tetrazepam (MIOGALAN), miotonolitik
Teofilin (DUROFILIN), bronhopsamolitik
Tinidazol (TRIAGIL), antiinfektiv
Trazodon (DEVIDON), antidepresiv
Triazolam (TRIASAN), sedativ
Trimetadion
Valproat Na (EFTIL, APILEPSIN, DEPAKINE),
Valpromid (DIPROZIN), antiepileptik
Veraliprid
Viloksazin (VIVALAN), antidepresiv
www.belimantil.info
LEKOVI KOJI SE MOGU DAVATI BOLESNICIMA OBOLELIM OD AKUTNE
INTERMITENTNE PORFIRIJE
Svi navedeni lekovi su registrovani u Jugoslaviji
BOLESTI I TEGOBE
Akutni napad porfirije
KATEGORIJA
LEKA
Sizbijanje napada
NAZIV LEKA
1. Ugljeni hidrati 400gr dnevno
( glukoza 10% 4X500ml
intravenski + slatki rastvori
per os)
2. Hematin arginin 250 mg u
infuziji NaCl 0,9% a 250 ml
(u od svetla zaštićenom
sistemu da istekne za 1/ 2 h)
1X dnevno
3. Folna kiselina 45-60 mg
dnevno
4. Vitamini B1, B6, B12
5. Nadoknada Na i Mg
Chlorpromazin (Largaktil)
Domperidon ( Motilium)
Cisaprid (Cisap)
Prochlorperazin (Stemetil)
Famotidin (Famosan)
Omeprazol (Omeprol)
Aluminijum sulfat (Alfogel)
Stomačne tegobe:
Muka, povraćanje
Antiemetici
Gastritis, Ulkus
Antiulkusni
Proliv
Zatvor
Antidijaroici
Laksansi
Loperamid ( Imodium)
Neostigmin (Prostigmin)
Magnezium sulfat
Sorbitol
Senna
Bol
Opijatni analgetici
Diamorphin
Droperidol
Methadon (Metadon)
Pethidin (Dolantin)
Acetisal (Aspirin, Lazdol)
Codein Phosphas (Kafetin)
Paracetamol (Miralgin)
Analgetici
Hrana i krv
Svi vitamini, Haem Arginat,
Transfuzije, Albumin
www.belimantil.info
Bolesti srca
Bolesti nervnog sistema
Bolesti disajnih organa
Kardiotonici
Preparati gvožđa
Digoxin (Dilakor)
Euritmici
Procainamid (Novocamid)
Quinidin
Drugo
Atropin
Adrenalin
Diuretici
Acetazolamid (Diamox)
Amilorid (Hemopres)
Bunetanid (Yurinex)
Antihipertenzivi
Atenolol (Prinorm)
Dizoxid (Hyperstat)
Metoprolol (Presolol)
Propranolol (Inderal)
Reserpin (Serpasil)
Antikoagulansi
Heparin
Warfarin (Farin)
Cirkulatorni
poremećaji
Dipyridamol (Persantin)
Naftidrofuryl (Dusodril)
Antikonvulzivi
Neurontin (Gabapentin)
Midazolam (Flormidal)
Clonazepam (Rivotril)
Bromidi
Pareldehyd
Magnezijum sulfat
Hipnotoci, Sedativi
Psihoanaleptici
Anabolici
Triazolam (Triasan)
Chlorpromazin (Largactil)
Promazin (Prazine)
Trifluoroperazin (Perfluzin)
Droperidol
Fluoxetin (Flunirin, Prozac)
Fluvoxaminmaleat (Fevarin)
Lithium carbonat
Piracetam (Oikamid)
Antitusici
Codein phosphas (Kodein)
Bronhospazmolitici
Ketotifen (Galitifen)
Salbutamol (Ventolin)
www.belimantil.info
Alergijske reakcije
Kortikosteroidi
Antihistaminici
Beclomethazon (Beconase)
Chlorpheniramin (Lentostamin)
Reumatske bolesti
Antireumatici
Flubiprofen (Flugalin)
Ibuprofen (Brufen)
Ketoprofen (Ketonal)
Tiaprofenska kis. (Turganil)
Indomethacin (Indometacin)
Dexamethazon (Deksazon)
Specifični lekovi
Allopurinol (Zyloric)
Penicillamin
Colchicin
Antibiotici
Aminoglycosidi (Amikacin)
Netilmicin (Nekomicin)
Amoxycillin (Sinacilin)
Amphotericin B
Ampicillin (Pentrexyl)
Ciprofloxacin (Ciprocinal)
Clavulinska kis.(Amoksiklav)
Gentamycin (Garamycin)
Tetracyclin
Doxiciclin (Dovicin, Amracin)
Norfloxacin (Uracin)
Ofloxacin (Viziren)
Pefloxsacin
Penicillin
Streptomycin
Vancomycin (Vancogal)
Fucidinska kis. (Stanicid)
Etanbutol (Myambutol)
Quinine
Aciclovir (Virolex, Zovirax)
Zidovudin (Retrovir, Zidosan)
Flucitozin ( Ancotil)
Metronidazol (Orvagil)
Infekcije
Antituberkulotik
Antimalarik
Antivirotik
Antimikotik
Maligne bolesti
Antineoplastični
lekovi
Imunomodulatori
Cisplatin (Belplatin, Elain)
Doxorubicin (Adriablastin)
Vincristin (Oncovin)
Melphalan (Alceran)
Cyproteron (Androcur)
Buserelin (Suprefakt)
Goserelin (Zoladex)
Azathioprin (Imuran)
www.belimantil.info
Porodiljstvo-ginekologija
Prostaglandini (Dinoprost)
Oxytocin (Sytocinon)
LHRH
Clomiphen (Klonifen citrat)
Hormonske bolesti
Hormoni
ACTH, FSH
Detoxamethason (Dexason)
Glicocorticoidi
Hydrocortison
Propylthiouracil
Levotiroxin (Tivoral)
Šećerna bolest
Antidiabetici
Insulin
Metformin (Tefor)
Operativni zahvati
Opšti anestetici
Fentanyl (Fentanil)
Droperidol
(Dehydrobensperidol)
Fentanyl droperidol (Talamonal)
Diethylether (Etar)
Azotoxidul (Nitrogenoksid)
Procain
Tetracain (Gingicain)
Bupivacain (Marcain)
Suxametonium (Midrine)
Tubocurarin (Tubarin)
Flumazenil (Anxat)
Lokalni antestetici
Miorelaksansi
Antidoti
Vakcine
Nije dokazano štetno dejstvo
Kontrsastna sredstva
Nije dokazano štetno dejstvo
Očne bolesti
Acetazolamid (Daimox)
Atropin sulfat (Hemotropin)
Dexamethason (Deksason)
Gentamycin (Gentokulin)
Tetracyclini (Amracin)
Zincsulfat
Aciclovir (Virocul)
Hydrocortison (Hidrokorton)
Prednisolon (Oftalmol)
Timolol (Glaumol)
Zinc, Hydrocortison
Kožne bolesti
www.belimantil.info
Drugs that are considered safe in the acute
porphyrias:
Categorised List
Anti-emetics
Antivirals/Antifungals
Analgesics (cont.)
Cyclizine
Domperidone
Meclozine
Prochlorperazine
Promazine
Aciclovir
Amphotericin
Famciclovir
Flucytosine
Ganciclovir
Valaciclovir
Zalcitabine
Co-dydramol
Codeine phosphate
Dextromethorphan
Dextromoramide
Dextropropoxyphene
Diamorphine
Diflunisal
Antibacterial agents
Aminoglycosides
Cardiovascular agents
Amiloride
Beta blockers
Bumetanide
Chlorothiazide
Cyclopenthiazide
Dalteparin
Diazoxide
Dihydrocodeine
Fenbufen
Fentanyl
Flurbiprofen
Ibuprofen
Indomethacin
Ketoprofen
Methadone
Morphine
Co-amoxiclav
Ethambutol
Flucloxacillin 1
Penicillins
Pentamidine
Digoxin
Dipyridamole
Dobutamine
Dopamine
Enalapril
Nalbuphine
Naproxen
Paracetamol
Pethidine
Sulindac
Sodium fusidate
Streptomycin
Vancomycin
Enoxaparin
Glyceryl trinitrate
Guanethidine
Heparin
Tiaprofenic acid
Lipid lowering agents
Hydrochlorothiazide
Beclomethasone
Bezafibrate
Cholestyramine
Colestipol
Fenofibrate
Gemfibrozil
Lisinopril 4
Naftidrofuryl
Prazosin
Procainamide
Quinidine
Ciclosporin 5
Corticosteroids
Hydrocortisone
Methylprednisolone
Prednisolone
Local Anaesthetics
Amethocaine
Bupivacaine
Streptokinase
Tinzaparin
Triamterene
Urokinase
Miscellaneous
Acetazolamide
Acetylcysteine
Anticonvulsants
Allopurinol
Alpha tocopheryl
Procaine
Clobazam
Aluminium salts
Tetracaine
Clonazepam
Amantadine
Gabapentin
Ascorbic acid
Antihistamines
Chlorpheniramine
Diphenhydramine
Ketotifen
Loratadine
Promethazine
Trimeprazine
Lignocaine
Prilocaine
Corticosteroids + other
immunosuppressants
2
3
Immunisations
Immunoglobulins
Sodium valproate
Valproate 3
Vaccines
Vigabatrin
Antidepressants
Amitriptyline
Drugs used in anaesthesia
Adrenaline
Azathioprine
Bismuth
Bromazepam
Buserelin
Calcitonin
Calcium carbonate
www.belimantil.info
Miscellaneo
us (cont.)
Flumazenil
Fructose
FSH
Glipizide
Glucagon
Glucose
Glycopyrroni
um
Gonadorelin
Goserelin
Hetastarch
Insulin
Iron
Ispaghula
Lactulose
Leuprorelin
Levothyroxin
e
LHRH
Lithium
Loperamide
Lorazepam
Magnesium
sulphate
Melphalan
Mesalazine
Metformin
Methotrimepr
azine
Methylphenid
ate
Midazolam
Naloxone
Octreotide
Omeprazole
Oxybuprocai
ne
Oxytocin
Paraldehyde
Penicillamine
Phytomenadi
one
Primaquine
Propanthelin
e
Propylthioura
cil
Proxymetaca
ine
Pseudoephe
drine
Pyridoxine
Pyrimethami
ne
Quinine
Resorcinol
Salbutamol
Senna
Fluoxetine
Atropine
Carbimazole
Lofepramine
Cyclopropane
Chloral hydrate
Mianserin
Epinephrine
Ether
Isoflurane
Neostigmine
Nitrous oxide
Pancuronium
Cisplatin
Clomiphene
Colchicine
Corticotrophin
Danthron
Desferrioxamine
Phentolamine
Propofol
Suxamethonium
Dextran
Dextrose
Dicyclomine
Analgesics
Alfentanil
Aspirin
Buprenorphine
Co-codamol
Dimercaprol
Dimethicone
Diphenoxylate
Distigmine
Doxorubicin
Droperidol
Antipsychotics
Chlorpromazine
Fluphenazine
Haloperidol
Pipothiazine
Trifluoperazine
Malaria Prophylaxis
Chloroquine
Mefloquine
Proguanil
Sodium acid
phos
Sodium
bicarbonate
Sorbitol
Sucralfate
Temazepam
Thiamine
Thyroxine
Tranexamic
acid
Vitamins
Warfarin
Zinc
preparations
1. Large intravenous doses may be associated with acute attacks (unproven as causative
agent)
2. Intravenous doses should be avoided
3. Sodium valproate should only be used where other safe antiepileptics are ineffective or
inappropriate
4. Safety under review, contact WMIC
5. Contact WMIC for information regarding other immunosuppressants
www.belimantil.info
B. DRUGS THOUGHT TO BE SAFE FOR USE IN ACUTE PORPHYRIA (1996)
Each bracketed drug ( ) has had conflicting evidence of experimental porphyrinogenicity.
Occasionally positive, but mainly negative - none of the drugs in this List have been associated
with human porphyric attacks.
A:
ETOPOSIDE
ACETAZOLAMIDE
OXYBUPROCAINE
(OXYPHENBUTAZONE)
F:
ACETYLCHOLINE
OXYTOCIN
FAMOTIDINE
ACTINOMYCIN D
ACYCLOVIR
FENBRUFEN
(FENOFIBRATE)
ADENOSINE MONOPHOSPHATE
FENOPROFEN
ADRENALINE
FENTANYL
ALCLOFENAC
FLUCYTOSINE
ALLOPURINOL
FLUMAZENIL
ALPHA TOCOPHERYL ACETATE
FLUOXETINE HCl
AMETHOCAINE
FLURBIPROFEN
AMILORIDE
FLUVOXAMINE MALEATE
AMINOCAPROIC ACID
FOLIC ACID
AMINOGLYCOSIDES
FRUCTOSE
AMOXYCILLIN
FUSIDIC ACID
AMPHOTERICIN
F.S.H.
P:
(PANCURONIUM BROMIDE)
PARACETAMOL
PARALDEHYDE
PARAPENZOLATE Br
PENICILLAMINE
PENICILLIN
PENTOLINIUM
PERICYAZINE
PETHIDINE
PHENFORMIN
PHENOPERIDINE
PHENTOLAMINE MESYLATE
AMPICILLIN
G:
PIPOTHIAZINE PALMITATE
GENTAMICIN
PIRACETAM
GLAFENINE
PIRBUTEROL
GLUCAGON
PIRENZEPINE
GLUCOSE
PIZOTIFEN
ASCORBIC ACID
ASPIRIN
ATENOLOL
ATROPINE
AZATHIOPRINE
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GLYCERYL TRINITRATE
(PRAZOSIN)
GOSERELIN
(PREDNISOLONE)
GUANETHIDINE
PRIMAQUINE
GUANFACINE HCl
PROBUCOL
B:
BECLOMETHASONE
BENZHEXOL HCl
BETA-CAROTENE
PROCAINAMIDE HCl
BIGUANIDES
H:
(BROMAZEPAM)
HAEM ARGINATE
BROMIDES
(HALOPERIDOL)
BUFLOMEDIL HCl
HEPARIN
BUMETANIDE
HEPTAMINOL HCl
BUPIVACAINE
HEXAMINE
BUPRENORPHINE
(HYDROCORTISONE)
PROCAINE
PROCHLORPERAZINE
PROGUANIL HCl
PROMAZINE
PROPANTHELINE Br
PROPOFOL
PROPRANOLOL
BUSERELIN
I:
PROPYLTHIOURACIL
IBUPROFEN
(PROXYMETACAINE)
C:
INDOMETHACIN
PSEUDOEPHEDRINE HCl
CANTHAXANTHIN
INSULIN
PYRIDOXINE
CARBIMAZOLE
IRON
(PYRIMETHAMINE)
J:
Q:
JOSAMYCIN
QUINIDINE
BUTACAINE SO4
(CARPIPRAMINE HCl)
CHLORAL HYDRATE
(CHLORMETHIAZOLE)
QUININE
(CHLOROQUINE)
K:
(CHLOROTHIAZIDE)
(KETAMINE)
R:
CHLORPHENIRAMINE
KETOPROFEN
(RANITIDINE)
CHLORPROMAZINE
KETOTIFEN
RESERPINE
CIPROFLOXACIN
RESORCINOL
L:
CISAPRIDE
LABETALOL
www.belimantil.info
S:
CISPLATIN
L.H.R.H.
SALBUTAMOL
CLAVULANIC ACID
LIQUORICE
SENNA
CLOFIBRATE
LITHIUM SALTS
SODIUM BROMIDE
CLOMIPHENE
LOFEPRAMINE
SODIUM Ca EDTA
CLOXACILLIN
LOPERAMIDE
SODIUM FUSIDATE
CO-CODAMOL
(LORAZEPAM)
SORBITOL
CODEINE PHOSPHATE
STREPTOMYCIN
M:
COLCHICINE
SULBUTIAMINE
MAGNESIUM-SULPHATE
(CORTICOSTEROIDS)
SULINDAC
(MEBENDAZOLE)
CORTICOTROPHIN (ACTH)
SULFADOXINE
MECAMYLAMINE
COUMARINS
SUXAMETHONIUM
MECLOFENOXATE HCl
CYCLIZINE
MECLOZINE
T:
MEFLOQUINE HCl
TALAMPICILLIN
(MELPHALAN)
TEMAZEPAM
MEPTAZINOL
TETRACAINE
D:
MEQUITAZINE
(TETRACYCLINES)
DANTHRON
METFORMIN
THIOURACILS
DESFERRIOXAMINE
METHADONE
THYROXINE
DEXAMETHASONE
(METHOTRIMEPRAZINE)
TIAPROFENIC ACID
(DEXTROMORAMIDE)
METHYLPHENIDATE
TICARCILLIN
DEXTROSE
METHYLURACIL
TIENILIC ACID
DIAMORPHINE
METIPROPRANOLOL
TIMOLOL MALEATE
DIAZOXIDE
METOPIMAZINE
TOLAZOLINE
DICYCLOMINE HCl
METOPROLOL
TRANEXAMIC ACID
DIFLUNISAL
(METRONIDAZOLE)
TRIACETYLOLEANDOMYCIN
CYCLOPENTHIAZIDE
CYCLOPROPANE
(CYPROTERONE ACETATE)
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DIGOXIN
(MIDAZOLAM)
TRIAMTERENE
DIHYDROCODEINE
MINAPRINE HCl
TRIAZOLAM
DIMERCAPROL
MINAXOLONE
(TRICHLORMETHIAZIDE)
DIMETHICONE
MORPHINE
TRIFLUOPERAZINE
DINOPROST
TRIMEPRAZINE TARTRATE
N:
DIPHENOXYLATE HCl
TRIMETAZIDINE HCl
NADOLOL
DIPYRIDAMOLE
TRIPELENNAMINE
NAFTIDROFURYL OXALATE
(DISOPYRAMIDE)
TUBOCURARINE
(NAPROXEN SODIUM)
DOMPERIDONE
NATAMYCIN
V:
NEFOPAM HCl
VANCOMYCIN
NEOSTIGMINE
(VINCRISTINE)
E:
NETILMICIN
VITAMINS
(ESTAZOLAM)
NIFLUMIC ACID
ETHACRYNIC ACID
NITROUS OXIDE
DOXORUBICIN HCl
DROPERIDOL
W:
WARFARIN SODIUM
ETHAMBUTOL
NORFLOXACIN
Z:
(ETHINYL OESTRADIOL)
O:
ZIDOVUDINE
OFLOXACIN
ZINC PREPARATIONS (TOPICAL)
ETHOHEPTAZINE CITRATE
OXOLINIC ACID
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List of drugs which can precipitate porphyria
Drugs that should be avoided at all cost (*), as they are known to precipitate acute porphyria, or
drugs that should be used with extreme caution, are:
Cardiovascular drugs
Amiodorone*
Torisamide*
Bretilium*
Pirentanide
Flecainade*
Amlodipine
Mexitilene*
Nifidipine
Propafenone*
Nimodipine
Clonidine*
Felodipine
Dihydrylazine*
Isradipine
Hydralazine
Losartan*
Metyldopa*
Fenofibrate
Minoxidil
Fluvastatin
Indapamide
Pravastatin
Metolazone
Simvastatin
Respiratory drugs
Aminophylline*
Acrivastine*
Theophylline
Azatadine*
Etofylline*
Cyproheptadine*
Montelukast*
Ebastine*
Carbocisteine*
Fexofenadine*
Clobutinol*
Oxatomide*
Fedrilate*
Terfenadine
Drugs Active in alimentary tract and metabolism
www.belimantil.info
Lansoprazole
Hyoscine
Misoprostol
Tropisetron*
Omeprazole
Sulfasalazine*
Belladonna*
Amfepramone
Cisapride*
Phendimetrazine
Hyoscine butylbromide*
Phentermine
Mebeverine
Acarbose*
Betahistine
Chlorpropamide
Buclizine*
Glibenclamide
Cinnarizine
Glicazide
Doxylamine*
Glimepiride*
Granisitron*
Tolbutamide*
Genitourinary system and sex hormones (Including oral contraceptives)
Bromocriptine
Medroxyprogesterone
Carbergoline*
Mesterolone
Dinoprost
Mestranol
Dinoprostone
Methyltestosterone
Ergotamine*
Norgestimate*
Metergoline
Oral Contraceptives
Desogestrel
Testosterone
Dydrogesterone
Tibolone
Estradiol
Cinoxacin
Estriol
Finasteride
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Estrone
Flavoxate*
Ethinylestradiol
Nalidixic acid*
Etynodiol
Nitrofurantoin
Fluoxymesterone*
Nitroxoline*
Gestondene
Phenazopyridine*
Gestrinone*
Pipemidic acid
Levonorgestrel
Medrogestondene
Neurological medication
Dantrolene
Oxcarbazepine*
Desflurane*
Phenobarbitol*
Etomidate*
Phenotoin*
Oxethazaine*
Primidone*
Thiopental sodium*
Topiramide*
Pentazocine*
Valproic acid*
Tilidine
Benzerazide*
Clonidine*
Biperiden*
Dihydroergotamine*
Bromocriptine
Ergotamine*
Carbidopa*
Flunarizine*
Orphenadrine*
Methysergide*
Pergolide*
Pizotifen*
Selegiline
Carbamazipine*
Buspiroon*
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Ethosuximide
Chlordiazepoxide
Lamotrigine*
Clotiapine*
Flupentixol
ImipramineLofepramine
Fluzepam
Mirtazapine*
Hydroxyzine
Moclobemide*
Meprobamate
Nefazodone
Pimozide*
Nortriptyline
Risperidone*
Pemoline
Sulpiride
Phenelzine
Zopiclone*
Sertraline*
Zolpidem*
Tranylcypromine
Amitriptyline
Trazodone
Amphetamines
Trimipramine
Dothiepin
Venlafaxine
Fluvoxamine
Bethaecol
Haematological agents
Ticlopidine
Aprotinin
Musculoskeletal and rheumatological agents
Auranofin
Baclofen
Aurothiomalate
Benzbromarone
Diclofenac
Nabumetone
Dipyrone
Phenylbutazone
Ketorolac
Probenecid
Antimicrobials and antiparasitic products
Azithromycin
Itroconazole
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Chloramphenicol*
Ketokonazole*
Ciprofloxacin
Miconazole*
Clindamycin*
Clofazimine
Co-trimoxazole*
Dapsone*
Doxycycline*
Ethionamide*
Enoxacin
Isoniazid
Erythromycin*
Pyrazinamide*
Fosfomycin*
Rifabutin
Imipenem*
Rifampicin
Lincomycin
Terizidone*
Lomefloxacin
Didanosine*
Lorcarbef
Foscarnet*
Lymecycline
Indinavir
Minocycline
Lamivudine
Norfloxacin
Ritonivir
Ofloxacin
Saquinavir*
Oxytetracycline
Zidovudine (AZT)
Pivampicillin
Atovaquone*
Roxythromycin
Halofantrene*
Sparfloxacin
Melarsoprol*
Sulphonamides*
Metronidazole
Tazobactam*
Sulfadoxime*
Tetracycline
Suramin
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Trimethoprim
Tinidazole
Fluconazole
Ivermectin*
Niclosamide
Praziquantel
Piperazine*
Pyrantil*
Dermatologicals
Griseofulvin
Methoxsalen
Terbinafine
Isoretinoin
Acitretin
Anticancer and immuno-modulating agents
Bleomycin*
Mitomycin
Busulfan
Mitoxantrone
Carboplatin
Paclitaxel*
Cytarabine*
Procarbazine
Dacarbazine*
Teniposide*
Docetaxel
Troguanine
Estramustine*
Vinblastine
Etoposide*
Vindesine
Gemcitabine*
Cilcosporin
Hydroxyurea
Aminoglutethemide*
Idarubicin
Flutamide
Ifosfamide
Formestane
Lomustine*
Medroxyprogesterone
Mercaptopurine
Tamoxifen
Other drugs
alcium carbimide*
pecacuanha*
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isulfiram*
Obidoxime*
www.belimantil.info
TABLE 1:
A. DRUGS UNSAFE FOR USE IN ACUTE PORPHYRIA (1996)
These drugs have been classified as 'unsafe' because all have been shown to be porphyrinogenic
in animals or in vitro systems, or to have been associated with acute attacks in humans.
( ) Bracketed drugs are those in which there is conflicting experimental evidence of
porphyrinogenicity - some positive, - some negative
* Those marked with an asterisk have been associated with acute attacks of porphyria.
While very great care has been taken in the compilation of lists and the drug information is given
in the belief that it is correct at the time of publication, all information contained herein and
opinions expressed must be taken as information and opinions given for general guidance only.
Drug names given herein are approved names not trade or common names. The authors hereby
disclaim for themselves , the Porphyria Services, The National Health and Medical Research
Council, The University of Queensland, Griffith University, Queensland Health and the
Porphyria Charitable Trust, all responsibility for any misstatement or for the consequences to any
person of any person acting in reliance on any statement or opinion contained herein. Medical
practitioners and patients must make their own decisions in the circumstances of the particular
case about therapy appropriate in any case of acute porphyria.
A:
*ETHOTOIN
OXANAMIDE
ALCURONIUM
ETIDOCAINE
(OXAZEPAM)
*ALPHAXALONE: ALPHADOLONE
ETOMIDATE F: FENFLURAMINE
OXYBUTYNIN HCl
ALPRAZOLAM
*FLUCLOXACILLIN
OXYCODONE
ALUMINIUM PREPARATIONS
*FLUFENAMIC ACID
*OXYMETAZOLINE
AMIDOPYRINE
FLUNITRAZEPAM
*OXYPHENBUTAZONE
AMINOGLUTETHIMIDE
FLUPENTHIXOL
OXYTETRACYCLINE
AMINOPHYLLINE
FLURAZEPAM
P:
AMIODARONE
*FRUSEMIDE
PARAMETHADIONE
*AMITRIPTYLINE
G:
PARGYLINE
*GLIBENCLAMIDE
*PENTAZOCINE
*GLUTETHIMIDE
PERHEXILINE
*GLIPIZIDE
PHENACETIN
(AMPHETAMINES)
*AMYLOBARBITONE
ANTIPYRINE
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*AURANOFIN
GRAMICIDIN
PHENELZINE
*AUROTHIOMALATE
*GRISEOFULVIN
*PHENOBARBITONE
AZAPROPAZONE
PHENOXYBENZAMINE
H:
*PHENSUXIMIDE
B:
(HALOPERIDOL)
BACLOFEN
*HALOTHANE
*BARBITURATES
*HYDANTOINS
*BEMEGRIDE
*HYDRALAZINE
BENDROFLUAZIDE
*HYDROCHLOROTHIAZIDE
BENOXAPROFEN
*HYDROXYZINE
BENZBROMARONE
HYOSCINE
*PHENYLBUTAZONE
PHENYLHYDRAZINE
*PHENYTOIN
PIPEBUZONE
PIPEMIDIC ACID
PIRITRAMIDE
*PIROXICAM
(BENZYLTHIOURACIL)
I:
*PIVAMPICILLIN
*IMIPRAMINE
*PIVMECILLINAM
IPRONIAZID
PRAZEPAM
ISOMETHEPTENE MUCATE
PRENYLAMINE
(ISONIAZID)
*PRILOCAINE
(BEPRIDIL)
BROMOCRIPTINE
BUSULPHAN
*BUTYLSCOPOLAMINE
C:
*PRIMIDONE
K:
CAPTOPRIL
(PROBENECID)
KEBUZONE
*CARBAMAZEPINE
*PROGESTERONE
KETOCONAZOLE
*CARBROMAL
PROGABIDE
*CARISOPRODOL
L:
(CEFUROXIME)
*LEVONORGESTROL
(CEPHALEXIN)
LIGNOCAINE
(CEPHALOSPORINS)
*LISINOPRIL
(CEPHRADINE)
LOPRAZOLAM
(CHLORAMBUCIL)
LOXAPINE
PROMETHAZINE
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(PROPANIDID)
*PYRAZINAMIDE
PYRROCAINE
Q:
QUINALBARBITONE
*CHLORAMPHENICOL
*LYNESTRENOL
R:
*CHLORDIAZEPOXIDE
LYSURIDE MALEATE
RIFAMPICIN
*CHLORMEZANONE
M:
CHLOROFORM
S:
MAPROTILINE HCl
*CHLORPROPAMIDE
SIMVASTATIN
MEBEVERINE HCl
CIMETIDINE
SODIUM AUROTHIOMALATE
*MECILLINAM
CINNARIZINE
SODIUM OXYBATE
*MEDROXYPROGESTERONE
CLEMASTINE
(SODIUM VALPROATE)
(MEFENAMIC ACID)
(CLOBAZAM)
*SPIRONOLACTONE
MEGESTROL ACETATE
(CLOMIPRAMINE HCl)
STANOZOLOL
*MEPHENYTOIN
(CLONAZEPAM)
SUCCINIMIDES
MEPIVACAINE
CLONIDINE HCL
*SULPHACETAMIDE
*MEPROBAMATE
*CLORAZEPATE
*SULPHADIAZINE
MERCAPTOPURINE
COCAINE
*SULPHADIMIDINE
MERCURY COMPOUNDS
(COLISTIN)
*SULPHADOXINE
MESTRANOL
CO-TRIMOXAZOLE
*SULPHAMETHOXAZOLE
(METAPRAMINE HCl)
CYCLOPHOSPHAMIDE
*SULPHASALAZINE
METHAMPHETAMINE
CYCLOSERINE
*SULPHONYLUREAS
METHOHEXITONE
CYCLOSPORIN
SULPHINPYRAZONE
METHOTREXATE
SULPIRIDE
D:
METHOXYFLURANE
DANAZOL
METHSUXIMIDE
*DAPSONE
*METHYL DOPA
DEXFENFLURAMINE
*METHYL SULPHONAL
T:
DEXTROPROPOXYPHENE
*METHYPRYLONE
*TAMOXIFEN
DIAZEPAM
METHYSERGIDE
*TERFENADINE
SULTHIAME
SULTOPRIDE
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*DICHLORALPHENAZONE
*METOCLOPRAMIDE
TETRAZEPAM
*DICLOFENAC Na
METYRAPONE
*THEOPHYLLINE
DIENOESTROL
MIANSERIN HCl
*THIOPENTONE Na
DIETHYLPROPION
MICONAZOLE
THIORIDAZINE
DIHYDRALAZINE
(MIFEPRISTONE)
TILIDATE
*DIHYDROERGOTAMINE
MINOXIDIL
TINIDAZOLE
DILTIAZEM
*TOLAZAMIDE
N:
*DIMENHYDRINATE
*TOLBUTAMIDE
*NADROLONE
*DIPHENHYDRAMINE
TRANYLCYPROMINE
*NALIDIXIC ACID
(DOTHIEPIN HCl)
TRAZODONE HCl
NATAMYCIN
DOXYCYCLINE
TRIMETHOPRIM
*NANDROLONE
*DYDROGESTERONE)
(TRIMIPRAMINE)
(NICERGOLINE)
TROXIDONE
E:
*NIFEDIPINE
*ECONAZOLE NO3
*NIKETHAMIDE
V:
*ENALAPRIL
NITRAZEPAM
VALPROATE
ENFLURANE
*NITROFURANTOIN
VALPROMIDE
*ERGOT COMPOUNDS
NORDAZEPAM
VERALIPRIDE
ERGOMETRINE MALEATE
NORETHYNODREL
*VERAPAMIL
ERGOTAMINE TARTRATE
*NORETHISTERONE
*VIBRAMYCIN
*ERYTHROMYCIN
(NORTRIPTYLINE)
VILOXAZINE HCl
*ESTRAMUSTINE
NOVOBIOCIN
(VINBLASTINE)
ETHAMSYLATE
(VINCRISTINE)
O:
*ETHANOL
*ORAL CONTRACEPTIVES
Z:
*ORPHENADRINE
ZUCLOPENTHIXOL
ETHIONAMIDE
*ETHOSUXIMIDE
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www.belimantil.info
Table 1. Drugs Thought Safe in Porphyria*
Acetazolamide
acetylcholine
Actinomycin D
Acyclovir
Adenosine
monophosphate
Adrenaline
Alclofenac
Allopurinol
Alpha tocopheryl
Acetate
Amethocaine
Amiloride
Aminocaproic acid
Aminoglycosides
Amoxicillin
Amphotericin
Ampicillin
Ascorbic acid
Aspirin
Atenolol
Atropine
Azathioprine
Beclomethasone
Benzhexol HCl
Beta-carotene
Biguanides
[Bromazepam]
Bromides
Buflomedil HCl
Bumetanide
Bupivacaine
Buprenorphine
Buserelin
Butacaine SO4
Canthaxanthin
Carbimazole
[Carpipramine HCl]
Chloral hydrate
[Chlormethiazole]
[Chloroquine]
[Chlorothiazide]
Chlorpheniramine
Chlorpromazine
Coumarins
Cyclizine
Cyclopenthiazide
Cyclopropane
[Cyproterone
acetate]
Danthron
Desferrioxamine
Dexamethasone
[Dextromoramide]
Dextrose
Diamorphine
Diazoxide
Dicyclomine HCl
Diflunisal
Digoxin
Dihydrocodeine
Dimercaprol
Dimethicone
Dinoprost
Diphenoxylate
HCl
Dipyridamole
[Disopyramide]
Domperidone
Doxorubicin HCl
Droperidol
[Estazolam]
Ethacrynic acid
Ethambutol
[Ethinyl
oestradiol]
Ethoheptazine
citrate
Etoposide
Famotidine
Fenbufen
[Fenofibrate]
Fenoprofen
Fentanyl
Flucytosine
Flumazenil
Fluoxetine HCl
Flurbiprofen
Ketoprofen
Ketotifen
Labetalol
Luteinizing
hormone–releasing
hormone
Liquorice
Lithium
Salts lofepramine
Loperamide
[Lorazepam]
Magnesiumsulphate
[Mebendazole]
Mecamylamine
Meclofenoxate HCl
Meclozine
Mefloquine HCl
[Melphalan]
Meptazinol
Mequitazine
Metformin
Methadone
[Methotrimeprazine]
Methylphenidate
Methyluracil
Metipropranolol
Metopimazine
Metoprolol
[Metronidazole]
[Midazolam]
Minaprine HCl
Minaxolone
Morphine
Nadolol
Naftidrofuryl
Oxalate
[Naproxen sodium]
Natamycin
Nefopam HCl
Neostigmine
Netilmicin
Niflumic acid
Nitrous oxide
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Palmitate
Piracetam
Pirbuterol
Pirenzepine
Pizotifen
[Prazosin]
[Prednisolone]
Primaquine
Probucol
Procainamide HCl
Procaine
Prochlorperazine
Proguanil HCl
Promazine
Propantheline Br
Propofol
Propranolol
Propylthiouracil
[Proxymetacaine]
Pseudoephedrine HCl
Pyridoxine
[Pyrimethamine]
Quinidine
Quinine
[Ranitidine]
Reserpine
Resorcinol
Salbutamol
Senna
Sodium bromide
Sodium
ethylenediaminetetraacetic
acid
Sodium fusidate
Sorbitol
Streptomycin
Sulbutiamine
Sulindac
Sulfadoxine
Suxamethonium
Talampicillin
Temazepam
Tetracaine
[Tetracyclines]
Ciprofloxacin
Cisapride
Cisplatin
Clavulanic acid
Clofibrate
Clomiphene
Cloxacillin
Co-codamol
Codeine phosphate
Colchicine
[Corticosteroids]
Corticotrophin
(adrenocorticotropic
hormone [ACTH])
Fluvoxamine
Maleate
Folic acid
Fructose
Fusidic acid
Folliclestimulating
hormone
Gentamicin
Glafenine
Glucagon
Glucose
Glyceryl trinitrate
Goserelin
Guanethidine
Guanfacine HCl
Haem arginate
[Haloperidol]
Heparin
Heptaminol HCl
Hexamine
[Hydrocortisone]
Ibuprofen
Indomethacin
Insulin
Iron
Josamycin
[Ketamine]
Norfloxacin
Ofloxacin
Oxolinic acid
Oxybuprocaine
[Oxyphenbutazone]
Oxytocin
[Pancuronium
bromide]
Paracetamol
Paraldehyde
Parapenzolate Br
Penicillamine
Penicillin
Pentolinium
Pericyazine
Pethidine
Phenformin
Phenoperidine
Phentolamine
mesylate
Pipotiazine
Thiouracils
Thyroxine
Tiaprofenic acid
Ticarcillin
Tienilic acid
Timolol maleate
Tolazoline
Tranexamic acid
Triacetyloleandomycin
Triamterene
Triazolam
[Trichlormethiazide]
Trifluoperazine
Trimeprazine
Tartrate
Trimetazidine HCl
Tripelennamine
Tubocurarine
Vancomycin
[Vincristine]
Vitamins
Warfarin sodium
Zidovudine
Zinc Preparations
*Bracketed [ ] drugs are those in which experimental evidence of porphyrin
genicity is conflicting.
Table 2. Drugs Thought Unsafe in Porphyria†
Alcuronium
*Alphaxalone
Alphadolone
Alprazolam
Aluminium
Preparations
Amidopyrine
Aminoglutethimide
Aminophylline
Amiodarone
*Amitriptyline
Cyclophosphamide
Cycloserine
Cyclosporin
Danazol
*Dapsone
Dexfenfluramine
Dextropropoxyphene
Diazepam
*Dichloralphenazone
*Diclofenac Na
Dienoestrol
Maleate
Maprotiline HCl
Mebeverine HCl
*Mecillinam
*Medroxyprogesterone
[Mefenamic acid]
Megestrol acetate
*Mephenytoin
Mepivacaine
*Meprobamate
Mercaptopurine
www.belimantil.info
*Pivampicillin
*Pivmecillinam
Prazepam
Prenylamine
*Prilocaine
*Primidone
[Probenecid]
*Progesterone
Progabide
Promethazine
[Propanidid]
[Amphetamines]
*Amylobarbitone
Antipyrine
*Auranofin
*Aurothiomalate
Azapropazone
Baclofen
*Barbiturates
*Bemegride
Bendrofluazide
Benoxaprofen
Benzbromarone
[Benzylthiouracil]
[Bepridil]
Bromocriptine
Busulphan
*Butylscopolamine
Captopril
*Carbamazepine
*Carbromal
*Carisoprodol
[Cefuroxime]
[Cephalexin]
[Cephalosporins]
[Cephradine]
[Chlorambucil]
*Chloramphenicol
*Chlordiazepoxide
*Chlormezanone
Chloroform
*Chlorpropamide
Cinnarizine
Clemastine
[Clobazam]
[Clomipramine
HCl]
[Clonazepam]
Clonidine HCl
*Clorazepate
Cocaine
[Colistin]
Co-trimoxazole
Diethylpropion
Dihydralazine
*Dihydroergotamine
Diltiazem
*Dimenhydrinate
*Diphenhydramine
[Dothiepin HCl]
Doxycycline
*Dydrogesterone
*Econazole NO3
*Enalapril
Enflurane
*Ergot compounds
Ergometrine maleate
Ergotamine tartrate
*Erythromycin
*Estramustine
Ethamsylate
*Ethanol
Ethionamide
*Ethosuximide
*Ethotoin
Etidocaine
Etomidate
Fenfluramine
*Flucloxacillin
*Flufenamic acid
Flunitrazepam
Flupenthixol
Flurazepam
*Frusemide
*Glibenclamide
*Glutethimide
*Glipizide
Gramicidin
*Griseofulvin
[Haloperidol]
*Halothane
*Hydantoins
*Hydralazine
*Hydrochlorothiazide
*Hydroxyzine
Hyoscine
*Imipramine
Iproniazid
Isometheptene
Mercury compounds
Mestranol
[Metapramine HCl]
Methamphetamine
Methohexitone
Methotrexate
Methoxyflurane
Methsuximide
*Methyldopa
*Methylsulphonal
*Methyprylone
Methysergide
*Metoclopramide
Metyrapone
Mianserin HCl
Miconazole
[Mifepristone]
Minoxidil
*Nandrolone
*Nalidixic acid
Natamycin
*Nandrolone
[Nicergoline]
*Nifedipine
*Nikethamide
Nitrazepam
*Nitrofurantoin
Nordazepam
Norethynodrel
*Norethisterone
[Nortriptyline]
Novobiocin
*Oral contraceptives
*Orphenadrine
Oxanamide
[Oxazepam]
Oxybutynin HCl
Oxycodone
*Oxymetazoline
*Oxyphenbutazone
Oxytetracycline
Paramethadione
Pargyline
*Pentazocine
Perhexiline
Phenacetin
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*Pyrazinamide
Pyrrocaine
Quinalbarbitone
Rifampicin
Simvastatin
Sodium
aurothiomalate
Sodium oxybate
[Sodium valproate]
*Spironolactone
Stanozolol
Succinimides
*Sulfacetamide
*Sulfadiazine
*Sulfadimidine
*Sulfadoxine
*Sulfamethoxazole
*Sulfasalazine
*Sulfonylureas
Sulfinpyrazone
Sulpiride
Sulthiame
Sultopride
*Tamoxifen
*Terfenadine
Tetrazepam
*Theophylline
*Thiopentone Na
Thioridazine
Tilidate
Tinidazole
*Tolazamide
*Tolbutamide
Tranylcypromine
Trazodone HCl
Trimethoprim
[Trimipramine]
Troxidone
Valproate
Valpromide
Veralipride
*Verapamil
*Vibramycin
Viloxazine HCl
[Vinblastine]
[Vincristine]
mucate
[Isoniazid]
Kebuzone
Ketoconazole
*Levonorgestrel
Lignocaine
*Lisinopril
Loprazolam
Loxapine
*Lynestrenol
Lysuride
Phenelzine
*Phenobarbitone
Phenoxybenzamine
*Phensuximide
*Phenylbutazone
Phenylhydrazine
*Phenytoin
Pipebuzone
Pipemidic
Acid
Piritramide
*Piroxicam
Zuclopenthixol
*These drugs have been associated with acute attacks of porphyria.
†Bracketed [ ] drugs are those in which experimental evidence of
porphyringenicity is conflicting.
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PREKURSORI METABOLITA HEMOGLOBINA U 24-ČASOVNOM URINU
( REFERENTNE VREDNOSTI)
KOPROPORFIRIN
<
0,180 mikromola/l
UROPORFIRIN
<
1,2
PORFOBILINOGEN
mikromola/l
4,4 - 8,84 mikromola/l
ALK(deltaaminolevulinska kiselina) < 76,3 mikromola/l
www.belimantil.info
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