Genetics & Molecular Biology
GlgS, previously described as a glycogen synthesis control protein, is a major negative
regulator of flagellar synthesis and motility, type 1 fimbriae adhesins and biofilm
polysaccharides production in Escherichia coli
Rahimpour M, Montero M, Almagro G, Viale AM, Sevilla A, Cánovas M, Muñoz FJ, BarojaFernández E, Bahaji A, Eydallin G, Dose H, Takeuchi R, Mori H,Pozueta-Romero J.
[email protected]
Public University of Navarra
Trustee of the paper: Javier Pozueta Romero
Introduction: Escherichia coli glycogen metabolism involves regulation of the glgBXCAP operon
expression and allosteric control of GlgC catalyzing the conversion of ATP and glucose-1-phosphate
(G1P) into ADP-glucose linked to glycogen biosynthesis. E. coli glycogen metabolism is also affected
by glgS, which encodes a small protein of still unknown function whose deficiency causes both
reduced glycogen content and enhanced levels of the GlgC negative allosteric regulator AMP.
Aim of the study: To get insight into the cellular function(s) of GlgS
Materials and methods: , we conducted a transcriptomic analysis of E. coli BW25113 ∆glgS cells.
Results: Transcriptomic analyses reported in this work revealed that, compared with their isogenic
BW25113 wild type strain, glgS null mutants of E. coli have increased expression of operons involved
in the synthesis of type 1 fimbriae adhesins, flagella, and nucleotides. In concordance, glgS null
mutant cells were hyperflagellated and hyperfimbriated, and displayed elevated swarming motility,
phenotypes which were all reverted by ectopic glgS expression. Also, ∆glgS cells accumulated high
colanic acid content, and displayed increased ability to form biofilms on polysterene surfaces. F-driven
conjugation based large-scale interaction studies of glgS with all the nonessential genes of E. coli
showed that deletion of purine biosynthesis genes complement the glycogen-deficient, high motility
and high biofilm content phenotypes of glgS null mutants cells.
Conclusions: The overall data thus indicated that glycogen deficiency in ∆glgS mutants can be
ascribed to high flagellar propulsion and high exopolysaccharide and purine nucleotides biosynthetic
activites competing with GlgC for the same ATP and G1P pools. Supporting this proposal, the
impairment of motility by the introduction of a ∆flhC null allele reverted the glycogen deficient
phenotype in ∆glgS mutants. Moreover, glycogen-less ∆glgC cells displayed elevated swarming
motility phenotype, and accumulated high levels of colanic acid and biofilm. Furthermore, glgC overexpression reverted the glycogen-deficient, high swarming motility, high colanic acid and high biofilm
content phenotypes of ∆glgS cells.
The paper was withdrawn by the author
The comparison of blood plasma proteomic profiles of colorectal cancer patients and the
control group.
D. Khmelevskoy, Y. Romanova
[email protected]
Saint Petersburg State University
Trustee of the paper: O. Vostryukhina, senior scientist of the laboratory of molecular genetics
Petersburg Nuclear Physics Institute
Introduction: One of the most common oncological diseases is colorectal cancer (CC). Every day
about one million cases of the disease is recorded in the world. The five-year survival rates for patients
who had the tumor diagnosed at the first stage and then removed is 90%. Thus, the search of CC
protein markers in blood plasma appears to be a crucial issue in a present day research and will
certainly help to develop new methods of early diagnostics in the future years.
Aim of the study: The aim of the research was the search of CC protein markers using twodimensional electrophoresis. In order to achieve this goal the following tasks were set: to develop
methodology for purification of albumin (Al) and immunoglobulin G (IgG) from plasma
Materials and methods: The blood samples were sent to Saint Petersburg State I. P. Pavlov Medical
University. The formed elements were sedimented by centrifugation at 4000g. The purification of such
proteins as Al and IgG, was conducted in two chromatographic stages with the usage of the following
carriers: sepharose Cibacron blue and protein-A-sepharose. Samples formed in that way were
separated in 2DPAGE in order to compare their proteomic profiles and identify proteins. In the present
research we compared the blood plasma protein profiles of healthy people (5 people + 2 people with
colonic pathology, but free from CC) and patients with diagnosed CC (3 patients).
Results: The assumption was made, on the basis of UniProt data base and protein profiles gained in
two-dimensional electrophoregrams, that some patterns correlate with particular proteins:
apolipoprotein Al, complement C4-B, haptoglobin, prealbumin, retinol-binding protein 4.
Conclusions: The following conclusions can be made: the procedure was developed for the
preparation of blood plasma samples to compare their proteomic profiles after 2DPAGE. The potential
CC biomarkers were chosen from the sources.
Law & Medicine
Prof. dr hab. Eleonora Zielińska
Dr Leszek Bosek
Dr Anna Augustynowicz
Mgr Katarzyna Syroka
Dr Maciej Niewada
Dr Adam Goszczycki (Expert’s lecture)
Coordinator of the Session:
Aleksander Zarzeka
Maja Czyżewska
Ewa Celi
Patronage of the Session:
Dean of Department of Health Sciences – Medical University of Warsaw
“Galen – Medical University of Warsaw Students’ Magazine”
“Lexuss – University of Warsaw Law Students’ Magazine”
Organizers of the session:
Cooperation with:
Friday, 10.05.2013
Aula A
Oral presentations:
Agnieszka Barańska
Artem S. Kuleshov
Anna Kornakiewicz
Joanna Wiszniewska
Michał Gajdus
Adrian Marcin Bielecki
Piotr Lech
Bartłomiej Sasin
Aleksandra Orzeł
Tomasz Szekalski
Katarzyna Orzeł
Maciej Barański
Mirona M. Klorek
Adriana Lubiejewska
Maria Dzięgielewska
Wiktor Krzymowski
Krzysztof Olszak
Krzysztof Kumala
Barbara Radoń
Anna Laszczyk
Ezgi Vural
The problem of parallel trade - how to kill two birds with one stone?
Anna Laszczyk
[email protected]
University of Łódź / Linklaters law firm
Introduction: Polish patients suffer from the shortages of medicines... – how many times a year
one can read such notices. The first question is, who is to be blamed? Government,
pharmaceutical companies, wholesalers or maybe pharmacies? Nevertheless, the shortages
on one market in the European Union suppose to mean oversupply on the market in another
country of the EU. It happens because of parallel trade. The second question is who wins and
takes the money – patients who obtain cheaper medicines or wholesalers? This issue is even
more complicated. On the one hand, pharmaceutical companies are expected to minimise
shortages and on the other, when they take action and introduce new distribution systems they
face competition and pharmaceutical probes by relevant authorities. At this point, it is worth
noticing that limiting parallel trade constitutes a restriction of competition and limiting supply
to pharmacies is contrary to relevant provisions of Polish pharmaceutical law.
Aim of the study: The aim of this paper is to tackle a problem of parallel trade of
pharmaceuticals. The author will assess various distribution systems, applied by the
companies, from the perspectives of competition law and pharmaceutical law. Moreover, the
opposite approach of Polish Competition Authority and General Pharmaceutical Inspectorate
towards Astra Zeneca Direct to Pharmacy system will be analysed in details. Acknowledging
that pharmaceutical companies are allowed to limit supply and introducing quotas to a certain
extent, the author will analyse a recent report published by the European Association of EuroPharmaceutical Companies on the parallel import which clearly states that such a procedure
benefits consumers.
Materials and methods: The author will use dogmatic and comparative methods as well as
methods of the economic analysis of law. The author will analyse decision and judgments of
the national competition authorities as well as of the European Commission and the Court of
Justice of the European as regards parallel trade in the pharmaceutical sector.
Results: In the view of the author, bearing in mind characteristics of the pharmaceutical sector
and its vital role for consumers, the competition authorities shall adopt more effects-based
approach towards practices of pharmaceutical companies.
Conclusions: Acknowledging that consumers are final users who shall benefit from
competition, both competition and pharmaceutical law should have satisfying patients needs
as an objective.
Internal Diseases
This paper was presented in Endocrynology&Diabetology session
The differences between patients with and without family history of diabetic foot occurrence in
neuropathic diabetic foot population with type 2 diabetes mellitus.
Kaszuba A; Maroszek P; Krzyżewska M; Łukawska M; Bizoń M; Mrozikiewicz-Rakowska B, MD,PhD;
Krasnodębski P, MD,PhD; Nehring P,M
[email protected]
Gastroenterological Scientific Group, Department of Gastroenterology and Metabolic Diseases,
Medical University of Warsaw
Trustee of the paper: Beata Mrozikiewicz-Rakowska, MD, PhD; Przemysław Krasnodębski, MD,PhD
Introduction: Diabetic foot (DF) of neuropathic origin is the most common form of DF present in about
65% of cases of this complication. Clinical observations shows that among patients with DF there are
differences resulting from the presence of DF family history.
Aim of the Study: The aim of the study was to identify differences between patient with and without
DF family history in T2DM population with DF of neuropathic origin presence.
Material and methods: The study included 76 individuals with T2DM and DF of neuropathic origin, 15
with DF family history 61 without. The study was conducted in Gastroenterology and Metabolic
Diseases Department, Medical University of Warsaw. Statistical analysis was performed with
STATISTICA 10. (StatSoft, Inc. 2011) software.
Results: There were no differences between studied groups in age (61.63±8.85 vs. 65.57±10.83) and
gender (male– 8, female-7 vs. male- 40, female- 21) structure. Patients with DF family history had
T2DM diagnosed earlier (37.43±12.74 vs. 45.75±11.40; p=0.02). Patients from study group started
insulin therapy earlier (43.36±14.57 vs. 51.98±11.09; p=0,02). Individuals with DF family history had
positive T2DM family history more often (p=0.005), in male younger age of myocardium infarction
(47.00±5.08 vs. 56.14±7.67; p=0.04). Women with DF family history were younger (55.57±14.33 vs.
68.45±12.92; p=0.04), had higher WHR (0.97±0.02 vs. 0.59±0.09; p=0.03). T2DM was diagnosed in
younger age (33.29 ± 14.84 vs. 48.40 ± 14.53; p=0.03) and insulin therapy was initiated in younger
age (36.71±16.46 vs. 55.06±12.33; p=0.006) and the age of DF onset was younger (49.14±13.95 vs.
61.95±13.81; p=0.04).
Conclusions: Due to several differences between studied groups, there is a necessity to turn
attention at patients with positive history of DF in family. Patients with DF of neuropathic origin and
positive family history of DF are of high risk of severe complications of long lasting diabetes.
Endocrinology and Diabetology
Friday, 10.05.2013
Room 232
Oral presentations:
Kahlon Rramandeep Singh
Małgorzata Grzanka
Ewa Żurawska-Płaksej
Tatsiana Reshetskaya
Joanna Kania
Paweł Maroszek
Anna Poradzka
Natālija Nikrus
Marcin Miadziółko
Ieva Kalere
Aleksander Kuś
Poster presentations:
Nestan Bostoganashvili
Mariya Mardamshina
Ilona Kazek
Magdalena Kmiecik
Hanna Demyashkevich
Mateusz Pyrzyński
Olga Gulinskaya
Emilia Mórawska
Prashant Kumar Prusty
Ewelina Bucior
Anja Kaszuba
Analysis of type 2 diabetes pharmacotherapy under outpatient diabetes care
Magdalena Kmiecik, Anna Poradzka, Mariusz Jasik, Elzbieta Wojcik-Sosnowska, Waldemar Karnafel
[email protected]
Department of Gastroenterology and Metabolic Diseases, Medical University of Warsaw
Trustee of the paper: Prof. Waldemar Karnafel
Introduction: According to Polish Diabetes Association (2013) recommendations reduction of
hyperglycemia in type 2 diabetes is crucial in reducing the progression of chronic complications of
diabetes. Treatment algorithm for type 2 diabetes at any stage includes lifestyle modification,
monotherapy, combination oral therapy and insulin.
Aim of the study: The analysis of pharmacotherapy type 2 diabetes in a diabetes outpatient care and
its effect on glycemic control, weight maintenance, lipid parameters, blood pressure, presence of late
diabetic micro-and macrovascular complications.
Materials and methods: The analysis included 575 patients with type 2 diabetes (305 women, 270
men, average age: 66.8 years; average diabetes duration: 10.8 years, average HbA1c: 7.3%) under
outpatient diabetes care in 2010 -2012.
A retrospective analysis of data on applied pharmacology, metabolic control of diabetes, metabolic
syndrome components, the occurrence of late complications.
Results: Oral hypoglycemic drugs were used in 69% of patients, including 59% of metformin,
sulphonylureas in 32%. The use of incretin drugs and thiazolidinediones were not used. The use of
oral antidiabetic medications showed a negative correlation with fasting glucose, after-meal glucose
and HbA1c. Sulfonylureas used in patients with a lower body weight and metformin in people with
overweight and obesity. Insulin was used in 50% of patients, 42% of patients was treated by at least
one specimen of human insulin, in 30% of patients prescribed a rapid analog, in 7% long-acting
analog. In patients receiving different insulin specimens have shown a positive correlation with the
presence of micro-and macrovascular disease, hyperglycemia in the fasting state and after meals and
increased HbA1c.The use of insulin (except long-acting analogs) showed a positive correlation with
the occurrence of long-term complications.
Conclusions: 1. In-patient care is the most commonly used diabetes metformin, sulfonylureas rarely
2. Insulin was used in half of the patients, typically human insulin specimens, more than one third of
insulin analogues.
3. Patients receiving oral antidiabetic drugs have better controlled diabetes, less have metabolic
syndrome and less long-term complications than insulin-treated patients.
General Surgery
prof. dr hab. n. med. Krzysztof Bielecki
prof. dr hab. n. med. Waldemar Kostewicz
prof. dr hab. n. med. Ireneusz Krasnodębski
prof. dr hab. n. med. Andrzej Szczepanik
dr n. med. Marcin Osęka
dr n. med. Katarzyna Grygiel
Coordinator of the Session:
Milena Duralska
Katarzyna Malinowska
Patronage of the Session:
Sponsors of the Session:
This paper was withdrawn by the author and is not valid
Gallbladder perforation during laparoscopic cholecystectomy/ 1013 cholecystectomies
analyzed until March 2013
Mariusz Ligocki, Joanna Ligocka, Sylwia Gajda, Marcin Morawski
[email protected]
Medical University of Warsaw
Trustee of the paper: Oskar Kornasiewicz, MD PhD
Introduction: Laparoscopic cholecystectomy is accepted as the treatment of choice for acute
cholecystitis. Perforation of the gallbladder may occur during cholecystectomy and leads to spillage of
bile and gallstones. Because of spreading contamination, the influence on morbidity may be expected.
Aim of the study: The aim of this study was to compare laparoscopic with open cholecystectomy
technic by assessing the morbidity and mortality rates, with a special consideration of the incidence of
the gallbladder perforation.
Materials and methods: 1013 cholecystectomies between January 2004 and March 2013 were
included in this retrospective examination. The rate of gallbladder perforation was established on the
basis of the operative charts data. Gender, age, type of cholecystectomy, postoperative complications
and duration of hospitalization were collected. Statistical analysis was performed.
Results: 689 of 1013 (68.02%) patients underwent laparoscopic cholecystectomy. Morbidity and
mortality rates in laparoscopic and open cholecystectomy were 1.31% vs. 8.64% (p<0.01) and 0.00%
vs. 1.23% (p<0.01) respectively. Median duration of hospitalization in laparoscopic and open
cholecystectomy were 2 and 7 days (p<0.01). Compared to laparotomy, gallbladder perforation
occurred more often during laparoscopic cholecystectomy (8.27% vs. 1.85%; p<0.01). Wound
infection and fever were observed more frequently in the group of patients with gallbladder perforation
(8.56% vs. 1.85%; p<0.01). No incidence of biliary peritonitis or sepsis were observed.
Conclusions: Gallbladder perforation may occur more often during laparoscopic cholecystectomy.
Although the overall complication rate in laparoscopic is less than the open approach, complications
that occur with greater frequency during it is iatrogenic gall bladder perforation. It can be associated
with increased risk of fever and wound infection. However comparing overall morbidity and mortality
rates, laparoscopic cholecystectomy is associated with better treatment results. IGBP is not a direct
indication to a conversion. Moreover the incidence of perforation probably decreases with learning
curve, what would improve the results more.
Case Report
dr hab. n. med. Grzegorz Basak
dr n. med. Katarzyna Grygiel
dr n. med. Dominika Karkocha
lek. Adam Koleśnik
lek. Tomasz Mitek
lek. Emilia Karchier
dr n. med. Anna Ścibisz
lek. Michalina Galas
dr n. med. Tomasz Guzel
dr n. med. Magdalena Dylewska
lek. Leszek Kraj
lek. Radosław Wilimski
dr n. med. Ewa Talarek
dr n. med. Ewa Duszczyk
dr n. med. Marta Maskey-Warzęchowska
dr n. med. Maciej Cićkiewicz
lek. dent. Karolina Kowalczyk
lek. stom. Piotr Regulski
Coordinators of the Session:
Aleksandra Piechuta
Rafał Roszkowski
Paweł Sobczuk
Michał Piekarz
Sponsor of the Session:
Surgical: 10.05.2013
Internal: 11.05.2013
Dentistry: 12.05.2013
Surgical: room 233
Internal: Aula A
Dentistry: Aula A
Oral presentations:
Maciej Piotr Książyk
Magdalena Chorążka
Jakub Mrozek
Marta Zygmunt
Przemysław Zwierz
Michał Andrzej Lipa
Katarzyna Zbierska
Izabela Lenczewska
Jakub Edward Kempisty
Katarzyna Baranowska
Marta Paulina Wiącek
Tomasz Wesołowski
Tomasz Kozłowski
Agata Katarzyna Kupiec
Łukasz Szczerbiński
Mateusz Klukowski
Mariusz Kowalewski
Melih Ucan
Paulina Maria Nowicka
Anna Kowalewska
Bartosz Rymuza
Monika Walankiewicz
Karolina Gąsiorowska
Emilia Mórawska
Sandra Monika Mrozińska
Katarzyna Nowak
Piotr Kwiatkowski
Anna Maria Śladowska
Aleksandra Berkan
Anna Lasek
Katarzyna Maria Piec
Magdalena Kwiatkowska
Sebastian Nowak
Adam Arndt
Magdalena Banach
Ilga Grinberga
Sylwia Gajda
Anita Sirenko
Paulina Kosińska
Małgorzata Bilińska
Sylwia Gajda
Olga Izabela Kuczkiewicz
Arturs Balodis
Tomasz Artur Tokarek
Olga Marta Zaucha
Hanna Błaszczyk
Katarzyna Zawiślak
Urszula Coupland
Krystian Kaczmarek
Nino Zarkua
Anna Janiszewska
Grzegorz Łukasz Biedroń
Klaudia Juszczuk
Aleksandra Alicja Brutkiewicz
Agnieszka Pęczuła
Hubert Gołąbek
Radosław Tomasz Nisztor
Luiza Kamila Zalewska
Jakub Zieliński
Joanna Ligocka
Thomas Robert Wojda
Paulina Czarnecka
Katarzyna Żukowska
Paweł Gajkowski
Aleksandra Piechuta
Małgorzata Barbara Bizoń
Agata Łoczewska
Emilia Milczarek
Sara Zawadzka
Anna Danowska
Firman Hasan
Anastasiya Zasimovich
Miłosz Dymon
Małgorzata Natalia Osmola
Dariusz Grzelecki
Grzegorz Gula
Rafał Roszkowski
Pulmonology & Alergology
Dr hab. n. med. Piotr Gutkowski
Prof. dr hab. n. med. Tomasz Targowski
Prof. dr hab. n. med. Monika Szturmowicz
Coordinator of the session:
Kamila Łukasiak
Olga Radlińska
Expert’s lecture:
"Non-tuberculous mycobacterial lung diseases - epidemiology and predisposing factors"
Prof. dr hab. n. med. Monika Szturmowicz
Patronage of the Session:
Health Sciences & Epidemiology
Prof. dr hab. n .med. Mirosław Jarosz
Prof. dr hab. n. med. Józef Knap
Dr n. med Mariusz Gujski
Dr n.med. Beata Sokół-Leszczyńska
Dr inż. Beata Sińska
Coordinators of the session:
Adriana Bałazy
Małgorzata Myślińska
Patronage of the session:
Sponsor of the session:
Prof. dr hab. n. med. Janina Stępińska
Prof. dr hab. n. med. Zbigniew Gaciong
Prof. nadzw. dr hab. n. med. Dariusz Kosior
Dr hab. n. med. Marek Kuch
Prof. nadzw. dr hab. n. med. Mariusz Kruk
Dr n. med. Renata Główczyńska
Prof. nadzw. dr hab. n. med. Elżbieta Katarzyna Biernacka
Dr hab. n. med. Agnieszka Kuch-Wocial
Coordinator of the Session:
Magdalena Pawelec
Maciej Łuba
Aleksander Szczęsny
Patronage of the Session:
Sponsors of the Session:
Friday, 10.05.2013
Aula B
Oral presentations:
Anton Zaneuski
Karolina Chojnacka
Petrulevich Yulija
Łukasz Wardziak
Baiba Lurina
Agnieszka Babińska
Magdalena Bajer
Patrycja Gajda
Rafał Reguła
Jarosław Skowroński
Radosław Sierpiński
Dominika Klimczak
Anna Kowalewska
Martyna Wróblewska
Bartosz Rymuza
Poster presentations:
Mariusz Kowalewski
A.V. Boltach
Stefan Simovic
Sopio Ghonghadze
Katsiaryna Galkina
Marta Hadrian
Stefan Simovic
Tomasz Artur Tokarek
Agija Rancāne
L. Sheybak
Anastasiia Vvedenska
Sylwia Iwańczyk
Aliaksandra Lapukhova
Agnieszka Grzyb
Edyta Prokop
Anastasiia Vvedenska
Maciej Bartoszek
Karolina Malesa
Bartosz Rymuza
Anna Malwina Kamelska
Infectious diseases
Prof. dr hab. n. med. Magdalena Marczyńska
Prof. dr hab. n. med. Józef Knap
Dr hab. n. med. Andrzej Horban
Dr n. med. Ewa Duszczyk
Coordinators of the Session:
Aleksandra Herman
Jan Orlewski
Patronage of the Session:
Sponsor of the Session:
Prof. Andrzej Friedman
Dr hab. n. med. Anna Kostera-Pruszczyk
Dr hab. n. med. Dagmara Mirowska-Guzel
Dr hab. n. med. Elżbieta Szmidt-Sałkowska
Dr hab. n. med. Ewa Kublik
Dr n. med. Piotr Janik
Dr n. med. Anna Potulska-Chromik
Coordinators of the Session:
Marlena Janoska
Monika Figura
Patronage of the session:
Polish Neuroscience Society
Sponsors of the session:
Sunday, 12 of May, 2013
Room 234
Oral Presentations:
Kamil Chorążka
Katarzyna Kaczmarek
Magdalena Kobierska
Magdalena Stachura
Svetlana Leshchenko
Łukasz Milanowski
Paweł Bartnik
Djordje Mijailovic
Martyna Naduk
Beata Rojecka
Poster Presentations:
Katarzyna Kaczmarek
Igor Petrusic
Ruta Reca
Konrad Stawiski
Natalia Szejko
dr hab. n. med. Ireneusz Bogdan Kantor
prof. dr hab. n. med. Antoni Krzeski
prof. dr hab. n. med. Kazimierz Niemczyk
prof. dr hab. n. med. Ewa Osuch - Wójcikiewicz
prof. dr hab. n. med. Henryk Skarżynski
dr n. med. Agata Szkiełkowska
dr hab. n. med. Lidia Zawadzka – Głos
dr n. med. Jarosław Balcerzak
Coordinator of the Session:
Paulina Czarnecka
Łukasz Kralczyński
Patronage of the Session:
Prof. dr hab. n. med. Kazimierz Niemczyk
Oddział Mazowiecki Polskiego Towarzystwa Otolaryngologów Chirurgów Głowy i Szyi
Sponsors of the Session:
Head & Neck Surgery
Saturday, 11.05.2013
Room 141
Oral Presentations:
Aleksandra Michalska
Natalia Bartek
Mateusz Celej
Kamil Garbas
Wojciech Grabczan
Aleksandra Kalina
Kamil Kikowicz
Ieva Bunce
Piotr Oczkowski
Maria Pędzisz
Danuta Szafran
Poster Presentations:
Michał Dudziński
Aleksandra Michalska
Alicja Strzałka
Marcin Tłuczewicz
Julia Wiśniewska
Bleeding from intracranial aneurysms, dependent on their size and localization
Karolina Kopińska, Joanna Knapik, Paweł Kram, Katarzyna Stanisławska
[email protected]
Poznan University of Medical Siences
Trustee of the paper: Robert Juszkat
Introduction: Intracranial aneurysms are frequent anomaly of cerebral vessels. The mortality, as a
result from their rupture, reaches 50%. The presence in the population is estimated as 0,2-7,9%.
Aim of the Study: The aim of this study was to prove the correlation between the size and localization
in ruptured aneurysms.
Material and methods: The data used in this work has been collected between years 2004-2012 in
the Department of Neurosurgery and Neurotraumatology,
Poznan University of Medical Sciences.
Records include 838 patients with meningo-cerebral bleeding from ruptured aneurysms, therein 509
women (60.74%) and 329 men (39.26%) aged between 17 and 87 years. Statistical analyzes were
performed in Statistica (U Mann-Whitney and chi-square tests). Predetermined significance level was
established as p <0.05 and p<0.005. Aneurysms size ranges were determined according to
International Subarachnoid Aneurysm Trial (ISAT).
Results: The ratio of small ruptured aneurysms to medium-sized and large ones (0-5 mm : ≥ 6.0 mm)
was highly statistically significant for anterior communicans artery (ACoA) and posterior inferior
cerebellar artery (PICA) in comparison to middle cerebral artery (MCA) and internal carotid artery
(ICA), statistically significant for ACoA and PICA in comparison to basilar artery (BA). The ratio of
ruptured aneurysms 0-10 mm : ≥11.0 mm was highly statistically significant for ACoA in comparison to
MCA, ICA and BA.
Conclusions: The analysis revealed that there is a correlation between the location and size of the
ruptured aneurysms. Most aneurysms ≤ 5 mm are located on the arteries ACoA and PICA, which
means that when guidelines for embolization are being constructed, aneurysms in that size should be
taken under consideration. Small aneurysms ruptured more frequently in patients <40 y., which
strongly supports previous embolization in this age group. Particular arterys where small aneurysms
are the vast majority are posterior inferior cerebellar artery (74.29%) and anterior communicans artery
Sunday, 12.05.2013
Room 232
Oral presentations:
Jerzy Bukowczan
Paulina Kłyszejko
Ewa Grzebyk
Renata Paprocka
Marcin Kownacki
Sebastian Kowalski
Katarzyna Błaszczak-Świątkiewicz
Irmina Włodarczyk
Teresa Kucharska
Sylwia Borowska
Anna Kluk
Maciej Trylowski
Paweł Halik
Miroslaw Malec
Volha Barysenak
Rafał Wyrębiak
Magdalena Pływaczewska
Shahbutdzinau Savva
Sunday, 12.05.2013
Room 141
Oral presentations:
Natallia Tsikhan
Tatsiana Krasochka
Aleksandra Wasiuk
Alina Aligera
Magdalena Dymińska
Electronic posters:
Alena Kalinouskaya
Mariya Mardamshina
Yana Blashko
Olena German
Małgorzata Goszcz
Aliaksandra Yatsevich
Klaudia Ziemiańska
Inna Nemchenko
Anna Tikhankova
Barbara Dejniak
Izabela Jamiołkowska
Agnieszka Grzyb
Anna Kućko
Magdalena Chojnowska
Justyna Witek
Aleksandra Dąbkowska
Diacova Olga
Ada Borowiec
Agata Szczepkowska
Teona Zubiashvili

LSR _budżet kwota 839__07.03.2012