,661
*RGLQD,EURM
+,9ELOWHQ
%,+_&51$*25$_+59$76.$_65%,-$
2012./II
ƒ†”āƒŒǣ
UVODNIK 3
HIV BILTEN DODATAK 3 IZVEŠTAJI SA KONFERENCIJA 4
ͳͻǤ˜‡–•ƒ‘ˆ‡”‡…‹Œƒ 4
Ȉ ”‡ƒŽ‹Œ‡—ǣƒ‹”ƒœ˜‘Œ‹’”‹Œƒ˜ŽŒ‡‹ƒǦ—ǡʹǤ†‹‘
Ȉ ‘˜‹’‘Œƒ«‹˜ƒ«Ǧ…‘„‹…‹•–ƒ–ƒ‘ƒŽ–‡”ƒ–‹˜ƒœƒ”‹–‘ƒ˜‹”
Ȉ ‘”‘ƒŽƒ‘–”ƒ…‡’…‹Œƒ‹”‹œ‹‹ˆ‡…‹Œ‡Ǧ‘
ͳͳǤ‡¯—ƒ”‘†‹‘‰”‡•‘–‡”ƒ’‹Œ‹ 12
Ȉ Uvod
Ȉ ‹–ƒŒƒ‘Œƒ†‘˜‘†‡†‘’‘†‡ŽŒ‡‹Š‹æŽŒ‡Œƒ•–”—«Œƒƒǣƒ†ƒ
’‘«‡–‹ǡ‹•–ƒ”‡Œ‡‹—–‹…ƒŒǦƒƒ‘«‡‹˜ƒ‹ā‹˜‘–‹˜‡
Ȉ ‘Ž—–‡‰”ƒ˜‹”ǣ ”‡œ‹•–‡–‘•– ‹–‡‰”ƒœ‡ ‹ —–‹…ƒŒ ‘•‘˜‘‰
”‡ā‹ƒ
Ȉ Ȁ‘‹ˆ‡…‹Œƒǣ”ƒ‹‘„”‹•‹„—†—©‘•–‹„‡œ‹–‡”ˆ‡”‘ƒ‹
’‘†ƒ…‹‘‹…‹†‡…‹Œ‹—”‘Ǧ‡
SPECIJALNI IZVJEŠTAJ 21
Ȉ ‘‘˜‹ƒ–‹”‡–”‘˜‹”—•‹Š‹•–”ƒā‹˜ƒŒƒʹͲͳʹǤȋ‹’‡Ž‹‡”‡’‘”–Ȍ
TB KONIFEKCIJA 34
Ȉ ƒā‹ƒ’”‡†…‹—”ƒœ˜‹ŒƒŒ—Ž‡ƒœƒ–—„‡”—Ž‘œ—
ANTI-­‐RETROVIRUSNA TERAPIJA 37
Ȉ Œ‡ ‘†„”Ž‹Žƒ —ƒ† ȋ–”‹„‹Ž†Ȍ — Ȃ …‡ƒ ‘ā‡ ‘–‡āƒ–‹
†‘•–—’‘•–—
Ȉ ‡”… •–‹«‡ ͳͷ͹ ‹ † ‹ ’‘«‹Œ‡ ˆƒœ— ʹ •–—†‹Œ‡ œƒ ‘˜‹
Ȉ ƒ”—ƒ˜‹”ͺͲͲ‰‘†‘„”‡—
LOKALNE STRANE 40
Ȉ ~‡‡—”„‹Œ‹ƒ‘ƒ•‹’”‡œ‡–‡”‹Ȃ”ƒœŽ‘‰œƒ„”‹‰—
OSTALE VESTI 43
Ȉ ‡Ǧ”‡āƒœ‡ƒŽŒƒ†ƒ‹•‘’”‡˜ƒŽ‡…‹Œ‘Ǧƒ—‡Ǧ
–”ƒŽ‘Œ‹—‰‘‹•–‘«‘Œ˜”‘’‹
Ȉ ƒ”›„—Ž©‡„‹–‹‹œ˜”搋†‹”‡–‘”
Ž‘„ƒŽ‘‰ˆ‘†ƒ
FILM 45
Ȉ ƒ‘ ’”‡ā‹˜‡–‹ ’‘惕– Ȃ ’”˜‡ ‰‘†‹‡ ”ƒ†ƒ ǦǦƒ — Œ—Ǧ
Œ‘”—
~Ȁ 47
+,9%,/7(1+7%
+,9ELOWHQ
%,+_&51$*25$_+59$76.$_65%,-$
HIV bilten HTB
za Bosnu i Hercegovinu, Crnu Goru, Hrvatsku i Srbiju
‘†‹ƒʹͲͳʹȀ„”‘Œ’”˜‹
ͳͲͲͲ’”‹‡”ƒƒ
Urednik:‡ƒ†‡–‘˜‹©
‡Š‹«‹—”‡†‹ǣƒ†‡—œƒ‘˜‹©
”‡†‹ Ž‘ƒŽ‹Š •–”ƒƒǣ Tomislav —”—æ‹©
‹œƒŒ‡”ǣ”‡ƒƒ”‘˜‹©
œ†ƒ˜ƒ«ǣǦŽ—„
ƒ‹œ†ƒ˜ƒ«ƒǣƒ†ƒ‹©‹©
eƒˆƒ”‹‘˜ƒ͸ǡͳͳͲͲͲ‡‘‰”ƒ†ǡ”„‹Œƒ
ȀǣΪ͵ͺͳͳͳ͵͵Ͷͷͺͷʹ
ǣ‹ˆ‘̷“Ǧ…Ž—„Ǥ‘”‰Ǥ”•
ǣŠ––’ǣȀȀ“Ǧ…Ž—„Ǥ‘”‰Ǥ”•
e–ƒ’ƒ”‹Œƒǣ”’•‹
—–‡„‡”‰
”‡¯‹˜ƒ«‹‘†„‘”ǣ
Ž‡•ƒ†”ƒƒ”Œƒ‘˜‹©ǡPodgorica
‡•ƒƒ†ā‹‘•ƒ‘˜‹©ǡMedicinski fakultet, Univerzitet u Sarajevu
0‘”¯‡‡˜–‘˜‹©ǡMedicinski fakultet, Univerzitet u Beogradu
‘•‹’‡‰‘˜ƒ…ǡMedicinski fakultet, Univerzitet u Zagrebu
ƒ†ƒ‹©‹©ǡBeograd
ƒƒeƒ„‘˜‹©ǡTuzla
‡āƒƒ”‹©ǡMedicinski fakultet, Univerzitet u Novom Sadu
‘‹•Žƒ˜—”—æ‹©ǡPula
HIV bilten HTB je besplatni,
SHULRGLþQL åXUQDO NRML L]YHãWDYD
R QDMQRYLMLP L QDMYDåQLMLP
PHGLFLQVNLP LVWUDåLYDQMLPD L
QDSUHGFLPD L] REODVWL +,9D L
VURGQLKVWDQMDNDRLRGRVWXSQR
VWLWHUDSLMHLSULSUHPDVH]D%RV
QX L +HUFHJRYLQX &UQX *RUX
+UYDWVNX L 6UELMX 1DPHQMHQ MH
]GUDYVWYHQLPUDGQLFLPDGUXJLP
SURIHVLRQDOFLPD L RVREDPD
SRJRÿHQLP+,9RPDOLLRVWDOLP
]DLQWHUHVRYDQLPD]DWHPX+,9D
*ODYQL FLOM L]GDYDQMD ELOWHQD MH
REH]EHÿLYDQMH SRX]GDQLK LQIRU
PDFLMD NDR SODWIRUPH ]D SULVWXS
NYDOLWHWQRM ]GUDYVWYHQRM ]DãWLWL
RVRED NRMH åLYH VD +,9RP X
VYLP]HPOMDPDUHJLMH
+,9ELOWHQVHL]GDMHXãWDPSDQRM
IRUPL NRMD MH GRVWXSQD X YHüLQL
]GUDYVWYHQLKXVWDQRYDXUHJLRQX
D PRåH VH QDUXþLWL L QD NXüQX
DGUHVX HOHNWURQVNL X 3')IRU
PL NRMX PRåHWH GRELMDWL SXWHP
HPHMODLXRQOLQHYHU]LMLQDLQ
WHUQHWVDMWX
HIV bilten HTB je nastao je na
LQLFLMDWLYX4NOXEDL,QWHUQDWLRQ
DO+,93DUWQHUVKLSV9HüLQDWHN
VWRYDX+,9ELOWHQXMHSUHYHGHQD
L]HQJOHVNRJþDVRSLVD+,97UHDW
PHQW %XOOHWLQ X] SRGUãNX RUJD
QL]DFLMH L%DVH NRMD WDM þDVRSLV
L]GDMH8VYRPXUHGQLþNRPWLPX
+,9ELOWHQRNXSOMDOHNDUHDNWLY
LVWHLRVREHNRMHåLYHVD+,9RP
L] %RVQH L +HUFHJRYLQH &UQH
*RUH+UYDWVNHL6UELMH
Izdavanje HIV biltena HTB za Bosnu i Hercegovinu, Crnu Goru, Hrvatsku i Srbiju su grantovima pomogli Gilead Sciences Europe i Merck Sharp & Dohme. Ova sredstva •‡‡‘†‘•‡ƒϔ‹ƒ•‹”ƒŒ‡‘”‰ƒ‹œƒ…‹Œ‡‹Ȃƒ•‡Ǥ
*RGLQD,EURM
ZZZKLYELOWHQLQIR
L
X
P
+,9%,/7(1+7%
892'1,.
'UDJLþLWDRFL
4&OXEL,QWHUQDWLRQDO+,93DUWQHUVKLSQDVWDYOMDMXVDL]
GDYDQMHP+,9ELOWHQD+7%]D%RVQXL+HUFHJRYLQX&UQX
*RUX+UYDWVNXL6UELMX2YLPEURMHP]DRNUXåXMHPRRE
MDYOMLYDQMHLQIRUPDFLMDL]JRGLQH1DSUYRPPHVWX
SUHGVWDYOMDPRL]YHãWDMHVDNRQIHUHQFLMD6D6YHWVNH
$,'6NRQIHUHQFLMHGDMHPRGUXJLGHRSUH]HQWDFLMDR+,9
OHNXQRYRPSRMDþLYDþX±FRELFLVWDWXLKRUPRQDOQRMNRQ
WDUFHSFLMLLUL]LFLPDRGLQIHNFLMH+,9RP.UDMHPJRGLQH
RGUåDQDMHLMHGQDRGQDM]QDþDMQLKNRQIHUHQFLMDL]REODVWL
+,9WHUDSLMHX(YURSL0HÿXQDURGQLNRQJUHVR+,9
WHUDSLMLRGUåDQMHNDRLVYDNHGYHJRGLQHX*OD]JRYX
2GDWOHYDPGRQRVLPRRGJRYRUHQDQHNDSLWDQMDâWDWR
GHOLVYHWVNHVWXþQMDNH".DGDSRþHWLVDWHUDSLMRP".DNR
+,9XWLþHQDVWDUHQMHLRþHNLYDQLåLYRWQLYHN"3UHGVWDY
OMDPRLQRYLLQKLELWRULQWHJUD]HGRXWHJUDYLULQDGDPRVH
EXGXüQRVWLEH]LQWHUIHURQDGRNSULþDPRR+&9XLSUHG
VWDYOMDPRQDMQRYLMHSRGDWNH(852VLGDH2GOXþLOLVPRGD
þLWDRFHXRYRPEURMXREUDGXMHPRREDMYOMLYDQMHPþLWDYRJ
L]YHãWDMDRWRNRYLPDDQWLUHWURYLUXVQLKLVWUDåLYDQMDNRMLMH
SULSUHPLR+,9,EDVHNDRLVYDNHJRGLQH3LSHOLQHUHSRUW
8]VYHSRãWRYDQMH
1HQDG3HWNRYLü
a
D
V
X
P
H
u a MH VYHREXKYDWQD DQDOL]D L SULND] LVWUDåLYDþNLK QDSRUD X
REODVWL$59WHUDSLMHWRNRPJRGLQHLGUDJRFHQRMH
ãWLYR]DVYHLVWUDåLYDþHOHNDUHLSDFLMHQWHNRMLVHLQWHUH
VXMX]DPHGLFLQVNHQDSUHWNHDOLüHVYDNDNRSRVOXåLWLNDR
RVQRYD]DEROMHLQIRUPLVDQMHQDãLKþLWDRFDXVXVUHWRUJD
QL]RYDQLMHP]DODJDQMX]DXQDSUHÿHQMHOHþHQMDLNOLQLþNLK
LVWUDåLYDQMDXUHJLRQX
6OHGH QRYH LQIRUPDFLMH R +&9 NRLQIHNFLML L QRYRVWL R
DQWLUHWURYLUXVQLPOHNRYLPDDRGPDK]DWLPMHGQDGRPDüD
VWXGLMD VD ]DQLPOMLYRP L DNWXHOQRP WHPRP ÄäHQH NDR
NDVQL SUH]HQWHUL³ 1RYL EURM GRQRVL YDP L GUXJH LQIRU
PDFLMHXYH]L+,9$,'6DLDNWLYL]PDRQHDNWXHOQH]D
QDãUHJLRQLOLFHRVYHW
3ULPLOL VPR SXQR SR]LWLYQLK NRPHQWDUD L þHVWLWLNL ]D
SUYL EURM NDR L QDUXGåEHQLFD =DKYDOMXMHPR VYLPD L
WUXGLüHPRVHGDRSUDYGDPRSRYHUHQMH1DGDPRVHGDüH
YDPVHGRSDVWLLRYRL]GDQMH+,9ELOWHQD+7%GDüHWH
XQMHPXXåLYDWLLSURQDüLNRULVQHLQIRUPDFLMH2þHNXMHWH
QRYDL]GDQMDXJRGLQLMHUQDVWDYOMDPRGDUDGLPR
QDSULSUHPLQDMDNWXHOQLMHJVDGUåDMD]DQDãHþLWDRFH
+,9%,/7(1'2'$7$.
.DRGRGDWDNRYRPEURMXSRNODQMDPRLOXVWURYDQXEURãXUX
L] VHULMH +,9$,'6 RVQRYH %URãXUH VX SULSUHPOMHQH L
SULODJRÿHQHQDRVQRYXRUJLQDOQRJ1$0L]GDQMD2EXK
YDWDMX GHVHW UD]OLþLWLK WHPD 6HGDP UD]OLþLWLK QDþLQD GD
VHSRVYHWLWHVYRP]GUDYOMX&'LEURMYLUXVQLKNRSLMD
,PDWLEHEX+,9LLPXQRORãNLVLVWHP3XWOHþHQMD+,9D
.DNRGHOXMH$59WHUDSLMD3URSUDWQLHIHNWL8]HWLWHUDSLMX
QDYUHPH.DGDWUHEDGDRWSRþQHPVD$59WHUDSLMRPL
ZZZKLYELOWHQLQIR
1HSUHSR]QDWOMLYEURMYLUXVQLKNRSLMD1DPHQMHQHVXRVR
EDPDNRMHåLYHVD+,9RPGDLPRODNãDOHUD]XPHYDQMH
]QDþDMDOHþHQMDLSULPHQH$59WHUDSLMH6OLNRYLWSULND]
L NUDWNL WHNVWRYL QD QDMMHGQRVWDYQLML QDþLQ REMDãQMDYDMX
QHNH RVQRYQH SRMPRYH L] REODVWL åLYRWD VD +,9RP L
OHþHQMD +,9D 'RNWRUL LK XYHN PRJX SRNORQLWL VYRLMP
SDFLMHQWLPD$NRåHOLWH]DSLV$YHOLþLQH3')YHU]LMX]D
ãWDPSXPRåHWHQDüLQDZHEVDMWXZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%
,=9(â7$-,6$.21)(5(1&,-$
19. Svetska AIDS konferencija
22. – 25. 7. 2012. Vašington DC, SAD
Prema HIV lijeku: Rani razvoji prijavljeni na IAS-u, 2. dio
Muirgen Stog, HIV i-Base
Najava IAS-ove znanstvene strategije prema
HIV lijeku na 3. IAS-ovom pred konferencijskom
VLPSR]LMX RGUåDQRP RYH JRGLQH RG ± GDODMHQRYLQDJODVDNQDQDSUHWNXXSRGUXþMX
LVWUDåLYDQMDOLMHND>@
6WUDWHJLMDRFUWDYDVHGDPYDåQLKSRGUXþMDLVWUDåLYDQMD
XNRMHPMHSRWUHEDQQDSUHGDNGDELVHOLMHNSURQDãDR
IXQNFLRQDOQLLOLVWHULOL]LUDMXüL
‡ =DãWR MH +,9 XSRUDQ LPXQRORãNL L YLUXVQL
þLPEHQLFL
‡*GMHMH+,9XSRUDQUH]HUYRDULWNLYDLVWDQLFD
‡,PXQRORãNDDNWLYDFLMDLGLVIXQNFLMDX$57X
‡3ULURGQLPRGHOL+,96,9NRQWUROH
‡.DNRPMHULWLXSRUQHLQIHNFLMH
‡.DNRSUHRNUHQXWLODWHQFLMXWUHWPDQL
‡,PXQRORãNLSULVWXSLJHQVNDWHUDSLMDFMHSLYD
6UHüRP QHND REHüDYDMXüD LVWUDåLYDQMD R OLMHNX ]D
L]OMHþHQMHSUHGVWDYOMHQDVXQD$,'6QHãWRãWR
þHVHQDGDPRRGUåDWLLSURãLULWLQDGDOMQMHVDVWDQNH
Novi terapijski pristupi
9HüHUD]XPLMHYDQMHYLUXVQHODWHQFLMHLXSRUQRVWLX]
SURãLUHQMH SRVWRMHüLK WHUDSLMDYMHURMDWQR üH ELWL MH
GDQ GLR X SURQDODVNX EXGXüHJ +,9 OLMHND YLGL GLRRYRJL]YMHãüDREMDYOMHQRJXSURãORPEURMX+,9
ELOWHQD 6WYDUDQMH QRYLK WUHWPDQD PRåH ELWL MHG
QDNRELWQRDNRFLOMDWHYLUXVQXSURL]YRGQMXLLOLUHS
OLNDFLMXXXWRþLãWLPDLLOLUH]HUYRDULPD
.DUROLQD *DUULGR L NROHJH L] 81& &KDSHO +LOO
1RUWK &DUROLQD SUHGVWDYLOL VX SRVWHU R NRULãWHQMX
]ODWQLKQDQRþHVWLFD]DFLOMDQMHYLUXVQLKUH]HUYRDUDX
PR]JX>@
5DQDLVWUDåLYDQMDL]RYHJUXSHVXSRND]DODGDÀXR
*RGLQD,EURM
UHVFHQWQR R]QDþHQH 7$05$ ]ODWQH QDQRþHVWLFH
XVSMHãQR XOD]H X OLPIRFLWH PDNURIDJH DVWURFLWH
L PLNURYDVNXODUQH HQGRWHOQH VWDQLFDPH OMXGVNRJ
PR]JD +%0(&V QDNRQ VDWQH LQNXEDFLMH
)$&6 DQDOL]D MH SRND]DOD GD GR &' 7
VWDQLFD VDGUåDQL 7$05$X âWRYLãH VSRVREQRVW
QDQRþHVWLFD GD SULMHÿL NUYQRPRåGDQX EDULMHUX
SRWYUÿHQRMHLQYLYRLQWUDYHQVNRPLQMHNFLMRPXUHS
PLãHYD6DGUåDM]ODWDXPR]JXPLãDMHGRVWLJDR
SSEJUDP WNLYD D WDNRÿHU MH YLGOMLY PLNURVNRSRP
1DQRþHVWLFH VX WDGD NRQMXJLUDQHV GHULYDWRP UDOWH
JUDYLUD]DSURFMHQXDQWLYLUXVQHDNWLYQRVWL2YRMHGR
RJGDQDVPDQMLORUHSOLNDFLMXYLUXVDQDX
RGQRVXQDUHSOLNDFLMX+,9DXVDPRPPHGLMX
1DåDORVWRYDMUH]XOWDWQLMHXVSRUHÿHQVQHNRQMXJL
UDQLP GHULYDWRP UDOWHJUDYLUDLOL GUXJLP $59RP
,SDN RYL SUHOLPLQDUQL UH]XOWDWL SRND]XMX SRþHWQX
H¿NDVQRVWLVSHFL¿þQRVWFLOMDQMD]DQDQRPHGLFLQRP
ED]LUDQLSULVWXSOLMHþHQMX+,9LDNRVYHLPSOLNDFLMH
]D JRPLODQMH ]ODWQLK QDQRþHVWLFD X WNLYX PR]JD V
NURQLþQLPOLMHþHQMHPQLVXULMHãHQH>@
)UDXNH.ULVWVD6YHXþLOLãWDX/HXYHQX%HOJLMDSUHG
VWDYLRMHSUHGNOLQLþNHSRGDWNHRQRYRMNODVLLQKLEL
WRUDLQWHJUD]HSR]QDWRJNDR/('*,1>@/('*,1
VHYHåHDORVWHUQRQDPMHVWX]DPMHVWRLQWHJUD]HJGMH
VHVWDQLþQLNRIDNWRU/('*)SYHåH/('*)S
GMHOXMHNDR VLGUR YLUXVQH '1$ ]D NURPDWLQ NRML MH
GRPDüLQSULMHLQWHJUDFLMH=D/('*,1VHSUHWKRGQR
SRND]DOR GD LQKLELUD XPQRåDYDQMH +,9D LQ YLWUR
SXWHPRYRJPHKDQL]PD>@
8WUHQXWQRMVWXGLMLLVWUDåLYDþLVXSURFLMHQLOLVSRVRE
QRVW /('*,1D GD L]UDYQR EORNLUD NDWDOLWLþNX DN
WLYQRVW LQWHJUD]H L]YMHãüXMXüL R GDOMQMRM LQKLELFLML
UHSOLNDFLMH +,9D X 07 L 3%0& VWDQLFDPD NDR
L GMHORYDQMH QDG ãLURNLP UDVSRQRP YLUXVQLK JHQ
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
HUDFLMD SD þDN L VD YLUXVLPD NRML VDGUåH PXWDFLMH
VDRWSRUQRãüXSUHPDGUXJLPLQKLELWRULPDLQWHJUD]H
,DNR MH MRã X UD]YRMQLP SRYRMLPD SRVWRML EDUHP
PRJXüDEXGXüDXSRUDEX]D/('*,1V±ELORVDPR
VWDOQRLOLLVWRGREQRVGUXJLPLQKLELWRULPDLQWHJUD]H
0HÿXWLPGDOLüH]DGUåDWLVYRMXSUHGNOLQLþNXGMHORW
YRUQRVW X åLYRWLQMVNLP L OMXGVNLP NOLQLþNLP LVSLWL
YDQMLPDWHNVHWUHEDYLGMHWL
Ciljanje integriranog virusa i imunoterapije
+HOJD +RIPDQQ6LHEHU L] +HLQULFK 3HWWH ,QVWL
WXWD +DPEXUJ SUHGVWDYLOD MH LVWUDåLYDQMH NRMH VH
L]UDYQR RGQRVLOR QD +,9 OLMHN ELOR IXQNFLRQDODQ
LOL VWHULOL]LUDMXü VWYDUDQMHP VXVWDYD NRML PRåH XN
ORQLWL LQWHJULUDQL +,9 SURYLUDOQL '1$ L] ]DUDåHQLK
OMXGVNLK VWDQLþQLK NXOWXUD >@ 2YDM SULVWXS NRULVWL
YLUDOQX /75VSHFL¿þQX UHNRPELQD]X 7UHUHFRP
ELQDVH ]D NRMX VX ]QDQVWYHQLFL UDQLMH SRND]DOL GD
L]EDFXMH +,9 SURYLUDOQX '1$ L] ]DUDåHQLK OMXG
VNLKVWDQLþQLKNXOWXUD7UHUHFRPELQDVDMHHQ]LPED
]LUDQQDEDNWHULMVNRMNUHUHNRPELQD]LNRMDXNODQMD
GLMHORYH'1$NRMLVXERþQRREORåHQLSRVHEQLPVHUL
MDPD QXNOHRWLGD SRG QD]LYRP OR[3 1DåDORVW +,9
SURYLUDOQL '1. QH VDGUåL QLNDNYH OR[3 VHNYHQFH
=DWR LVWUDåLYDþL EUDMX PXWLUDQX NUHUHNRPELQD]X
NRMD PRåH SUHSR]QDWL VOLMHG QXNOHRWLGD X /75LPD
LQWHJULUDQRJ+,9D
3ULPMHQD RYH WHKQLNH ]D +,9 SR]LWLYQH KXPDQ
L]LUDQH PLãHYH ]QDþLOR MH VWYDUDQMH QDSUHGQLK
OHQWLYLUDOQLKVDPRLQDNWLYQLK 6,1 YHNWRUD NRML
L]UDåDYDMX 7UHUHNRPELQD]X XYMHWQX X VWDQLFDPD
]DUDåHQPD+,9RP2EMHOMXGVNH&'7VWDQLFHL
&'NUYRWYRUQHPDWLþQHVWDQLFH+6&XVSMHãQR
VXWUDQVGXFLUDQHSULMHXVDÿLYDQMDX+,9SR]LWLYQH
5DJJDPPDFPLãHYH,VWDNQXWDDQWLYLUXVQDDN
WLYQRVWSXWHP7UHUHNRPELQD]HHQLMHELODSRYH]DQD
VQHåHOMHQLPFLWRSDWVNLPXþLQFLPDXWUDQVGXFLUDQLP
VWDQLFDPDL]7UHUHNRPELQD]H
3RVWRMHüL LQWHJULUDQL +,9 '1. WHRUHWVNL EL VH
PRJDR NRULVWLWL ]D LVNRUMHQMLYDQMH +,9 L] WLMHOD
0HÿXWLP WUDQVGXNFLMD VYLK ODWHQWQR LQ¿FLUDQLK
VWDQLFDSRPRüX 7UHUHNRPELQD]H X PQRJLP YL
UXVQLP UH]HUYRDULPD NRML VH QDOD]H X WLMHOX RVWDMH
QHPRJXüH6WRJDVH7UHVXVWDYWUHEDPLMHQMDWLNDNR
ELVHRPRJXüLORODNãHSULPMQMLYDQMHSULMHQHJRãWRVH
PRåHUD]PDWUDWL]DNOLQLþNLDLVSLWLYDQMDSRSXWGUXJLK
³DQWLODWHQWQLK´OLMHNRYDNDRãWRVXKLVWRQGHDFHW\
ODVH+'$&LQKLELWRUYRULQRVWDW>@0HÿXWLPSULMH
WRJDLVWUDåLYDþLPRUDMXRGJRYRULWLQDSLWDQMHNRMHMH
SRVWDYOMHQRQDNUDMXSUH]HQWDFLMHNRMHQDJODãDYDGD
ZZZKLYELOWHQLQIR
MHVXVWDY7UHUHNRPQLQD]HRYLVDQRWUDQVNULSFLMLYL
UXVQLKSURWHLQD7$71DåDORVWSUHNLGXL]UDåDYDQMX
7$7D MH PDUNHU ODWHQFLMH ãWR ]QDþL GD üH VXVWDY
7UHUHNRPELQD]H LPDWL PLQLPDOQX XþLQNRYLWRVW QD
SRVWRMHüX SURYLUDOQX '1$ L] ODWHQWQR LQ¿FLUDQLK
VWDQLFD >@ 0HÿXWLP WR þLQL VXVWDY 7UHUHNRPEL
QD]H VXYLãDQ L PRåGD EL XSDULYDQMH V GUXJLP MHG
QDNRQRYLPOHQWLYLUDOQLPYHNWRULPDNRML QDPMHUQR
SUHWMHUDQR SRWLþX 7$7 VXVWDY PRJDR EL L GDOMH ELWL
XVSMHãDQ>@
8GDOMDYDQMHPRGQRYLKPROHNXODUQLKWHUDSLMD/\GLD
7UDXWPDQQ L] 9*7, )ORULGD MH GDOD]DQLPOMLYX SU
H]HQWDFLMXRPRJXüHPQDSUHWNXXSRGUXþMXLPXQRW
HUDSLMH >@ 8VPMHULOD VH QD EROMH RSLVLYDQMH UD]
OLNDL]PHÿX+,9VSHFL¿þQLK&'7VWDQLFDSULMH
LWLMHNRP$57D1MH]LQLUH]XOWDWLXNOMXþXMXGDSRG
QLVNLP RSWHUHüHQMHP +,9 DQWLJHQD X]URNRYDQLP
YLUXVQRP VXSUHVLMRPL] $57D GRPLQDQWQLK +,9
VSHFL¿þQLK&'7VWDQLFDNORQRWLSDGRELMDMXSROL
IXQNFLRQDOQRVW SUHSR]QDMXüLYLãH HSLWRSD +,9 DQ
WLJHQD7RGRYRGLGRPDORJDOLXþLQNRYLWRJUD]YRMD
NORQRWLSDSRG$57RP'U7UDXWPDQQMH]DNOMXþLOD
GDDNRVHSURQDÿXQDþLQL]DSURãLUHQMHRYLKYLVRNR
VNORQLK+,9VSHFL¿þQLK&'7VWDQLFDLQYLYRRQL
ELPRJOLNRQWUROLUDWLYLUXVEH]$57D
6UHüRPXVPHQLVDåHWDN6FRWWD.LWFKHQDVD8&/$
,QVWLWXWD]D$,'6/RV$QJHOHVSRNULYHQDRYXWHPX
>@ 1DNRQ SUHSR]QDYDQMD RGJRYRUD FLWRWRNVLþQLK
&'7OLPIRFLWD&7/NDRNULWLþQHNRPSRQHQWHX
NRQWUROLLQIHNFLMH+,9RPLVWUDåLYDþLVXVHXVPMHULOL
QDWRNDNRELVHSREROMãDOLLSURãLULOLXþLQFL&7/D
LQYLYR,VNRULVWLOLVXPROHNXODUQRNORQLUDQMHUHFHS
WRUD+,9VSHFL¿þQLK7VWDQLFD7&5DGRELYHQLKL]
&'7VWDQLFDNRMHVXSRWRPNRULVWLOL]DJHQHWVNR
SUHWYDUDQMH OMXGVNLK NUYRWYRUQLK PDWLþQLK VWDQLFD
+6& 3UHWYRUHQH VWDQLFH VX ]DWLP XYHGHQH X KX
PDQL]LUDQRJPLãDLELORLPMHGRSXãWHQRGDVHGLIHU
HQFLUDMX X ]UHOH OMXGVNH &' &7/RYH 0LãHYL
NRML VX L]UD]LOL WUDQVJHQH +,9VSHFL¿þQH 7&5RYH
XVSRUHÿHQLVXVNRQWUROQLPPLãHYLPDQDNRQVXREMH
JUXSH]DUDåHQH+,9
'DOMHVXSURPDWUDOLXXVSMHãQXGLIHUHQFLMDFLMXX]UHOH
&7/RYH L PLJUDFLMXQD YLãH DQDWRPVNLP PMHVWD
7DNRÿHU MH YLÿHQR ]QDþDMQR VPDQMHQMH UD]LQH +,9
51$ X SOD]PL ãWR NRUHOLUD V REMH UD]LQH UHNRQVWL
WXFLMHVDVWDQLFDPDQRVH+,9VSHFL¿þDQ7&5LVHN
VSDQ]LMRP7VWDQLFDYRÿHQRPDQWLJHQLPD
2YL UDQL UH]XOWDWL L] PRGHOD KXPDQL]LUDQRJ PLãD
SRND]XMXYDåQRVW&7/RGJRYRULNDNRWRPRåHELWL
SURãLUHQR L SREROMãDQR 2VODQMDMXüL VH QD YODVWLWH
*RGLQD,EURM
+,9%,/7(1+7%
VSRVREQRVWL&7/DGDVHSURåPHNUR]YLãHRGMHOMDND
XWLMHOXWRWDNRÿHUPRåHSRWHQFLMDOQRQDGLüLQHNHRG
SRWUãNRüDNRMH$59LPDXGRVHJXUH]HUYRDUD
7UDQVSODQWDFLMHPDWLþQLKVWDQLFD
8]LPDMXüL PRGL¿NDFLMH LPXQRORãNRJ VXVWDYD
GRPDüLQDMRãLGDOMH7LPRWK\+HQULFKL]%ULJKDPL
:RPHQEROQLFHX%RVWRQXSUHGVWDYLRMHGYDVOXþDMD
WUDQVSODQWDFLMH JHQHWVNL UD]OLþLWLK PDWLþQLK VWDQLFD
X GYLMH +,9 SR]LWLYQH RVREH >@ 2EMH VX LPDOH
KHPDWRORãNHPDOLJRVWLLSUHWKRGQRVXELOLSRGYUJQX
WLWUDQVSODQWDFLMLPDWLþQLKVWDQLFD3DFLMHQWLVXRVWDOL
QD$57XWHLPMHREDYOMHQDWUDQVSODQDFLMDDORJHQLK
PDWLþQLK VWDQLFD ,PXQRVXSUHVLYQD WHUDSLMD GDQD MH
X REOLNX SUHGQL]RQD LOL WDNUROLPXVDVLUROLPXVD ]D
OLMHþHQMHNURQLþQHJUDIWYHUVXVKRVWEROHVWL*9+'
QDNRQWUDQVSODQWDFLMH
.RG EROHVQLND $ VH +,9 '1. YLUXVD YLGLR MRã
XYLMHN QDNRQ PMHVHFD QDNRQ WUDQVSODQWDFLMH NRSLMD PLOLMXQ 3%0&D WHNRG EROHVQLND % GR PMHVHFDQDNRQWUDQVSODQWDFLMHNRSLMDPLOLMXQ
3%0&D 0HÿXWLP QDNRQ RVDP RGQRVQR GHYHW
PMHVHFLQLMHELORPRJXüHGHWHNWLUDWL+,9'1.L
/75+,9'1.NRSLMDPLOLMXQ3%0&D2YR
WDNRÿHUYULMHGLL]DSOD]PD+,951$NRMDMH]ERJ
RVMHWOMLYRVWLWHVWDSRND]DODNRSLMHPO
3RYXþHQD MH SDUDOHOD QDUDYQR L VD ³%HUOLQVNLP
SDFLMHQWRP´ 7LPRWK\ %URZQ NRPH MH REDYOMHQR
SUHVDÿLYDQMHPDWLþQLKVWDQLFDRGGRQRUDKRPR]LJQRJ
]D&&5GHOWDPXWDFLMX>@0HÿXWLPPDWLþQH
VWDQLFHNRMHVXSULPLOLREDEROHVQLND$L%ELOLVXRG
GRQRUDVQRUPDOQRP&&5HNVSUHVLMRP3RWNRSDYD
OL WR þLQMHQLFX GD MH &&5 GHOWD PXWDFLMDQHR
SKRGQDNDRPHKDQL]DPREMDãQMHQMDãWRMH7LPRWK\
%URZQR]QDþHQNDR³L]OLMHþHQ´RVWDMHQHMDVQR
$XWRULSUHGODåXYLãHPRJXüQRVWLNDRREMDVQLWL]DãWR
VH +,9 QLMH PRJDR GHWHNWLUDWL QDMYLãH *Y+' LLOL
XþLQDNFLWRWRNVLþQLHWHUDSLMHSULPMHQMHQHXOLMHþHQMX
0HÿXWLP EROMH UD]XPLMHYDQMH PRUDWL üH SULþHNDWL
GRNVHGDOMQMLX]RUFLQHDQDOL]LUDMXNDNRELVHYLGMHOR
MHOL+,9PRåGDRWNULYHQ9LãHLQIRUPDFLMDPRåHVH
QDüL X QHGDYQRP LQWHUYMXX VDVXLVWUDåLYDþHP 'D
QRP.XULW]NHVRPV+DUYDUG0HGLFDO6FKRRO%RV
WRQJGMHRQLVWLþH]DãWLWQXXORJX$57D±NRMLGMHOXMH
NDR³3U(3QDVWDQLþQRMUD]LQL´>@
-DVQR MH GD MH LVWUDåLYDQMH OLMHND REXKYDüD PQRJR
UD]OLþLWLKSRGUXþMDDGDVHVYLPRJXüLXVSMHVLPRJX
ED]LUDWL QD SULVWXSX NRPELQLUDQH WHUDSLMH 7R VX
SUREQHID]HX]QDQRVWLROLMHNXDOLMRãXYLMHNSRVWRMH
UD]OR]L]DRSWLPL]DP1DMRþLWLMDMHRWYRUHQDSULURGD
LVWUDåLYDQMDOLMHND NRMD QDJODãDYD YDåQRVW VXUDGQMH
L]PHÿX]QDQVWYHQLNDQDSRGUXþMXWHMHSRWYUÿHQDRG
VWUDQHUDGQHJUXSH³3UHPD+,9OLMHNX´7RRVWDYOMD
SURVWRUD]DQRYRVWLRQDSUHWNXYH]DQRP]DOLMHNNDR
SULYODþQXWHPXQDPHÿXQDURGQRMNRQIHUHQFLMLR
$,'6$,'6X0HOERXUQHX$XVWUDOLMD>@
5HIHUHQFH
,QWHUQDWLRQDO$,'66RFLHW\,$67RZDUGVDQ+,9&XUH*OREDO6FLHQWL¿F6WUDWHJ\-XO\
ZZZLDVRFLHW\RUJ:HE:HE&RQWHQW)LOH+,9B&XUHB)XOOBUHFRPPHQGDWLRQVB-XO\BSGI
*DUULGR&HWDO*ROGQDQRSDUWLFOHVWRLPSURYHGUXJGHOLYHU\WRWKHFHQWUDOQHUYRXVV\VWHPWDUJHWLQJ+,9UHVHUYRLUVLQWKHEUDLQ3RVWHUH[KLEL
WLRQ7+3(
KWWSSDJDLGVRUJ(3RVWHU+DQGOHUD[G"DLG $ONLODQ\$DQG0XUSK\&7R[LFLW\DQGFHOOXODUXSWDNHRIJROGQDQRSDUWLFOHVZKDWZHKDYHOHDUQHGVRIDU"-1DQRSDUW5HV6HSWHPEHU
KWWSZZZQFELQOPQLKJRYSPFDUWLFOHV30&
&KULVW)HWDO3UHFOLQLFDOHYDOXDWLRQRI+,9UHSOLFDWLRQLQKLELWRUVWKDWWDUJHWWKH+,9LQWHJUDVH/('*)SLQWHUDFWLRQ2UDODEVWUDFW78
$$
KWWSSDJDLGVRUJ$EVWUDFWVDVS["$,' &KULVW)HWDO5DWLRQDOGHVLJQRIVPDOOPROHFXOHLQKLELWRUVRIWKH/('*)SLQWHJUDVHLQWHUDFWLRQDQG+,9UHSOLFDWLRQ1DW&KHP%LRO-XQH
KWWSZZZQFELQOPQLKJRYSXEPHG
+RIPDQQ6LHEHU+HWDO7RZDUGV+,9HUDGLFDWLRQH[FLVLRQRI+,9SURYLUDO'1$E\7UHUHFRPELQDVHLQ+,9SRVLWLYHKXPDQL]HGPLFH2UDO
DEVWUDFW78$$
KWWSSDJDLGVRUJDEVWUDFWVDVS["DLG $UFKLQ1HWDO$GPLQLVWUDWLRQRIYRULQRVWDWGLVUXSWV+,9ODWHQF\LQSDWLHQWVRQDQWLUHWURYLUDOWKHUDS\1DWXUH-XO\
KWWSZZZQDWXUHFRPQDWXUHMRXUQDOYQIXOOQDWXUHKWPO
.DUQ-7KHPROHFXODUELRORJ\RI+,9ODWHQF\EUHDNLQJDQGUHVWRULQJWKH7DWGHSHQGHQWWUDQVFULSWLRQDOFLUFXLW&XUU2SLQ+,9$,'6-DQXDU\
KWWSZZZQFELQOPQLKJRYSXEPHG
0DFLDV'HWDO$OHQWLYLUDOYHFWRUWKDWDFWLYDWHVODWHQWKXPDQLPPXQRGH¿FLHQF\YLUXVSURYLUXVHVE\WKHRYHUH[SUHVVLRQRIWDWDQGWKDWNLOOVWKH
LQIHFWHGFHOOV+XP*HQH7KHU1RYHPEHU
*RGLQD,EURM
ZZZKLYELOWHQLQIR
H
O
\
H
+,9%,/7(1+7%
KWWSZZZQFELQOPQLKJRYSXEPHG
7UDXWPDQQ/1RYHODSSURDFKHVWUHDWPHQWDQG+,9SDWKRJHQHVLV,PPXQRSDWKRJHQHVLVDQGLWVWUHDWPHQW6\PSRVLD6HVVLRQ-XO\
SP:DVKLQJWRQ
KWWSSDJDLGVRUJÀDVKDVS["SLG .LWFKHQ6HWDO,QYLYRVXSSUHVVLRQRI+,9DQWLJHQVSHFL¿F7FHOOVGHULYHGIURPHQJLQHHUHGKHPDWRSRLHWLFVWHPFHOOV2UDODEVWUDFW78
$$
KWWSSDJDLGVRUJ$EVWUDFWVDVS["$,' +HQULFK7HWDO/RQJWHUPUHGXFWLRQLQSHULSKHUDOEORRG+,9UHVHUYRLUVIROORZLQJUHGXFHGLQWHQVLW\FRQGLWLRQLQJDOORJHQHLFVWHPFHOOWUDQV
SODQWDWLRQLQWZR+,9SRVLWLYHLQGLYLGXDOV2UDODEVWUDFW7+$$
KWWSSDJDLGVRUJ$EVWUDFWVDVS["$,' $OOHUV.HWDO(YLGHQFHIRUWKHFXUHRI+,9LQIHFWLRQE\&&5GHOWDGHOOWDVWHPFHOOWUDQVSODQWDWLRQ%ORRG0DUFK
KWWSEORRGMRXUQDOKHPDWRORJ\OLEUDU\RUJFRQWHQWIXOO
$%DUWRQ3DWKVWRDFXUH'U'DQ.XULW]NHVGLVFXVVHVH[SHULHQFHVRIWZRSDWLHQWV$XJXVW
KWWSVFLHQFHVSHDNVEORJRUJSDWKVWRDFXUHGUGDQNXULW]NHVGLVFXVVHVH[SHULHQFHVRIWZRSDWLHQWVD[]]2DFWO=
7KHWK,QWHUQDWLRQDO$,'6FRQIHUHQFH-XO\0HOERXUQH$XVWUDOLD
KWWSZZZDLGVRUJ
1RYLSRMDþLYDþFRELFLVWDWNDRDOWHUQDWLYD]DULWRQDYLU
Simon Collins, HIV i-Base
)DUPDNRNLQHWLþNL SRMDþLYDþ FRELFLVWDW MH MHGQD
NRPSRQHQWDQHGDYQRRGVWUDQH)'$RGREUHQH
NRPELQDFLMH6WULELOGD4XDGQDED]LLQKLELWRUD
integraze u vidu jedne pilule.
&RELFLVWDWLPDVOLþQHNDUDNWHULVWLNHIDUPDNRNLQHWLþNLK
SRMDþLYDþDNDRãWRMHULWRQDYLUXVPLVOXLQKLELUDQMD
FLWRKURPD 3 $ HQ]LPD MHWUH DOL EH] GLUHNW
QLK DQWLUHWURYLUXVQLK DNWLYQRVWL 8 :DVKLQJWRQX
UH]XOWDWL VX SUHGVWDYOMHQL L] ID]H UHJLVWURYDQH
VWXGLMH NRMD MH SRUHGLOD FRELFLVWDW VD ULWRQDYLURP
X VYUKX SRMDþDYDQMD DWD]DQDYLUD NRG SUYL SXW
WUHWLUDQD SDFLMHQWD X NRPELQDFLML VD WHQRIRYLURP
)7&.ULWHULMXPLVNOMXþLYDQMDSRGUD]XPHYDRMHYHü
SRVWRMHüD QDUXãDYDQMD UHQDOQLK IXQNFLMD GH¿QLVDQ
NDRH*)5P/PLQ
*UXSHVXELOHSULEOLåQHVDSURVHþQLPRVQRYQLPNDUD
NWHULVWLNDPD XNOMXþXMXüL PXãNDUDFD EH
ODFDLSURVHþQXVWDURVWRGJRGLQD3URVHþQL&'
LEURMYLUXVQLKNRSLMDELOLVXRNRüHOLMDPPL
NRSLMDP/
6D SULPDUQH WDþNH YLUDOQH H¿NDVQRVWL NRSLMD
P/ X QHGHOML SULMDYOMHQL VX VOLþQL UH]XOWDWL ]D
REHJUXSHVDNRGFRELFLVWDWDXRGQRVXQD
NRGUHWRQDYLUDUD]OLND&,GR
LXVYDNRMJUXSL]DSDFLMHQWHVDRVQRYQLPYLUDO
QLPVDGUåDMHP!NRSLMDP/
ZZZKLYELOWHQLQIR
6OLþQH LVKRGH LPDOH VX REH JUXSH X EH]EHGQRVQLP
DQDOL]DPDVDSDFLMHQDWDNRGNRMLKVHMDYLRGLV
NRQWLQXLWHWXVOHGRFHQHQHåHOMHQLKHIHNDWD
3URVHþQLSRUDVWXNXSQRJELOLUXELQDXQHGHOMLNRG
FRELFLVWDWDXRGQRVXQDULWRQDYLUJUXSXELRMHL
PJG/ VD QDVSUDP QHåHOMHQLK HIHNDWD
YH]DQLK ]D ELOLUXELQ 3URVHþQR SRYHüDQMH VHUXP
VNRJ NUHDWLQLQD ELOR MH RGQRVQR PJG/
3URVHþQHSURPHQHXXNXSQRPKROHVWHUROXELOHVX
L PJG/ D SRYHüDQMH WULJOLFHULGD ELOR MH L
PJG/
3URVHþQRVWDQMHPLURYDQMDL]ORåHQRVWLDWD]DQDYLUXX
SOD]PLELORMHXSRUHGLYR&WDX YVQJ
P/
5DQD VWXGLMD RYH JRGLQH SULMDYLOD MH GD VH XWLFDM
SRMDþDYDQMD FRELFLVWDWD QH SRNODSD VD ULWRQDYLURP
NRGVYLKLQKLELWRUDSURWHD]HLGDPRåGDQLMHSULNOD
GDQ]DXSRWUHEXVDWLSUDQDYLURP7DNRÿHFRELFLVWDW
SRYHüDYDVHUXPVNLNUHDWLQLQãWRRSHW]DSRVOHGLFX
XWLþH QD UDþXQDQMH H*)5D ãWR NRPSOLNXMH VWDQ
GDUGQRSUDüHQMHUHQDOQHWRNVLþQRVWLYH]DQH]HWHQR
IRYLU7UHQXWQRMHSRYHüDQMHRGPJG/LOLYHüH
SUHGORåHQR NDR NRQ]HUYDWLYQL SUHVHN ]D UHãDYDQMH
SUREOHPDYH]DQLK]DSRWHQFLMDOQXUHQDOQRWXEXODUQX
WRNVLþQRVWXVOHGWHQRIRYLUD
ýLQLVHGDFRELFLVWDWQHSREROMãDYDJDVWURLQWHVWLQDOQH
*RGLQD,EURM
+,9%,/7(1+7%
LOLOLSLGQHQHåHOMHQHHIHNWHULWRQDYLUDYHüMHGRYHR
GR QRYLK NRIRUPXODFLMD NRMH VH WUHQXWQR LVSLWXMX
8NOMXþHQH VX NRPELQDFLMH ÄþHWLUL X MHGDQ³ QRYRJ
4XDG VD GDUXQDYLURPNRELFLVWDWRP)7&RP SOXV
LVSLWLYDQL WHQRIRYLU SUROHN *6 SUYL MH IRU
PXODFLMDLQKLELWRUDSURWHD]HGDUXQDYLUDFRELFLVWDWD
*6)7&DXMHGQRMSLOXOLDGUXJDNRPELQXMH
3,SLOXOH SRMDþLYDþD DWD]DQDYLUDFRELFLVWDWD L GDUX
QDYLUDFRELFLVWDWD
&RELFLVWDW MH RGREUHQ RG VWUDQH )'$ X RVPRP
PHVHFX JRGLQH D QD RGREUHQMH L] (YURSVNH
XQLMHVHMRãþHND
7
Q
Hormonalna kontracepcija i rizik infekcije HIV-om
Polly Clayden, HIV i-Base
Hormonalna kontracepcija je široko primenjena
L LJUD NULWLþQX XORJX X ]GUDYOMX åHQH HGXNDFLML
zaposlenju, ekonomskom razvoju i njenoj autonomiji.
0HÿXWLPRXOR]LKRUPRQDOQHNRQWUDFHSFLMHNRGLQ
¿FLUDQMD +,9RP SRVWRML ]QDþDMQD NRQWUDYHU]QRVW
7DNRÿH SRVWRML ]DEULQXWRVW R QMHQRM SRWHQFLMDOQRM
XOR]L X QDSUHGRYDQMX EROHVWL 1D NRQIHUHQFLML ,$6
LVSLWDQLVXGRVDGDãQMLGRND]L>@
3RWHQFLMDOQR VDUDGQLþNR LVSLWLYDQMH SDURYD L]
,VWRþQH L -XåQH$IULNH VWXGLMD 3DUWQHU X SUHYHQFLML
SUHQRVD+69+,9DQHGDYQRMH]DNOMXþLODGDVX+,9
QHJDWLYQH åHQH NRMH VX X YH]L VD +,9 SR]LWLYQLP
PXãNDUFLPDLNRMHNRULVWHLQMHNWDELOQXNRQWUDFHSFL
MXSRGGYRVWUXNRYHüLPUL]LNRPRGGRELMDQMD+,9D
D+5 &, S >@ 2YL
UH]XOWDWL VX SULYXNOL YHOLNX PHÿXQDURGQX SDåQMX
1DNRQ NRQVXOWRYDQMD VWUXþQMDND L VLVWHPDWVNH SUR
YHUH SRVWRMHüLK SRGDWDND 6YHWVND ]GUDYVWYHQD
RUJDQL]DFLMD MH GDOD L]MDYX R VYRMLP SUHWKRGQLP
SUDYLOQLFLPD R XSRWUHEL KRUPRQDOQH NRQWUDFHSFLMH
LSRQRYRMHLVWDNOD]QDþDMXSRWUHEHSUH]HUYDWLYD]D
GYRMDNX]DãWLWX>@
5HQHH +HIIURQ MH SUHGVWDYLOD UH]XOWDWH YLãH DQDOL]D
GRGDWQHRVHWOMLYRVWLJGHMHLVSLWDQDUREXVQRVWUH]XO
WDWDLVWUDåLYDQMD3DUWQHULXSUHYHQFLML>@,VWDNODMH
GDVXQDOD]LL]RYRJLGUXJLKREVHUYDFLRQLKVWXGLMD
QHNRQ]LVWHQWQL WHãNL ]D LQWHUSUHWDFLMX L GD PRJX
LPDWLELKHYLRUDOQRLLOLELRORãNRREMDãHQMH
8SUHWKRGQRSULMDYOMHQRMSULPDUQRMDQDOL]LLVWUDåLYDþL
VX NRULVWLOL &R[RYX SURSRUFLRQDOQX UHJUHVLMX KD]
DUGQLK XWLFDMD SULODJRÿHQX JRGLQDPD EURMX YLUXV
QLKNRSLMDNRGPXãNRJSDUWQHUDLYUHPHQVNL]DYLV
QRP QH]DãWLüHQRP VHNVXDOQRP RGQRVX L WUXGQRüL
*RGLQD,EURM
UDGLSRUHÿHQMDSRMDYH+,9DNRGåHQDNRMHNRULVWH
LQMHNWLELOQX KRUPRQDOQX NRQWUDFHSFLMX L NRG åHQD
NRMHQLVXSULMDYLOHQLNDNYXKRUPRQDOQXPHWRGX
1RYLMH DQDOL]H RVHWOMLYRVWL LVSLWDOH VX PRJXüH
HIHNWH SRQDãDQMD SRJUHãQX NODVL¿NDFLMX åHQD NRMH
VX SURPHQLOH KRUPRQDOQX NRQWUDFHSFLMX QDNRQ
LVWUDåLYDQMD L HIHNDW VNODGLãWD PHGURNVLSURJHVWHURQ
DFHWDWD '03$ X SRUHÿHQMX VD GUXJLP PHWRGDPD
KRUPRQDOQH NRQWUDFHSFLMH .DNR SRGDFL R EUHQGX
KRUPRQDOQH NRQWUDFHSFLMH QLMVX ELOL SULNXSOMHQL
WRNRPVWXGLMHDNDNRELVHL]RORYDRHIHNDW'03$
SRGDFL ]D åHQH L] -XåQH$IULNH ELOL VX FHQ]XULVDQL
MHU MH WR MHGLQD GUåDYD VD ORNDFLMDPD ]D LVSLWLYDQMH
JGHVXNRULãüHQHGUXJHPHWRGHKRUPRQDOQHNRQWUD
FHSFLMH
'U+HIIURQMHSULMDYLODNRQVWDQWQRSRYHüDQMHUL]LND
RGLQIHNFLMH+,9RPNRMLMHVNRURGYRVWUXNRYHüLX
VYLPDQDOL]DPD.DGDVHRJUDQLþLVDPRQDNRULVQLNH
'03$ LQMHNWLELOQD KRUPRQDOQD NRQWUDFHSFLMD MH
SRYH]DQDVDVNRURþHWYRURVWUXNLPSRYHüDQMHPUL]
LNDRGLQIHNFLMH+,9RPYLGHWLWDEHOX
'U+HIIURQMHLVWDNODGDVXQHNHDQDOL]HL]JXELOHSUH
FL]QRVWXVOHGVPDQMHQHYHOLþLQHX]RUNDSRGJUXSDDOL
MHSULODJRÿHQLRGQRVKD]DUGDXYHNSRWYUÿLYDRWUHQG
NDSRYHüDQMXUL]LND2QDMH]DNOMXþLODGDWLUH]XOWDWL
PRUDMX ELWL XUDYQRWHåHQL VD QHGYRVPLVOHQLP SUHG
QRVWLPDLQMHNWLELOQHNRQWUDFHSFLMH7DNRÿHMHGRGDOD
GDVXSRWUHEQHNYDOLWHWQLMHVWXGLMHKRUPRQDOQHNRQ
WUDFHSFLMH L UL]LND RG LQIHNFLMH +,9RP L LVWDNOD MH
]QDþDM LQWHJULVDQMD UHSURGXNWLYQRJ ]GUDYOMD L SUR
JUDPDSUHYHQFLMH+,9D
3UDWHüL SUH]HQWDFLMX &KHOVHD 3ROLV L] 86$,'D L]
.DQFHODULMH ]D ]GUDYOMH SRSXODFLMH L UHSURGXNWLYQR
]GUDYOMH L] 9DãLQJWRQD SRND]DOD MH UH]XOWDWH L]
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
VLVWHPDWVNRJ SUHJOHGD HSLGHPLRORãNH OLWHUDWXUH R
YH]DPDL]PHÿXKRUPRQDOQHNRQWUDFHSFLMHLGRELMDQ
MD+,9DXNOMXþXMXLREMDYOMHQMHLOLãWDPSDQHþODQNH
GRGYDQDHVWRJ
7DEHOD5H]XOWDWLDQDOL]DRVHWOMLYRVWLSRMDYH+,9DNRGåHQDNRMHNRULVWHLQMHNWLELOQXNRQWUDFHSFLMX
QDVSUDPåHQDNRMHQHNRULVWHKRUPRQDOQXNRQWUDFHSFLMX
$QDOL]H
%URMVHNVXDOQLKRGQRVD
0XãNDUFLNRMLVXSULMDYLOLRGQRVEH]]DãWLWH
äHQHNRMHVXSULMDYLOHRGQRVEH]]DãWLWH
2JUDQLþHQMHQDSHULRGHSUHSUHODVNDQDPHWRG+&
'03$NRULVQLFL
D+5
&,
SYUHGQRVW
3ULODJRÿHQRJRGLQDPDRVQRYQRPEURMXYLUXVQLKNRSLMDNRG+,9SR]LWLYQLKSDUWQHUDLYUHPHQVNL]DYLVQRMSULMDYOMHQRMWUXGQRüL
3ULODJRÿHQRJRUHQDYHGHQRPLSULMDYOMHQRPVHNVXDOQRPRGQRVXEH]]DãWLWHRGVWUDQHGUXJRJSDUWQHUD
,VWUDåLYDþL VX LGHQWL¿NRYDOL GYDGHVHW UHOHYDQWLK
VWXGLMDRGNRMLKMHRVDPLVSXQLORPLQLPDOQHNULWHUL
MXPHNYDOLWHWD6DPRMH]DMHGQXVWXGLMXSURQDÿHQR
GDLPDVWDWLVWLþNLYDåQXYH]XL]PHÿXRUDOQHXSRWUHEH
SLOXOD]DNRQWUDFHSFLMXLGRELMDQMD+,9D
1L MHGQD VWXGLMD QLMH SULMDYLOD VWDWLVWLþNL ]QDþDMQX
YH]X L]PHÿX XSRWUHEH QRUHWLVWHURQ HQDQDWDWD 1HW
(QLGRELMDQMD+,9DDOLVXLVWUDåLYDþLQDSRPHQXOL
GD VX WL SRGDFL ELOL RJUDQLþHQL 3RGDFL GRVWXSQL X
YUHPH SUHJOHGD ]D '03$ QLVX XWYUGLOL QLWL MDVQX
YH]X QLWL GH¿QLWLYQR LVNOMXþHQMH PRJXüQRVWL HIHNWD
QDLQ¿FLUDQMH+,9RP
.DNRELVHVWHNDRXYLGXUD]YRMREROMHQMDNRG+,9
SR]LWLYQLKåHQD6KDURQ3KLOOLSVL]6YHWVNH]GUDYVW
YHQH RUJDQL]DFLMH MH SULND]DOD QDOD]H L] VOLþQH
VLVWHPDWVNHSURYHUHUH]XOWDWD>@
2YDSURYHUDUH]XOWDWDMHRWNULODGYDQDHVWL]YHãWDMDL]
MHGDQDHVWVWXGLMDNRMHLVSXQMDYDMXNULWHULMXPLQNOX]
LMH -HGDQ QDVXPLþQL NRQWUROLVDQL SRNXãDM QDãDR MH
SRYHüDQMHUL]LNDNRPSR]LWQHNUDMQMHWDþNHRGRSD
GDQMD&'LOLVPUWLNRGNRULVQLNDKRUPRQDOQHNRQ
WUDFHSFLMH X SRUHÿHQMX VD NRULVQLFLPD ,8' EDNUD
'HVHWRSVHUYDFLRQLKVWXGLMDQLMHSULMDYLOR SRYHüDQL
UL]LNRGUD]YRMD+,9REROMHQMDRGUHÿHQVPUüXWUH
QXWNRPNDGDMH&'LVSRGYUHPHQRPSRþHWND
X]LPDQMD DQWLUHWURYLUXVQH WHUDSLMH SRYHüDQLP YL
UXVQLPRSWHUHüHQMHPLOLSDGRPEURMD&'üHOLMDVD
XSRWUHERP KRUPRQDOQH NRQWUDFHSFLMH X RGQRVX QD
QHXSRWUHEXLVWH
,VWUDåLYDþLVXLVWDNOLGDLDNRMHMHGQDQDVXPLþQDNRQ
WUROLVDQDVWXGLMD]DNOMXþLODGDXSRWUHEDKRUPRQDOQH
NRQWUDFHSFLMH LPD YH]H VD SRYHüDQMHP UL]LND RG
SURJUHVLMH +,9 REROMHQMD WD LVWD VWXGLMD LPD YDåQH
PHWRGRORãNHQHGRVWDWNH1LMHGQDRGVURGQLKVWXGLMD
QLMH QDãOD YH]X L]PHÿX XSRWUHEH KRUPRQDOQH NRQ
WUDFHSFLMHLSURJUHVLMH+,9REROMHQMDXSRUHÿHQMXVD
QHNRULãüHQMHPKRUPRQDOQHNRQWUDFHSFLMH
2QL ]DNOMXþXMX GD ³prevaga dokaza ukazuje na to
GD +,9 SR]LWLYQH åHQH PRJX NRULVWLWL PHWRGX KRUPRQDOQH NRQWUDFHSFLMH EH] ]DELUQXWRVWL YH]DQH ]D
UD]YRM+,9REROMHQMD´
Komentar
U prvoj sistematskoj proveri rezultata sprovedenoj za konsultacije sa Svetskom zdravstvenom orgaQL]DFLMRPLSUH]HQWDFLMXQDRYRMNRQIHUHQFLMLQDOD]LVXELOLPHãRYLWLLQHXVNODÿHQL1LMHGQDRGSUHJOHGDQLKVWXGLMDQLMHELODQDPHQMHQDSURFHQLUL]LNDRGSUHQRVD+,9DLNDRNRGVYLKUH]XOWDWDSRVPDWUDQMDLPDPQRJRSRWHQFLMDOQLKVXPQML
2VDPRGUHOHYDQWQLKSUHJOHGDQLKVWXGLMDLVSXQLORMHPLQLPDOQHNULWHULMXPHNYDOLWHWDYH]DQLK]D
ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%
XSRWUHEXPXOWLYDULMDQWQLKDQDOL]DPDOLJXELWDNSUDüHQMDLMDVQXGH¿QLFLMXXSRUHEHKRUPRQDOQHNRQWUDFHSFLMH6DPRMHMHGQRLVSLWLYDQMHãHVWUDGQLNDX.HQLMLSRND]DORYH]XL]PHÿXRUDOQHNRQWUDFHSFLMH
L UL]LND RG SUHQRVD +,9D SRYHüDQLP ]D >@ +HIIURP VWXGLMD RSLVDQD L]QDG SRND]XMH SURFHQH
SRYHüDQRJQLYRDDOLWRQLMHELOR]QDþDMQR
1LMHGQDVWXGLMDQLMHSULMDYLODVWDWLVWLþNLYDåQXYH]XL]PHÿXXSRWUHEHQRUHWLVWHURQHQDWDWD1HW(QL
SRYHüDQRJUL]LNDRGSUHQRVDDOLVXVDPRQMLKWULGDOHSURFHQXNRQNUHWQRYH]DQX]DRYDMPHWRG
7ULRGRVDPVWXGLMDVXLPDOHVWDWLVWLþNL]QDþDMQRSRYHüDQUHODWLYQLUL]LNVD'03$LOLQHRGUHÿHQRPLQMHNWLELOQRPPHWRGRPXNOMXþXMXüLGXSOLUDQLUL]LNNRG+HIIURQSRYHüDQMHRGLX]DNLQWHUYDO
SRYHUHQMDNRG%DHWRQDLSRYHüDQMHUL]LNDRGVDPDUJLQDOQLPVWUXNWXUDOQLPPRGHOLUDQMHP
NRG0RUULVRQDDOLQHVD&R[RYLPSURSRUFLRQDOQLPPRGHORPXSUHWKRGQLPDQDOL]DPD>@
'UXJHVWXGLMHQLVXLPDOH]QDþDMQDSRYHüDQMDLVPDQMHQMDUHODWLYQLKUL]LND2YDKHWHURJHQRVWVHQHPRåH
REMDVQLWL UD]OLNDPD X SRMDYL +,9D VYUKRP SULNXSOMDQMD SRGDWDND YHOLþLQRP LVSLWLYDQH SRSXODFLMH
SULVWXSRPWUXGQRüLEURMHPVHURNRQYHUWHUDLOLXRSãWHQLPVWDWLVWLþNLPSULVWXSRP5D]OLNHXQDþLQXXSRUHEHNRQGRPDGXåLQLLQWHUYDODLQWHUQRJLVSLWLYDQMDLDQDOL]LVHURGLVNRUGDQWQLKSDURYD]DKWHYDMXGXEOMDUD]PDWUDQMDNDRL]DEULQXWRVW]ERJSRWHQFLMDOQRSULVXWQLKQHXVNODÿHQLKSUHRVWDOLKSRGDWDND
6LVWHPDWVNLSUHJOHGLVWUXþQHNRQVXOWDFLMH6YHWVNH]GUDYVWYHQHRUJDQL]DFLMH]DNOMXþLOHVXGDWHORGRND]D
RLQMHNWLELOQLPNRQWUDFHSFLMDPDQHXWYUÿXMHMDVQXX]URþQXYH]XVDGRELMDQMHP+,9DQLWLLVNOMXþXMH
PRJXüQRVWXWLFDMD
.ULWHULMXPPHGLFLQVNHSULNODGQRVWL0(&]DXSRWUHEXNRQWUDFHSFLMHQXGLYRGLþREH]EHGQRMXSRWUHEL
UD]OLþLWLKPHWRGD]DåHQHLPXãNDUFHVDSRVHEQLPNDUDNWHULVWLNDPDLOLSR]QDWLPPHGLFLQVNLPVWDQMLPDL
NRULVWHJDNUHDWRULSROLWLNHPHQDGåHULSURJUDPDLQDXþQH]DMHGQLFH]DSRGUãNXQDFLRQDOQLKSURJUDPD
]DSULSUHPXSUDYLOQLNDRSUXåDQMXXVOXJH0(&VHQLMHSURPHQLRQDNRQNRQVXOWDFLMD6YHWVNH]GUDYVWYHQHRUJDQL]DFLMHLQHSRVWRMHRJUDQLþHQMDXXSRWUHELELORNRMHPHWRGHKRUPRQDOQHNRQWUDFHSFLMH]D
åHQHNRMHåLYHVD+,9RPLOLSRGYLVRNLPUL]LNRPRG+,9DLDNRMHGRGDWRVOHGHüHUD]MDãQMHQMH³1HNH
VWXGLMHJRYRUHGDåHQHNRMHNRULVWHLQMHNWLELOQXNRQWUDFHSFLMXNRMDVDGUåLVDPRSURJHVWHURPPRJXELWL
L]ORåHQHSRYHüDQRPUL]LNXRGGRELMDQMD+,9DGUXJHVWXGLMHQHSRND]XMXWXYH]XJUXSDVWUXþQMDND
6YHWVNH]GUDYVWYHQHRUJDQL]DFLMHMHSURYHULODVYHGRVWXSQHGRND]HLVORåLODVHGDSRGDFLQLVXGRYROMQR
XYHUOMLYLGDSURPHQHWUHQXWQLSUDYLOQLN0HÿXWLP]ERJQHXYHUOMLYHSULURGHWHODGRND]DRPRJXüHP
SRYHüDQRPUL]LNXRGGRELMDQMD+,9DåHQHNRMHNRULVWHLQMHNWLELOQXNRQWUDFHSFLMXVDPRVDVDGUåDMHP
SURJHVWHURQDWUHEDVDYHWRYDWLGDWDNRÿHNRULVWHNRQGRPHPXãNHLOLåHQVNHLGUXJHPHUH]DSUHYHQFLMX
+,9D(NVSDQ]LMDPHãDYLQHNRQWUDFHSWLYQLKPHWRGDLGDOMHLVWUDåLYDQMHRGQRVDL]PHÿXKRUPRQDOQH
NRQWUDFHSFLMH L +,9 LQIHNFLMH MH RG VXãWLQVNRJ ]QDþDMD 2YH SUHSRUXNH üH ELWL VWDOQR SUHLVSLWLYDQH X
VYHWOXQRYLKGRND]D´
0HÿXWLPYDåQRMHLVWDüLGDRYDNDYVLVWHPQXPHUDFLMHQHPRåHUHÀHNWRYDWLQLMDQVHXNOMXþHQXQHVLJXUQRVWLNRPSOHNVQRVWGLVNXVLMH
äHQHNRMHåLYHVD+,9RPLDNWLYLVWLXNOMXþHQLXVWUXþQHNRQVXOWDFLMHLNDVQLMHGLVNXVLMHRSUDWHüLPRSHUDWLYQLPUD]PDWUDQMLLPDLVWDNOLVXNULWLþQL]QDþDMMDVQLKLQIRUPDFLMDL]DåHQHNRMHNRULVWHKRUPRQDOQH
kontracepcije i za zdravstvene radnike.
5HIHUHQFH
+RUPRQDOFRQWUDFHSWLRQDQG+,9DQHYROYLQJFRQWURYHUV\WK,QWHUQDWLRQDO$,'6&RQIHUHQFH-XO\:DVKLQJWRQ'&6HVVLRQ
:($&
KWWSSDJDLGVRUJ6HVVLRQDVS["V +HIIURQHWDO8VHRIKRUPRQDOFRQWUDFHSWLYHVDQGULVNRI+,9WUDQVPLVVLRQDSURVSHFWLYHFRKRUWVWXG\/DQFHW,QIHFWLRXV'LVHDVHV9ROXPH
,VVXH-DQXDU\
:+2XSKROGVJXLGDQFHRQKRUPRQDOFRQWUDFHSWLYHXVHDQG+,9*HQHYD)HEUXDU\
KWWSZZZZKRLQWPHGLDFHQWUHQHZVQRWHVFRQWUDFHSWLYHVBHQLQGH[KWPO
+HIIURQ5HWDO$VVRFLDWLRQRILQMHFWDEOHFRQWUDFHSWLRQDQGULVNRI+,9DFTXLVLWLRQLQZRPHQLQ+,9VHURGLVFRUGDQWSDUWQHUVKLSVSHUVLVWHQFH
RIHIIHFWLQPXOWLSOHVHQVLWLYLW\DQDO\VHVWK,QWHUQDWLRQDO$,'6&RQIHUHQFH-XO\:DVKLQJWRQ'&2UDODEVWUDFW:($&
3ROLV&HWDO+RUPRQDOFRQWUDFHSWLRQDQG+,9DFTXLVLWLRQLQZRPHQDV\VWHPDWLFUHYLHZRIWKHHSLGHPLRORJLFDOHYLGHQFHWK,QWHUQDWLRQDO
$,'6&RQIHUHQFH-XO\:DVKLQJWRQ'&2UDODEVWUDFW:($&
3KLOOLSV6HWDO+RUPRQDOFRQWUDFHSWLRQDQG+,9GLVHDVHSURJUHVVLRQDV\VWHPDWLFUHYLHZRIWKHHSLGHPLRORJLFDOHYLGHQFHWK,QWHUQDWLRQDO
$,'6&RQIHUHQFH-XO\:DVKLQJWRQ'&2UDODEVWUDFW:($&
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
0HÿXQDURGQLNRQJUHVR+,9WHUDSLML
11.-15. 11. 2012, Glazgow, Ujedinjeno kraljevstvo
Uvod
0HÿXQDURGQL NRQJUHV R +,9 WHUDSLML VH RGUåDYD
X *ODVJRZX VYDNH GYLMH JRGLQH L LPD WX SUHGQRVW
GDLPDSURJUDPXMHGQRMVWD]LWDNRVDVHVYHPRåH
RODNãDQRSUDWLWL3URJUDPMHRYHJRGLQHXNOMXþLYDR
L]YUVWDQSUHJOHGSUHGDYDQMDLYLãHRGSODNDWD
6DåHFL VD VDVWDQND VX REMDYOMHQL NDR GRGDWDN X
åXUQDOX0HÿXQDURGQRJ$,'6GUXãWYDDWDNRÿHUVX
GRVWXSQL L PRJX VH EHVSODWQR SUHX]HWL X 3') IRU
PDWXQDZHEVWUDQLFDPDNRQIHUHQFLMH
:HEFDVWL]XVPHQLKSUH]HQWDFLMDELWüHREMDYOMHQH
QDVWUDQLFDPDNRQIHUHQFLMHNUDMHP
KWWSZZZKLYFRP
3LWDQMDNRMDGRYRGHGRSRGHOMHQLKPLãOMHQMDVWUXþQMDNDNDGDSRþHWL+,9LVWDUHQMHL
XWLFDM+,9DQDRþHNLYDQLåLYRWQLYHN
6LPRQ&ROOLQV+,9LEDVH
3URJUDP X *ODVJRZX MH XNOMXþLYDR SUHJOHG WUL
NOMXþQDDVSHNWD+,9DNRMDLGDOMHGHOHVWXþQMDNH
7XVXSLWDQMDNDGDSRþHWL$57SUHNODSDQMHNRPSOHNVQRVWL +,9D L VWDUHQMD L XWLFDM RED RYD SLWDQMDQDRþHNLYDQLåLYRWQLYHN
5D]QRYUVQLVWDYRYLRVYDNRPVXEMHNWXPRJXXþLQLWL
RYH GLVNXVLMH X]EXGOMLYLP LVNXVWYRP ]D SDFLMHQWD
NRMLVDPRåHOLGDXþLQLRQRãWRMHQDMEROMH]DVYRMH
]GUDYOMHLNRMLMHVXRþHQVDVXNREOMHQLPPLãOMHQMLPD
VWUXþQMDND
‡'DOLVYDNRWUHEDGD]DSRþQHWUHWPDQLOLVXSRWUHE
QLYHüLRSUH]LGRGDWQLSRGDFLQDQLYRXSRSXODFLMHL
SRVHEQR]DRQHVDQDMYHüLPEURMHYLPD&'"
‡'DOL+,9X]URNXMHUDQLMHLVORåHQLMHVWDUHQMHLOL
GD OL VH SUHWKRGQR SULMDYOMHQH UD]OLNH PRJX REMDV
QLWL XSRWUHERP QHSULNODGQLK NRQWUROQLK JUXSD L
PRGL¿NXMXüLPIDNWRULPDVWLODåLYRWD"
‡'DOLVHRþHNLYDQLåLYRWQLYHN]D+,9SR]LWLYQH
RVREH SULEOLåDYD RQRP ]D +,9 QHJDWLYQH RVREH
LOLQDPLGDOMHQHGRVWDMHJRGLQD]ERJVDPRJ
+,9DLOLNRPSOHNVQLKGHPRJUD¿MD+,9NRKRUWL"
ZZZKLYELOWHQLQIR
$NR MH RYR ]EXQMXMXüH ]D UDQLMH GLMDJQRVWLNRYDQH
OMXGHNDGDVXQMLKRYL&'EURMHYLLGDOMHYLVRNLLNRML
LPDMX GREDU SULVWXS WHUDSLML MRã YLãH MH ]EXQMXMXüH
]D OMXGH VD NRPSOHNVQLMLP LVWRULMDPD 2YD SLWDQMD
VX YLãH RG DNDGHPVNH GHEDWH L SUHNODSDMXüH YH]H
L]PHÿX RYH WUL WHPH VX X]URNRYDOH ]DQLPOMLYX GLV
NXVLMXQDNRQIHUHQFLML
.DGDSRþHWLãWRSUHLOLQHWDNREU]R"
3UHSDUJRGLQDNDGDMHPHÿXQDURGQD67$57VWXGLMD
SODQLUDQD SRYUDWQH LQIRUPDFLMH GRNWRUD L] 9HOLNH
%ULWDQLMH JRYRULOH VX GD SUDJ &' ]D UDQX WHUDS
LMX WUHED ELWL MHU MH SRVWDMDOD ]DEULQXWRVW GD EL
SUDJ RG XþLQLR L]YUãHQMH VWXGLMH QHPRJXüLP
2þHNLYDOR VH GD þDN L EXGH L]D]RY V RE]LURP
QDNRQFHQ]XVRRGODJDQMXVYHGRNWUHWPDQQLMH³VWYDUQRSRWUHEDQ´
0QRJR WRJD VH SURPHQLOR RG WDGD 9HüD SDåQMD MH
SRVYHüHQDSUREOHPLPDXVOHGQHSRWLVQXWHYLUHPLMHL
SUDWHüLKLPXQLWHWQLKLQÀDPDFLMD7DNRÿHSRVWRMLYHüH
SRYHUHQMH GD MH$57 ]DãWLWD RG R]ELOMQLK QH$,'6
GRJDÿDMDXNOMXþXMXüLNDUGLRYDVNXODUQHUHQDOQHLKH
SDWVNH EROHVWL L QHNH NDQFHUH XPHVWR PRUELGQRVWL
*RGLQD,EURM
+,9%,/7(1+7%
XVOHGVSRUHGQLKHIHNDWD.RQDþQRVPDQMHQDLQIHN
WLYQRVWGHPRQVWULUDQDX+371VWXGLMLGRND]XMH
SRWHQFLMDO$57DGDVPDQMLSUHQRãHQMHLQIHNFLMH
8 *ODVJRYX MHGQD RG SUYLK VHVLMD VDGUåDOD MH GH
EDWXRWDMPLQJX$57DQDQLYRXSRSXODFLMHVDHN
VWUHPQLPVWDYRYLPDLOLXQLYHU]DOQRJWUHWPDQDXGL
MDJQRVWLFLXSRUHÿHQMXVDRGODJDQMHPVYHGRN&'
EURMHYLQHGRVWLJQXüHOLMDPP
0LFKDHO6DDJVD8QLYHU]LWHWD$ODEDPDLþODQ6$'
'++6 SDQHOD SUDYLOQLND VPDWUD GD VX JRUH QDYH
GHQH SUHGQRVWL GRYROMQH VDPH SR VHEL GD EL SUHãOH
X SROLWLNX XYRÿHQMD WHUDSLMH QDNRQ GLMDJQR]H EH]
RE]LUDQD&'EURMHYH
2YR VH X YHOLNRM PHUL SUHSRUXþXMH X 6$' '++6
SUDYLOQLFLPDDOLMHHNVWUHPQLMHL]UDåHQRSUDYLOQLFL
PD,$66$'2EHJUXSHYHUXMXGDVXNRPS
OLNDFLMHWUHQXWQLKWUHWPDQDGRYROMQRNRQWURODELOQH]D
UD]OLNXRGSURVHþQRXPHVWRJRGLQDåLYRWDGD
ELVHWUHWPDQ]DQHPDULRLGDMDYQR]GUDYVWYRPRåH
LPDWL NRULVWL RG VPDQMHQMD YLUDOQRJ RSWHUHüHQMD X
SRSXODFLML ,DNR SRGDFL L] QDVXPLþQLK VWXGLMD QLVX
GRVWXSQL]DOMXGHVDYLVRNLP&'EURMHYLPD6DDJ
VPDWUDGDSRGDFLNRKRUWHJRYRUHGDUDQLMLWUHWPDQ
EDUHP NUDWNRURþQR QH XND]XMH QD ]QDþDMQX ãWHWX
7DNRÿH ]D QHNH GRNWRUH SRYHüDQD ]DEULQXWRVW R
GXJRURþQLP LPSOLNDFLMDPD XVOHG QHNRQWUROLVDQH
+,9 YLUDOQH UHSOLNDFLMH SUH SRþHWND WUHWPDQD L X
PDQMRM PHUL þDN SRVWRMHüH YLUHPLMH X WUHWPDQX
SRVWDMHWDNRXEHGOMLYGDRQLYLGHRGODJDQMHWUHWPD
QDþDNLNRGOMXGLVDQDMYHüLP&'EURMHYLPDNDR
SULEOLåDYDQMHPHGLFLQVNRMQHPDUQRVWL
'D EL VH RYD LQWHUSUHWDFLMD REXKYDWLOD X WUHQXWQLP
GRND]LPD -HQV /XQGJUHQ VD 8QLYHU]LWHWD X .R
SHQKDJHQX þODQ ($&6 SDQHOD SUDYLOQLND L NR
SUHGVHGDYDMXüL67$57VWXGLMHVPDWUDGDSUHOD]DNQD
XQLYHU]DOQLWUHWPDQSUHGVWDYOMDGRYROMQRYDåQXSROL
WLNXMDYQRJ]GUDYVWYDGDELVHRQDYRGLODULJRUR]QLP
GRND]LPDRWRPHGDOLþQHSUHGQRVWLQDGPDãXMXUL]
LNH]DSDFLMHQWHVD&'EURMHYLPDYHüLPRGL
SRVHEQRYHüLPRG3RWUHEDGDRYREXGHSRVOHGL
FDQDVXPLþQHVWXGLMHMHYDåQDMHUGRVDGDVXVWXGLMH
YHOLNLKNRKRUWLSULMDYOMLYDOHNRQWUDGLNWRUQHUH]XOWDWH
]DRYHSDFLMHQWH1HGRVWDWDNGRND]DL]VWXGLMDNRMH
VXGL]DMQLUDQHGDQDÿXSRWHQFLMDOQHãWHWQHHIHNWHUD
QLMLKWUHWPDQDWRMHPDQDVWXGLMDNRKRUWLMHGRYHR
GRRVODQMDQMD]DRYDMDVSHNWSUDYLOQLNDQDPLãOMHQMH
VWUXþQMDND NRMH MH XQLYHU]DOQR SULKYDüHQR NDR QD
MPDQMH SRX]GDQD GRND]QD RVQRYD ]D SUHSRUXNH X
WHUDSLML
-HGDQ RSUH] NRML WUHED GD XNURWL ELOR NDNYX åXUEX
*RGLQD,EURM
X XQLYHU]DOQRP WUHWPDQX ]D YLãH &' EURMHYH
GROD]L L] SRGDWDND NRML SRND]XMX GD YDQ NRQWHNVWD
NOLQLþNLK VWXGLMD SDFLMHQDWD QLMH SRVWLJOR
RSWLPDOQX YLUDOQX VXSUHVLMX SUL VYRMRM SUYRM NRP
ELQDFLML SRYHüDYDMXüL YHURYDWQRüX UH]LVWHQFLMH
QD OHN YHURYDWQR JRGLQDPD SUH QDVWDQND NOLQLþNH
SRWUHEH ]D WHUDSLMRP 7DNRÿH LDNR MH WROHUDQWQRVW
VD GDQDãQMLP WUHWPDQLPD VWDELOQR SREROMãDQD SR
WHQFLMDOQDWRNVLþQRVWPRåHELWLVPDQMHQDGRGDWQRX
EXGXüLPWUHWPDQLPD
2YRX]URNXMHUD]XPQXRSUH]QRVWNRGELORNRJDNR
SRþLQMHWUHWPDQVD&'!NDGDMHDSVROXWQLUL]LN
RG +,9 YH]DQLK GRJDÿDMD YHü YUOR QL]DN SRVHE
QR V RE]LURP GD VH LVWRULMVNL UDQLML WUHWPDQ SUHPD
PLãOMHQMXVWUXþQMDNDGRND]DRSRJUHãQLP5DYQRWHåD
SRGUåDQDWUHQXWQLPSRGDFLPDMHSRVHEQRYDåQD]D
REXKYDWDQMHOMXGLNRMLVXWUHQXWQRX67$57VWXGLML
2YD YHOLND PHÿXQDURGQD VWXGLMD üH XNOMXþLWL QDM
PDQMHSUHGORåHQLKXþHVQLNDUDQLMHXVYH
VD&'EURMHYLPDYHüLPRGüHOLMDPPXRVQR
YL1DNRQUDQGRPL]UDFLMHGRLOLWUHQXWQRJ$57DLOL
RGODJDQMDGRN&'EURMHYLQHGRÿXGRUH]XOWDWL
VHRþHNXMXGRJRGLQHLOLUDQLMHDNRVXUD]OLNH
L]PHÿXGYHJUXSH]QDWQRYHOLNH
8þHVQLFL NRML VH WUHQXWQR QDOD]H X RGORåHQRM JUXSL
67$57VWXGLMHWUHEDMXRVWDWLXYHUHQLLSRGUåDQLSR
GDFLPD L] YHOLNLK (YURSVNLK NRKRUWL NRML SRND]XMX
DSVROXWQLUL]LNRGQDVWDQNDSUREOHPDGRNVXQMLKRYL
&'EURMLL]PHÿXLLPDORMHYHURYDWQRGD
üHVHUD]OLNRYDWL]QDþDQRDNRELSRþHOLVD
6OLþQRXþHVQLFLXWUHQXWQRMJUXSL67$57DWUHEDMX
ELWLUD]XYHUHQLGDSRGDFLNRKRUWHSRGUåDYDMXQL]DN
UL]LNVODJDQMDL]UDQLMHJ$57DDOLLGDWR]DYLVLRG
RGUåDYDQMD QHGHWHNWRYDQRJ YLUDOQRJ RSWHUHüHQMD
NRMH MH VDPR YH]DQR ]D SDåOMLYR SURYHUDYDQMH
7DNRÿHQLåLNYDOLWHWåLYRWDQHWUHEDGDSRVWDQHFHQD
]DVPDQMHQMH]DMHGQLþNRJYLUDOQRJRSWHUHüHQMDLDNR
MH L]D]RYQR PHULWL L MHGQR L GUXJR WUHWPDQ MH ODNR
PRGL¿NRYDWLLOLSURPHQLWLDNRVHSUYDNRPELQDFLMD
WHãNRWROHULãH
'RN67$57VWXGLMDQHSURL]YHGHUH]XOWDWHSRMHGLQFL
VDYLVRNLP&'EURMHYLPDWUHEDMXELWLSRGUåDQLDNR
åHOHGDSRþQXVDWHUDSLMRP+,9WHUDSLMDMHYLVRNR
LQGLYLGXDOQDLWDRGOXNDüHELWLLVSUDYQD]DQHNHDOL
QHL]DGUXJH
=D SDFLMHQWH YDQ 67$57 VWXGLMH PRWLY ]D WUHWPDQ
UDGLSUHYHQFLMHüHVHYHURYDWQRSRYHüDWLRGVDGDGR
JRGLQH EH] RE]LUD QD NOLQLþNL XWLFDM UDQLMH
WHUDSLMH SD MH YDåQR RGUåDWL MDVQX UD]OLNX L]PHÿX
SUHGQRVWLQDQLYRXSRSXODFLMHLOLþQLK]GUDYVWYHQLK
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
SUHGQRVWLNDGDVHLQGLYLGXDOL]XMHRGOXNDRSRþHWNX
WHUDSLMH
+,9 L VWDUHQMH NOLQLþNH EULJH LOL ]EXQMHQRVW
QHRGJRYDUDMXüLPNRQWURODPD"
8WLFDM L SRYH]DQRVW +,9 L VWDUHQMD MH GUXJD WHPD
UD]PDWUDQDX*ODVJRZX]ERJNRMHVXVWUXþQMDFLL]
UD]LOLUD]OLþLWDPLãOMHQMD2SHWRYLVWDYRYLXWLþXQD
NOLQLþNH RGOXNH XNOMXþXMXüL RGOXNX GD OL WUHED UD
QLMH ]DSRþHWL WHUDSLMX 6 MHGQH VWUDQH SLWDQMH MH GD
OL +,9 GLUHNWQR GRSULQRVL ]QDþDMQR EUåHP VWDUHQMX
L SRYHüDQLP NRPRUELGQRVWLPD þDN L X NRQWHNVWX
VWDELOQH WHUDSLMH LOL GD OL SUHWKRGQL L]YHãWDML UD
QRJLOLSUHYUHPHQRJVWDUHQMDPRJXELWLREMDãHQMHQL
SRWHãNRüDPD X LGHQWL¿NRYDQMX SULNODGQH NRQWUROH
+,9QHJDWLYQHSRSXODFLMH"
1HNROLNR YDåQLK LVWUDåLYDþNLK JUXSD MH GRSULQH
OR RYRM GHEDWL 8 VHGPRP PHVHFX GRSXQD
-$,'6XREMDYOMHQDXLVWRYUHPHNDGDVHRGUåDYDOD
,$6 NRQIHUHQFLMD X :DVKLQJWRQX SUHJOHGDOD MH
þHWLULNOMXþQHREODVWLR+,9XLVWDUHQMX8NOMXþLYDOD
MHPHKDQL]PH]DIXQNFLQDOQLSDGNRGXURÿHQLKLXV
YRMHQLKLPXQLWHWDNRG+,9SR]LWLYQLKRVREDGRND]H
]DSRYHüDQMHQHNLKELRPDUNHUDYH]DQLKL]D+,9L
]D VWDUHQMH XORJX NRPRUELGQRVWL L UD]QRYUVQLK EL
KHYLRUDOQLK L VRFLRHNRQRPVNLK IDNWRUD NRML þLQH
+,9 SR]LWLYQX SRSXODFLMX WDNR NRPSOHNVQRP GH
PRJUDIVNRP JUXSRP 3RUHG SUL]QDQMD GD $57
SRYHüDYDRþHNLYDQLåLYRWQLYHNGRJRGLQDGRNX
PHQWMHIRNXVLUDQQDWR]DãWRRYRQLMHQRUPDOL]RYD
QR]D+,9QHJDWLYQHQLYRH7DNRÿHSUHGODåHNOMXþQH
L]D]RYH LVWUDåLYDQMD NRML PRUDMX ELWL RGUHÿHQL NDR
SULURLWHWLNDNRELVHRGJRYRULORQDWDSLWDQMD
1D&52,$P\-XVLFHL]=GUDYVWYHQRJVLVWHPD
]D YHWHUDQHLNRDXWRU-$,'6 SUHJOHGDLVWLþHUD]
OLNXL]PHÿXSRWHQFLMDOQHXORJH+,9DLX³XEU]DQRP
VWDUHQMX´JGHVHNRPRUELGQRVWPRåHMDYLWLXUDQLMLP
JRGLQDPDLX³QDJODãHQRPVWDUHQMX´JGHQDVWDMHSR
YLãRMVWRSLLGDWLHIHNWLQLVXPHÿXVREQRLVNOMXþLYL
2YD RUDOQD SUH]HQWDFLMD WDNRÿH SULMDYOMXMH SRGDWNH
NRML SRND]XMX NDNR QHGRVWDWDN SULODJRÿDYDQMD ]D
PODÿH+,9SR]LWLYQHRVREHXRGQRVXQDJHQHUDOQX
SRSXODFLMX NRKRUWH PRåH REMDVQLWL VWXGLMH NRMH VX
SUHWKRGQRWYUGLOHGD+,9SR]LWLYQHRVREHPRJXRV
WDULWLJRGLQDUDQLMHRG+,9QHJDWLYQLKOMXGL
8*ODVJRZX3HWHU5HLVVVD8QLYHU]LWHWDX$PVWHU
ZZZKLYELOWHQLQIR
GDPX+RODQGLMDLNRDXWRU-$',6GRSXQHRVWDUHQMX
L þODQ ($&6 L ,$66$' SDQHOD SUDYLOQLND SUHG
VWDYLR MH SUHJOHG SRWHQFLMDOQLK PHKDQL]DPD QDþLQD
QDNRML+,9PRåHQHJDWLYQRXWLFDWLQDNRPRUELGQRVW
LVWDUHQMH
.DR SRWSRUD PQRJH ]DSDGQH HSLGHPLMH GRVWLåX
WUHQXWDN NDGD üH YLãH RG SRORYLQH +,9 SR]LWLYQH
SRSXODFLMH ELWL VWDULMH RG JRGLQD L NDGD üH HN
VSRQHQFLMDOQR SRYHüDQMH KURQLþQLK VWDQMD ]DMHGQR
LGHQWL¿NRYDWLJRGLQHVWDURVWLNDRMHGLQLQDMYHüLUL]
LN2YRXNOMXþXMHNDUGLRYDVNXODUQHUHQDOQHSOXåQH
LKHSDWVNHEROHVWL]GUDYOMHNRVWLMXQHXURNRJQLWLYQH
IXQNFLMHGLMDEHWHVLVPUW
=DEULQXWRVWR+,9XLVWDUHQMXMHSRVHEQRIRNXVLUDQD
QDOMXGHNRMLVX]DSRþHOLWUHWPDQVDQLåLP&'EURMH
YLPDNRMLüHPDQMHYHURYDWQRGRVWLüL&'EURMHYH
! üHOLMDPP SUL WUHWPDQX þHVWR ]ERJ NDVQLMH
SUH]HQWDFLMH3ULODJRÿDYDQMHPODÿRM+,9SR]LWLYQRM
NRKRUWLMHREMDVQLORUDQLMHL]YHãWDMHGD+,9SR]LWLYQL
OMXGLUD]YLMDMXNDQFHUHYDQ$,'6DXUDQLMLPJRGL
QDPD0HÿXWLPQHNROLNRVWXGLMDMHWDNRÿHSULMDYLOR
GDSRVWRMLYHOLNDXSRWUHEDSURSUDWQLKOHNRYDXUDQL
MLP JRGLQDPD SROLIDUPDFLMD LDNR RYR PRåH ELWL
YRÿHQREROMRPEULJRPLþHãüLPSUDüHQMHPNRMH+,9
SR]LWLYQHRVREHSULPDMX
3UH WUHWPDQD LPXQRORãNL SUHNLG +,9 L &09 UHS
OLNDFLMH JXELWDN LQWHJULWHWD PLãLüQH PDVH L PLNUR
ELDOQD WUDQVORNDFLMD ]DMHGQR GRSULQVRH SRMDþDQRP
VWDQMX DNWLYDFLMH LPXQLWHWD ,DNR X YHOLNRM PHUL
VPDQMHQD$57RPXURÿHQDDNWLYQRVWPRåHRGUåDWL
LQÀDPDWRUQRVWDQMHNRMHQDVWDYOMDGDSRYHüDYDUL]LN
RG ¿EUR]QLK L NRDJXODFLRQLK VWDQMD L RQD VX SRY
H]DQD VD YHüRP NRPRUELGQRãüX 6WHSHQ GR NRMHJ
RYRXEU]DYD]GUDYSURFHVVWDUHQMDNRMLSRGH¿QLFLML
XNOMXþXMHSURPHQHXLPXQLPIXQNFLDPDLVWUXNWXUL
WNLYDLüHOLMDPRUDVHXWYUGLWLLVWUDåLYDQMHP
7DNRNROLNRJRGGDVXRþDUDYDMXüHL]DGRYROMDYDMXüH
EULJH]ERJLQÀDPDFLMH5HLVVLVWLþHGDRYDMNRQFHSW
WUHQXWQRRVWDMHKLSRWH]DNRMDPRUDELWLLOLGRND]DQD
LOLRGEDþHQDLGDMHWRYHüIRNXVQHNROLNRYHOLNLK
VWXGLMD 'R WDGD L]ERUL åLYRWQRJ VWLOD XNOMXþXMXüL
GLMHWH YHåEDQMH SUHVWDQDN SXãHQMD PRJX XEODåLWL
PQRJHRGRYLKGRGDWQLKIDNWRUDUL]LNDNRMLGRSULQR
VH NRPRUELGQRVWL NRG +,9 SR]LWLYQLK OMXGL NDR L
X JHQHUDOQRM SRSXODFLML 7DNR üH L SLWDQMH +,9D L
VWDUHQMDSRVWDWLVYH]QDþDMQLMHJOREDOQR
*RGLQD,EURM
+,9%,/7(1+7%
2þHNLYDQLåLYRWQLYHNPRGHOL]DNRQDþQLLVKRG
-$,'6GRSXQDRVWDUHQMXSUHPDSUHWKRGQLPQDYRGL
PDX]SUL]QDQMHGD$57GUDPDWLþQRSURGXåDYDåLYRW
WDNRÿH XNOMXþXMH VOHGHüH SURYRNDWLYQH UHþHQLFH X
XYRGQRPSDUDJUDIXL]YUãQRJSUHJOHGDL]YHãWDMD³U
SURVHNXRJRGLãQMDNNRMLX]LPD$57MHPRåGDYHü
L]JXELRMHGQXWUHüLQXRþHNLYDQLKSUHRVWDOLKJRGLQD
åLYRWDXSRUHÿHQMXVDGHPRJUDIVNLVOLþQLP+,9QHLQ¿FLUDQRPSRSXODFLMRP´QDRVQRYXVWXGLMH.RODER
UDFLMH NRKRUWH DQWLUHWURYLUDOQH WHUDSLMH $57&&
REMDYOMHQH
.RQIHUHQFLMD X *ODVJRZX XNOMXþLYDOD MH VHVLMH R
+,9XLRþHNLYDQRPåLYRWQRPYHNX3UYDRGWULSU
H]HQWDFLMHELODMHSUHJOHG&DURORQH6DELQVD8QLYHU
]LWHWDX/RQGRQX.DNRMHRYDMNRQDþQLLVKRGWDNR
YDåQRSLWDQMHSULPHüXMHVHGDMHRYRPRåGDSUYLSXW
GDMHRYRMWHPLGDWDSRVYHüHQDVHVLMDXNRQIHUHQFL
MVNRPSURJUDPX
2þHNLYDQL åLYRWQL YHN NDR YDåDQ LQGLNDWRU ]GUDY
OMD VH SRQHNDG SRVPDWUD RG URÿHQMD DOL X NRQWHN
VWX+,9DþHVWRSUHGVWDYOMDGRGDWQHJRGLQHåLYRWDX
RGQRVXQDVWDURVWSULGLMDJQRVWLNRYDQMXLQIHNFLML
'UXJHPHUHXNOMXþXMX
‡L]JXEOMHQHJRGLQHåLYRWD
‡SRWHQFLMDOQDGRELWXRþHNLYDQRPåLYRWQRPYHNX
‡ GRVWL]DQMH PRUWDOLWHWD QD SDFLMHQWRYLK JR
GLQDL
‡ VWDQGDUGL]RYDQH RGQRVH PRUWDOLWHWD 605 X
SRUHÿHQMXVDJRGLQDPDLSROQRXNORSOMHQRPJHQHU
DOQRPSRSXODFLMRPNRQWUROQHJUXSH
6DWUDMQRãüX$57DQHNROLNRLVWUDåLYDþNLKJUXSDMH
SULMDYLORSRYHüDQHQLYRHRþHNLYDQRJåLYRWQRJYHND
NRML VH VDGD SULEOLåDYDMX RQRP NRML RGJRYDUD +,9
QHJDWLYQRM JHQHUDOQRM SRSXODFLML 2QH XNOMXþXMX
PRGHOH L] VWXGLMD NRKRUWL XNOMXþXMXüL $57 && L
8. &+,& NRML SURFHQMXMX GRDWQLK JRGLQD
åLYRWQRJ YHND ]D QHNRJD NRPH MH RGUHÿHQD GLMDJ
QR]D]DJRGLQDX=DSDGQLP]HPOMDPDVDGREULP
SULVWXSRPQH]L
1RYLMLPRGHOREMDYOMHQX$,'6UDQLMHRYHJR
GLQHSURGXåLRMHRþHNLYDQLåLYRWQLYHNQDJRGLQD
&,]DKRPRVHNVXDOFHGLMDJQRVWLNRYDQH
X VD JRGQD L &' EURMHP RG VD JX
ELWNRPRNRJRGLQDåLYRWD]ERJ+,9D2þHNLYDQL
åLYRWQLYHNSDGDDNRVX&'EURMHYLSULGL
MDJQRVWLNRYDQMXJGHVHJXELRNRJRGLQD
2YHVWXGLMHVXXYHOLNRMPHULVOLþQHSUHPDSULMDYOML
YDQMXGDIDNWRULYH]DQL]DGXåLRþHNLYDQLåLYRWQLYHN
XNOMXþXMXNDOHQGDUVNXJRGLQXYHüL&'EURMSRWLV
QXWRYLUDOQRRSWHUHüHQMHUDQLMXSUH]HQWDFLMXPDQMH
*RGLQD,EURM
NRLQIHNFLMHLQH,'8SRSXODFLMH3ULODJRÿYDQMHIDN
WRUD VWLOD åLYRWD WDNRÿH PRåH þLQLWL YHüLQX UD]OLND
L]PHÿX SURFHQD +,9 SR]LWLYQH L JHQHUDOQH SRSX
ODFLMH RNR GR JRGLQD UD]OLNH X 6$' VWXGLML
3RO UDVD XSRWUHED OHND LQMHNFLMRP ,'8 NDVQD
SUH]HQWDFLMDL]DXVWDYOMDQMHWUHWPDQDVXSRYH]DQLVD
YHüLPUD]OLNDPD
$QDOL]H YUãHQH QDG YLãH RG +,9 SR]LWLYQLK
RVREDX(YURSVNRM&2+(5(VDUDGQMLNRKRUWL
SULMDYLOH VX GD ,'8 NRKRUWH L QLVNL &'
EURMHYL REMDãQMDYDMX YHüLQX UD]OLND X RþHNLYDQRP
åLYRWQRPYHNXL]PHÿX+,9SR]LWLYQLKL+,9QHJD
WLYQLKJUXSD
6WRSD PRUWDOLWHWD SRVWDMH VOLþQD RQRM ]D JHQHUDOQX
SRSXODFLMXNDGD&'EURMHYLGRVWLJQX!SULWUHW
PDQX NRG QH,'8 PXãNDUDFD 605 &,
L NRG åHQD QDNRQ WUL JRGLQH QD RYRP QL
YRX605&,1H]YDQLþQRLDNR
VHVWRSDPRUWDOLWHWDSRYHüDYDVDVWDURãüXNRG+,9
SR]LWLYQLK060DVWDULMLKRGJRGLQDNRMLQLVXUD
QLMHLPDOLGLMDJQRVWLNRYDQ$,'6SRVWLJQXWMHVPDQ
MQL 605 PRUWDOLWHW X SRUHÿHQMX VD RGJRYDUDMXüRP
JHQHUDOQRPSRSXODFLMRP
0HÿXWLP VWRSH PRUWDOLWHWD ]D FHOX NRKRUWX RVWDMX
þHWLUL SXWD YHüH RG JHQHUDOQH SRSXODFLMH 605 ]D
PXãNDUFH]DåHQH]DOMXGVNLKJR
GLQD0RUWDOLWHW]D,'8MHELRSXWDYHüL
&,RGJHQHUDOQHSRSXODFLMHDSUHPDSROX
UH]XODWDWLVXSXWDYHüL&,NRG
PXãNDUDFDLSXWD&,YHüLNRG
åHQD 0RUWDOLWHW MH WDNRÿH RVWDR SRYHüDQ NRG ,'8
þDNLVD&'!605&,,DNR
MH WUDMDQMH WUHWPDQD SRPRJOR þDN L QDNRQ SHW JR
GLQDVWRSHVXRVWDOH]QDþDMQRSRYHüDQH
8 FHORVWL RYR YUDüD IRNXV VWXGLMD R VWDUHQMX L
RþHNLYDQRPåLYRWQRPYHNXQD]DGQDSRWHãNRüHSUL
QDODåHQMX RGJRYDUDMXüLK NRQWUROQLK JUXSD JHQHU
DOQHSRSXODFLMH8QXWDU9HOLNH%ULWDQLMHQDSULPHU
SURVHþQLRþHNLYDQLåLYRWQLYHNPRåHYDULUDWLL]D
JRGLQD X ]DYLVQRVWL RG JHRJUDIVNRJ UHJLRQD L þHN
PHÿXSRãWDQVNLPNRGRYLPD/RQGRQDPRåHGRüLGR
YDULMDFLMD YHüLK RG JRGLQD 3URPHQOMLYL IDNWRUL
åLYRWQRJVWLODVXYDåQXEH]RE]LUDQD+,9VWDWXV
.UR] VYH VWXGLMH PRGHOLUDQH SURFHQH ]DYLVH RG
HNVWUDSRODFLMH UHODWLYQR NUDWNRURþQLK SRGDWDND
2QLPRJXSRGFHQLWLRþHNLYDQLåLYRWQLYHNWDNRãWR
QHüHREXKYDWLWLEXGXüDQDSUHGRYDQMDXWUHWPDQLPD
UD]PLãOMDQMHRWUDåQMXOHNDLSRGFHQLWLJDWDNRãWR
QHüH REXKYDWLWL WUHQXWQR QHSR]QDWH EXGXüH NRPS
OLNDFLMHELORXVOHG$57WRNVLþQRVWLUH]LVWHQWQRVWLQD
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
OHNLOLXORJHLQÀDPDFLMH6DELQVXPLUDGDRþHNLYDQL
åLYRWQLYHNRVWDMHORãHREMDãQMHQ]DGHFXLGDüHSRS
XODFLMDNRMDVWDULLPDWLRþLJOHGQRYDåQHLPSOLNDFLMH
]DJOREDOQXHSLGHPLMX
Komentar
2YDWULSLWDQMDVXEOLVNRSRYH]DQDDOLVUHüRPVUHGLQD]DYHüLQXOMXGLVPDQMXMHKLWQRVW]DHNVWUHPQLP
VWDYRYLPDNRMLELWUHEDORGDEXGXSRGUåDQLSRGDFLPDL]GREURGL]DMQLUDQLKVWXGLMD
$57RþLJOHGQRSRYHüDYDRþHNLYDQLåLYRWQLYHN]DVYHJUXSHLWRPRåHELWLQRUPDOL]RYDQRNRGOMXGLVD
NDVQLP GLMDJQR]DPD NRPSOLNRYDQLP +,9 LVWRULMDPD NRPRUELGQRVWLPD LOL XSRWUHERP OHND LQMHNWRYDQMHPSRVHEQRDNRVH&'EURMHYLYUDWHQD!SULWUHWPDQX'DOLQHNHGRGDWQH]GUDYVWYHQHSUHGQRVWLSURL]LOD]H]DOMXGHNRMLVXSRþHOLWUHWPDQVDPQRJRYHüLP&'EURMHYLPDRVWDMHGDVHYLGLNUR]
67$57LQMHJRYHNULWLþQHSRGVWXGLMH
1DMYHüLXWLFDMQDPRUWDOLWHWSRSXODFLMHüHYHURYDWQRELWLSRVOHGLFDVPDQMHQMDSURPHQOMLYLKIDNWRUDUL]LNDXNOMXþXMXüLUDQXGLMDJQRVWLNXLSULVWXSQH]LLVPDQMHQMHUL]LNDYH]DQLK]D,'8
5HIHUHQFH
6DDJ0:KHQWRVWDUWDVVRRQDVSRVVLEOHWK,QWHUQDWLRQDO&RQJUHVVRQ'UXJ7KHUDS\LQ+,9,QIHFWLRQ1RYHPEHU2UDODEVWUDFW
2
KWWSG[GRLRUJ,$6
/XQGJUHQ-:KHQWRVWDUWQRWVRIDVWWK,QWHUQDWLRQDO&RQJUHVVRQ'UXJ7KHUDS\LQ+,9,QIHFWLRQ1RYHPEHU2UDODEVWUDFW
2
KWWSG[GRLRUJ,$6
+LJK.3HWDO+,9DQGDJLQJVWDWHRINQRZOHGJHDQGDUHDVRIFULWLFDOQHHGIRUUHVHDUFK$UHSRUWWRWKH1,+2I¿FHRI$,'65HVHDUFKE\WKH
+,9DQG$JLQJ:RUNLQJ*URXS-$,'6-XO\9ROXPH6XSSOHPHQW
KWWSMRXUQDOVOZZFRPMDLGVWRF
-XVWLFH$HWDO$JLQJZLWK+,9RQHVL]HGRHVQRW¿WDOOWK&RQIHUHQFHRQ5HWURYLUXVHVDQG2SSRUWXQLVWLF,QIHFWLRQV±0DUFK6HDWWOH
2UDODEVWUDFW
KWWSUHWURFRQIHUHQFHRUJVWDWLFZHEFDVWV
:HEFDVW
KWWSDSSFDSLWDOUHDFKFRPHVSVHUYOHWWF"F FQ UHWURV GS SOD\HUMVSH PHGLD7\SH SRGLXP9LGHR
5HLVV3+,9FRPRUELGLW\DQGDJHLQJWK,QWO&RQJUHVV*ODVJRZ2UDODEVWUDFW2
KWWSG[GRLRUJ,$6
6KLHOV06HWDO$JHDW&DQFHU'LDJQRVLVDPRQJSHUVRQVZLWK$,'6LQWKH86$QQ,QWHUQ0HG
KWWSDQQDOVRUJDUWLFOHDVS["DUWLFOHLG 6FKRXWHQ-HWDO&RPRUELGLW\DQGDJHLQJLQ+,9LQIHFWLRQWKH$*(K,9&RKRUW6WXG\WK,$6&RQIHUHQFH:DVKLQJWRQ$EVWUDFW
7+$%+,9L%DVHSXEOLFDWLRQ9RO1R1RYHPEHU'HFHPEHU+,97UHDWPHQW%XOOHWLQH
6DELQ&5HYLHZRIOLIHH[SHFWDQF\LQSHRSOHZLWK+,9LQVHWWLQJVZLWKRSWLPDO$57DFFHVVZKDWZHNQRZDQGZKDWZHGRQ¶WWK,QWHUQDWLRQDO
&RQJUHVVRQ'UXJ7KHUDS\LQ+,9,QIHFWLRQ1RYHPEHU2UDODEVWUDFW2
KWWSG[GRLRUJ,$6
$QWLUHWURYLUDO7KHUDS\&RKRUW&ROODERUDWLRQ$57&&/LIHH[SHFWDQF\RILQGLYLGXDOVRQFRPELQDWLRQDQWLUHWURYLUDOWKHUDS\LQKLJKLQFRPH
FRXQWULHVDFROODERUDWLYHDQDO\VLVRIFRKRUWVWXGLHV/DQFHW±
KWWSZZZWKHODQFHWFRPMRXUQDOVODQFHWDUWLFOH3,,6DEVWUDFW
0D\0HWDO,PSDFWRIODWHGLDJQRVLVDQGWUHDWPHQWRQOLIHH[SHFWDQF\LQSHRSOHZLWK+,98.&ROODERUDWLYH+,9&RKRUW8.&+,&6WXG\
%0-GRLEPMG
KWWSZZZEPMFRPFRQWHQWEPMG
1DNDJDZD)HWDO3URMHFWHGOLIHH[SHFWDQF\RISHRSOHZLWK+,9DFFRUGLQJWRWLPLQJRIGLDJQRVLV$,'6
KWWSMRXUQDOVOZZFRPDLGVRQOLQH)XOOWH[W3URMHFWHGBOLIHBH[SHFWDQF\BRIBSHRSOHBZLWKB+,9DVS[
/RVLQD(5DFLDODQG6H['LVSDULWLHVLQ/LIH([SHFWDQF\/RVVHVDPRQJ+,9,QIHFWHG3HUVRQVLQWKH8QLWHG6WDWHV,PSDFWRI5LVN%HKDYLRU
/DWH,QLWLDWLRQDQG(DUO\'LVFRQWLQXDWLRQRI$QWLUHWURYLUDO7KHUDS\&OLQ,QIHFW'LV
KWWSFLGR[IRUGMRXUQDOVRUJFRQWHQWIXOOSGI
/HZGHQ&$OOFDXVHPRUWDOLW\LQWUHDWHG+,9LQIHFWHGDGXOWVZLWK&'•PPFRPSDUHGZLWKWKHJHQHUDOSRSXODWLRQHYLGHQFHIURPD
ODUJH(XURSHDQREVHUYDWLRQDOFRKRUWFROODERUDWLRQ&ROODERUDWLRQRI2EVHUYDWLRQDO+,9(SLGHPLRORJLFDO5HVHDUFK(XURSH&2+(5(LQ(XUR&R
RUG,QW-(SLGHPLRO$SULO(SXE1RY
KWWSZZZQFELQOPQLKJRYSXEPHG
6WUDWHJLF7LPLQJRI$QWL5HWURYLUDO7UHDWPHQW67$57VWXG\
KWWSLQVLJKWFFEUXPQHGXVWDUW
ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%
7
'ROXWHJUDYLUUH]LVWHQWQRVWLQWHJUD]HLXWLFDMRVQRYQRJUHåLPD
Simon Collins, HIV i-Base
'YH RUDOQH SUH]HQWDFLMH L SRVWHU VD DåXULUDQLP
LQIRUPDFLMDPDRLQKLELWRUXLQWHJUD]HGROXWHJUDviru.
5H]XOWDWL 9,.,1* VWXGLMH VD SDFLMHQWD NRML
VX YHü ELOL QD WHUDSLML L NRML VX UD]YLOL UH]LVWHQLFLX
QD LQKLELWRU LQWHJUD]H L MRã QD QDMPDQMH GYH GUXJH
NODVH OHNRYD L þLML MH WUHQXWQL EURM YLUXVQLK NRSLMD
! NRSLMDP/ 6WXGLMD MH SODQLUDQD WDNR GD QDV
WDYL RVQRYQHWHUDSLMVNH UHåHLPH WRNRP RVDP GDQD
]DPHQRP WUHQXWQRJ LQKLELWRUD LQWHJUD]H GROXWHJUD
YLURPRGPJGYDSXWDGQHYQRSDGDSRWRPRSWL
PL]XMHRVQRYQLUHåLP]DQDUHGQHQHGHOMH>@
7R MH ELOD QDSUHGQD JUXSD VD VUHGQMLP SRþHWQLP
EURMHP&'üHOLMDRGüHOLMDPPXUDVSRQX
VUHGQMHJSUHWKRGQRJNRULãüHQMD$59WHUDSLMH
RGJRGLQDXUDVSRQXJRGLQDJGHMHQMLK
SR NODVL¿NDFLML &'&D ELOR X NODVL & 3RUHG
UH]LVWHQFLMHLQWHJUD]HSULSUHJOHGXQ LOLWRNRP
LVWRULMHEROHVWLEDUHPGYHYHüHPXWDFLMHX57,LPD
L3,LPDVXELOHUHJLVWURYDQH]DRGQRVQR
XþHVQLNDRGNRMLKMHLPDORYLãHRGMHGQHYHüH
1157,PXWDFLMH3UHWKRGQD$59WHUDSLMDMHVDGUåDOD
GDUXQDYLU HWUDYLULQ 7 L
PDUDYLURFNRGVH5WURSVNLYLUXVQLMH
PRJDRGHWHNWRYDWL'HPRJUD¿MDMHXNOMXþLYDOD
åHQD $IULþNLK $PHULNDQDFD L +%9 LOL
+&9SR]LWLYQLKRVRED
'RGDQDVUHGQMLEURMYLUXVQLKNRSLMDMHELRVPDQ
MHQ]DORJNRSLMDP/&,S
'RQHGHOMHSDFLMHQDWDþLMLVXNUDMQLSRGD
FL ELOL LPDOR MH VPDQMHQ EURM YLXVQLK NR
SLMDQDNRSLMDP/GRNNRGQLMH
ELOR RGJRYRUD D MH ELOR RWSLVDQR XVOHG
QHåHOMHQLKHIHNDWD
6WRSHRGJRYRUDXREHYUHPHQVNHWDþNHELOHVXEOLVNR
YH]DQH]DSUHWKRGQLãDEORQUH]LVWHQWQRVWLLQWHJUD]H
VDQLåLP]DEHOHåHQLPRGJRYRULPDNRGOMXGLVDPXW
DFLMDPDQD4YH]LVPDQMHQMDRGRNRORJGR
GDQDLVXSUHVLMHRGQDNRSLMDP/GR
QHGHOMH XNROLNR VX SDFLMHQWL LPDOL 4 PXWDFLMX
LGYHLOLYLãHVHQNXQGDUQHPXWDFLMHYLGHWLWDEHOX
6WRSDYLURORãNHUHDNFLMHXQHGHOMLELODMHLQYHU
]QRSURSRUFLRQDOQDVDSRVWRMDQMHP4GRGDW
QHSULPDUQHPXWDFLMHLVDLVNULYOMHQRPSURPHQRP
XRVHWOMLYRVWLQDGROXWHJUDYLUDOLQLMHELODSRYH]DQD
VDJHQHUDOQRPRFHQRPRVHWOMLYRVWL266OHNRYDX
RSWLPDOQRPRVQRYQRPUHåLPXYLGHWLWDEHOX2YR
MHYUORQHRELþQR]DQRYLOHNNRULãüHQNRMLVHNRULVWL
NRG SDFLMHQDWD NRML VX YHü ELOL QD WHUDSLML .DNR MH
RSLVDQL PHKDQL]DP WHãNR UD]XPHWL RYL UH]XOWDWL üH
PRUDWLGDVHSRWYUGHNRGYHüHJEURMDSDFLMHQDWD
7DEHOD9LURORãNHUHDNFLMHQDGROXWHJUDYLUSUHPDYH]LL]PHÿXJHQRWLSD
Primarne INI mutacije na
SRþHWNX
8NXSQR
7
<
1
4VHFPXWDFLMH
4!VHFPXWDFLMH
!SULPDUQLKPXWDFLMD
%H]SULPDUQLKPXWDFLMD
N
SURVHþQD6'9/SURPHQD
GRGDQD
±
±
±
±
±
±
±
±
7
9/GRQHdelje
6HNXQGDUQHPXWDFLMH*$&6/($.7
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
7DEHOD6WRSDYLURORãNHUHDNFLMHSUHPD266RFHQDPD
'RELMHQDJUXSDVDPXWDFLMRPLQWHJUD]H
1R4
4
4
OSS = 0
OSS = 1
266!
Total
VDPRLVWRULMVNLGRND]L*$&6($.7/,
/MXGL NRML VX LPDOL UH]LVWHQWQRVW LQWHJUD]H VDPR X
SURãORVWLüHYHURYDWQRLPDWLEROMLYLUDOQLRGJRYRUGR
GDQDMHUüHYHURYDWQRWUHEDWLYLãHRGQHGHOMXGDQD
]DSRYUDWDNVHOHNWLYQRJSULWLVNDSDMHELOR]QDþDMQR
GDRYDJUXSDGRVWLJQHMHGQXRGQDMYLãLKVWRSDRGJR
YRUDGRQHGHOMH.RGRYLKSDFLMHQDWDVHQLMHMDYLR
VORPREUD]DFDUH]LVWHQWQRVWL
8L]YHãWDMX9,.,1*MHWDNRÿHELORGDRSãWDRFHQD
RVHWOMLYRVWL QD OHN 266 X RVQRYQRP UHåLPX QLMH
SRYH]DQDVDUHDNFLMRPXQHGHOMLNDGDMHNRG
LSDFLMHQDWDEURMYLUXVQLKNRSLMDSDR
NRSLMDP/]D266L!UHVSHNWLYQR
3UHNLGL XVOHG QHåHOMHQLK HIHNDWD ELOL VX UHWNL SUL
MDYOMHQL]DXþHVQLND1DMþHãüLQHåHOMHQL
HIHNWLRYRJOHNDELOLVXGLMDUHMDPXþQLQDLJODYRER
OMDRGNRMLKVHVYDNLMDYLRNRGSDFLMHQDWD
'UXJD SUH]HQWDFLMD ELR MH SRVWHU VD SUHGVWDYOMH
QLRP NRPELQDFLMRP UH]XOWDWD )D]H 635,1*
LVWUDåLYDQMD NRMD MH WUDMDOD QHGHOMD L 6,1*/(
VWXGLMD NRULãüHQMD GROXWHJUDYLUD NRG SDFLMHQDWD
NRML QLVX SUHWKRGQR ELOL QD WHUDSLML D SRVWHU MH ELR
NDUDNWHULVWLþDQ SR VWUDWL¿NDFLML RGJRYRUD X RGQRVX
QDSRþHWQLEURMYLUXVQLKNRSLMDLSUHWKRGQRX]LPDQMH
QXNOHR]LGDVRE]LURPGDVHXYRGLþLPDWUHQXWQRQH
SUHSRUXþXMHDEDNDYLU7&NDGDMHEURMYLUXVQLKNR
SLMD9/!NRSLMDP/PLãOMHQMH*OD[R6PLWK
.OLQHD
8635,1*LVWUDåLYDQMXSDFLMHQWDMHQDVXPLþQR
SRGYUJQXRGROXWHJUDYLUXRGPJMHGQRPGQHYQR
LOL UDOWHJUDYLUX PJ GYD SXWD GQHYQRL 157,
OHNX NRML VX RGDEUDOL LVWUDåLYDþL WHQRIRYLU)7& LOL
DEDNDYLU7&XNRPELQDFLMLVDNRLMLPGROXWHJUDYLU
QLMHLQIHULRUDQ86,1*/(LVWUDåLYDQMLPDSDFL
MHQWDMHQDVXPLþQRSRGYUJQXRUHåLPLPDGR]LUDQMDLOL
GROXWHJUDYLUDRGPJDEDNDYLU7&LOLHIDYLUHQ]
WHQRIRYLU)7& $WULSOD MHGQRP GQHYQR QDRVQRYX
þHJDMHRWNULYHQRGDMHNRPELQDFLMDLQWHJUD]HVXSH
ULRUQDQDRVQRYXEURMDQHåHOMHQLKHIHNDWD
,DNRVXVWXGLMHXQDNUVQRJSRUHÿHQMDUD]OLþLWLKNRPEL
QDFLMDNRGUD]OLþLWLKSRSXODFLMDELOHVDPRRJUDQLþHQH
YUHGQRVWL L]YODþHQMH UH]XOWDWD QD RVQRYX YLVRNRJ
SRþHWQRJ EURMD YLUXVQLK NRSLMD PRåH ELWL NRULVQR
NDGDMH]DLVWUDåLYDQMDSRWUHEDQ]QDþDMDQRSUH]NDR
ãWRMHELRVOXþDMVD$&7*2YLUH]XOWDWLVXGDWL
GHWDOMQRXWDEHOL
7DEHOD5H]XOWDWL635,1*L6,1*/(VWXGLMDVWUDWL¿NRYDQLSUHPDSRþHWQRPEURMXYLUXVQLKNRSLMD
SPRING-2
'ROXWHJUDYLU57,V
6,1*/(
5DOWHJUDYLU57,V 'ROXWHJUDYLU
DEDFDYLU7&
(IDYLUHQ]WHQRIRYLU)7&
3RþHWQLEURMYLUXVQLKNRSLMDNRSLMDP/
$%&7& 7'))7&
3RþHWQLEURMYLUXVQLKNRSLMD!NRSLMDP/
$%&7& 7'))7& ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%
7DNRÿH VX SUHGVWDYOMHQL UH]XOWDWL UHDNFLMD L]
635,1*LVWUDåLYDQMDGDOMRPVWUDWL¿NDFLMRP]DEURM
YLUXVQLKNRSLMD!NRSLMDP/8JUXSLVDN
YLUDOQDVXSUHVLMDQDNRSLMDP/XQHGHOMLRVW
YDUHQDMHNRG]DDEDNDYLU7&JUXSX
RGQRVQR]DWHQRIRYLU)7&JUXSX
2GJRYRULVXELOLQDVSUDP
]DNNQDVSUDP]D
NNLQDVSUDP]D
!NJUXSHUHVSHNWLYQR%URMHYLSDFLMHQDWDXRYLP
DQDOL]DPDVXVHYUORVPDQMLOL
.RQDþQRGUXJDRUDOQDSUH]HQWDFLMDSULMDYLODMHSUHG
VWDYOMDODUH]XOWDWHL]LQYLWURXQRVDSRYHüDQLKGR]D
GROXWHJUDYLUD RG Q0 (& GR Q0 WRNRP ãHVW PHVHFL X 07 üHOLMDPD L 3%0&
üHOLMDPD
1DMþHãüDPXWDFLMDLQWHJUD]HYDULUDODMHSUHPD+,9
SRGWLSX 5. PXWDFLMD SUDüHQD +< NRG SRG
WLSD % L$* *5 PXWDFLMD SUDüHQD +< NRG
SRGWLSD&
5H]XOWDWLXVOXþDMHYLPDVDVDPR5.EOLVXRNR
QHXVSHOLK QLYRD UH]LVWHQFLMH X NXOWXUL SDG RG
X QLYRLPD DNWLYQRVWL WUDQVIHUD YODNDQD UH
NRPELQRYDQH LQWHJUD]H NDR L SULEOLåDQ JXELWDN RG
XNDSDFLWHWXUHSOLNDFLMHYLUXVD
6DPRVWDOQD+<PXWDFLMDMHLPDODPDOLXWLFDMDOLX
NRPELQDFLMLVD5.L]D]YDRMHSRYHüQMHUH]LVWHQ
FLMHQDGROXWHJUDYLUSXWDVDRNRJXELWNDLX
NDSDFLWHWXUHSOLNDFLMHYLUXVDLXDNWLYQRVWLWUDQVIHUD
YODNDQLQWHJUD]H
Komentar
1HGRVWDWDNUD]OLNDL]PHÿXDQDOL]DVDYHOLNLPEURMHPYLUXVQLKNRSLMDLDNRVXWLEURMHYLELOLPDQMLRG
$&7*LSDNSUXåDQHNXSRGUãNXGDXSRVWDYFLNOLQLþNRJLVSLWLYDQMDNDGDVHGROXWHJUDYLUNRULVWLNDRWUHüLOHNDEDNDYLU7&QHSRND]XMHLVWLSUREOHPSRWHQWQRVWLNDRNRG1157,DLOLLQKLELWRUD
proteaze.
7RMHYDåQRVRE]LURPQDIRUPXODFLMXMHGQHSLOXOHGROXWHJUDYLUDDEDNDYLUD7&DNRMDMHYHüXID]L
ispitivanja.
5HIHUHQFH
1LFKROV*HWDO$QWLYLUDODFWLYLW\RIGROXWHJUDYLULQVXEMHFWVZLWKIDLOXUHRQDQLQWHJUDVHLQKLELWRUEDVHGUHJLPHQZHHNSKDVHUHVXOWV
IURP9,.,1*2UDODEVWUDFW2
KWWSG[GRLRUJ,$6
KWWSZZZQDWDSRUJLQWHU+,9,QWHU+,9BKWP
(URQ-HWDO'ROXWHJUDYLUWUHDWPHQWUHVSRQVHE\EDVHOLQHYLUDOORDGDQG157,EDFNERQHLQWUHDWPHQWQDLYH+,9LQIHFWHGLQGLYLGXDOV3RVWHU
DEVWUDFW3
KWWSG[GRLRUJ,$6
KWWSZZZQDWDSRUJLQWHU+,9,QWHU+,9BKWP
0HVSOHGH7HWDO6HOHFWLRQLQFXOWXUHRI+,9UHVLVWDQFHWRGROXWHJUDYLUE\PXWDWLRQVDWLQWHJUDVHSRVLWLRQV5.DQG+<WKDWGLPLQLVK
YLUDOUHSOLFDWLRQ¿WQHVV2UDODEVWUDFW2
KWWSG[GRLRUJ,$6
+,9+&9NRLQIHNFLMDUDQLREULVLEXGXüQRVWL
EH]LQWHUIHURQDLSRGDFLRLQFLGHQFLML(XUR6,'$H
6LPRQ&ROOLQV+,9LEDVH
0HÿX QDMX]EXOMLYLMLP SUH]HQWDFLMDPD X *ODVgow-u, vezanim za preliminarne rezultate iz raQLKVWXGLMDELODMHVWXGLMDEH]LQWHUIHURQDLQWHU
*RGLQD,EURM
IHURQ,)1IUHHNRMDMHWHNSUHGVWDYOMHQDQD
$$6/'NRQIHUHQFLMLREROHVWLPDMHWUHX6$'X
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
-XUHJQ 5RFNVWURK VD 8QLYHU]LWHWD %RQQ 1HPDþND
SUHGVWDYLRMHX*ODVJRZXSULND]QRYLKWHUDSLMDVD
UH]XOWDWLPDL]GYHVWXGLMHVDPDOLPJUXSDPDSDFLMH
QDWDVD+&9PRQRLQIHNFLMRPSUHWKRGQRSUHGVWDY
OMHQHQDDPHULþNRPVDVWDQNX
8 SRþHWNX YLURORãNH UHDNFLMH X QHGHOML
695 VX SULMDYOMHQH ]D SDFLMHQDWD NRML QLVX
SUHWKRGQR WUHWLUDQL ]D +&9 JHQRWLS 3RUHG WRJD
UH]XOWDWL]DSUHWKRGQLKQXOWLKLVSLWDQLNDSULMDYLOLVX
RVWYDUHQMHQDNUDMXUHDNFLMHQDWUHWPDQL695
XVDGRVWXSQLPSRGDFLPDþHNDMXVHUH]XOWDWL]D
RVWDOLKRXSRWUHELDQORJQRJQXNOHRWLGDXULGLQD
VRIREXYLU*6L16$LQKLELWRUD*6
REDXUD]YRMXRGVWUDQH*LOHDGD3RWSXQDVWXGLMDMH
VWXGLMDPDORJEURMDJUXSDSRSRVOHGQMHPEURMDQMX
JUXSDVDSDFLMHQDWDVDJHQRWLSRPL
8 GUXJRM VWXGLML .RZGOH\ L NROHJH SULMDYLOL VX
695 VWRSX RG NRG SDFLMHQDWD NRML QLVX
SUHWKRGQR WUHWLUDQL L NRG SUHWKRGQLK QXOWD
SDFLMHQDWD X SUHOLPLQDUQLP DQDOL]DPD WUHWLUDQMD
XYHNRSUH]QRXSRWUHERPNRPELQDFLMHL]$EERWWD
$%7U +&9 LQKELWRU SURWHD]H SRMDþDQ VD
PJ ULWRQDYLUD$%7 16$ LQKLELWRU LLOL
$%7QHQXNOHRVLG16%LQKLELWRU“ULEDYLULQ
3RWSXQDVWXGLMDMHXNOMXþLYDODSDFLMHQWDQ QDLYQLKLQXOWDLVSLWDQLND
2EHVWXGLMHVXWDNRÿHXNOMXþLYDOHULEDYLULQXNRPEL
QDFLMLLYDåQRWUDMDQMHWUHWPDQDMHELORVDPRQH
GHOMD,DNR+,9+&9NRLQIHNFLMDPRåHELWLWHåD]D
WUHWLUDQMH YHüH RVQRYQR +&9 YLUDOQR RSWHUHüHQMH
YHüD UH]LVWHQWQRVW L XNOMXþXMH SRWHQFLMDOQR NRP
SOHNVQXLQWHUDNFLMXOHNDLSUHNODSDQMHWRNVLþQRVWLVD
$57RP RYR VX YUOR SR]LWLYQH LQGLNDFLMH EXGXüLK
+&9WUHWPDQD
,VWLþHPR GD VX RYD QDSUHGRYDQMD SULMDYOMHQD X JR
GLQL NDGD VX VWXGLMH PRUWDOLWHWD SRND]DOH GD MH RG
JRGLQH +&9 QDGPDãLR +,9 L SRVWDR YRGHüL
X]URNVPUWLX6$'X2YRMHGRYHORGR6$'&'&
SUHSRUXþH SRPHUDQMH +&9 SUHJOHGD VD ³UL]LþQLK´
JUXSDQDXQLYHU]DOQRWHVWLUDQMHOMXGLURÿHQLKL]PHÿX
LJRGLQH
0QRJLOMXGLVD+,9+&9NRLQIHNFLMRPRGORåLOLVX
+&9WUHWPDQSRPRüX3(*,)1LULEDYLULQRPXVOHG
QLVNHVWRSHUHDNFLMDXJHQRWLSXLWRNVLþQRVWLýDN
L QDNRQ RGREUHQMD ERFHSUDYLUD L WHODSUDYLUD JRGLQH ãWR MH SRYHüDOR VWRSX OHND ]D JHQRWLS VD
RNRQDWUHWPDQMHLGDOMHRGODJDQMHUWL
GLUHNWQR GHOXMXüL DQWLYLUDOL '$$L ]DKWHYDMX GR]
LUDQMHWULSXWDGQHYQRVDKUDQRPLLPDMXWHåDNSUR
¿OQHåHOMHQLKHIHNDWDSOXVQDVWDYOMDMXGD]DKWHYDMX
ZZZKLYELOWHQLQIR
3(*,)1LULEDYLULQ6WRSDUHDNFLMHXRYLPVWXGLMDPD
WDNRÿHMH]DYLVLODRGYLãHIDNWRUDXNOMXþXMXüLVWDURVW
SROUDVXJHQHWLNX,/%VWDQMHMHWUHID]D+&9
YLUDOQRRSWHUHüHQMHLNRPRUELGQRVWJRMD]QRVWGL
MDEHWHVXSRWUHEDDONRKROD
8SRWUHED LOL ERFHSUDYLUD L WHODSUHYLUD VD 3(*
,)1 L ULEDYLULQRP VH QH SUHSRUXþXMH X (YURSVNRP
SUDYLOQLNX]DWUHWPDQ($&6MHUVWDQGDUGLX
WUHWLUDQMXNRG+,9+&9NRQIHNFLMHLDNRRSWLPDOQL
WRNRP WUHWPDQD QLVX XVWDQRYOMHQL ]D NRLQIHNFLMX
'LVNXVLMDWDNRÿHXNOMXþXMHRSUH]SULNRPSOHNVQRVWL
LQWHUDNFLMH OHND VD OHNRP L]$57D NRML þLQL QHNH
+,9OHNRYHNRQWUDLQGLNDWLYQLP%XGXüQRVWMHLSDN
]DQLPOMLYD VD EDUHP RVDP SODQLUDQLK LOL WHNXüLK
VWXGLMD NRLQIHNFLMH XNOMXþXMXüL QRYH VWXGLMH 9HU
WH[D %RHKULQJHU ,QJHOKHLPD 7LERWHFD %06D
*LOHDGDL$EERWWD
3UH]HQWDFLMDMHWDNRÿHUD]PDWUDODSRYHüDQMH+&9D
GRELMHQRJVHNVXODQLPRGQRVLPDNRG+,9SR]LWLYQLK
KRPRVHNVXDODFDDOLLNRG+,9QHJDWLYQLKKRPRVHN
VXDODFDJGHMHYHüLQDSRWHQFLMDOQRQHGLMDJQRVWLNR
YDQD 8 RGVXVWYX VSRQWDQRJ RGREUHQMD WUHWLUDQMH
WRNRPDNXWQHLQIHNFLMHVHLGDOMHþHVWRSUHSRUXþXMH
]ERJYLVRNHVWRSHOHNDþDNLVD3(',)1RPSOXVULE
DYLULQ3RVWRML]DEULQXWRVWGDQLVSRQWDQRRGREUHQMH
QLXVSHãDQWUHWPDQQHSUXåDMX]DãWLWXRG+&9UHLQ
IHNFLMHLQHNROLNRL]YHãWDMDRVOXþDMHYLPDXNOMXþXMX
SULPHUHVXNFHVLYQRJWUHWPDQDLUHLQIHNFLMH
3URIHVRU 5RFNVWURK LVWLþH GD QHGRVWDWDN GRND]D
NRMLREMDãQMDYDMXWDþDQREOLNVHNVXDOQRSUHQRVLYRJ
+&9D SUHGVWDYOMD RVQRYQX SUHSUHNX ]D HIHNWLYQX
+&9 SUHYHQFLMX SRVHEQR X NRQWHNVWX PXãNDUDFD
NRMLSULPHQMXMXVHURVRUWLUDQMHGDELRJUDQLþLOLãDQVX
]DSUHQRV+,9D,DNRHSLGHPLRORãNHVWXGLMHSULMDYO
MDMXVQDåQHYH]HL]PHÿXVHNVXDOQRSUHQHWRJ+&9D
L UHNUHDWLYQH XSRWUHEH QDUNRWLND JUXSQRJ VHNVD L
RUJLMD SRVWRMH PQRJL VOXþDMHYL PXãNDUDFD NRML VX
GRELOL+&9NUR]VHNVXDOQLNRQWDNWEH]ELORNRMHJRG
RYLKIDNWRUDUL]LND
6WXGLMH ELRSVLMH NRMH WUDåH FLOMQH üHOLMH L WNLYD EL
RPRJXüLOHHIHNWLYQHLQWHUDNFLMHNRMHELVPDQMLOHUL]
LNHSUHQRVDQDRVQRYXUHDOQRJSXWDLQIHNFLMH+&9
LPDYHüLYLUDOQLWHUHWLYLUDOQLSUHRNUHWRGQHWUHWLUD
QRJ+,9DXJODYQRPVHSUHQRVLNRQWDNWRPNUYLL
RVWDMHLQIHNWLYDQYDQWHODGDOHNRGXåHRG+,9DNRML
VHEUåHXQLãWDYDXNRQWDNWXVDYD]GXKRP
,DNR +&9 QLYRL PRJX ELWL GHWHNWDELOQL X VSHUPL
SUL YLãHP QLYRX NRG +,9 SR]LWLYQLK QDVSUDP +,9
QHJDWLYQLK PXãNDUDFD QLMH NRQDþQR GRND]DQR GD
MH L]ORåHQRVW VHPHQX SXW ]D VHNVXDOQL SUHQRV$NR
*RGLQD,EURM
+,9%,/7(1+7%
WRQLMHVOXþDMRQGDVDYHWRYDQMHXSRWUHEHNRQGRPD
LDNRSRSXODUQRNRG]GUDYVWYHQLKUDGQLNDUDGLVPDQ
MHQMDGUXJLKLQIHNFLMDPRåGDQLMHSULNODGQRLOLHIHN
WLYQR]DVPDQMHQMH+&9SUHQRVDSXWHPVHNVXODQRJ
RGQRVD
'YH QDUHGQH RUDOQH SUH]HQWDFLMH R +,9+&9
NRLQIHNFLML L] YHOLNH (XUR6,'$ NRKRUWH VX WDNRÿH
XNOMXþHQHXLVWXNRQIHUHQFLMVNXVHVLMX
2OH .LUN L] +,9 SURJUDPD .RSHQKDJHQ 'DQVND
SUHGVWDYLR MH SRGDWNH R VOXþDMX +&9 LQIHNFLMH RG
GR X (XUR6,'$ VD RVODQMHQMHP QD
UD]OLþLWHJUXSHSDFLMHQDWDLLGHQWL¿NRYDQMHPIDNWRUD
UL]LNDYH]DQLK]D+&9LQIHNFLMX
(XUR6,'$ MH SULMDYLOD GD VH +&9 DNXWQLK LQ
IHNFLMDX060XGHVLORNRGSDFL
MHQDWDWRNRPJRGLQDSUDüHQMDOMXGVNLKåLYRWD
3<)8 GDMXüL JHQHUDOQX SRMDYX RG QD 3<)8&,*HQHUDOQDSRMDYDSUH
PDNDOHQGDUVNRMJRGLQLþLQLODVHVWDELOQRPL]PHÿX
L VD SULEOLåQRP PHGLMDQRP RG LQ
IHNFLMDQD3<)8YDULUDQMHL]PHÿXL
0HÿXWLP VWRSH VX ELOH YHüH ]D X X L &, QD 3<)8
8 PXOWLYDULMDQWQLP DQDOL]DPD ,'8 MH YH]DQ VD
YHüLP RGQRVPR VWRSH VOXþDMHYD ,55 RG 060D
S-XåQDL,VWRþQD(YURSD
VXLPDOHYHüH,55HXSRUHÿHQMXVD=DSDGQRP(YUR
SRPS L
S .DOHQGDUVNDJRGLQD]DJRGLQHMHWDNRÿH
YH]DQD]DYHüL,55S
'DYLG*ULQWVD8&/D5R\DO)UHH.DPSXV/RQGRQ
SUHGVWDYLRMHSRGDWNHVD(XUR6,'$RL]YUãHQMX+&9
WUHWPDQD3(*,)1ULEDYLULQWRNRPSHULRGDRG
2NR þHWYUWLQD RG VNRUR OMXGL VD +,9+&9
NRLQIHNFLMRPQ SULPLORMH+&9
WUHWPDQWRNRPSURVHþQRJYUHPHQDSUDüHQMDRG
PHVHFL,45
6OXþDMHYL +&9 WHUDSLMH VX VH SRYHüDOL ]QDþDMQR
RG &, QD 3<)8 GR &, X DOL MH RSDR QD
&,X6OXþDMHYLSULPHQH
WHUDSLMHSRYHüDOLVXVHQD&,
S ]D NDOHQGDUVNH JRGLQH ,DNR VH WUHW
PDQSRYHüDRXVYLP(YURSVNLPUHJLRQLPDELORMH
]QDþDMQLKUD]OLNDL]PHÿXUHJLRQD
8 PXOWLYDULMDQWQRP PRGHOX IDNWRUL YH]DQL ]D XS
RWUHEX WHUDSLMH XNOMXþLYDOL VX EURM &' üHOLMD YHüL
RGüHOLMDPPRGQRVVWRSHVOXþDMD,55
S +,9 YLUDOQR RSWHUHüHQMH
NRSLMDP/,55S +&9JHQRWLS,55S X
SRUHÿHQMXVDJHQRWLSRPL]DRQHVDMXJD,55
S L LVWRþQR FHQWUDOQH (YURSH
,55S VYHXSRUHÿHQMX
VD]DSDGQRP(YURSRP+&9WUHWPDQQLMHYH]DQ]D
VYHX]URNHVPUWLVPUWQLKVOXþDMHYD,55
&, S R LOL ]D VPUWQH VOXþHYH
X]URNRYDQH VWDQMHP MHWUH VPUWQLK VOXþDMHYD
,55&,S 5HIHUHQFH
5RFNVWURK-1HZDJHQWVIRUKHSDWLWLV&DQGWKHFKDOOHQJHVLQWUHDWLQJFRLQIHFWHGSDWLHQWVWK,QWHUQDWLRQDO&RQJUHVVRQ'UXJ7KHUDS\LQ
+,9,QIHFWLRQ1RYHPEHU2UDODEVWUDFW2
KWWSG[GRLRUJ,$6
*DQH(-HWDO2QFHGDLO\VRIRVEXYLU*6SOXVULEDYLULQLQSDWLHQWVZLWK+&9JHQRW\SHVDQGWKH(/(&7521WULDOUG$QQXDO
0HHWLQJRIWKH$PHULFDQ$VVRFLDWLRQIRUWKHVWXG\RI/LYHU'LVHDVHV$$6/'1RYHPEHU%RVWRQ2UDODEVWUDFW
.RZGOH\.9HWDO$ZHHNLQWHUIHURQIUHHWUHDWPHQWUHJLPHQZLWK$%7U$%7$%7DQGULEDYLULQDFKLHYHV695UDWHV
REVHUYHGGDWDRILQWUHDWPHQWQDwYHSDWLHQWVDQGLQSULRUQXOOUHVSRQGHUVZLWK+&9JHQRW\SHLQIHFWLRQUG$QQXDO0HHWLQJRIWKH
$PHULFDQ$VVRFLDWLRQIRUWKHVWXG\RI/LYHU'LVHDVHV$$6/'1RYHPEHU%RVWRQ/DWHEUHDNHUDEVWUDFW/%
/\.1HWDO7KHLQFUHDVLQJEXUGHQRIPRUWDOLW\IURPYLUDOKHSDWLWLVLQWKH8QLWHG6WDWHVEHWZHHQDQG$QQ,QWHUQ0HG)HE
KWWSDQQDOVRUJDUWLFOHDVS["DUWLFOHLG &'&5HFRPPHQGDWLRQVIRUWKH,GHQWL¿FDWLRQRI&KURQLF+HSDWLWLV&9LUXV,QIHFWLRQ$PRQJ3HUVRQV%RUQ'XULQJ±5HFRPPHQGD
WLRQVDQG5HSRUWV$XJXVW55
KWWSZZZFGFJRYPPZUSUHYLHZPPZUKWPOUUDKWP
.LUN2HWDO,QFUHDVHVLQDFXWHKHSDWLWLV&+&9LQFLGHQFHDFURVV(XURSHZKLFKUHJLRQVDQGSDWLHQWJURXSVDUHDIIHFWHG"WK,QWHUQDWLRQDO
&RQJUHVVRQ'UXJ7KHUDS\LQ+,9,QIHFWLRQ1RYHPEHU2UDODEVWUDFW2
KWWSG[GRLRUJ,$6
*ULQW'HWDO7HPSRUDOFKDQJHVDQGUHJLRQDOGLIIHUHQFHVLQWUHDWPHQWXSWDNHRIKHSDWLWLV&WKHUDS\LQ(XUR6,'$WK,QWHUQDWLRQDO&RQJUHVV
RQ'UXJ7KHUDS\LQ+,9,QIHFWLRQ1RYHPEHU2UDODEVWUDFW2
KWWSG[GRLRUJ,$6
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
63(&,-$/1,,=9-(â7$7RNRYLDQWLUHWURYLUXVQLKLVWUDåLYDQMD3LSHOLQHUHSRUW
Simon Collins, HIV i-Base
Uvod
'YD DVSHNWD DQWLUHWURYLUXVQH WHUDSLMH WRNRP SUH
WKRGQH JRGLQH MH UD]YLMHQR RGYRMHQLP SXWDQMDPD
XSUNRVQMLKRYRMMDVQRMSRYH]DQRVWL6WHSHQGRNRMHJ
VXYH]DQLODNãHMHQDJDÿDWLQHJRSUHGYLÿDWLLWRLPD
QRYL]QDþDM]DLVWUDåLYDQMHUD]YRMDDQWL+,9OLMHNR
YD
3UYLLWUDGLFLRQDOQLIRNXV]DRYDMJRGLãQMLSUHJOHG
WRNRYD±MHUD]YRMQRYLKNRPSRQHQWLNUR]UDQHLUHJ
XODWRUQHID]HUD]YRMDX]QDGXGDüHELWLRGREUHQHL
LVWUDåLYDQHQDNRQSODVLUDQMDQDWUåLãWX
,]YMHãWDMRSLVXMHUD]YRMSLUDPLGHNRMDVHIRUPLUDRG
KLOMDGH SRWHQFLMDOQLK PROHNXOD VSRMHQLK ]D SRVWL
]DQMH MHGQRJ OLMHND NRML üH VH SRMDYLWL QD WUåLãWX
7DNRÿHU VXPLUD SURJUHV NRPSRQHQWL NRMH JHQHUDO
QRGDMXUH]XOWDWHXID]DPD,,,,,LVWUDåLYDQMDLRYH
JRGLQH LVWLþH QRYX GLQDPLNX NRMD LGH X SUDYFX GD
NRIRUPXOLUDQL NUDMQML SURL]YRG EXGH X]GLJQXW X
PQRJLP VOXþDMHYLPD L]QDG UD]LQH LQGLYLGXDOQRJ
QRYRJOLMHND
7DNRüH]DSDUJRGLQDSRVWRMDWLEH]EURMNRPELQDFL
MD ¿NVQLK GR]D ]D SULPMHQX MHGQRP GQHYQR X MHG
QRMSLOXOL)'&.DGDGRNWRUEXGHPRJDRGDSLWD
Ä.RMX ELVWH RG RYLK ãHVW SLOXOD åHOMHOL GD X]LPDWH
VYDNL GDQ"³ ELüH ]QDþDMQR GRVWLJQXüH ]D VYDNRJD
NR VH VMHüD NRPSOHNVQRVWL UDQRJ +$$57D SXQH
UXNH SLOXOD VD YLãHVWUXNLP GR]DPD L RJUDQLþHQMLPD
XLVKUDQL±þDNLDNRGHWDOMQRYLURORãNLQHXVSMHKX
UH]LVWHQFLMLMHGQRJ)'&DGRYRGLGRSRVOMHGQLþNRJ
RVODQMDQMDQDGUXJL6DUDGQMDL]PHÿXNRPSDQLMDMH
QHRELþQD X GUXJLP ]GUDYVWYHQLP REODVWLPD DOL VX
WUDGLFLRQDOQHSUHSUHNHSUHYD]LÿHQHRGVWUDQHQHNLK
NRPSDQLMDNRMHVHEDYHSURL]YRGQMRP+,9IRUPX
ODFLMDýLQMHQLFDMHGDMH]DSDGQRWUåLãWH]DEROMHOL
MHNRYHLGDOMHYUORNRQNXUHQWQRLSUR¿WDELOQR
0HÿXWLP GUXJR RJUDQLþHQMH X UD]YRMX D RQGD L X
SURJUHVXMHREDYH]QLSULWLVDNQDPHWQXW]GUDYVWYHQ
LPVOXåEDPDSRVHEQRX]HPOMDPDNRMHVHED]LUDMX
QDMDYQRP]GUDYVWYX±LOLSRPRüLGRQDWRUD7RNRP
ZZZKLYELOWHQLQIR
HNRQRPVNH UHFHVLMH L X ERJDWLP L X VLURPDãQLP
GUåDYDPD SRWHQFLMDOQL XWMHFDM RþLJOHGQRJ LVWHND
URNDþHVWRNRULãWHQLKSRWYUÿHQLKOLMHNRYDL]D]YDRMH
LVWUDåLYDþNHNRPSDQLMHQHVDPRGDSURL]YRGHEROMH
HIHNWLYQLMH L VLJXUQLMH OLMHNRYH YHü L GD LK GRYHGX
QDWUåLãWHSRFLMHQLNRMDüHRPRJXüLWLQMLKRYXãLURNX
SULPMHQX
2YDM HNRQRPVNL SULWLVDN YHü VDGUåL SUREOHPH
]GUDYVWYHQLKUDGQLNDLDNWLYLVWDXLVWRMPMHULNDRLNR
ULVQLND]GUDYVWYHQHQMHJH=DYHüLQXOMXGLNRMLLPDMX
SULVWXSWHUDSLML+,9MHSRVWDRXYHOLNRMPMHULEROHVW
NRMDVHPRåHNRQWUROLUDWL.DRWDNYDRQDVDGDPRUD
GD IXQNFLRQLUD X RNYLUX SRVWRMHüLK ]GUDYVWYHQLK
EXGåHWD.DGDVXUHVXUVLRJUDQLþHQL±DSRGH¿QLFLML
XYLMHN MHVX ± SULRULWHW ]D SULVWXS ¿QDQVLUDQMX PRUD
ELWL RGUHÿHQ SRPRüX QHNH NRPSDUDWLYQH SURFMHQH
SRWUHED'RWDGDFLMHQD]DQRYHOLMHNRYHJHQHUDOQR
VDGUåLQHNRSRYHüDQMH]DGRGDQXYULMHGQRVWDOLDQWL
UHWURYLUXVQH$59NRPELQDFLMH]DRVQRYQXWHUDSLMX
XYHOLNRMPMHULPRUDMXIXQNFLRQLUDWLQDLVWRPWHUHQX
VDRNR6$'JRGLãQMH
3RWHQFLMDO ]D JHQHULþNH YHU]LMH ãLURNR SULPMHQML
YDQLKOLMHNRYDNDNRELVHVPDQMLOLWURãNRYLOLMHNRYD
X UD]YLMHQLP ]HPOMDPD PRJX XSUDYOMDWL SRWUHERP
]D VOLþQR NRQNXUHQWQLP FLMHQDPD QRYLK RGREUHQLK
OLMHNRYD EDUHP ]D GUåDYH þLML ]GUDYVWYHQL VLVWHPL
LPDMX QDMPDQMX ÀHNVLELOQRVW QD SURGDMQH FLMHQH
9HüLQD RVLJXUDQLK X ]GUDYVWYHQRM ]DãWLWL X 6MHGLQ
MHQLP $PHULþNLP 'UåDYDPD PRåH ELWL ]DãWLüHQR
DOL X JRGLQL 3URJUDP SRPRüL X OLMHNRYLPD
]D$,'6$'$3LGDOMHLPDYLãHRGOMXGLQD
VYRMRMOLVWLþHNDQMD3DWHQW]DHIDYLUHQ]X6$'NRML
LVWLþHJRGLQHPRåHGRåLYMHWLSURPMHQXSUDNVH
SUHSLVLYDQMD]DNRPELQDFLMX¿NVQLKGR]D$WULSODV
RE]LURP QD QMHJRYX GRPLQDQWQX XORJX NDR SUHIHU
LUDQRJRVQRYQRJOLMHND3DWHQW]DQHYLUDSLQX6$'
MH LVWHNDR X MHGDQDHVWRP PMHVHFX JRGLQH
L GR SHWRJ PMHVHFD JRGLQH )'$ MH RGREULOD
*RGLQD,EURM
+,9%,/7(1+7%
JHQHULþNX IRUPXODFLMX GRELMHQX RG GHVHW UD]OLþLWLK
SURL]YRÿDþD .RPELQLUDQD IRUPXODFLMD$=77&D
VDGDWDNRÿHUQLMHGRVWXSQDSDFLMHQWLPDVWLPGDLP
MHGRVWXSQDJHQHULþNDYHU]LMD
6XSURWQRHIHNWLYQRVWWURãNRYDOLMHþHQMDXGDQDãQMRM
SUDNVL WDNRÿHU PRåH SRGVWDüL JHQHULþNHNRPSDQLMH
GDQDSODüXMXYHüHFLMHQHþDNLX]NRQNXUHQFLMX.DGD
VXGG,$=77&LQRYLMLQHYLUDSLQSUHVWDOLGDEXGX
GRVWXSQLSDFLMHQWLPDþDNLX]RJUDQLþHQLMXNOLQLþNX
XSRWUHEX FLMHQH JHQHULþNLK OLMHNRYD X ]DSDGQLP
]HPOMDPDVPDQMHQHVXVDPR]DQLMDQVXXSRUHÿHQMX
VDFLMHQDPDEUHQGLUDQLKOLMHNRYD3RND]DWHOM]QDþDMD
¿QDQVLMVNLKRJUDQLþHQMDXVLVWHPXMDYQH]GUDYVWYHQH
QMHJHPHÿXWLPMHVWHGDþDNLPDOHXãWHGHMHVXGR
YROMQH]DQHNH]HPOMHGDSUHEDFHSDFLMHQWHNRMLVX
ELOLSUHWKRGQRVWDELOQLSRPRüXNRIRUPXOLUDQLKOLMHN
RYDNDRãWRMH7UXYDGDWHQRIRYLU)7&LOL(S]LNRP
.LYHNVD DEDNDYLU7& QD LOL WHQRIRYLU LOL DEDND
YLU SOXV JHQHULþNL 7& QD RVQRYX PDOH UD]OLNH
L]PHÿX7&DL)7&D'UXJHPMHUH]DVPDQMHQMH
EXGåHWD]DOLMHNRYHLVWDNQXWHXRWYRUHQRMOLWHUDWXUL
]D UDGLRQLFX IDUPDNRORJLMH RYH JRGLQH XNOMXþXMX
SRGVWLFDQMHNRPSDQLMDQDYHüHSRSXVWHQDVQLåHQMH
FLMHQDQDMVNXSOMLKOLMHNRYDXSRWUHERPSUYHQVWYHQR
MH¿WQLMLK RSFLMD L XSRWUHERP SRMDþDQH3, PRQRW
*RGLQD,EURM
HUSDLMH±VWUDWHJLMDNRMDMHXSRþHWNXUD]YLMHQDED
UHPGMHOLPLþQR]DSDFLMHQWHX6$'VDRJUDQLþHQLP
]GUDYVWYHQLP RVLJXUDQMHP 8 (YURSL PQRJH RG
RYLKPMHUDVXYHüXSRWUHEOMHQHX3RUWXJDOXâSDQLML
L9HOLNRM%ULWDQLML
1D VUHüX ¿VNDOQD RVQRYD ]D VLVWHP ]GUDYVWYHQH
QMHJHED]LUDQQDRVLJXUDQMXSRVHEQRX6$'NROLNR
JRG GD MH PRGHO MDYQRJ ]GUDYVWYD SUREOHPDWLþDQ
RVWDMH GRYROMQR MDND GD LQGXVWULMVNL DQDOLWLþDUL VD
VLJXUQRãüXSUHGYLGHGDüHUD]YRM+,9OLMHNRYDQDV
WDYLWLGDGDMHSUR¿WDELOQLSRYUDWLQYHVWLFLMHLGDüH
EXGXüD GRPLQDFLMD VNXSOMLK OLMHNRYD QDGRNQDGLWL
XWMHFDMJHQHULþNLK
=DELORNRJDNRSUDWLIDUPDFHXWVNL35XRþOMLYRMH
REHVKUDEUXMXüHSRQDãDQMHMHUQHNHNRPSDQLMHLVWLþX
QHDGHNYDWQRVWVYRMLKSRWYUÿHQLKOLMHNRYDGDELSUR
PRYLUDOL QRYH VDVWRMNH NRML VX UD]YLMHQL QD RVQRYX
VWXGLMDQHLQIHULRUQRVWL
3UHJOHGSURJUHVDWRNRYDLVWUDåLYDQMDVDVWRMDND
5D]YRMLQGLYLGXDOQLKVDVWRMDNDWRNRPSURãOHJRGLQH
SULND]DQ MH X7DEHOL 7DEHOD XNOMXþXMH DåXULUDQMH
SURãORJRGLãQMHJ L]YMHãWDMD L SRGDWDND R QRYLP VDV
WRMFLPD NRML VX QDSUHGRYDOL RG ID]H SUHGNOLQLþNRJ
UD]YRMD
6YDNLVDVWRMDNVHSRWRPGHWDOMQRGLVNXWLUD
ZZZKLYELOWHQLQIR
7
+,9%,/7(1+7%
7DEHOD3ULND]WRNRYDLVWUDåLYDQMDVDVWRMDNDX
Agens
Sponzor
.ODVDWLS
ULOSLYLULQWHQRIRYLU 7LERWHF-DQVVHQ .RPELQDFLMD¿NVQHGR]H
)7&
QHQXNOHR]LGQLLQKLEL
WRUUHYHU]QHWUDQVNULSWD]H
1157,QXNOHR]
LGQLLQKLELWRUUHYHU]QH
WUDQVNULSWD]H
Status
Komentari
2GREUHQ
2GREUHQRGVWUDQH)'$$YJXVWDLRGVWUDQH
(0$X6HSWHPEUX
4XDG
*LOHDG
.RPELQDFLMD¿NVQHGR]H
3RGQHVHQ 'YLMHID]H,,,VWXGLMDNRMHSRUHGH4XDGVD$WULS
SRMDþDQLLQKLELWRULQWHJUD]H ]DKWMHY]D ODRPLDWD]DQDYLUULWRQDYLU7UXYDGDSUHGVWDY
7UXYDGD
odobrenje OMHQRQD&52,XLREMDYOMHQRX/DQFHWX
GROXWHJUDYLU
*6.
6KLRQRJL9LL9
,QKLELWRULQWHJUD]H
)D]D,,,
3URãLUHQL
SULVWXS
9UKXQVNLUH]XOWDWLL]MHGQHRGþHWLULWHNXüLKID]D
,,,VWXGLMHVXREMDYOMHQL1HLQIHULRUDQXRGQRVX
QDUDOWHJUDYLUNRGSDFLMHQDWDXSUREQRPWUHW
PDQX
FRELFLVWDW
*LOHDG
)DUPDNRNLQHWLþNL3.
SRMDþLYDþ
)D]D,,,
9LGMHWL4XDGL]QDG7HNXüHVWXGLMHXNOMXþXMX
NRIRUPXODFLMXVDGDUXQDYLURPDWD]DQDYLURPL
GUXJLPþHWYUWLPOLMHNRP)'&D3ULMDYOMHQNDR
SRVHEQLVDVWRMDNX-XQX
HOYLWHJUDYLU
*LOHDG
,QKLELWRULQWHJUD]H
)D]D,,,
9LGMHWL4XDGL]QDG'UXJHVWXGLMHVXXWRNX
3ULMDYOMHQNDRSRVHEDQVDVWRMDNX-XQX
*6
*LOHDG
1XNOHRWLGSUROHNWHQRIR
YLUD
)D]D,,,
3ULEOLåQR±ORJVPDQMHQMHYLUDOQHNRQFHQ
WUDFLMHYVORJVDWHQRIRYLURP')QDNRQ
GDQDPRQRWHUDSLMH3RþHWQRMHRGDEUDQDGR]DRG
PJ]DUD]YRMDOLMHGR]DRGPJNRULãWHQDX
)'&XVDNRELFLVWDWRP7HNXüHVWXGLMHXNOMXþXMX
X4XDGIRUPXODFLML]DPMHQXWHQRIRYLUDLXSUYRM
3,ED]LUDQRMMHGQRMWDEOHWL)'&D
%06
%ULVWRO0D\HUV
6TXLEE
,QKLELWRUYH]LYDQMDJS
)D]D,,E
%H]SUH]HQWDFLMDRG&52,D1RYD
VHGPLþQDID]D,,WHNXüDVWXGLMDRWNULYDQMD
GR]HVDUDOWHJUDYLURPWHQRIRYLURYV
DWD]DQDYLUULWRQDYLUUHOWHJUDYLUWHQRIRYLU
%06
ELYãLIHVWLQDYLU
2%3
%ULVWRO0D\HUV
6TXLEE
157,VOLþDQVWDYXGLQXG7 )D]D,,E
2WNULYDQMHGR]HRGLPJMHGQRP
GQHYQRXSRUHÿHQMXVDWHQRIRYLURPLVDHID
YLUHQ]RP7&RVQRYRP157,D
OHUVLYLULQ8.
ViiV
1157,
)D]D,,E
5H]XOWDWLID]H,,EQHGHOMDSULMDYOMXMXQHLQIHUL
RUQRVWSUHPDHIDYLUHQ]XNRGSUREQLKSDFLMHQDWD
7HNXüDID]D,,XRGQRVXQDHWUDYLULQ1LMHREMDY
OMHQDID]D,,,VWXGLMH
DSULFLWDELQ
$YH[D
157,
)D]D,,
,DNRMHID]D,,,VWXGLMH]DSRþHWDSRYXþHQDMHRG
VWUDQH$YH[DXVOMHGQHVLJXUQRVWLRNR¿QDQVLMVNRJ
VSRQ]RUVWYD
FHQLNULYLURF7%5 Tobira
&&5LQKLELWRUWDNRÿHU
DNWLYDQSURWLY&&5
)D]D,,
7HNXüDID]D,,VWXGLMHNRGSUREQLKSDFLMHQDWDX
SRUHÿHQMXVDHIDYLUHQ]RPREDVDWHQRIRYLU)7&
RVQRYRP175,D
6*6.
6KLRQRJL
*OD[R6PLWK
.OLQH*6.
,QKLELWRULQWHJUD]H
)D]D,,
3UDWHüLVDVWRMDNGROXWHJUDYLUDNRMLPRåHLPDWL
WHUDSHXWVNXDNWLYQRVWSULGR]DPDRGPJ
LOLPDQMLP5D]YRMMHWUHQXWQRIRNXVLUDQQD
PMHVHþQXLQMHNFLMXIRUPXODFLMH
&0;
&KLPHUL[
157,VOLþDQWHQRIRYLUX
)D]D,
%H]VWXGLMDXSURãORMJRGLQL
LEDOL]XPDE70%
ELYãL71;
7DL0HG%LRORJ &']DYLVQDKXPDQL]R
LFV
YDQD,J*PRQRNORQDOQD
antitijela
)D]D,
,DNRMHID]D,VWXGLMHQDYHGHQD]DQLMHELOR
QRYLKUH]XOWDWDRRYRPVDVWRMNXQHNROLNRJRGLQD
UHOSLYLULQ/$
GXJRGMHOXMXüD
LQMHNFLMD
-DQVVHQ
)D]D,
-HGLQDVWXGLMDGXJRGMHOXMXüHIRUPXODFLMH
PMHVHþQDLQMHNFLMDVWRSLUDQDMHUDQRRGVWUDQH
VSRQ]RUD%XGXüHVWXGLMHXNOMXþXMXJDNDRNRP
SUDWRU]DVOLþQHIRUPXODFLMH6*6.
ZZZKLYELOWHQLQIR
1157,
*RGLQD,EURM
+,9%,/7(1+7%
2GREUHQMDRGJRGLQH
,]PHÿX GYD L]YMHãWDMD R WRNRYLPD L%DVHD RGR
EUHQDMHVDPRMHGQDQRYDNRPSRQHQWD7RMHNRP
ELQDFLMD ¿NVQLK GR]D )'& 1157, ULOSLYLULQD
NRIRUPXOLUDQRJVDWHQRIRYRLURPL)7&RPNRMLMH
RGREUHQRGVWUDQH$JHQFLMH]DKUDQXLOLMHNRYH6$'
)'$XRVPRPPMHVHFXNDR&RPSOHUDLRG
VWDQH(YURSVNH$JHQFLMH]DOLMHNRYH(0$GHYHWRJ
NDR(YLSOHUD
5LOSLYLULQMHYHüELRRGREUHQX6$'SDUPMHVHFLUD
QLMH3ULPMHWQRGRELRMHLQGLNDFLMHVDPR]DSRþHWQX
WHUDSLMXVDRSUH]RPSULXSRWUHELNRGSDFLMHQDWDVD
YLUXVQRPNRQFHQWUDFLMRPNRSLMDP/LX]
LVWLFDQMH ]QDþDMD DGKHUHQFLMH SULPMHQH X] KUDQX L
SRWHQFLMDOQD]DXQDNUVQXUH]LVWHQFLMXVD1157,LPD
SUYRJLGUXJRJUHGD
0HÿXWLPQHNROLNRSRVWRMHüLKVDVWRMDNDVXQDLYLFL
UHJXODWRUQH RGOXNH D GUXJL VX X QDSUHGQRM ID]L ,,,
VWXGLMH
$åXULUDQMHSRGDWDNDRVDVWRMFLPDVDUH]XOWDWLPD
L]ID]H,,,,,
'ROD]HüLWRNRYLPRJXVHNDWHJRUL]LUDWLãLURNRNDR
ÄRþHNLYDQMD³ÄUDQLGDQL³LÄSURED³
‡ 2þHNLYDQMD 4XDG HOYLWHJUDYLUNRELFLVWDWWHQRIR
YLU)7& HOYLWHJUDYLU FRELFLVWDW*6 GROXWH
JUDYLU7ULLGROXWHJUDYLUDEDNDYLU7&L4XDG
YDULMDFLMHXSRWUHED*6LGDUXQDYLUD
‡5DQLGDQL6*6.OHUVLYLULQ8.
%06ELYãL2%3%06FHQL
FULYRULF 7%5 ULOSLYLULQ/$ GXJRGMHOXMXüD
LQMHNFLMD
‡ 3URED DSULFLWDELQ LEDOL]XPDE 70% ELYãL
71;&0;&73
4XDG(OYLWHJUDYLU&RELFLVWDW7HQRIRYLU)7&
7UHQXWQRXUD]YRMXRGVWUDQH*LOHDGD4XDGMHMHG
QD WDEOHWD )'& HOYLWHJUDYLUD LQKLELWRU LQWHJUD]H
FRELFLVWDWD IDUPDNRNLQWHLþNL 3. SRMDþLYDþ WHQ
RIRYLUD QXNOHRWLG L )7&D QXNOHRVLG NRMD VH
X]LPDMHGQRPGQHYQRX]KUDQX4XDGMHSRGQHVHQ
QDRGREUHQMH)'$XGHVHWRJVDRGOXNRPNRMD
VHRþHNXMHXRVPRPPMHVHFX
1DM]QDþDMQLMLUH]XOWDWLGRELYHQLL]GYLMHQDVXPLþQH
SODFHERNRQWUROLUDQHGYRVWUXNRVOLMHSHVWXGLMHID]H
,,,REMDYOMHQLVXXRNWREUXLSUHGVWDYOMHQLQD
.RQIHUHQFLML R UHWURYULVXQLP L RSRUWXQLVWLþNLP
LQIHNFLMDPD&52,DREMDYOMHQLVXLX/DQ
FHWX3RUHÿHQMH4XDGVDHIDYLUHQ]RPWHQRIRYLURP
)7&RP $WULSOD X MHGQRM L VD DWD]DQDYLURPULWR
*RGLQD,EURM
QDYLURPVDWHQRIRYRULRP)7&RPXGUXJRMVWXGLML
7RNRPJRGLQH6DYMHWRGDYQLNRPLWHW)'$SUH
JOHGDRMH4XDGLJODVDRSUHPD]DSUHSRUXþHQR
RGREUHQMH QD RVQRYX JHQHUDOQH VLJXUQRVWL L H¿NDV
QRVWL DOL X] LVWLFDQMH UHQDOQLK NRPSOLNDFLMD JODV
SURWLY MH GDR VSHFLMDOLVWD ]D EXEUHåHQH EROHVWL QD
RVQRYXQHGRVWDWNDSRGDWDNDRVLJXUQRVWLXSRUHÿHQMX
VDSRVWRMHüLPPRJXüQRVWLPD2JUDQLþHQLSRGDFLR
XSRWUHEL NRG åHQD L DPHULNDQDFD DIULþNRJ SRULMHN
ODJGMHVXUHQDOQHEROHVWLþHãüDSRMDYDWDNRÿHUVX
SULPMHüHQLRGVWUDQH)'$
3ULPDUQDNUDMQMDWDþNDXREMHVWXGLMHID]H,,,ELODMH
XGLR SDFLMHQDWD VD QHXRþOMLYLP YLUDOQLP VDGUåDMHP
NRSLMDP/XVHGPLFLRWNULYHQLPSRPRüX
DQDOL]LUDQMDQDPMHUHOLMHþHQMDEH]GH¿QLUDQHVXSH
ULRUQRVWLSUHPDGRQMRMJUDQLFLRGLXNOMXþHQD
MH VWUDWL¿NDFLMD SDFLMHQWD SUHPD RVQRYQRP YLUDO
QRP VDGUåDMX L]QDG L LVSRG NRSLMDP/
9LURORJLþQD H¿NDVQRVW MH ELOD RNR LDNR MH
SURVMHþQL RVQRYQL YLUDOQL VDGUåDM ELR VDPR NRSLMDP/XMHGQRMVWXGLMLWROHUDQWQRVWMHELODGR
EUD D GLVNRQWLQXLWHW MH ELR SULPMHWQR QL]DN X VYLP
REODVWLPD8REMHVWXGLMHMH]DNOMXþHQRGDMH4XDG
VXSHULRUDQXRGQRVXQDXSRUHGLYHNRPELQDFLMH
6WXGLMD SRUHGLOD MH 4XDG VD$WULSODRP L
XNOMXþLYDODMHSUREQLKSDFLMHQDWDX6$'L3RUWR
5LNX
2VQRYQH NDUDNWHULVWLNH XNOMXþLYDOH VX VUHGQMX VWD
URVW RG JRGLQD L QLVNL SURVMHþQL YLUDOQL VDGUåDM
NRSLMHP/ LDNR MH MHGQD WUHüLQD XþHVQLND
SRþHODVD!NRSLMDP/3URVMHþQLQLYR&'
MHELRPDORLVSRGüHOLMDPPVDXþHVQLND
NRMLVXQDSRþHWNXELOLQDMHSRþHORVDUD]L
QRPRGLDMHSRþHORVDYLãH
RGSURFHQWLL]4XDGJUXSHDOLVOLþQLVXXJUXSL
VD$WULSODRP6WXGLMVNXJUXSXVXþLQLOLXJODYQRP
PXãNDUFL GRN MH HWQLþNX SULSDGQRVW þLQLOR
ELMHODFDDIURDPHULNDQDFDLGUXJLK
0DQMHRGXþHVQLNDXVYDNRPRJOHGXMHLPDORLOL
+%9LOL+&9NRLQIHNFLMX
'LVNRQWLQXLWHWSULMHVHGPLFHMDYLRVHXNRG
4XDGD QDVSUDP NRG $WULSODH L] XJODYQRP
VOLþQLKUD]ORJD
%URM YLUXVQLK NRSLMD MH SRWLVQXW GR QHXRþOMLYRJ
NRG SDFLMHQDWD QDVSUDP UD]OLND &, GR LVSXQMDYDMXüL NULWHULM ]D VX
SHULRUQRVWVDSDFLMHQDWDXVYDNRMJUXSLNRMLVX
SRND]DOLYLURORãNLQHXVSMHKLQDVSUDPVDQH
GRVWDWNRPSRGDWDNDVYHMH4XDGQDVSUDP$WULSODH
2GJRYRUL SR SRGJUXSDPD EURM YLUXVQLK NRSLMD
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
&'UD]LQDUDVDVSROVWDURVWLUD]LQDDGKHUHQFLMH
QLVX]QDþDMQRUD]OLþLWLDOLYLãHLGXXNRULVW4XDGX
3RYHüDQMH &' LGH X NRULVW 4XDG JUXSL VD üHOLMDPPQDVSUDPüHOLMDPP3 2NR SRORYLQH SDFLMHQDWD X VYDNRM JUXSL QLMH SRND
]DORXVSMHKNDGDVXXSLWDQMXPXWDFLMHYH]DQH]DRW
SRUQRVWQDLQKLELWRUHLQWHJUD]HXJODYQRP(4LOL
1157,D XJODYQRP .1 PXWDFLMH VX VH MDYLOH
NRGRGQDVSUDPRGSDFLMHQDWD
9HüLQD VSRUHGQLK HIHNDWD SULMDYOMHQD VX NDR EODJD
RFMHQD VD VWDWLVWLþNL ]QDþDMQLP UD]OLNDPD NRMH
XNOMXþXMX YHüX PXþQLQX X 4XDG JUXSL YV
LDEQRUPDOQLMHVQRYHYVQHVDQL
FXYVYUWRJODYLFXYVLRVLS
YVX$WULSODJUXSL
'LVNRQWLQXLWHWYH]DQ]DQHåHOMHQHHIHNWHQDVWDMHXV
OMHGRVLSDYVUHQDOQLKSRUHPHüDMD
YVGHSUHVLMHYVDEQRUPDOQRJVQD
YVVYHMH4XDGQDVSUDP$WULSODJUXSH
VDXVYDNRMJUXSLXVOMHGXPRUDLOLSDUDQRMH
1DMþHãüDRFMHQDLOLODERUDWRULMVNLKDEQRUPDOQRVWL
QDVWDODNRGYLãHRGSHWSDFLMHQDWDXVYDNRMJUXSLX
YHOLNRMPMHULMHVOLþQDLJHQHUDOQRQLVNDXNOMXþXMXüL
NUHDWLQLQ NLQD]X YV $67 YV $/7YV**7YVQHXWUR¿OLV
YVDPLOD]XXVYDNRMJUXSLLKHPDWXULMX
YV X VYLP VOXþDMHYLPD 4XDGD QDVSUDP
$WULSODH
6HUXPNUHDWLQLQDSRYHüDQMH]DRNRPJG/
GRVHGPLFHX4XDGJUXSLãWRMHRGUåDQRGRNUDMD
VHGPLFHXSRUHÿDQMXVDSURPMHQDPDNRG$WULSOD
JUXSH3
3RYHüDQMDXNXSQRJKROHVWHURODXVWDQMXJODGRYDQMD
7& /'/ KROHVWHUROD L +'/ KROHVWHUROD ELOD VX
]QDþDMQR YHüD X JUXSL$WULSOD QHJR X 4XDG JUXSL
DOLQLMHELORUD]OLNHPHÿXJUXSDPDXYLãHNOLQLþNLK
]QDþDMQRP7&+'/RGQRVXLOLNRGWULJOLFHULGD
PJG/XVYDNRMJUXSL
'UXJD 4XDG VWXGLMD QD]YDQD SRUHGL
4XDG VD DWD]DQDYLURPULWRQDYLURP SRMDþDQLP LQ
KLELWRURPSURWHD]H+,9DSOXVWHQRIRYLU)7&7UX
YDGDNRGSUREQLKSDFLMHQDWD2VQRYQHNDUDNWHU
LVWLNHVXELOHYUORVOLþQHVWXGLMLSURVMHþQD
VWDURVWJRGLQDPXãNDUDFDLELMHODFD
&'UD]LQDYLUDOQLVDGUåDMLNRLQIHNFLMDKHSDWLWLVD
WDNRÿHUVXELOLVOLþQLVDXþHVQLNDNRMLVXLPDOL
YLUDOQLVDGUåDM•NRSLMDPDP/DOLMHPHGL
MDQD ELOD PDOR YHüD NRSLMD P/ .ULWHULM
LVNOMXþLYDQMD ]D RYX VWXGLMX XNOMXþLYDR MH UHQDOQX
IXQNFLMXGH¿QLUDQXXYLGXH*)5DP/PLQ
ZZZKLYELOWHQLQIR
9LURORãNDH¿NDVQRVWNRSLMDP/XVHGPLFL
ELOD MH QDVSUDP UD]OLND &,
GRXNRULVW4XDGDãWRLVSXQMDYDNUL
WHULM ]D VXSHULRUQRVW .RG SDFLMHQDWD VD RVQRYQLP
YLUDOQLP VDGUåDMHP • NRSLMDP/ VWRSD
UHDNFLMHELODMHQDVSUDP3 169LURORãNL
QHXVSMHK)'$VQLPDNDOJRULWPDELRMHXREMH
JUXSH3RYHüDQMHPHGLMDQH&'XRYRMVWXGLMLELOR
MHEOL]XüHOLMDPPQDVSUDPüHOLMDPP
LVWRSHRWSLVD]DQHåHOMHQHHIHNWHELOHVXQDVSUDP
NRG4XDGRGQRVQRDWD]DQDYLUUJUXSH
1HåHOMHQLHIHNWLNRMLVHMDYOMDMXNRG•SDFLMHQDWD
ELOL VX VOLþQL X REMH JUXSH RVLP SRYLãHQRJ QLYRD
ELOLUXELQD NRML MH ELR ]QDþDMQR YHüL X JUXSL DWD]D
QDYLUULWRQDYLU'LVNRQWLQXLWHWVHMDYLRXVOMHGGLMDU
HMHYVSLUHNVLMHYVPXþQLQH
YV SRYUDüDQMD L XPRUD VYDNL YV
L åXWLFH YUWRJODYLFH åXWLK EHRQMDþD L DOHUJL
MVNHUHDNFLMHQDOLMHNVYDNLYV1DMþHãüD
RFMHQDLOLODERUDWRULMVNLKDEQRUPDOQRVWLQDVWDOLK
XEDUHPVOXþDMDXVYDNRMJUXSLELODMHSULOLþQR
VOLþQDXNOMXþXMXüLNUHDWLQNLQD]XYVKH
PDWXULMXYV$67YV$/7
YV DPLOD]X X VYDNRM JUXSL L SRYHüDQL
ELOLUXELQ YV VYH YDåL ]D 4XDG JUXSX
QDVSUDPDWD]DQDYLUULWRQDYLUJUXSH6HUXPVNLNUHD
WLQLQMHSRYHüDQ]DSULEOLåQRPJG/GRVHG
PLFHX4XDGJUXSLLELRMHPJG/XVHGPLFL
XSRUHÿHQMXVDPJG/NRGDWD]DQDYLUULWRQDYLU
JUXSH33URPMHQDPHGLMDQHNRG&/&UDVD
RVQRYQHUD]LQHELODMHP/PLQNRG4XDGL
P/PLQ 3 NRG JUXSH DWD]DQDYLUULWRQDYLU
3RYHüDQMHOLSLGDELORMHVOLþQR]D7& /'/ L +'/
KROHVWHURO]DVYH3 16DOLVXVHWULJOLFHULGLPDQMH
SRYHüDOL X 4XDG JUXSL PJG/ YV PJG/
3 3URPMHQD PHGLMDQH X JXVWLQL PLQHUDOD VDGUåDQLK X
NRVWLPDELODMHVOLþQD]DREMHJUXSH3URPMHQHNLþPH
VPDQMHQHVX]DRNRXVHGPLFLLRVWDOHVXLVWH
VD VPDQMHQMHP X VHGPLFL RG QDVSUDP
3 ]D RED SRUHÿHQMD JUXSD 6PDQ
MHQMHXNXNRYLPDELORMHSRGNRQVWDQWQLPQDJLERP
]DREMHNRPELQDFLMHRGRNRQDVSUDPX
VHGPLFLLQDVSUDPXVHGPLFL
3 3RGDFL R VLJXUQRVWL GDWL QD VWUDQL GRNXPHQWD
)'$SULMDYOMXMXUHQDOQHQHåHOMHQHHIHNWHRG]D
4XDG1 XSRUHÿHQMXVD1 ]D$WULSODL
]DDWD]DQDYLU1 ãWRMHGRYHORGRãHVWGLV
NRQWLQXLWHWDX4XDGJUXSLQDVSUDPMHGQRJNRGDWD
*RGLQD,EURM
+,9%,/7(1+7%
]DQDYLUD'YDRGRYLKSDFLMHQDWDLPDOLVXH*)5
QD SRþHWNX LOL SUL LVSLWLYDQMX 6WRSH ]D GRELYDQMH
)DQNRQLVLQGURPDLUHQDOQRWXEXODUQRJSRUHPHüDMD
SULMDYOMHQHVXXYULMHGQRVWLRGRGQRVQR
2YLUH]XOWDWLXYHOLNRMPMHULSRGUåDYDMXRYXYDåQX
QRYX)'&PRJXüQRVW1DMPDQMHWULVWXGLMHID]H,,,
VXYHüXWRNX]DSDFLMHQWHVDWUHQXWQRVWDELOQLP3/
LPD1157,LPDLOLGUXJLPNRPELQDFLMDPDQDED]L
LQWHJUD]H]DSUHOD]DNQD4XDG
(OYLWHJUDYLU*6
(OYLWHJUDYLUMHLQJLELWRULQWHJUD]HNRMLVHX]LPDMHG
QRP GQHYQR L NRML VD SRMDþDYDQMHP PJ FR
ELFLVWDWDW LOL PJ ULWRQDYLUD LPD SROXYULMHPH
HOLPLQDFLMHXSOD]PLRGVDWLLSRVWLåHSURVMHþQR
VPDQMHQMHYLUDOQRJVDGUåDMDRGRNRORJNRSLMDP/
QDNRQGDQDPRQRWHUDSLMH
(OYLWHJUDYLU VH PHWDEROLUD SULPDUQR RG VWUDQH &<
3$ L VHNXQGDUQR SUHNR 8*7$ L ]DKWLMHYD
VPDQMHQXGR]XVDPJQDPJGQHYQRDNR
VH NRULVWL X NRPELQDFLML VD DWD]DQDYLURP 1HGDYQH
VWXGLMHVXSRND]DOHGDQHSRVWRMLLQWHUDNFLMDVDURX
YDVWDWLQRP DOL MH LVWR SULPMHüHQR GD VX ULIDEXWLQ L
GUXJL PLNREDNWHULMVNL OLMHNRYL WUHQXWQR NRQWUDLQ
GLFLUDQL
,DNR MH YHü SRGQLMHW ]DKWMHY ]D ]DNRQVNR RGR
EUHQMH NDR NRPSRQHQWD 4XDGD L YHüLQD WHNXüLK
LVWUDåLYDQMD XNOMXþXMH 4XDG HYLWHJUDYLU MH WDNRÿHU
XNOMXþHQXVOLþQL)'&*LOHDGDNRMLNRULVWLWHQRIRYLU
SUROLMHN*6XPMHVWRWHQRIRYLUD
(OYLWHJUDYLUMHWDNRÿHUUD]YLMHQNDRRGYRMHQLVDVWR
MDNLDNRMHSUHGPHWRJUDQLþHQLMLKLVWUDåLYDQMD
)D]D ,,, UDQGRPL]LUDQH VWXGLMH WUHQXWQR SRUHGL HO
YLWHJUDYLUULWRQDYLUVDUDOWHJUDYLURPJGMHREMHJUXSH
NRULVWHGRGDWQHOLMHNRYHNRGSDFLMHQDWDNRMLLPDMX
LVNXVWYDVDWUHWPDQRP.DNRMHVDGDXWRNXVWXGLMD
ELWUHEDODXVNRURGDSURL]YHGHUH]XOWDWH
(OYLWHJUDYLUMHSUHGORåHQ)'$XNDRRGYRMHQDNRP
SRQHQWDXãHVWRPPMHVHFX
&RELFLVWDW*6
&RELFLVWDWMH3.SRMDþLYDþLSUHGVWDYOMDSRWHQWQLLQ
KLELWRU FLWRKURPD 3 $ 6ODE MH NDR LQKLELWRU
'DOLQHLGUXJLK&<3LOL8*7SXWHYDLLPDLQ
KLELWRUQLHIHNDWVOLþDQULWRQDYLUXQDGUXJHQRVLRFH
NRMLXWMHþXQDPHWDEROL]DPOLMHNDXNOMXþXMXüL3JS
%&53L2$73%
&RELFLVWDWWDNRÿHULPDSUR¿ONUDWNRURþQLKQHåHOMHQLK
HIHNDWD VOLþDQ RQRP NRG ULWRQDYLUD XNOMXþXMXüL
HIHNDWQDJDVWURLQWHVWLQDOQLWUDNWLOLSLGHDOLEH]DQ
*RGLQD,EURM
WLYLUXVQH DNWLYQRVWL ,DNR MH SRWHQFLMDO ]D UHQDOQH
NRPSOLNDFLMH LVSLWLYDQ X VWXGLML QD RVQRYX QMHJRYH
XSRWUHEH X 4XDGX SURVMHþQL H*)5L X VHGPLFL
ELOL VX VWDELOQL L VOLþQL ULWRQDYLUX X ID]L ,, VWXGLMH
RQRMNRMDXNOMXþXMHWHQRIRYLU6WUDWHãNL]QDþDMFR
ELFLVWDWDMHVWHWDMãWRSUHGVWDYOMDQRYXRSFLMX]DUD]
YRMQDSUHGRYDQMDNRGSRMDþDQLKIRUPXODFLMD
3ULNXSOMHQL SRGDFL R UHQDOQRP HIHNWX ]D SULMHGORJ
4XDGD)'$XSULMDYLOLVXVOLþQHUHQDOQHGRJDÿDMH
XVWXGLMLFRELFLVWDWDQDVSUDPULWRQDYLUD1 VYDNL
VD VWRSH GLVNRQWLQXLWHWD ]D FRELFLVWDW &REL
FLVWDWWDNRÿHUSURL]YRGLPDORSRYHüDQMHVHUXPVNRJ
NUHDWLQLQD NRML UH]XOWLUD PDOLP VPDQMHQMHP X SUR
FLMHQMHQRP DOL QH L VWYDUQRP *)5X ,]X]HWQR SL
WDQMHYH]DQR]DNOLQLþNRUXNRYDQMHSRYHüDQMHPVH
UXPVNRJNUHDWLQLQDYLÿHQRJXREMH4XDGVWXGLMHMH
SUHGORåHQRSRYHüDQMHRGPJG/LOLYHüHPRåGD
PRåH GD VH NRULVWL NDR NRQ]HUYDWLYQL SUHVMHN ]D
UMHãDYDQMHSUREOHPDYH]DQLK]DSRWHQFLMDOQXUHQDOQR
WXEXODUQXWRNVLþQRVWWHQRIRYLUD
.DR NRG HOYLWHJUDYLUD 3. SRMDþLYDþ FRELFLVWDW MH
YHü SUHGORåHQ ]D ]DNRQVNR RGREUHQMH NDR NRPSR
QHQWD 4XDGD 7DNRÿHU MH NRIRUPXOLUDQ X )'& VD
HOYLWHJUDYLURP)7&LSUROLMHNRPWHQRIRYLUD*6²
LXVDUDGQMLL]PHÿX*LOHDGDL-DQVVHQDVD
LQKLELWRURP+,9SURWHD]HGDUXQDYLURP)7&RPL
*6
7DNRÿHUSRVWRMHSODQRYL]DVDUDGQMXL]PHÿX*LOHDGD
L-DQVVHQD]DGDUXQDYLUL%06]DDWD]DQDYLUNDNR
EL VH FRELFLVWDW NRPELQLUDR VD RYLP 3,RYLPD UDGL
HOLPLQLUDQMDSRWUHEH]DRGYRMHQLPSRMDþLYDþHP
2JUDQLþHQRLVWUDåLYDQMHMHXWRNX]DFRELFLVWDWNDR
RGYRMHQXNRPSRQHQWXDOLRVHGPLþQLUH]XOWDWLVH
RþHNXMXXWRNXWHL]ID]H,,VWXGLMHJGMHVHFR
ELFLVWDWSRUHGLVDULWRQDYLURPNDRSRMDþLYDþ]DDWD
]DQDYLUNRGSDFLMHQDWDNRMLVHSUYLSXWWUHWLUDMX
5H]XOWDWL L] QHGDYQH VWXGLMH SUHGVWDYOMHQL QD 0HÿXQDURGQRM UDGLRQLFL IDUPDNRORJLMH XNOMXþLYDOL
VXSRGDWNHNRMLSRGUåDYDMXVLJXUQRVWXSRWUHEHFREL
FLVWDWDGYDSXWDGQHYQRPJ%,'UH]XOWLUDRMHVD
RNR þHWYHURVWUXNR YHüRP L]ORåHQRãüX X SRUHÿHQMX
VDPJMHGQRPGQHYQR,DNRMHXWMHFDMFRELFLVWD
WDNDRSRMDþLYDþDGDUXQDYLUDLVWLNDR]DULWRQDYLUWR
QLMHVOXþDMVDWLSUDQDYLURPLQKLELWRU+,9SURWHD]H
NRMLVHNRULVWL]DUH]LVWHQFLMXNRPELQDFLMHYLãHOLMHN
RYD,]ORåHQRVWWLSUDQDYLUDMH]QDþDMQRPDQMDNDGD
VHRQSRMDþDFRELFLVWDWRPDL]ORåHQRVWFRELFLVWDWDMH
PDQMDQHJRNRGVDPRVWDOQRJFRELFLVWDWD
8SRUHGLYLUH]XOWDWLELRGRVWXSQRVWLWDNRÿHUVXSUHG
VWDYOMHQL ]D GYLMH IRUPXODFLMH ¿NVQLK GR]D GDUXQD
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
YLUFRELFLVWDWPJPJXSRUHÿHQMXVDGDUX
QDYULULWRQDYLUPJPJ
7HNXüDID]D,,,VWXGLMHNRULVWLFRELFLVWDWXNRPELQDFL
MLNRMDSRMDþDYDGDUXQDYLULOLDWD]DQDYLULXNOMXþXMH
VWXGLMXVLJXUQRVWL]DSDFLMHQWHVDEODJLPGRXPMHUH
QRXPDQMHQLPUHQDOQLPIXQNFLMDPDXRVQRYL
&RELFLVWDWMHSUHGORåHQ)'$XNDRRGYRMHQDNRP
SRQHQWDXãHVWRPPMHVHFX
*6
*6VHUD]YLMDRGVWUDQH*LOHDGDNDRSUROL
MHN157,WHQRIRYLUDLPDYHüLSRWHQFLMDOSULPQRJR
PDQMLPNRQFHQWUDFLMDPDLWDNRÿHUüHNRULVWLWLPDQMH
DNWLYQHIDUPDFHXWVNHVDVWRMNH$3,YH]DQH]DYLUDO
QLXWMHFDMãWRMHYHRPD]QDþDMQRMHUXWMHþHQD¿QDOQH
WURãNRYHX]HPOMDPDVDRJUDQLþHQLPUHVXUVLPD2YR
MH YDåQR V RE]LURP QD RVODQMDQMH QD VWDYXGLQ NRML
± XSUNRV VYRMRM WRNVLþQRVWL ± L GDOMH NRULVWL PRåGD
OMXGLSULOLMHþHQMXJOREDOQRMHUQHPDMXSULVWXS
WHQRIRYLUX 'R]D RG PDQMH PLOLJUDPD üH WDNRÿHU
SURGXåLWL QMHJRYX XSRWUHEX X NRIRUPXODFLMDPD VD
GUXJLPDQWLUHWURYLUXVQLPOLMHNRYLPD
,DNR VH WHQRIRYLU XYHOLNR NRULVWL ± SURFMHQH JRY
RUH GD JD NRULVWL PRåGD SDFLMHQDWD X ]DSDG
QLP ]HPOMDPD D *LOHDG VDGD QDVWXSD QD WUåLãQX
QDRVQRYXÄGXJRJRGLãQMHJLVNXVWYDXXSRWUHELNRG
GHYHWPLOLRQDSDFLMHQDWD³±RVWDMXSLWDQMDRQMHJR
YRPSRWHQFLMDOQRPGXJRURþQRPXWMHFDMXQDUHQDOQH
IXQNFLMH7RNRPWHGYLMHYHOLNHVURGQHVWXGLMH
± VWXGLMD 3ULNXSOMDQMD SRGDWDND R QHåHOMHQLP HIHN
WLPDDQWL+,9OLMHNRYD'$'X(YURSLLVWXGLMD
X6$'2GMHOMHQMX]DSRVORYHYHWHUDQD±SULMDYOMXMX
SRYH]DQRVWL]PHÿXXSRWUHEHWHQRIRYLUDLUHQDOQRJ
]GUDYOMD NRG SDFLMHQDWD VD X RVQRYL QRUPDOQLP UH
QDOQLPIXQNFLMDPD
8SRUHÿHQMXVDWUHQXWQRPIRUPXODFLMRPWHQRIRYLUD
SURVMHþQD LQ YLWUR HIHNWLYQD NRQFHQWUDFLMD (&V
]D*6MHX0QDVSUDPX0X07
üHOLMDPDX0QDVSUDPX0X3%0&LPD
LX0QDVSUDPX0XPDNURIDJDPD,VSL
WLYDQMHSRþHWQHGR]HXRGQHYQRMPRQRWHUDSMLMVD
UDQLPIRUPXODFLMDPDSULMDYOMXMHVPDQMHQMHYLUDOQRJ
VDGUåDMDRGRNRORJSULGR]DPDRGPJL
PJXSRUHÿHQMXVDORJVD7')RPVDNRQFHQ
WUDFLMDPDXSOD]PL*6NRMHVXELOHQLåH
LLQWUDFHOXODUQLPNRQFHQWUDFLMDPDNRMHVXþHWLULSXWD
YHüHXSRUHÿHQMXVD7')RP
ZZZKLYELOWHQLQIR
1D&52,XWHVOLþQDVWXGLMDLVSLWLYDQMDGR]D
QDVXPLþQRMHRGDEUDODSDFLMHQDWDEH]LOLVDLVNXVW
YRPXOLMHþHQMXDOLRVMHWOMLYLKQDWHQRIRYLUSRGYUJ
QXWLKRGQHYQRMPRQRWHUDSLML*6DNRMLVX
NRULVWLOLPJPJLPJQRYHIRUPXODFLMHVD
SODFHERL7')JUXSDPD]DNRQWUROX3ULPDUQDNUD
MQMDWDþNDMHYUHPHQVNLPMHUHQDSURVMHþQDSURPMHQD
YLUDOQRJVDGUåDMD'$9*XGDQX
2VQRYQHNDUDNWHULVWLNHXNOMXþXMXVWDURVWJRGLQD
PXãNDUDFDLELMHODFD$IURDPHULND
QDFD3URVMHþQLYLUDOQLVDGUåDMLUD]LQD&'ELOLVX
NRSLMDP/RGQRVQRüHOLMDPP
'$9* UH]XOWDWL VX ELOL LORJNRSLMDP/ýNRGGR]DRGPJPJ
PJ7')RGQRVQRSODFHERJUXSHVDSURVMHþQLP
VPDQMHQMHP YLUDOQRJ VDGUåDMD RG ORJ PJ
ORJPJORJPJORJ7')
L ORJ SODFHER -DYLOH VX VH ]QDþDMQH UD]OLNH
L]PHÿXJUXSDRGPJLPJXRGQRVXQD7')
DOLWRQLMHVOXþDMVDGR]RPRGPJ
,]ORåHQRVWWHQRIRYLUXXSOD]PLQDG*6JUXSD
PDELODMHRNRPDQMDXSRUHÿHQMXVD7')
RPVDLQWUDFHOXODUQLPNRQFHQWUDFLMDPD3%0&DVH
GDPSXWDYHüLPNRGGR]HRGPJLGYDQDHVWSXWD
YHüLPNRGGR]HRGPJ
1LMH ELOR NOLQLþNL ]QDþDMQLK ODERUDWRULMVNLK DEQRU
PDOQRVWLLOLR]ELOMQLKOLMHNRPX]URNRYDQLKQHåHOMHQLK
HIHNDWD QLMH ELOR GLVNRQWLQXLWHWD L QHPD GRND]D R
UH]LVWHQFLML]DSHULRGRGGDQD
,DNR QLVX XRþHQL UHQDOQL SUREOHPL QDNRQ GDQD
WR üH VYDNDNR ELWL YDåDQ DVSHNW GDOMQMLK VWXGLMD
XNOMXþXMXüLWRGDOLVHSRYHüDQDLQWUDFHOXODUQDNRQ
FHQWUDFLMD*6DNXPXOLUDXUHQDOQRWXEXODUQLP
üHOLMDPD,QYLWURSRGDFLR07üHOLMDPD3%0&X
L PDNURIDJDPD QH XND]XMX QD SRYHüDQH UD]LQH LQ
WUDFHOXODUQRJGLIRVIDWD&16SHQHWUDFLMDXVOMHG*6
ELWUHEDODELWLVOLþQDNDRNRG7')D
,DNRMHRGDELUGR]HRGPJ]DMHGDQVDVWRMDNSUL
MDYOMHQIDUPDNRNLQHWLþNDLQWHUDNFLMDVDFRELFVLWDWRP
NRML SRMDþDYD *6 SRGUåDOD MH XSRWUHEX GR]D
RGPJXNRIRUPXODFLMDPDWRSRGUD]XPLMHYDXS
RWUHEXVDHOYLWHJUDYLURPNRELFLVWDWRP)7&RPLVD
GDUXQDYULRPFRELFLVWDWRP)7&RPXSUYRM3,ED
]LUDQRM MHGQRM WDEOHWL )'&D RG NRMLK VX REMH GLR
WHNXüLK ID]D ,, VWXGLMD ,QWHUDNFLMD UHQDOQLK NRPS
OLNDFLMDVDXWMHFDMHPFRELFLVWDWDQDUHQDOQHIXQNFLMH
WDNRÿHUüHELWLNOMXþQLDVSHNWRYLKVWXGLMD
*RGLQD,EURM
+,9%,/7(1+7%
Dolutegravir
'ROXWHJUDYLU MH LQKLELWRU LQWHJUD]H NRML MH UD]YLR
9LL9 +HDOWKFDUH L NRML LPD SUHGQRVWL X RGQRVX QD
UDOWHJUDYLULHOYLWHJUDYLU'R]LUDVHMHGQRPGQHYQR
NRG SDFLMHQDWD NRML VH SUYL SXW WUHWLUDMX L GYD SXWD
GQHYQRNRGSDFLMHQDWDNRMLLPDMXLVNXVWYRVDWHUDSL
MRP QH ]DKWLMHYD SRMDþDYDQMH LPD PDOX 3. YDUL
MDELOQRVW SRWHQFLMDOQR GUXJDþLML SUR¿O UH]LVWHQFLMH
RG UDOWHJUDYLUD L YLVRNL SRWHQFLMDO SUL GR]DPD VD
PDQMHPLOLJUDPD
'ROXWHJUDYLUVHPHWDEROLUDSULPDUQRRGVWUDQH8*
7$XSRWUHERP&<3$NDRPDQMHUXWH
DOLQHPDNOLQLþNLXWMHFDMQDLQGXFLUDQMHLOLLQKLELUDQMH
YHüLK&<38*7LOLSXWDQMDQRVLRFDRVLP2&7
2þHNXMHVHGDVHLQWHUDNFLMRPPRåHNOLQLþNLXSUDY
OMDWLSRPRüXSULODJRÿDYDQMDGR]HNDGDMHSRWUHEQR
7UHQXWQR SR]QDWD LQWHUDNFLMD XNOMXþXMH ]QDþDMQR
SRYHüDQXL]ORåHQRVWGROXWHJUDYLUXVDDWD]DQDYLURP
SRMDþDQRLOLQHLVPDQMHQXL]ORåHQRVWVDGDUXQDYL
URPIRVDPSUHQDYLURPWLSUDQDYLURPHIDYLUHQ]RP
L ULIDEXWLQRP ]D QH VPDWUD VH NOLQLþNL
]QDþDMQLP ]D SDFLMHQWH NRML VH SUYL SXW WUHWLUDMX
0HÿXWLP HWUDYLULQ VPDQMXMH L]ORåHQRVW GROXWHJUD
YLUX ]D L PRåH VH NRULVWLWL DNR VH SULPMHQMXMH
]DMHGQR VD ORSLQDYLURPU LOL GDUXQDYLURPU NRML
SRYHüDYDMX L]ORåHQRVW GROXWHJUDYLUX 'ROXWHJUDYLU
VHPRUDSULPMHQMLYDWLGYDSXWDGQHYQRVDULIDPLSL
QRPLDQWDFLGLPDXUD]PDNXRGQDMPDQMHGYDVDWD
]ERJKHODFLMHPHWDOQLKNDWMRQDXPMHVWRS+HIHNWD
3RVWRMH RKUDEUXMXüL VLJXUQRVQL SRGDFL GR VHG
PLFHL]ID]H,,VWXGLMDLUH]XOWDWLID]H,,,SULMDYOMXMX
VXSHULRUQH NUDMQMH UH]XOWDWH X SRUHÿHQMX VD UDOWH
JUDYLURP NRG SDFLMHQDWD NRML VH SUYL SXW WUHWLUDMX
'RGDWQRVWXGLMDVDGYLMH)'&IRUPXODFLMHGROXWUH
JUDYLUD VD DEDFDYLURP L 7& QD]LY VDVWRMND 7ULLMH]DYUãHQDL]DGRYROMDYDMXüLUH]XOWDWLVXYHü
SUHGVWDYOMHQL ]D SHGLMDWDUVNX IRUPXODFLMX X VSUHMX
'ROXWHJUDYLUMHYHüGRVWXSDQLSURJUDPXSURãLUHQRJ
SULVWXSD
8DSULOXUH]XOWDWLL]ID]H,,,635,1*VWXGLMH
NRMDSRUHGLGROXWHJUDYLUVDUDOWHJUDYLURPNRGSDFL
MHQDWDNRMLVHSUYLSXWWUHWLUDMXSULMDYOMXMXVXSHULRU
QRVWQDRVQRYXYLUDOQHVXSUHVLMHNRSLMDP/X
QDVSUDP X JUXSL GROXWHJUDYLUD QDVSUDP
UDOWHJUDYLUD &, GR VD GRQMRP
JUDQLFRPRGLQWHUYDODSRYMHUHQMDNRMDMHL]QDG
SUHGRGUHÿHQLK±1LVXSULPMHüHQHUD]OLNHXWRO
HUDQFLMLL]PHÿXJUXSD
5H]XOWDWL VWXGLMH 635,1* ]D LVSLWLYDQMH GR]H
GROXWHJUDYLUDEDFDYLU7& X RGQRVX QD HIDYLUHQ]
*RGLQD,EURM
WHQRIRYLU)7&$WULSODNRGSDFLMHQDWDNRMLVHSUYL
SXW WUHWLUDMX SUHGVWDYOMHQL VX QD &52,X WH X
YLGX NDVQH RUDOQH SULPMHQH L ELOL VX YUOR VOLþQL ]D
SHULRG RG VHGPLFH L VHGPLFD ]D JUXSX GR]H
RGPJ
'YLMHVWRWLQHLSHWXþHVQLNDMHQDVXPLþQRRGDEUDQRGD
VHSRGYUJQHWUHWLUDQMXGROXWHJUDYLURPXGR]DPDRG
PJPJLOLPJMHGQRPGQHYQRXSRUHÿHQMX
VD HIDYLUHQ]RP 2VQRYQD GHPRJUD¿MD XNOMXþLYDOD
MHPXãNDUDFDELMHODFDMHLPDORRV
QRYQLYLUDOQLVDGUåDM!NRSLMDP/LMH
NRULVWLORWHQRIRYLU)7&NDR157,VWUXNWXUX
8VHGPLFLGLRSDFLMHQDWDVDYLUDOQLPVDGUåDMHP
NRSLMDP/ 7/295 ELR MH RGQRV
QR]DJUXSHGR]DRGPJPJLPJ
QDVSUDPXJUXSLHIDYLUHQ]D9LURORãNLQHXVSMHK
MDYOMDRVHþHãüHXJUXSDPDVDPDQMLPGR]DPD
1 1 1 L1 ]DJUXSH
GR]D RG PJ PJ PJ RGQRVQR HIDYLUHQ]
DOLVXWRPDOLVWXGLMVNLEURMHYLLSRORYLQDRYLKSDFL
MHQDWD NRML þLQH QHXVSMHK WUHWPDQD SUHPD 7/295
DQDOL]DPD VX]ELOL VX YLUDOQL VDGUåDM QD NRSLMD
P/GRVHGPLFH.RGSDFLMHQDWDQLVXSULPMHüHQH
PXWDFLMHYH]DQH]DUH]LVWHQFLMXLQKLELWRUDLQWHJUD]H
LOL1157,D
3RYHüDQMDUD]LQH&'QLVXELODVWDWLVWLþNLUD]OLþLWDX
VHGPLFLüHOLMDPP]DNRPELQLUDQHJUXSH
GROXWHJUDYLUDQDVSUDPüHOLMHPP]DHIDYLUHQ]
3 6DPRGYRMHOMXGLMHSUHNLQXORXSRWUHEXGROXWHJUDYL
UDXVOMHGQHåHOMHQLKHIHNDWDMHGDQXVYDNRMRGJUXSD
GR]HRGPJLPJXSRUHÿHQMXVDSHWXJUXSL
HIDYLUHQ]D 1HåHOMHQL HIHNWL VX ELOL PDQML X JUXSL
GROXWHJUDYLUDLDNRVXR]ELOMQLMLQHåHOMHQLHIHNWLELOL
VOLþQL-HGLQDRFMHQDôODERUDWRULMVNLKDEQRUPDOQRV
WLMDYLODVHXMHGQRPVOXþDMXJGMHMHGRãORGRSRUDVWD
$/7DYH]DQR]DDNXWQLKHSDWLWLV&1LVX]DSDåHQH
UD]OLNHXUHQDOQLPIXQNFLMDPDL]PHÿXJUXSD
8WRNXVXID]H,,,VWXGLMDGROXWHJUDYLUDNRGSDFLMH
QDWDNRMLLPDMXLVNXVWYDXWUHWPDQXDNRMLVXUH]LV
WHQWQLQDUDOWHJUDYLULOLHOYLWHJUDYLULQDGDUXQDYLU
ULWRQDYLUNRGSDFLMHQDWDNRMLVHSUYLSXWWUHWLUDMX
5H]XOWDWL LVSLWLYDQMD SDFLMHQDWD VD LVNXVWYRP X
OLMHþHQMX SR SLWDQMX PXWDFLMD YH]DQLK ]D YLURORãNL
QHXVSMHKQDNRQXSRWUHEHLQKLELWRUDLQWHJUD]H]DLVWD
VXRKUDEUXMXüLQDNRQXVYDMDQMDSRYHüDQHGR]HQD
PJ GYD SXW GQHYQR V RE]LURP QD KLVWRULMVNH
SRWHãNRüHUH]LVWHQFLMHXQXWDUNODVH
3URãLUHQL SURJUDP LVSRUXNH ]D GROXWHJUDYLU YHü MH
SRNUHQXW X (YURSL L 6MHGLQMHQLP 'UåDYDPD LDNR
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
X] QDSRPHQX R ]QDþDMX XSRWUHEH X NRPELQDFLML VD
GUXJLPDNWLYQLPOLMHNRYLPDNDNRELVHL]EMHJODUDQD
UH]LVWHQFLMD L GDOMQMLL JXELWDN PRJXüQRVWL OLMHþHQMD
NRG SDFLMHQDWD VD NRPSOLFLUDQRP UH]LVWHQFLMRP QD
NRPELQDFLMHYLãHOLMHNRYD
6*6.
,DNR MH IRNXV QD GROXWHJUDYLUX VWYRULR ]QDþDMQR
X]EXÿHQMH WDNRÿHU SRVWRML LQWHUHVRYDQMH LDNR X]
PLQLPDOQX NROLþLQX SRGDWDND R SUDWHüHP VDVWRMNX
LQWHJUD]HL]*6.9LL9DQD]YDQRP6*6.
NRMLLPDGXåHSROXYULMHPHHOLPLQDFLMHRNRVDWL
YVVDWL]DGROXWHJUDYLU
5DQLUH]XOWDWLID]H,,,SUHGVWDYOMHQLQD0HÿXQDURGQRM
QDXþQRMNRQIHUHQFLMLRDQWLPLNURELDOQLPDJQHVLPDL
KHPRWHUDSML,&$$&SULMDYLOLVXEODJRVPDQ
MHQMHYLUDOQRJVDGUåDMDRGORJNRSLMDP/QDNRQ
PRQRWHUDSLMHRGGDQDSULXSRWUHELGR]HRGPJ
MHGQRPGQHYQRNRGSDFLMHQDWDNRMLVHSUYLSXWWUHWL
UDMXX]VWDYRYHGDGR]DRGPDQMHPLOLJUDPDPRåH
ELWLPRJXüD
'XJRWUDMQDLQMHNWLELOQDIRUPXODFLMDMHWDNRÿHULVSLWL
YDQDUDGLSRUHÿHQMDQMHQLKIDUPDNRORãNLKPRJXüQRVWL
VDRQLPDSULRUDOQRMSULPMHQLLGXJRGMHOXMXüRMIRU
PXODFLML 1157, ULOSLYLULQD VD SRWHQFLMDOQRP XS
RWUHERP L X YLGX WUHWPDQD L X SUHG L]ODJDQMX SUR
¿ODNVH3U(3
$åXULUDQMHGUXJLKVDVWRMDND
/HUVLYLULQ
/HULYLULQSUHWKRGQRSR]QDWNDR8.MHMHG
QRGQHYQL1157,XYODVQLãWYX9LL9DNRMLMHRULJL
QDOQRUD]YLR3¿]HULNRMLLPDUH]LVWHQWQXSXWDQMX]D
9,NRMLVHþLQLGUXJDþLMRPRG.1LOL<&
SXWDQMDYH]DQLK]DSUYRNUHLUDQMH1157,D
3RVOMHGQML SRGDFL GRELYHQL VX L] ID]H ,, SODFHER
NRQWUROLUDQHVWXGLMHVDGYRVWUXNLPL]ERURPNRMDMH
QDVXPLþQR SRGYUJOD SDFLMHQWD GR]DPD
RGPJLOLPJOHUVLYLULQDLOLVWDQGDUQLPGR
]DPD HIDYLUHQ]D VYDND VD SULPMHQRP WHQRIRYLUD
)7&MHGQRPGQHYQR3ULPDUQDNUDMQMDWDþNDELRMH
SURFHQDWSDFLMHQDWDVDYLUDOQLPVDGUåDMHPVPDQMHQ
LP QD NRSLMDP/ X VHGPLFL VD SUDüHQMHP
GRVHGPLFHSUHPD,77QHGRVWXSQLP QHXVSMHOLP
DQDOL]DPD
2VQRYQD&'UD]LQDLYLUDOQLVDGUåDMVXXSURVMHNX
ELOLüHOLMDPPUDVSRQRG±RGQRVQR
NRSLMDP/ UDVSRQ 2NR
SDFLMHQDWD LPDOR MH SRþHWQL YLUDOQL VDGUåDM
!NRSLMDP/LWRVHRGUD]LORXSUHGRGUHÿHQLP
DQDOL]DPDUH]XOWDWD
ZZZKLYELOWHQLQIR
'UXJH RVQRYQH NDUDNWHULVWLNH XNOMXþLYDOH VX
SURVMHþQXVWDURVWRGJRGLQDUDVSRQ
åHQDLELMHODFDFUQDFDRVWDOLK,DNR
MHYHüLQDOMXGLLPDODSRGWLS%RNROMXGLLPDOR
MH SRGWLS & YH]DQR ]D SDFLMHQWH ORFLUDQH X -XåQRM
$IULFL
8 VHGPLFL SURFHQDW SDFLMHQDWD VD YLUDOQLP
VDGUåDMHP!NRSLMDP/ELRMHLXJUX
SDPDRGPJLPJRGQRVQRXJUXSLHID
YLUHQ]D,DNRVWXGLMDQLMHELODQDPLMHQMHQDGHWHNFLML
UD]OLNDXH¿NDVQRVWLL]PHÿXJUXSDJUXSDOHUVLYLULQD
GDOD MH JRUX UHDNFLMX X SRUHÿHQMX VD HIDYLUHQ]RP
PJUD]OLNH&,LPJ
UD]OLNH&,
5H]XOWDWLVWUDWL¿NRYDQLSRþHWQLPYLUDOQLPVDGUåDMHP
NRML MH ELR PDQML X JUXSL ! NRSLMDP/
LOL JHRJUDIVNLP UHJLRQRP PDQML QD ORNDFLMDPD X
-XåQRM$IULFLQLVXVHVXSURWVWDYLOLRYLPUH]XODWLPD
3URVMHþQD UD]LQD &' SRYHüDOD VH ]D RNR üHOLMDPPRGSRþHWQHUD]LQHLELODMHVOLþQD
2JUDQLþHQLSRGDFLRYLURORãNRPQHXVSMHKXNRGL
SDFLMHQWD X JUXSDPD RG PJ LPJ RGQRVQR
XHIDYLUHQ]JUXSLXND]XMXQDWRGDVXJUXSHOHUVL
YLULQDSRYH]DQHVD09SOXV1157,PXWDFLMDPD
NDGDMHUH]LVWHQFLMDL]RORYDQD-HGQDRVREDVDSULP
MHWQLP PXWDFLMDPD X JUXSL HIDYLUHQ]D QLMH SURãOD
VDPRVD.1
*HQHUDOQRNRPELQLUDQDDQDOL]DVLJXUQRVWLSULMDYLOD
MHVOLþQHVOXþDMHYHQHåHOMHQLKHIHNDWDXVYDNRMJUXSL
DOLMHELORPDQMHRFLMHQMHQLKôGRJDÿDMDXJUXSDPD
OHUVLYLULQD 1 L X SRUHÿHQMX VD HIDYLUHQ]RP
1 /DERUDWRULMVNH DEQRUPDOQRVWL QLVX ELOH
XþHVWDOHLNRQDþQRVXUDVSRGLMHOMHQHPHÿXJUXSDPD
/LSLGL VX ELOL VWDELOQL ]D OHUVLYLULQ X SRUHÿHQMX VD
SRYHüDQMHP7&D/'/D+'/DLWULJOLFHULGD7*
]DHIDYLUHQ]DOLMHRYR]DSRVOMHGLFXLPDORPDOXUD
]OLNXL]PHÿXJUXSDOHUVLYLULQDLHIDYLUHQ]DL
YVXSURPMHQLRGQRVD7&+'/NRMLVH
NRULVWL]DSURFMHQXNDUGLRYDVNXODUQRJUL]LND
1DNUDMXVWXGLMD]DNOMXþXMHGDVXREMHGR]HOHUVLYLUL
QDSRND]DOHVOLþQXH¿NDVQRVWNDRLHIDYLUHQ]WRNRP
SHULRGD RG VHGPLFH NRG SDFLMHQDWD NRML VH SUYL
SXWWUHWLUDMXLGDLPDMXGUXJDþLMHSUR¿OHQHåHOMHQLK
HIHNDWDXSRUHÿHQMXVDHIDYLUHQ]RP
,DNR L GDOMH SRVWRML XORJD ]D QRYL 1157, VD
DNWLYQRãüXSURWLYUH]LVWHQFLMHYH]DQH]DQHYLUDSLQL
HIDYLUHQ]YHüLEURMSULMDYOMHQLKPXþQLQDLJODYRER
OMD þDN L QLVNH RFMHQH PRJX REMDVQLWL ]DãWR QHPD
GDOMQMLKNOLQLþNLKLVWUDåLYDQMDRVLPSUDüHQMDSDFLMH
QDWDL]SRþHWQLKVWXGLMD
*RGLQD,EURM
+,9%,/7(1+7%
%06157,
%06SUHWKRGQR2%3LNUDWNRIHVWL
QDYLUMH157,VDVWUXNWXURPVOLþQRPVWUXNWXULVWD
YXGLQDG7DOLVDVLJXUQRVQLPSUR¿ORPNRMLVHQH
PRåH SRYH]DWL VD VOLþQLP QHåHOMHQLP HIHNWLPD ,Q
YLWURVWXGLMHJRYRUHGDMH%06VODELQKLEL
WRU'1.VLQWH]HLGDMHPDORYMHURYDWQRGDüHXWMH
FDWLQDPLWRKRQGULMDOQHIXQNFLMH
1DMQRYLML SRGDFL SUYL SXW SULMDYOMHQL WH GR
ELYHQLVXL]SUHJOHGDDQDOL]DID]H,,,VWXGLMHLVSLWL
YDQMDGR]DNRGSDFLMHQDWDLVNXVQLKXWUHWPDQXQLVX
WUHWLUDQLQDMPDQMHWULPMHVHFD
1DNRQ GDQD PRQRWHUDSLMH SURVMHþQD VPDQMHQ
MD YLUDOQRJ VDGUåDMD RJ GDQD ELOD VX LORJNRGJUXSDRGLPJ
YVXSODFHERJUXSLXRGQRVXQDSURVMHþQH
SRþHWQH UD]LQH X JUXSDPD RG ORJ UDVSRQ
]DFLMHOXVWXGLMX
,QYLWURSRGDFLRVXVFHSWLELOQRVWLOLMHND%06
XNOMXþXMXüLVXVFHSWLELOQRVWPXWDFLMH0L157,
UH]LVWHQWQH QD NRPELQDFLMX YHüHJ EURMD OLMHNRYD
SUHGVWDYOMHQL VX QD SRVWHUX QD &52,X ,DNR
MHDQWLYLUDOQDDNWLYQRVWVPDQMHQDXSULVXVWYXYHüLQH
YLUXVDNRMLQRVHPXWDFLMHYH]DQH]DQXNOHXVH±GR
± SXWD XNOMXþXMXüL 0/ GR SXWD L
'1 GR SXWD UH]LVWHQWQH PXWDFLMH ]D
MHGQRVD.1VDLOLEH]099LUXVLNRMLQRVH
40PXWDFLMXELOLVXEODJRKLSHUVXVFHSWLELOQLQD
%06GRSXWDþDNLXSULVXVWYX
.5GRSXWD
1RYD VHGPLþQD ID]D ,, VWXGLMH LVSLWLYDQMD GR]H
SRUHGLMHGQRGQHYQHGR]HRGLPJSOXV
HIDYLUHQ]L7&]DNRQWUROXJUXSDHIDYLUHQ]DWHQR
IRYRULDL7&D
%06,QKLELWRUYH]LYDQMD
%06MHJSLQKLELWRUYH]LYDQMDUD]YLMHQ
RGVWUDQH%ULVWR0\HUV6TXLEED
,DNRQHPDQRYLKSUHGVWDYOMHQLKVWXGLMDRG&52,D
QRYH VWXGLMH VX QDYHGQH NDR WHNXüH 2QH
XNOMXþXMXRURVHGPLþQXID]X,,VWXGLMHLVSLWLYDQMD
GR]H VD %06 GR]LUDQLP X PJ LOL PJGYDSXWDGQHYQRLOLPJLOLPJMHGQRP
GQHYQR X NRPELQDFLML VD UDOWHJUDYLURP L WHQRIRYL
URPLYUãHSRUHÿHQMHVDNRPELQDFLMRPþHWLULOLMHND
SRMDþDQRJDWD]DQDYLUDSOXVUDOWHJUDYLULWHQRIRYLU
3RþHWQDVWXGLMDLVSLWLYDQMDGR]HNRULVWLODMHSULPMHQX
GR]DMHGQRPLGYDSXWDGQHYQRVDLOLEH]ULWRQDYLUD
*RGLQD,EURM
Cenicriviroc
&HQLFULYLURF SUHWKRGQR7%5 MH RUDOQL &&5
LQKLELWRUUD]YLMHQRGVWUDQH7RELUDNRMLLPD3.SUR¿O
NRMLRPRJXüDYDGR]LUDQMHMHGQRPGQHYQRDOL]DKWL
MHYDNRSULPMHQXVDKUDQRP&HQLFULYLURFMHWDNRÿHU
DNWLYQLDJHQV&&5NRMLLJUDXORJXXLQÀDPDWRUQLP
L PHWDEROLþNLP NUHWDQMLPD NOLQLþNH LPSOLNDFLMH VX
QHMDVQH DOL PRJX XNOMXþLYDWL SRWHQFLMDOQX NRULVW X
EXGXüLPVWXGLMDPD
5H]XOWDWL L] L] SRþHWQH ID]H ,, VWXGLMH LVSLWL
YDQMDGR]HSRND]DOHVXVPDQMHQMHYLUDOQRJVDGUåDMD
RGORJVDPJ
2YH JRGLQH QD &52,X LQWHUQL 3. SRGDFL VX
SULND]DQL ]D SUYLK SDFLMHQDWD PXãNDUDFD
åHQD XNOMXþHQLK X QRYLMX R VHGPLþQX ID]X
,, QDVXPLþQH VWXGLMH LVSLWLYDQMD GR]H RG PJ L
PJVDXSRWUHERPQRYHIRUPXODFLMHRGPJVD
HIDYLUHQ]RPNDRNRQWURORPLWHQRIRYLURP)7&RPD
NDR RVQRYQLP 157,RP ]D VYH JUXSH 3UHOLPLQDUQL
UH]XOWDWL SRND]DOL VX IDUPDNRNLQHWLNX SURSRUFLRQD
OQXGR]DPDVDSURVMHþQLPNRQFHQWUDFLMDPDXSOD]PL
L]PHÿXQJP/LQJP/SURFLMHQMHQR,&
MHQJP/LSURVMHþQLP&9&PLQYULMHGQRV
WLPDRGLQJP/]D
PJLPJGR]HUHVSHNWLYQRED]LUDQRQDPMHUHQ
MXWRNRPRJGDQD]DSDFLMHQDWD'YDSDFLMHQWD
VXVHSRYXNODXVOMHGQHVODJDQMDVDSURWRNRORPLGYD
]ERJWROHUDQFLMHVYLSULMHRJGDQD2YDVWXGLMDMH
MRãXYLMHNXWRNXDSRGDFLRYLURORãNRMH¿NDVQRVWL
L VLJXUQRVWL üH WHN ELWL SULMDYOMHQL 1D RVQRYX RYLK
UH]XOWDWD VWXGLMD üH XNOMXþLWL L SUHRVWDOLK SDFL
MHQDWD
'XJRGMHOXMXüD/$IRUPXODFLMDULOSLYLULQD
5D]YRM QDQRVXVSHQ]LYQH IRUPXODFLMH 1157, ULOSL
YLULQDNRMLVHPRåHSULPMHQMLYDWLLQWUDPXVNXODUQRP
LQMHNFLMRP SULMDYOMHQ MH SULMH QHNROLNR JRGLQD 3.
VWXGLMDVDMHGQRPGR]RPNRG+,9QHJDWLYQLKRVRED
SUHGVWDYOMHQD QD &52,X RYH JRGLQH SRND]DOD MH
SURGXåHQR L]ODJDQMH X SOD]PL JHQLWDOQLP L UHNWDO
QLP GLMHORYLPD QDNRQ GR]D RG LOL PJ
,DNRMHULOSLYLULQ/$LVWDNQXW]ERJVYRJSRWHQFLMDOD
GD VPDQML RVODQMDQMH QD GQHYQX SRVOXãQRVW X NRQ
WHNVWX3U(3DPRåHSUHGVWDYOMDWLLYDåQXRSFLMX]D
+,9 WUHWPDQ WDNRÿHU ]D WR MH SRWUHEQR NUHLUDQMH
NRPELQDFLMH VD GUXJLP$59LPD VOLþQH IRUPXODFL
MH1HGRVWDWDNQHJDWLYQLKLQWHUDNFLMDOLMHNDL]PHÿX
ULOSLYLULQD L UDOWHJUDYLUD WDNRÿHU SUHGVWDYOMHQR
QD &52,X L UD]YRM VOLþQH IRUPXODFLMH ]D 6*6.
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
MDVQRVXRGYHOLNRJ]QDþDMD
6LJXUQRVQR SLWDQMH ]D GXJRGMHOXMXüH IRUPXODFLMH
SRVHEQRXRGVXVWYXSURWXRWURYD]DEU]RHOLPLQLUDQ
MH DNWLYQRJ VDVWRMND X VOXþDMX R]ELOMQH QHåHOMHQH
UHDNFLMHPRåHVHSRNULWLSHULRGRPRUDOQRJGR]LUDQ
MDGDELVHXWYUGLODWROHUDQFLMDSRMHGLQFDSRVHEQRMHU
VXLNODVH1157,DLLQWHJUD]HYH]DQH]DKLSHUVHQ
]LWLYQHUHDNFLMH
1HGDYQR LVSLWLYDQMH +,9 SR]LWLYQLK SDFLMH
QDWD QD GYLMH 6$' NOLQLNH GDOR MH LQWHUHVRYDQMH
RG L ]D $57 LQMHNFLMH QD RVQRYX
VHGPLþQLK GYRVHGPLþQLK L PMHVHþQLK IRUPXODFLMD
VDYHüLPLQWHUHVRYDQMHPOMXGLNRMLLPDMXSUREOHPVD
SRãWRYDQMHPSUHSRUXNDLDNRMHWDNRÿHU]DEUL
QXWR]ERJXSRWUHEHLJOH
$SULFLWDELQ
$SULFLWDELQMH157,NRMLMHXNOMXþHQXSUHWKRGQDGYD
L]YMHãWDMD,%DVHDRWRNRYLPDLVWUDåLYDQMDXYHOLNRM
PMHUL QD RVQRYX ]DQLPOMLYLK UH]XOWDWD ID]H ,,E L]
L SRVYHüHQRVWL PDOH DXVWUDOLMVNH NRPSDQLMH
]DELRWHKQRORJLMX$YH[DNRMDMHSULVYRMLODSUDYDQD
UD]YRMRG6KLUHD]DSURãLUHQMHPRJXüQRVWLOLMHþHQMD
OMXGLVDUH]LVWHQFLMRPQDYHüLEURMOLMHNRYD
6DVWRMDNMHDQDORJDQFLWLGLQXVOLþDQ7&XLGR]LUD
VHGYDSXWDGQHYQRVWLPGDUH]XOWDWLL]ID]H,,SRND
]XMXDNWLYQRVWSURWL09UH]LVWHQFLMHQH]DYLVQR
RG SULVXVWYD GUXJLK DQDORJQLK PXWDFLMD QXNOHXVD
7$0SXWDQMH/9LWGLWDNRÿHUSRND]XMXVPDQ
MHQMHYLUDOQRJVDGUåDMDRGORJ]DOMXGHVDWULLOL
YLãHPXWDFLMDDQDORJQLKWLPLGLQX7$0RYL
7HRUHWVNLXSRWUHEDQHNROLNRVOLþQLKVDVWRMDNDVDXP
MHUHQRP YLUDOQRP DNWLYQRãüX NRML PRJX SUHYD]LüL
DVSHNWHUH]LVWHQFLMHQDOLMHNPRåHLGDOMHLPDWLWHUD
SHXWVNXXORJX]DOMXGHNRMLVXL]DEUDOLGUXJHRSFL
MH1DQHVUHüXUHJXODWRUQHNRPSOLNDFLMHXUD]YRMX
YLãHVWUXNLK HNVSHULPHQWDOQLK RSFLMD QLNDGD QLVX
ULMHãHQH
3ODQLUDQHID]H,,,,,VWXGLMDVWRSLUDQHVXLOLSRYXþHQH
L$YH[DLGDOMHWUDåL¿QDQVLMVNHSDUWQHUHNRMLüHQDV
WDYLWLUD]YRM$YH[DWDNRÿHULPDPROHNXOHLQWHJUD]H
XSUHNOLQLþNRPUD]YRMX
ZZZKLYELOWHQLQIR
,EDOL]XPDE
,EDOL]XPDE SUHWKRGQR 70% L 71; MH
PRQRNORQVNRDQWLWLMHORNRMHVDGDSRVMHGXMH7DL0HG
NRMH MH QDYHGHQR NDR ID]D , VWXGLMH X SUYRP 7$%
L]YMHãWDMXRWRNRYLPDLVWUDåLYDQMD,DNRMHQRYD
ID]D,VWXGLMHQDYHGHQDNDRRWYRUHQD]DXNOMXþLYDQMH
SDFLMHQDWD VD LVNXVWYRP X OLMHþHQMX ID]D ,, MH
]DYUãHQD X PHÿXYUHPHQX YMHURYDWQR MH UD]XPQR
UHüL GD VX RSWLPLVWLþND SUHGYLÿDQMD ]D SODVLUDQMH X
VOMHGHüRMJRGLQLVNURPQRVODED
&0;L&73
7RNRPSURãOHJRGLQHQLMHELORGRSXQVNLKSRGDWDND
R&0;157,XVOLþQRPWHQRIRYRUXNRMLMHGDR
]DQLPOMLYHSRGDWNHRH¿NDVQRVWLXID]L,SULMHGYLMH
JRGLQH LOL R LQKLELWRUX SURWHD]H &73 VOLþQRP
DQWD]DQDYLUX NRML MH *6. SULVYRMLR ]D SUHNOLQLþNL
UD]YRM
3UHJOHGNRPELQDFLMD¿NVQLKGR]D
2SWLPLVWLþNL SHJOHG ]D NRPELQDFLMH ¿NVQLK GR]D
VXPLUDQMHXWDEHOL
6DQHNROLNRNRPELQDFLMDLOLYHüRGREUHQLKLOLXID]L,,,
UD]YRMDSUHGQRVWLSRQMHJXSDFLMHQDWDNDRSRVOMHGL
FDVDUDGQMHL]PHÿXNRPSDQLMDMDVDQVXSULPMHUGDWR
PRåHELWLRGNRULVWLLQDGUXJLPPHGLFLQVNLPSROMLPD
7UåLãWHWMHUD]DSDGQHNRPSDQLMHGDXþHL]JHQHULND
NRPELQDFLMH¿NVQLKGR]DSRMHGQRVWDYOMXMXOLMHþHQMH
]D SDFLMHQWH X ]HPOMDPD X UD]YRMX VD EURMQLP IRU
PXODFLMDPDNRMHQLNDGDQLVXELOHGRVWXSQHNDGDMH
SDFLMHQWLPDELRRJUDQLþHQSULVWXS
8VSMHK $WULSODH MH GREUR XWYUÿHQ DOL MH WDNRÿHU
]DVQRYDQ QD H¿NDVQRVWL WUL SRMHGLQDþQD OLMHND NRMH
VDGUåL-DVQRWRüHELWLSRGMHGQDNRYDåQR]DEXGXüH
)'&H
3RWHQFLMDO NRIRUPXODFLMH LQKLELWRUD SURWHD]H VD 3.
SRMDþLYDþLPDMHYDåDQDOL]DKWLMHYDVDUDGQMXNRP
SDQLMD ,DNR MH ULWRQDYLU RULJLQDOQR RGREUHQ QDNQDGQR MH NRIRUPXOLUDQ VD $EERWWRYLP ORSLQD
YLURP DOL$EERWW QLMH OLFHQFLUDR VDPRVWDOQX
YHU]LMX GR L QLMH MH NRIRUPXOLUDR VD LQKLEL
WRULPD SURWHD]H GUXJLK SURL]YRÿDþD NRML ]DYLVH RG
SRMDþDYDQMDGDELGRVWLJOLWHUDSHXWVNHGR]H
=ERJWRJDMHYDåQRGDVHVNORSHVSRUD]XPL]DNR
IRUPXOLUDQMH FRELFLVWDWD VD DWD]DQDYLURP L GDUXQD
YLURP
*RGLQD,EURM
+,9%,/7(1+7%
7DEHOD2GREUHQLL)'&LXWRNXLVWUDåLYDQMDLVDUDGQMD]D]DMHGQLþNHIRUPXODFLMHRGVWUDQHRUJLQDOQLKSURL]YRÿDþD
Agensi
Sponzori
Status
.RPELQDFLMH¿NVQLKGR]D
$=77&DEDFDYLU7UL]LYLU
*6.
HIDYLUHQ]HPWULFLWDELQWHQRIRYLU
$WULSOD
ULOSLYLULQHPWULFLWDELQWHQRIRYLU
.RPSOHUD(YLSOHUD
HOYLWHJUDYLUNRELFLVWDWWHQRIRYLU
HPWULFLWDELQ4XDG
HOYLWHJUDYLUNRELFLVWDWHPWULFLWDELQ
*6
GDUXQDYLUNRELFLVWDW*6
HPWULFLWDELQ3,ED]LUDQL)'&
GROXWHJUDYLUDEDFDYLU7&7ULL
*LOHDG%06
7URVWUXND157,NRPELQDFLMD2GREUHQD
6DGDVHULMHWNRNRULVWL
2GREUHQâLURNRSUHSRUXþHQLNR
ULVWLVHRGWDGD
2GREUHQ
*LOHDG-DQVVHQ
*LOHDG
*LOHDG
3RGQHVHQ]DKWMHY]DRGREUHQMHRþHNXMH
VH
)D]D,,
*LOHDG-DQVVHQ
)D]D,,
9LL9*6.
)D]D,,,
GDUXQDYLUFRELFLVWDW
7LERWHF-DQVVHQ
*LOHDG
DWD]DQDYLUFRELFLVWDW
%06*LOHDG
5H]XOWDWLELRGRVWXSQRVWLVOLþQLRQLPD]D
GDUXQDYLUULWRQDYLUYHüVXSULMDYOMHQL]D
GYLMHIRUPXODFLMH
1HPDGDOMQMLKLQIRUPDFLMD
3,SRMDþLYDþIRUPXODFLMH
1RYHNRPSRQHQWHRG]QDþDMD
,DNR MH *LOHDG REMDYLR VYRMX OLFHQFX QHNDWDOLWLþNH
ORNDFLRQH LQKLELWRUH LQWHJU]H 1&,1,L SURãOH JR
GLQH RG %RHKULQJHUD ,QJHOKHLPD XNOMXþXMXüL
YRGHüXNRPSRQHQWX%,ID]DDVWXGLMHHV
NDODFLMHGR]HNRG+,9QHJDWLYQLKYRORQWHUDRGWDGD
MHSRYXþHQD
3HSWLGLNRMLIXQNFLRQLUDMXVOLþQRNDRVDVWRMFLVOLþQL
LQWHJUD]L /('*,1L LDNR LQWULJDQWQL L GDOMH VX X
SUHGNOLQLþNRPUD]YRMX
1DQRIRUPXODFLMH SRVWRMHüLK $59D L GDOMH LPDMX
LVWDRþHNLYDQMDNDRLXSUHWKRGQLPJRGLQDPDSUHPD
L]YMHãWDMLPDSULQFLSLMHOQRXSRVWL]DQMXYHüLKFLOMQLK
UD]LQD OLMHNRYD XSRWUHERP NRPSRQHQWL NRMH ]DKWL
MHYDMXPDQMH$3,D9HüLPGLMHORPPHÿXWLP]DQ
LPOMLYH NRPSRQHQWH L GDOMH RVWDMX X SUHGNOLQLþNLP
ID]DPDUD]YRMDLDNRVHRþHNXMXQHNHVWXGLMHRGRND
]XNRQFHSWDNRGOMXGL
)DNWRULüHOLMVNHWUDQVNULSFLMH
3RWHQFLMDO]DQRYHFLOMHYHLGDOMHMHIRNXVLUDQNDUDQLP
ID]DPDUD]YRMDOLMHNRYDLSURãORJRGLãQML,]YMHãWDMR
*RGLQD,EURM
WRNRYLPD LVWUDåLYDQMD XNUDWNR MH VSRPHQXR PRGL
¿NDFLMX DQWLYLUXVQLK OMXGVNLK SURWHLQD XNOMXþXMXüL
$32%(&* 75,0DOID L WHWHULQ NRML VX DNWLYQL
SURWLY+,9DDOLVHQHXWUDOL]LUDMXYLãNRP+,9YLUDO
QLKSURWHLQD
6DVWRMFL XVPMHUHQL ND +,9 NDSVLGX XNOMXþXMX 7DW
LQKLELWRUH 51DVH + LQKLELWRUH VDVWRMNH ED]LUDQH
QD ]ODWX WHWHULQ SURWHLQ NRML ]DGUåDYD YLUXV X
üHOLML GRPDüLQX L 51 VDVWRMDN NRML LQKLELUD
9LI L SRYHüDYD $%2%(&* L MRã XYLMHN VX GLR
SUHGNOLQLþNLKLVSLWLYDQMD
,VWUDåLYDQMDRYLKVDVWRMDNDEOLVNRVXSRYH]DQDVDQH
NLPVWUDWHJLMDPD]DLVWUDåLYDQMHOLMHNDNRMHMHRSLVDR
5LFKDUG-HIIHU\VXGUXJRPSRJODYOMX,]YMHãWDMDRWRN
RYLPDLVWUDåLYDQMDXXOR]LNRMXQRYLOLMHNRYL
PRJXLJUDWLDNRVXQDPLMHQMHQL]DFLOMQHUH]HUYRDUH
NRML WUHQXWQR QLVX GRVWLJQXWL SRVWRMHüLP $57RYL
PD3RVWRMDQMHWDNYLKVYHWLKPMHVWDLDNRNRQWUDYHU
]QR MDVQR MH SRåHOMQR L SRGUåDQR RG VWUDQH QHNLK
LVWUDåLYDþNLKJUXSDLDNRQHRGVWUDQHVYLK
'RGDWQRGL]DMQLUDQMXOLMHNRYDQDPLMHQMHQLKFLOMQLP
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
NRQNUHWQLP UH]HUYRDULPD VWXGLMD QD &52,X RYH
JRGLQHSULMDYLODMHSRWHQFLMDO$32%(&*GDSRMDþD
XWMHFDMUDOWHJUDYLUD
=DNOMXþDN
,DNR MH SURãOH JRGLQH RGREUHQD VDPR MHGQD $59
NRPSRQHQWD QHNROLNR QRYLK NRPSRQHQWL L NRPEL
QDFLMD¿NVQLKGR]D)'&GRãORMHGR]DNRQVNHID]H
LRGQMLKVHRþHNXMHSURPMHQDPRJXüQRVWLOLMHþHQMD
LDNRüHWRWDNRÿHU]DYLVLWLRGQDþLQDRGUHÿLYDQMDFL
MHQDOLMHNRYDQDUD]OLþLWLPWUåLãWLPD
7DNRÿHURVWDMHGDVHYLGLGDOLVHREHüDYDMXüLUH]XO
WDWLSULMDYOMHQLXNOLQLþNLPSUREDPDRGNRMLKQHNH
XNOMXþXMX SDFLMHQWHVD PDQMHX]QDSUHGRYDOLPVWDQ
MHPPRJXELWLRVWYDUHQLXUXWLQVNLPLOLUHDOQLPXV
ORYLPDJGMHVXNDUDNWHULVWLNHSDFLMHQDWDþHVWRYUOR
UD]OLþLWH
2YL QRYL OLMHNRYL LDNR UD]YLMHQL ]D LQGLNDFLMH
SRþHWQLK WUHWPDQD WDNRÿHU LPDMX REHüDYDMXüX DN
WLYQRVW]DOMXGHUH]LVWHQWQHQDOLMHNLDNRQHNHSRWHQ
FLMDOQRNRULVQHNRPSRQHQWH]DUH]LVWHQWQHSDFLMHQWH
LGDOMHVWRMHþHNDMXüLSDUWQHUVWYRVDYHüLPNRPSDQL
ZZZKLYELOWHQLQIR
MDPD
3RWHQFLMDOQL UD]YRM WUHWPDQD NRML IXQNFLRQLUDMX VD
IDNWRULPD OMXGVNH WUDQVNULSFLMH L GUXJLP üHOLMVNLP
PHKDQL]PLPDLGDOMHVHþLQLREHüDYDMXüLP
.RQDþQRLQGXVWULMVNLVWDYSUHPDQRYLPOLMHNRYLPD
þDNLSRFLMHQLVOLþQRMLOLYHüRMRGFLMHQHSRVWRMHüLK
OLMHNRYDGRYROMQRMHVQDåDQGDRVLJXUDNRQWLQXLUDQR
LVWUDåLYDQMHXEOLVNRMEXGXüQRVWL7RMHYDåQR7UH
QXWQLOLMHNRYLVXGDOHNRRGVDYUãHQLKDOLMHN]D+,9
þDNLDNRMHGRVWLåDQRSWLPLVWLþQRVHVPDWUDGDOHNLP
GRJRGLQD
3ULVWXS QRYLP WUHWPDQLPD X ELOR NRP VWDQMX RVLP
GREUH¿QDQVLMVNHVLWXLUDQRVWLXNOMXþXMXüLHYURSVNH
]HPOMHPDQMHMHVWDELODQLOLVLJXUDQLSDNLWRPRåH
ELWL UH]XOWDW GDOMQMH SRGMHOH PRJXüQRVWL WUHWPDQD X
]DSDGQLP]HPOMDPD
2YRPRåHGRYHVWLGRVLWXDFLMHJGMHWHNXüHNRPSR
QHQWHVDYUORPDORPGR]RPXPLOLJUDPLPDLPDMXSR
WHQFLMDOGDSRVWDQXãLUHXSRWUHEOMDYDQHX]HPOMDPDX
UD]YRMXXPMHVWRXUD]YLMHQLP]HPOMDPD]DYLVQRRG
SROLWLNHFLMHQD]DVUHGLQHVDRJUDQLþHQLPUHVXUVLPD
DNRLVWLSURL]YRÿDþLRGOXþXMXXSURGDMQLPFLMHQDPD
]DQRYHOLMHNRYHQD]DSDGQRPWUåLãWX
*RGLQD,EURM
+,9%,/7(1+7%
7%.2,1)(.&,-$
9DåQLQDSUHGFLXUD]YLMDQMXOHND]DWXEHUNXOR]X
1DWKDQ*HIIHQ&665
7ULQHGDYQHVWXGLMHVX]QDþDMQRXQDSUHGLOHUD]YRMOHND]DWXEHUNXOR]X7%
'HODPDQLG ]D PXOWL UH]LVWHQWQX WXEUHNXOR]X
0'57%
'HODPDQLG UDQLMH SR]QDW NDR 23& MH QL
WURPLGD]ROLMHGDQMHRGGYDQRYDOHNDXRYRMNODVL
NRULãüHQD]DOHþHQMH7%,QKLELUDVLQWH]XPLNROLþQH
NLVHOLQH NRPSRQHQWX üHOLMVNRJ ]LGD EDNWHULMH 7%
5D]YODJDMH-DSDQVNDIDUPDFHXWVNDNRPSDQLMD2W
VXND
5H]XOWDWHYHOLNHID]HLVSLWLYDQMDRYDNRPSDQLMDMH
REMDYLOD X MXQX X 0HGLFLQVNRP äXUQDOX 1RYH (Q
JOHVNH,VSLWLYDQMHMHL]YUãHQRQD)LOLSLQLPDX3HUXX
/HWRQLML(VWRQLML.LQL-DSDQX(JLSWXL6MHGLQMHQ
LP'UåDYDPD3DFLMHQWLPDMHQDVXPLþQRSUHSLVDQR
GDSULPDMXVWDQGDUGQLUHåLP0'5OHND]D7%X]LOL
GHODPDQLGPJGYDSXWGQHYQRQ LOLGHOD
PDQLGPJGYDSXWDGQHYHQRQ LOLSODFHER
GYDSXWDGQHYQRQ WRNRPRVDPQHGHOMDXERO
QLFL'HODPDQLGVHX]LPDRVDKUDQRP
6YLP XþHVQLFLPD MH GLMDJQRVWL¿NRYDQD UH]LVWHQWQD
7% QD YLãH OHNRYD 6NRUR VYL VX ELOL +,9 QHJDWLY
QL3URVHNJRGLQDMHELR2VQRYQLLQGHNVWHOHVQH
PDVH MH ELR 6NRUR SDFLMHQDWD MH LPDOR
SOXüQDRãWHüHQMD6YLSDFLMHQWLVXELOLSUHWKRGQRQD
WHUDSLML]D7%2GSDFLMHQWDMHLPDORLVSOMX
YDNSR]LWLYDQQDXSRWUHEX0*,7D
-HGDQ SDFLMHQW MH SUHPLQXR RG 7% 2VDPQDHVWRUR
OMXGLVHSRYXNORL]JUXSHNRMDMHSULPDODGHODPDQLG
PJL]JUXSHNRMDMHSULPDODGHODPDQLGPJ
LOMXGLVHSRYXNORL]NRQWUROQHJUXSHSDFLMH
QDWDUDYQRPHUQRL]VYLKJUXSDSUHNLQXORMHLVSLWL
YDQMHOHNDXVOHGQHåHOMHQLKHIHNDWD
2VLP LQWHUYDOD 47 QLMH ELOR ]QDþDMQLK UD]OLND X
QHåHOMQLPHIHNWLPDL]PHÿXJUXSD,QWHUYDO47MHELR
YHüLXJUXSLNRMDMHX]LPDODPJQHJR
XJUXSLNRMDMHX]LPDODPJNRMDMHELOD
YHüDRGJUXSHNRMDMHX]LPDODSODFHER1LMH
*RGLQD,EURM
ELORNOLQLþNLKGRJDÿDMDYH]DQLK]DLQWHUYDO47
,]ORåHQRVWGHODPDQLGXVHSRYHüDODPDQMHRGSURSRU
FLRQDOQRJVDSRYHüDQMHPGR]H9UHPHSROXUDVSDGD
NRQFHQWUDFLMHGHODPDQLGDXSOD]PLELORMHVDWLQD
NRQãWRVXSDFLMHQWLSUHVWDOLGDX]LPDMXOHN
*ODYQL]DNOMXþDNVWXGLMHMHELRGDVXSDFLMHQWLNRML
VXSULPLOLGHODPDQLGRGPJLPJLPDOLVWRSX
NRQYHU]LMH X LVSOMXYNX VD XSRWUHERP 0*,7D RG
RGQRVQRQDNRQGYDPHVHFDXSRUHÿHQMX
VDXJUXSLNRMDMHX]LPDODSODFHERS ]DPJXSRUHÿHQMXVDS ]DPJ
$XWRULVXREMDVQLOLGDMH]DSRþHWRGUXJRYHüHUDQ
GRPL]LUDQRNRQWUROLVDQRLVSLWLYDQMH]DOHþHQMDRG
PHVHFLXNRMRMMHGHODPDQLGGHRSRWSXQRJRVQRYQRJ
UHåLPDLNRMHXNOMXþXMHSDFLMHQWHVD+,9RPNRMLVX
QD$59X3ODQLUDQRMHWDNRGDREH]EHGLSRGDWNH]D
PHVHFLSUDüHQMDSDFLMHQDWDQDNRQWLKPHVHFL
0RJXüLNUDüLWHUDSLMVNLUHåLP]D7%XSRWUHERP
3$
-HGDQ RG FLOMHYD$OLMDQVH ]D ERUEX SURWLY 7%D MH
UD]YRM NUDüHJ HIHNWLYQLMHJ L EH]EHGQLMHJ UHåLPD
]D WHUDSLMX 7%D 0HÿXWLP SRVWRMH PQRJL PRJXüL
UHåLPLX]LPDQMDOHNRYDSRVHEQRVDQHNROLNRQRYLK
DJHQDVDXUD]YRMXL]DVYDNLüHELWLSRWUHEQHJRGLQH
]D WHVWLUDQMH ,WHUDWLYQR GRGDYDQMH MHGQRJ DJHQVD
VWDQGDUGQRP UHåLPX L WHVWLUDQMH LVWRJ X NOLQLþNRP
LVSLWLYDQMX ELOR EL YUOR VNXS L YUHPHQVNL ]DKWHYDQ
QDþLQ]DLGHQWL¿NRYDQMHRSWLPDOQRJQRYRJUHåLPD
3LWDQMHMHRQGDNDNRLGHQWL¿NRYDWLUHåLPNRMLQDMYLãH
REHüDYD]DYHOLNDGXJDVNXSDLVSLWLYDQMD
$QGUHDV'LDFRQVD8QLYHU]LWHWDX6WHOOHQERVFKXMH
VDWLPRPL]QHNROLNRLVWUDåLYDþNLKLQVLWXFLMDREMDYLR
þODQDNXþDVRSLVX7KH/DQFHWRSLVXMXüXID]XDRYRJ
LVSLWLYDQMD ýODQDN MH SULYXNDR YHOLNL SXEOLFLWHW MHU
MH GDR MDVDQ SXW ]D QDSUHGRYDQMH X LGHQWL¿NRYDQMX
QRYLKUHåLPDOHNRYD]D7%]DYHOLNDLVSLWLYDQMD>@
7%SDFLMHQWLXEROQLFDPDX&DSH7RZQXQDVXPLþQR
VX RGDEUDQL ]D QHNROLNR WHUDSLMVNLK UHåLPD (IHNDW
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
UHåLPD MH PHUHQ XSRWUHERP UDQH EDNWHULMVNH DN
WLYQRVWLWRNRPGDQD(%$2YRMHUDÿHQRUDGL
LGHQWL¿NRYDQMDUHåLPDNRMLQDMYLãHREDüDYDLOLYLãH
UHåLPD]DGDOMHWHVWLUDQMH%DNWHULMVNDDNWLYQRVWMH
PHUHQD XSRWUHERP 0*,7D L] X]RUDND LVSOMXYND
VYDNRGQHYQRSULNXSOMDQRPRGSDFLMHQDWD
'DELELOLXNOMXþHQLXLVSLWLYDQMHSDFLMHQWLVXPRUDOL
GD LPDMX RG GR JRGLQD 0RUDOL VX GD LPDMX
WHOHVQXWHåLQXRGGRNJSR]LWLYQLQDPDUNHUH
GD LPDMX UDGLRJUDI SOXüD NRQ]LVWHQWDQ VD 7% L GD
LPDMXLVSOMXYDN
7HVWLUDQLVXVOHGHüLWHUDSLVMNLUHåLPL
%HGDTXLOLQHPJSUYRJGDQDPJGUXJRJL
PJVYDNRGQHYQRQDNRQWRJD
,VWRNDRSUHWKRGQRX]3PJVYDNRGQHY
no
,VWRNDRVDPRUHåLPEHGDTXLOLQHX]SLUD]LQDPLG
PJNJVYDNRGQHYQR
3$PJGQHYQRX]SLUD]LQDPLGPJNJ
VYDNRGQHYQR
3$PJVYDNRGQHYQRSLUD]LQDPLGPJ
NJGQHYQRLPRNVLÀRNDFLQPJVYDNRGQHYQR
6WDQGDUGQL LVRQLD]LG ULIDPSLFLQ SLUD]LQDPLG
HWDPEXWROUHåLPGR]LUDQSUHPDWHOHVQRMWHåLQL
3$MHQRYLOHN]D7%NRMLMHUD]YLOD$OLMDQVD]D
ERUEXSURWLY7%D.DRLNRGGHODQDPLGDXSLWDQMX
MHQLWURLPLGD]RO
2GSUHJOHGDQLKSDFLMHQDWDMHELORXNOMXþHQR
X LVSLWLYDQMH 2G QMLK MH QDVXPLþQR GRGHOMHQR
VYDNRM JUXSL RVLP JUXSL VD VWDQGDUGQLP UHåLPRP
JGHMHGRGHOMHQRQMLK
3RORYLQDSDFLMHQDWDMHSULMDYLORQHåHOMHQHHIHNWHLDNR
VXPQRJLELOLEODJLLQHYH]DQL]DOHNýHWUQDHVWRUR
SDFLMHQDWD MH ]DYUãLOR VYRMH UHåLPH X JUXSDPD RG
GRMH]DYUãLORUHåLPLVYLKMH]DYUãLOR
VWDQGDUGQL UHåLP 3HW RG VHGDP SRYODþHQMD ELOR MH
SRVOHGLFDSRYHüDQRJ$/7D-HGDQSDFLMHQWQD3$
PRNVLÀRNVDFLQSLUD]LQDPLGX MH LPDR LQWHUYDO
47NRMLMHLVSXQMDYDRNULWHULMXPSRYODþHQMD-HGDQ
MHLVNXVLRVWDQMHSURPHQHVYHVWLXVOHGQRYRGLMDJQRV
WLNRYDQHQHXURFLVWLþQHHUNR]LMH6YDRYDSRYODþHQMD
RVLP SDFLMHQWD VD QHXURFLVWLþQRP HUNR]LMRP ELOD
VXDVLPSWRPDWLþQD
6YLSDFLMHQWLVXLPDOL7%RVHWOMLYQDUHåLPHOHþHQMD
NRMLPDVXELOLSRGYUJQXWL
.OMXþQL UH]XOWDW LVSLWLYDQMD MH ELR GD MH SURVHþQD
þHWUQDHVWRGQHYQD EDNWHULMVND DNWLYQRVW ]D UHåLP
3$PRNVLÀRNVDFLQSLUD]LQDPLGD VWDQ
ZZZKLYELOWHQLQIR
GDUGQD GHYLMDFLMD ELOD ]QDþDMQR YHüD QHJR
NRG UHåLPD EHGDTXLOLQRP EHGDTXLOLQH 6'
EGDTXLOLQHSLUD]LQDPLGRP 6'
LEHGDTXLOLQH3$6'
%DNWHULMVND DNWLYQRVW ]D UHåLP 3$PRNVLÀRN
VDFLQSLUD]LQDPLGD VH QLMH PQRJR UD]OLNRYDOD RG
UHåLPD 3$SLUD]LQDPLGD 6' L
VWDQGDUGQRJUHåLPD6'
$XWRULVX]DNOMXþLOLGDMHUHåLPD3$PRNVLÀRN
VDFLQSLUD]LQDPLGD SRWHQFLMDOQR SRJRGDQ ]D WHUDS
LMX]D7%RVHWLOMLYXQDOHNL0'53UHGORåLOLGDOMD
NOLQLþND LVSLWLYDQMD ]D RYDM WHUDSLMVNL UHåLP $OL
WDNRÿHVXQDYHOLGDVXEHGDTXLOLQH3$L3$
SLUD]LQDPLGLPDOLXSRUHGLYHEDNWHULMVNHDNWLYQRVWL
VDVWDQGDUGQLPUHåLPRPSD]DWR³PRJXSRVWDWLYDåQL
HOHPHQWL L]JUDGQMH EXGXüLK WHUDSLMVNLK UHåLPD´
,VWDNOLVXYDåQXSRUHQWXGDEL³WHUDSLMVNLUHåLPEH]
LVRQLD]LGD L ULIDPSLFLQD SUHGVWDYOMDR ]QDþDMDQ NRUDNNDQRYRPUHåLPXVDQLVNRPLQWHUDNFLRPSRWHQFLMDOQRSRJRGQRP]DSRWSXQRWXEHUNXOR]XRVHWOMLYXQD
OHNL0'56DRYRPVWXGLMRPSXW]DSUDYOMHQMHQRYLK
WHUDSLMVNLKUHåLPDSRVWDMHMDVQLML´
318
6XWH]ROLG 318 MH QRYL RNVD]ROLGLQRQ
2YRMHLVWDNODVDOHNRYDNDRLOLQH]ROLG2YLOHNRYL
VSUHþDYDMX IRUPLUDQMH EDNWHULMVNLK SURWHLQD XVOHG
PHãDQMDVDHQ]LPLPDNRMLYH]XMXULER]RPHEDNWHUL
MD>@
8L]YHãWDML%DVHDL7$*DL]REMDãQMHQRMHGD
VHVXWH]ROLGþLQLSRWHQWQLMLPSURWLY7%RGOLQH]ROLGD
LQYLWURNRGH[YLYRFHORNXSQHNUYQHNXOWXUHLNRG
PLãHYD8RYRPL]YHãWDMXVHWDNRÿHREMDãQMDYDGD
VHQDRVRYXSRWSXQRJLVSLWLYDQMHDNUYLPRåHSUHGYL
GHWLGDüHVXWH]ROLG64LEHGDTXLOLQHELOLDGLWLYL
SD GD LK WUHED WHVWLUDWL NDR GHR QRYLK NRPELQDFLMD
WHUDSLMVNLKUHåLPD>@
5H]XOWDWLID]HVWXGLMHVSURYHGHQHX-XåQRM$IULFL
RSLVDQLVXXYHUEDOQRPDSVWUDNWX5REHUWD:DOOLVDVD
3¿]HUDLQMHJRYLKNROHJDQDNRQIHUHQFLML,$6
3DFLMHQWLPDVDSR]LWLYQLPLVSOMXYNRPQDVXPLþQRVX
SUHSLVDQL LOL VXWH]ROLG RG PJ GYD SXWD GQHYQR
Q LOLPJMHGQRPGQHYQRQ LOLVWDQ
GDUGQQL -XåQRDIULþNL WHUDSLMVNL UHåLP SUYH OLQLMH
LVRQLD]LGULIDPSLFLQHWDPEXWRLSLUD]LQDPLGQ WRNRPSUYLKGDQDWHUDSLMH6DPRSDFLMHQDWD
MHELOR+,9SR]LWLYQRMRãXYHNQHQD$59XL
VXELOHåHQH>@
6YL GREURYROMFL VX ]DYUãLOL LVSLWLYDQMH 1LMH ELOR
R]ELOMQLK QHåHOMQLK GRJDÿDMD YH]DQLK ]D WHUDSLMX
*RGLQD,EURM
+,9%,/7(1+7%
7DNRÿH QLMH ELOR XWLFDMD QD LQWHUYDO 47 6HGPRUR
SDFLMHQDWDXJUXSLNRMDMHSULPDODVXWH]ROLGMHLPDOR
SUHOD]QRDVLPSWRPDWLþQRSRYHüDQMH$/7D
8RVQRYLSURVHþQDORJDULWDPVNDNRORQLMDIRUPLUDQLK
MHGLLFDSRPLOLOLWUX&)8POELODMH3URVHþQR
YUHPH GHWHNFLMH XSRWUHEH 0*,7D ELOR MH VDWL
8SRWUHERP LQWHUYDOD SRYHUHQMD RG VYH WUL
JUXSH WUHWPDQD VPDQMLOH VX NRORQLMH IRUPLUDQLK MH
GLQLFDL]QDþDMQRSRYHüDOHYUHPHGHWHNFLMH0*,7D
DOL VWDQGDUGQD SREROMãDQMD UHåLPD ELOD VX PQRJR
YHüD6WYDUQDVPDQMHQMDVXSULND]DQDJUD¿þNLXDE
VWUDNWXSD]DWRQLVXGDWHWDþQHYUHGQRVWL9UHGQRVWL
VXRGSULOLNHRYDNYH
‡ 9UHPH ]D GHWHNFLMX 0*,7D RNR VDWL GXåH
]DUHåLPVXWH]ROLGDQDVSUDPVDWL]DVWDQGDUGQL
UHåLP
‡ 6PDQMHQMH &),PO RNR ORJ ]D VXWH]ROLG
QDVSUDPORJ]DVWDQGDUGQL
$XWRULVX]DNOMXþLOLGDVXGDOMDLVSLWLYDQMDOHND]D
JDUDQWRYDQD
Komentar
2YRMHMHGDQRGQDMX]EXGOMLYLMLKLQDMEUåLKSHULRGDXUD]YRMXOHND]D7%RGLK'HODPDQLGMHEH]
VXPQMHSUHWHNDREHGDTXLOLQHGRSUYHOLQLMHUD]YRMDQRYLKOHNRYD$OLREDVXYDåQD2EDOHNDVHPRUDMX
EU]RSURYHVWLNUR]RVWDOHVWXGLMHSRWUHEQH]D]DNRQVNRRGREUHQMHãWRXNOMXþXMHREH]EHÿQMHSODQRYD]D
SHGLMDWULMVNLUD]YRMLREDOHNDVHPRUDMXXþLQLWLGRVWXSQXLP]DSULVWXSSUHGRGREUHQMHSDFLMHQWLPDVD
7%RPUH]LVWHQWQLPQDOHNNRMLVXELOLQDWHUDSLMLXGREURYRÿHQLP7%XVWDQRYDPD7DNRÿHREDOHND
PRUDMXELWLWHVWLUDQL]DMHGQR6DYHWRGDYQLRGERU6YHWVNH7%=DMHGQLFHMHSLVDR2WVXNLSRVWDYOMDMXüL
ova pitanja i iz Otsuke su dali detaljne odgovore u vezi sa svojim planovima.
2VLPGHODPDQLGDUHåLPLLOHNRYLUD]PDWUDQLRYGHVXQHNROLNRJRGLQDRGL]ODVNDQDWUåLãWH.RUDNRG
RWNULYDQMDOHNDGRWUåLãWD]DQRYHOHNRYH]D7%MHSUHYLãHVSRU%HGDTXLOLQHMHXUD]YRMXEDUHPRG
LMRãXYHNQLMHQLJGHRGREUHQ3UHPD5DGQRM*UXSL]DQRYHOHNRYH]D7%WUHQXWQLEXGåHW]DVXWH]ROLGMH
PDOL86'GR86'*RGLãQMLEXGåHW]D3$MH]QDþDMQRYHüLPLOLRQD86'DOL
QLEOL]XRQRJDãWRüHELWLSRWURãHQRQDJUDQGLR]QLOHN
,DNRMHSURFHVUD]YRMDORND]D7%SREROMãDQEROHVWLNRMHVNRURLVNOMXþLYRXWLþXQDVLURPDãQHQDVWDYOMDMXGDGRELMDMXVYHPDQMHLQYHVWLFLMHL]IDUPDFHXWVNHLQGXVWULMHLLVWUDåLYDþNLKLQVWLWXFLMDXSRUHÿHQMX
VDOHNRYLPDNRMLVHPRJXSUR¿WDELOQLMHWUåLãQRSURELWLXERJDWLMLP]HPOMDPD
5HIHUHQFH
*OHU07HWDO'HODPDQLGIRU0XOWLGUXJ5HVLVWDQW3XOPRQDU\7XEHUFXORVLV1(QJO-0HG-XQ
KWWSZZZQHMPRUJGRLIXOO1(-0RD
'LDFRQ$HWDOGD\EDFWHULFLGDODFWLYLW\RI3$EHGDTXLOLQHS\UD]LQDPLGHDQGPR[LÀR[DFLQFRPELQDWLRQVDUDQGRPLVHGWULDO
/DQFHW-XO
KWWSZZZQFELQOPQLKJRYSXEPHG
6KLQDEDUJHU'0HFKDQLVPRIDFWLRQRIWKHR[D]ROLGLQRQHDQWLEDFWHULDODJHQWV([SHUW2SLQ,QYHVWLJ'UXJV$XJ
KWWSZZZQFELQOPQLKJRYSXEPHG
&OD\GHQHWDO3LSHOLQH5HSRUW
KWWSZZZSLSHOLQHUHSRUWRUJEURZVHWEWUHDWPHQWVVXWH]ROLGSQX
:DOOLV56HWDO6DIHW\WROHUDELOLW\DQGHDUO\EDFWHULFLGDODFWLYLW\LQVSXWXPRI318VXWH]ROLGLQSDWLHQWVZLWKSXOPRQDU\WXEHU
FXORVLV2UDODEVWUDFW7+/%%WK,QWHUQDWLRQDO$,'6&RQIHUHQFH-XO\:DVKLQJWRQ'&
KWWSSDJDLGVRUJDEVWUDFWVDVS["DLG &OD\GHQ3HWDO/HWWHUE\*OREDO7%&$%WR2WVXND
KWWSZZZWERQOLQHLQIRDUFKLYHGRFXPHQW
&DUOHYDUR35HVSRQVHWRRSHQOHWWHUE\*OREDO7%&$%
KWWSZZZWERQOLQHLQIRDUFKLYHGRFXPHQW
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
$597(5$3,-$
)'$RGREULOD4XDGX6$'FHQDPRåHRJUDQLþLWLGRVWXSQRVW
u Velikoj Britaniji
Simon Collins, HIV i-Base
$PHULþNDRUJDQL]DFLMD]DKUDQXLOHNRYH)'$
L*LOHDG6FLHQFHVRGYRMHQRVXREMDYLOLVRSãWHQMH
]DMDYQRVWXNRMLPDMHSRWYUÿHQRGDMHRGREUHQD
SLOXOD ¿NVQH NRPELQDFLMH SRMDþDQRJ LQKLELWRUD
LQWHJUD]H]DWHUDSLMX+,9DNRGRGUDVOLKRVRED
5D]YLMHQD SRG LPHQRP 4XDG D VDGD VD QRYLP
PDUNHWLQãNLP LPHQRP 6WULELOG NRPELQDFLMD VDGUåL
HOYLWHJUDYLU QRYL IDUPDNRNLQHWLþNL SRMDþLYDþ QD]
YDQ FRELFLVWDW )7& L WHQRIRYLU ,QGLNDFLMD MH ]D
OHþHQMHWN]YQDLYQLKSDFLMHQDWDRQLKNRMLQLVXLPDOL
LVNXVWYD VD WHUDSLMRP ± VD SURFHQMHQLP NOLUHQVRP
NUHDWLQLQDFUFORG!POPLQ>@
'YH YHOLNH VWXGLMH ID]H QD NRMLPD MH ]DVQRYDQR
RGREUHQMH SRUHGH 4XDG VD $WULSODRP HIDYLUHQ]
)7&WHQRIRYLULDWD]DQDYLUULWRQDYLURPSOXV]DVHE
QR )7&WHQRIRYLU 2EH VWXGLMH VX ]DNOMXþLOH GD MH
6WULELOG QHLQIHULRUDQ X RGQRVX QD NRPSDUDFLMX VD
QHGHWHNWDELOQRJ YLUXVD X RM QHGHOML X
SRUHÿHQMXVDVWRSDPDRGNRG$WULSODHL
NRGSRMDþDQRJDWD]DQDYLUD
8 VDRSãWHQMX VH QDYRGH PXþQLQD L SUROLY NDR
QDMþHãüLQHåHOMHQLHIHNWLDVWYDUDQMHLOLSRJRUãDQMH
SUREOHPD VD EXEUH]LPD VPDQMHQMH JXVWLQH NRVWL
MX UHGLVWULEXFLMD PDVWL L SURPHQH X LPXQRORãNRP
VLVWHPXVLQGURPLPXQRORãHUHNRQVWLWXFLMHNDRQD
MR]ELOMQLMLQHåHOMHQLHIHNDWL(WLNHWD6WULELOGDGDMH
VDYHWH]GUDYVWYHQLPUDGQLFLPDRWRPHNDNRGDSUDWH
SURSUDWQHHIHNWHNRGEXEUHJDLOLNRVWLMX
6WULELOGWUHEDX]LPDWLVDKUDQRP2YRVH]DVQRYDQD
SRYHüDQRM L]ORåHQRVWL HOYLWHJUDYLUX L WHQRIRYLUX RG
RGQRVQRVDODJDQLPREURNRPNFDO
PDVWLLOLRGRGQRVQRVDYLãHPDV
QLPREURNRPaNFDOPDVWL>@
7UHEDQDSRPHQXWLGDVX6$''++6VPHUQLFHYHü
DåXULUDQHLSUHSRUXþXMX6WULELOGNDRDOWHUQDWLYXSUH
QHJRXRSFLMLSUYHOLQLMHWHUDSLMH2YDNYDRGOXNDMH
]DVQRYDQDQD³]QDþDMDQRPSRWHQFLMDOX]DLQWHUDNFLMH
VDGUXJLPOHNRYLPDGRVWXSQRVWLSRGDWDNDREH]EHG
QRVWLRGVDPRQHGHOMDNRULãüHQMHPRJUDQLþHQLP
QDSRMHGLQFHVDVWDQMHPFUFO!POPLQSUHGWHUDS
LMXPRJXüHSRYHüDQMHUL]LNDRGKURQLþQHEXEUHåQH
LVX¿MHQFLMH RJUDQLþHQLP SRGDFLPD NRG SDFLMHQDWD
VDUD]YLMHQLP+,9RPLNRGåHQDNDRLSRWUHERPGD
VHOHNX]LPDVDKUDQRP´>@
2YDRGOXNDMHELODRþHNLYDQDQDNRQãWRMHVDYHWR
GDYQRWHOR)'$JODVDORUH]XOWDWRPXSHWRP
PHVHFX JRGLQH > @ QD RVQRYX VWUDQLFD
UH]LPHDSUHWNOLQLþNLKLNOLQLþNLKVWXGLMD>@
2þHNLYDQD GREURGRãOLFD ]D QRYX YDåQX RSFLMX X
OHþHQMX MH XEODåHQD VD]QDQMHP GD MH FHQD X 6$'
]DWUHüLQXYHüDQHJRFHQD$WULSODHRNR
SUHPDQDJRGLãQMHPQLYRXVDFHQDPDQD
YHOLNRX6$',DNRVHHYURSVNDRGOXNDRGDYDQMX
VDJODVQRVWLQHRþHNXMHGRNUDMDJRGLQHDFHQH
OHNRYDVHIRUPLUDMXQDVORåHQQDþLQVOLþQDUD]OLNDEL
R]ELOMQRRJUDQLþLODSURSLVLYDQMHX9HOLNRM%ULWDQLML
>@
Komentar:
4XDGQXGLSRWHQFLMDOQHSUHGQRVWLXRGQRVXQDSRVWRMHüHRSFLMHPDGDWHSUHGQRVWLQLVXSULND]DQHX
NOLQLþNLPLVWUDåLYDQMLPDNRMDVHGRYHODGRRGREUHQMDED]LUDQLPQDQDOD]LPDWLSD³QLMHYHURYDWQRGD
üHELWLJRUH´RGWUHQXWQHWHUDSLMHD]DVQRYDLKQDQH]QDþDMQRMUD]OLFLRGSDFLMHQWDVDQHGHWHNWDZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%
ELOQLPYLUXVRPQDNRQQHGHOMDWUHWPDQD
6YHGRN6WULELOGRGQRVXQD$WULSODXQLMHQHXWUDODQDFHQRYQDRSFLMDRYDMSRWHQFLMDOQRYDåQLQRYLOHN
QHüHSXQRELWLNRULãüHQX9HOLNRM%ULWDQLML%H]QHXWUDOQHFHQHXSRUHÿHQMXVDSRMDþDQLPDWD]DQDYLURPLOLSRMDþDQLPGDUXQDYLURPYHURYDWQRGDüHVHUHWNRNRULVWLWLXGUXJRMOLQLMLWHUDSLMHLOLNDRRSFLMD
]DPHQHXVOHGEROMHJSUR¿ODVSRUHGQLKHIHNDWDXRGQRVXQDHIDYLUHQ]$NRFHQDQHEXGHFHQDQHXWUDOQD
XRGQRVXQDUDOWHJUDYLUPDORMHYHURYDWQRGDüHVHãLURNRNRULVWLNRGSDFLMHQDWDVDPXOWLSORPUH]LVWHQcijom.
5D]OLNHXFHQLüHVHYHURYDWQRSURãLULWLNDGDHIDYLUHQ]XLVWHNQHSDWHQWXJRGLQLVDXãWHGRPRG
JHQHULþNLKIRUPXODFLMDRþHNXMHGDüHVHSDFLMHQWLUXWLQVNLSUHEDFLYDWLVD$WULSODHQDHIDYLUHQ]LWHQRIRYLU)7&
,DNRMHSUHEDFLYDQMHL]PHÿXRUJLQDOQLKLJHQHULþNLKIRUPXODFLMDRVQRYQLSULQFLSX]GUDYVWYXX9HOLNRM
%ULWDQLMLSUHEDFLYDQMHL]PHÿXUD]OLþLWLKNODVDOHNRYDQLMH
,]*LOHDGDVXL]MDYLOLGDMHRYRNRQNXUHQWQDFHQD]DDPHULþNRWUåLãWHDGDVXRQLRUJDQL]RYDOLSURJUDP
GRVWXSQRVWL]DSDFLMHQWH*LOHDGX9HOLNRM%ULWDQLMLQHåHOLGDNRPHQWDULãHFHQHQDHYURSVNRPWUåLãWX
SUH(8OLFHQFLUDQMD
5HIHUHQFH
*LOHDGSUHVVUHOHDVH)'$$SSURYHV*LOHDG¶V6WULELOGD&RPSOHWH2QFH'DLO\6LQJOH7DEOHW5HJLPHQIRU7UHDWPHQW1DwYH$GXOWVZLWK+,9
,QIHFWLRQ$XJXVW
KWWSZZZJLOHDGFRPSUB
)'$SUHVVUHOHDVH)'$DSSURYHVQHZFRPELQDWLRQSLOOIRU+,9WUHDWPHQWIRUVRPHSDWLHQWV$XJXVW
KWWSZZZIGDJRY1HZV(YHQWV1HZVURRP3UHVV$QQRXQFHPHQWVXFPKWP
*LOHDG863URGXFWLQIRUPDWLRQODEHOIRU6WULELOG6HFWLRQ3KDUPDFRNLQHWLFVSDJH$XJXVW
KWWSZZZJLOHDGFRPSGIVWULELOGBSLSGI
++63DQHO6WDWHPHQW++6SDQHORQDQWLUHWURYLUDOJXLGHOLQHVIRUDGXOWVDQGDGROHVFHQWVUHFRPPHQGVD¿[HGGRVHFRPELQDWLRQSURGXFWRI
HOYLWHJUDYLUFRELFLVWDWWHQRIRYLUHPWULFLWDELQHDVDQDOWHUQDWLYHUHJLPHQLQDQWLUHWURYLUDOWUHDWPHQWQDLYH,QGLYLGXDOVZLWK+,9LQIHFWLRQ
6HSWHPEHU
KWWSDLGVLQIRQLKJRYFRQWHQW¿OHV$GXOW$596WDWHPHQW2Q(9*B&2%,B7')B)7&SGI3')¿OH
)'$DGYLVRU\SDQHOYRWHIRUDSSURYDORI4XDG+7%-XQH
KWWSLEDVHLQIRKWE
(OYLWHJUDYLU&RELFLVWDWHPWULFLWDELQHWHQRIRYLUGLVRSUR[LOIXPHUDWHVLQJOHWDEOHWUHJLPHQ(9*&2%,)7&7')48$'675IRUWUHDWPHQWRI
+,9LQIHFWLRQLQDGXOWV$QWLYLUDO'UXJV$GYLVRU\&RPPLWWHH0HHWLQJ%ULH¿QJ'RFXPHQW0D\
KWWSZZZIGDJRYGRZQORDGV$GYLVRU\&RPPLWWHHV&RPPLWWHHV0HHWLQJ0DWHULDOV'UXJV$QWLYLUDO'UXJV$GYLVRU\&RPPLWWHH8&0SGI
4XDGDSSURYHGLQ86FRVWPD\OLPLWXVHLQ(XURSH2QOLQHFRPPHQW
KWWSLEDVHLQIRJLOHDGSULFHTXDG
0HUFNVWLþH&0;DQG()G$LSRþLQMHID]XVWXGLMH]DQRYL1157,
Simon Collins, HIV i-Base
6UHGLQRP JRGLQH 0HUFN MH VDRSãWLR GD MH
NRPSDQLMD SRWSLVDOD XJRYRU R OLFHQFLUDQMX ]D UD]
YRM GYD QRYD QXNOHR]LGQDDQDORJD L VSUHPQD MH GD
SRNUHQHID]XVWXGLMH]D1157,>@
&0.6MHQXNOHR]LGQLDQDORJXUD]YRMXQD&KL
PHUL[XNRGNRJDVXSULMDYOMHQLREHüDYDMXüLUH]XO
WDWLID]HMRãSUHþHWLULJRGLQHLGDþHND¿QDQVLMVNX
SRGUãNX RG WDGD >@ -HGLQMHQMH MH SUROHN WHQRIR
YLUD WHQRIRYLU GLIRVIDW NDR DNWLYQL VDVWRMDN VD
SREROMãDQLPIDUPDNRNLQHWLþNLPSUR¿ORPQDWHQRIR
*RGLQD,EURM
YLULSRþHWQLPUH]XOWDWLPDNRMLVXJHULãXSRWHQFLMDO]D
MHGQRQHGHOMQRGR]LUDQMH,QYLWURSUR¿OUH]LVWHQFLMH
XNOMXþXMHRVHWOMLYRVWQD.5VDQHNLPDOLQHVYLP
WK\PLGLQH DQDORJQLP PXWDFLMDPD 7R MH MHGLQMHQMH
þLMLMHUD]YRMRþHNLYDQMRãSUHQHNROLNRJRGLQD
()G$ ¶HWK\Q\OÀXRUR¶GHR[\DGHQRVLQH MH
MHGLQMHQMH X UD]YRMX X MDSDQVNRP ELRWHKQRORãNRP
RGHOHQMX<DVDPDNRUSRUDFLMHNRMLLPDLVWRULMXSURL]
YRGQMHVRMDVRVDRGYUHPHQDHQJOHVNRJJUDÿDQVNRJ
UDWD L þLML MH UD]YRM ¿QDVLUDQ RG VWUDQH DP)$5D L
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
DPHULþNRJ1,+3RVWHUMHSUHGVWDYOMHQQD$,'6
NRQIHUHQFLML X 9DãLQJWRQX RYRJ OHWD L SULMDYLR MH
]QDWQR MDþL LQ YLWUR SUR¿O UH]LVWHQFLMH X RGQRVX QD
WHQRIRYLU SRVOH YLãH SURYHUD VD PHãDYLQRP RG PXOWLQXFOHRVLGQLKUH]LVWHQWQLKYLUXVQLKPXWDFLMD
0HUFN MH WDNRÿH LVNRULVWLR SULOLNX GD QDMDYL VYRMH
LQKRXVH1157,MHGLQMHQMH0.NRMHüHXVNRUR
GDSULPHQLQDWHUDSLMVNLQDLYQLPSDFLMHQWLPDXID]L
VWXGLMH ]D SURQDODåHQMH RGJYRUDMDüH GR]H RG PJGRPJNRULVWHüLHIDYLUHQ]NDRNRPSDUDWRUL
WHQRIRYLU)7&NDRSR]DGLQVNL157,
Komentar:
2YRMHREHüDYDMXüDYHVWGD0HUFNUD]YLMDDNWLYDQSURJUDPLVWUDåLYDQMD]DQRYH+,9OHNRYHSDUDOHOQR
VDUD]YRMHPLQWHJUD]HLQKLELWRUD
,DNRVDPDQMHSXEOLFLWHWD0HUFNMHWDNRÿHMHGQDRGNRPSDQLMDNRMHLQYHVWLUDMXXLVWUDåLYDQMHOHND
5HIHUHQFH
0HUFNSUHVVUHOHDVH0HUFNVLJQVWZRGHDOVIRUQRYHO+,9GUXJFDQGLGDWHVDQGLQLWLDWHVSKDVH,,FOLQLFDOWULDORI0.IRU+,9-XO\
KWWSZZZPHUFNFRPQHZVURRPQHZVUHOHDVHDUFKLYHUHVHDUFKDQGGHYHORSPHQWBKWPO
/DQLHU(5HWDO+H[DGHF\OR[SURS\OWHQRIRYLU&0;KDVHQKDQFHGSRWHQF\LQYLWURDJDLQVW157,UHVLVWDQW+,9UHODWLYHWRWHQRIRYLUDQGD
IDYRUDEOHSUHFOLQLFDOSUR¿OH;9,,,+'5:6LWJHV3RVWHU
KWWSLEDVHLQIRKWE
0DHGD.HWDO'HOD\HGHPHUJHQFHRI+,9YDULDQWVUHVLVWDQWWR¶HWKQ\OÀXRUR¶GHR[\DGHQRVLQH()G$FRPSDUDWLYHVHTXHQWLDOSDVVDJH
VWXG\ZLWKWHQRIRYLUHPWULFLWDELQHDQGIHVWLQDYLUWK,$&-XO\:DVKLQJWRQ3RVWHUDEVWUDFW783(
KWWSSDJDLGVRUJDEVWUDFWVDVS["DLG $GRVHUDQJLQJVWXG\WRFRPSDUH0.SOXV7UXYDGDYHUVXVHIDYLUHQ]SOXV7UXYDGDLQKXPDQLPPXQRGH¿FLHQF\YLUXV+,9LQIHFWHG
SDUWLFLSDQWV0.$0
KWWSFOLQLFDOWULDOVJRYFWVKRZ1&7
'DUXQDYLUWDEOHWHRGPJRGREUHQHX6$'X
'DQDJRGLQH)'$MHRGREULODWDEOHWX
RG PJ GDUXQDYLUD 3UH]LVWD 'R]LUDQMH L DG
PLQLVWUDWLYQLGLRQDHWLNHWLSURL]YRGDMHSURPLMHQMHQ
X OLMHþHQMH WHUDSLMVNL QDLYQLK RGUDVOLK SDFLMHQDWD L
OLMHþHQMHWHUDSLMVNLLVNXVQLKRGUDVOLKSDFLMHQDWDEH]
SRYH]DQH UH]LVWHQFLMH VD GDUXQDYLURP LOL ]DPMHQD
PD PJ MHGQD PJ WDEOHWD LOL GYH PJ
ZZZKLYELOWHQLQIR
WDEOHWHX]HWLVULWRQDYLURPPJMHGQRPGQHYQR
LVDKUDQRP
,]YRU)'$QDMDYD
KWWSZZZIGDJRY)RU&RQVXPHUV%\$XGLHQFH
)RU3DWLHQW$GYRFDWHV+,9DQG$,'6$FWLYLWLHV
XFPKWP
*RGLQD,EURM
+,9%,/7(1+7%
/2.$/1(675$1(
äHQHX6UELMLNDRNDVQLSUH]HQWHUL±UD]ORJ]DEULJX
R
'UDJRYLü*RUGDQD5DQLQ-RYDQ6DOHPRYLü'XEUDYND2,
.XãLü-RYDQD2-HYWRYLüĈRUÿH2
Poster prezentacija autora iz Beograda predVWDYOMHQDQD0HÿXQDURGQRPNRQJUHVXR+,9
terapiji u Glazgovu, 2012.
Uvod
1DMYHüL EURM NOLQLþNLK LVWUDåLYDQMD QD WHPX H¿NDV
QRVWLLSURSUDWQLKHIHNDWD+$$57DELRMHREDYOMHQ
XJODYQRP QD PXãNRM SRSXODFLML LQ¿FLUDQRM +,9
RP WHN MH QHGDYQR SRYHüDQR XþHãüH åHQD X RYLP
LVWUDåLYDQMLPD JGH VYH RYR ]D SRVOHGLFX LPD NRQ
VWDQWDQQHGRVWDWDNGH¿QLWLYQLKSRGDWDNDYH]DQLK]D
H¿NDVQRVWLWRNVLþQRVWLDQWLUHWURYLUXVQLKOHNRYDNRG
åHQD
Ciljevi
2EDYLOL VPR VWXGLMX SRSUHþQRJ SUHVHND GD XWYUGL
PR IDNWRUH NRML XWLþX QD SUHåLYOMDYDQMH NRG åHQD
SDFLMHQDWDNRMHåLYHVD+,9$,'6RPDNRMHVXQD
+$$57WHUDSLMLXRNUXåHQMXVDRJUDQLþHQLPUHVXU
VLPD
3$&,-(17,,0(72'(
Pacijenti
8RYXVWXGLMXVXELOHXNOMXþHQHåHQHNRMHVXSRþHOH
VD X]LPDQMHP +$$57 WHUDSLMH L]PHÿX MDQXDUD
LGHFHPEUDJRGLQHQDRGHOMHQMX]D
+,9$,'6 XQLYHU]LWHWVNH .OLQLNH ]D LQIHNWLYQH L
WURSVNHEROHVWLX%HRJUDGX
.ULWHULMXPL]DXþHVWYRYDQMHXVWXGLMLELOLVXSR]LWLYDQ
+,9VWDWXVNRULãüHQMH+$$57DUHGRYQLNOLQLþNLL
ODERUDWRULMVNLSUHJOHGL.RQWURODMHWUDMDODGRSRVOHG
QMHJSUHJOHGDVPUWLLOLGHFHPEUDJRGLQH
5H]XOWDWLWHUDSLMHVXDQDOL]LUDQLQDNUDMXNRQWUROH
7
$QWLUHWURYLUXVQLOHNRYLX6UELML
86UELMLVHWUHQXWQRNRULVWHVOHGHüLDQWLUHWURYLUXVQL
OHNRYL
D157,]LGRYXGLQHLODPLYXGLQHVDPRVWDOQRLOLX
¿NVQRMNRPELQDFLMLGLGDQRVLQHVWDYXGLQHDEDFDYLU
NDRL¿NVQDNRPELQDFLMDDEDNDYLUDLODPLYXGLQD
E1157,QHYLUDSLQHLHIDYLUHQ]
F3,VDTXLQDYLUQHO¿QDYLULQGLQDYLUIRVDPSUHQD
YLUORSLQDYLUULWRQDYLULULWRQDYLUNDREXVWHU]DRV
WDOH3,OHNRYH
1HO¿QDYLULLQGLQDYLUVXELOLSRYXþHQLJRGLQH
1RYHOHNRYHNDRãWRVXWLSUDQDYLUWHQRIRYLUHPWULF
LWDELQH DWD]DQDYLU HWUDYLULQH UDOWHJUDYLU PDURYL
URF)RQG]D]GUDYVWYHQRRVLJXUDQMHQLMHUHIXQGLUDR
WRNRPWUDMDQMDRYHVWXGLMH
Terapija i rezultati
2GJRYRUQDWHUDSLMXMHVPDWUDQSRYROMQLPXVOXþDMX
SRVWL]DQMDQHGHWHNWDELOQRJEURMDYLUXVQLKNRSLMDS9/
FRS—/LSRYHüDQMDEURMD&'7üHOLMDSUHNR
üHOLMD—/1HXVSHãQDWHUDSLMDMHGH¿QLVDQDNDR
VOXþDMJGHMHEURMYLUXVQLKNRSLMDS9/!ORJNR
SLMD51.+,9DSRP/EH]RE]LUDQDLPXQRORãNR
SREROMãDQM 2GYDMDQMH LPXQRORãNRJ L YLUXVRORãNRJ
RGJRYRUD QD +$$57 MH GH¿QLVDQR NDR SRVWL]DQ
MH QHGHWHNWDELOQRJ EURMD YLUXVQLK NRSLMD DOL EH]
SRYHüDQMDEURMD&'7üHOLMDL]QDGüHOLMD—/
Statistika
9H]D L]PHÿX XVSHãQRJ +$$57D RGQRVQR
SUHåLYOMDYDQMD L YDULMDEOL NDR ãWR VX SRþHWQL QLYRL
&'7üHOLMDLEURMDYLUXVQLKNRSLMDLLVWLWLEURMHYL
QDNRQWHUDSLMHNDRLRVWDOLKSRWHQFLMDOQRSRYH]DQLK
.DWHGUD]DIDUPDNRORJLMXNOLQLþNXIDUPDNRORJLMXLWRNVLNRORJLMX0HGLFLQVNRJIDNXOWHWD8QLYHU]LWHWDX%HRJUDGX%HRJUDG6UELMD
2GHOMHQMH]D+,9$,'6,QVWLWXW]DLQIHNWLYQHLWURSVNHEROHVWLÄ'U.RVWD7RGRURYLü³0HGLFLQVNLIDNXOWHW8QLYHU]LWHWDX%HRJUDGX%HRJUDG
6UELMD
*RGLQD,EURM
ZZZKLYELOWHQLQIR
7
N
+,9%,/7(1+7%
YDULMDEOLELOLVXDQDOL]LUDQLNRULãüHQMHPXQLYDULMDQW
QLK L PXOWLYDULMDQWQLK PRGHOD ORJLVWLþNH UHJUHVLMH L
.DSODQ0HLHU SURFHQH SUHåLYOMDYDQMD 5H]XOWDWL VX
SUHGVWDYOMHQL X YLGX RGQRVD L]JOHGD 25 VD LQWHU
YDOLPDSRYHUHQMD&,1LYR]QDþDMQRVWLMHELR
Rezultati
7DEHOD.DUDNWHULVWLNHSDFLMHQDWD
9DULMDEOD
Pol
1DþLQSUHQRVD+,9D
Godine
AIDS
HCV pozitivne
HBV pozitivne
%URM
äHQVNL
+HWHURVHNVXDOQLPSXWHP
,QWUDYHQVNRNRULãüHQMHGURJD
1HSR]QDWR
7UDQVIX]LMRP
6UHGQMHRSVHJ
'$
'$
'$
6UHGQMD YUHGQRVW WUDMDQMD NRQWUROH MH ELOD “
X RSVHJX RG JRGLQD 9UHGQRVWL EURMD &'
7üHOLMDVXQDSRþHWNXWHUDSLMHNODVL¿NRYDQDXþHWLUL
QLYRDQDVOHGHüLQDþLQ
LVSRGüHOLMD—/
üHOLMD—/
üHOLMD—/L
YLãHRGüHOLMD—/
3UHPDRYRMSRGHOLSDFLMHQDWDMHSULSDGD
ORJUXSLQMLKJUXSLQMLK
JUXSLDQMLKJUXSL
7DEHOD0XOWLYDULMDQWQDORJLVWLþNDUHJUHVLYQDDQDOL]DIDNWRULNRMLXWLþXQDRGJRYRUQDWHUDSLMXQDNRQ“JRGLQDQD+$$57X
9DULMDEOD
JRGLQDLL]QDG
3RþHWQLEURM&'7üHOLMD
üHOLMD—/
Koinfekcija sa HCV-om
5HåLPLED]LUDQLQD1157,
'REUDUHDNFLMDQD+$$57
Odnos izgleda
LQWHUYDOSRYHUHQMD
±
P
±
±
±
±
SDFLMHQDWDMHSUHPLQXORGRNVXELOHQDWHUDSLMLRG
NRMLKMHELORPHÿXSDFLMHQWLPDVDSRY
ROMQLPRGJRYRURPQDWHUDSLMX
2SãWD SURFHQD YHURYDWQRüH SUHåLYOMDYDQMD RG JRGLQDMHELREOL]XGRNMHXSDFLMHQDWDNRMH
VX SRVWLJOH QHGHWHNWDELOQL EURM YLUXVQLK NRSLMD ]D
ZZZKLYELOWHQLQIR
MHGQRVDSRYROMQRPUHNRQVWLWXFLMRP&'7üHOLMD
SURFHQMHQD YHURYDWQRüD SUHåLYOMDYDQMD RVWDOD QDNRQJRGLQDQDWHUDSLML,DNRVXEURMHYL&'7
üHOLMD]QDþDMQRYDULUDOLPHÿXSRGJUXSDPDXSDFLMH
QDWDVDRGUåDQLPVX]ELMDQMHPYLUXVDRQLQLVXXWLFDOL
QDRSãWHSUHåLYOMDYDQMH3 ORJUDQN6OLND
*RGLQD,EURM
+,9%,/7(1+7%
6OLND 3URFHQMHQD YHURYDWQRüD SUHåLYOMDYDQMD .DSODQ0HLHU PHWRGRP X SDFLMHQDWD VD RGUåDQLP
VX]ELMDQMHPYLUXVDSUHPDQLYRXSRVWLJQXWRJRSUDYNDLPXQLWHWD3 ORJUDQNQDNUDMXNRQWUROH
=DNOMXþDN
,DNRVXSRþHWQLEURMHYL&'7üHOLMD]QDþDMQRXWL
FDOLQDQLYRRSUDYNDLPXQLWHWDQDNUDMXNRQWUROHRYH
UD]OLNHQLVXXWLFDOHQDSUHåLYOMDYDQMHPHÿXSDFLMHQ
WLPDVDRGUåDQLPVX]ELMDQMHPYLUXVD
5HIHUHQFH
0D\06WHUQH-$6DELQ&HWDO$,'6
+RJJ5/LPD96WHUQH-$HWDO/DQFHW
(JJHU00D\0HWDO/DQFHW
0D\076WHUQH-$HWDO/DQFHW
6D\OHV-1HWDO-:RPHQ¶V+HDOWK
)XUOHU0'HWDO$,'63DW&DUH67'6
&ROOD]RV-HWDO$,'6
)ORUHQFH(HWDO+,90HG
-HYWRYLF'M-&OLQ9LURO
7DLZR%HWDO+,90HGLFLQH
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
267$/(9(67,
6WUDWHãNLVDVWDQDN1H/3,,,
7UHüLVWUDWHãNLVDVWDQDN1H/30UHåH]HPDOMDVDQL
VNRPSUHYDOHQFLMRP+,9D&HQWUDOQHL-XJRLVWRþQH
(YURSH RGUåDQ MH X %HRJUDGX RG GR PHVHFD JRGLQH VD FLOMHP UD]YRMD VWUDWHãNRJ
LDNFLRQRJSODQD]DREH]EHÿLYDQMHHIHNWLYQRJLWUD
MQRJ]DJRYDUDQMDQDWHPX+,9DXUHJLRQX
1D VYHþDQRP RWYDUDQMX RYRJ UDGQRJ VDVWDQND
XþHVQLNH VX SR]GUDYLOL L SRåHOHOL XVSHãDQ UDG JRV
SRGLQ'DUNR5XQLüGLUHNWRU$JHQFLMH]D(YURSVNH
LQWHJUDFLMH L VDUDGQMX VD FLYLOQLP VHNWRURP JGLQ
1HQDG 3HWNRYLü LVSUHG 4NOXED JGLQ 1LQRVODY
0ODGHQRYLüLVSUHGRUJDQL]DFLMH+(5$JGLQ6HUJHM
9XMDþLü LVSUHG RUJDQL]DFLMH 7$&62 7HKQLþND
SRGUãND RUJDQL]DFLMDPD FLYLOQRJ GUXãWYD JGLQ
)HUHQ]%DJ\QV]NLLVSUHG($7*D(YURSVNHJUXSH
]DOHþHQMH$,'6DLJGLQ$QGUHM6HQLKLVSUHGXS
UDYQRJRGERUD1H/3D
2YR MH WUHüL SR UHGX VDVWDQDN 1H/3D L RNXSLR MH
GYDGHVHWWURMHDNWLYLVWDFLYLOQRJVHNWRUDLVWUXþQMDND
L] ãHVQDHVW ]HPDOMD þODQLFD PUHåH $OEDQLMH $XV
WULMH%RVQHL+HUFHJRYLQH%XJDUVNH.LSUDýHãNH
*UþNH +UYDWVNH .RVRYD 0DNHGRQLMH 0DÿDUVNH
&UQH*RUH6ORYDþNH6ORYHQLMH6UELMHL7XUVNH
7RNRP RYD WUL GDQD XþHVQLFL VDVWDQND VX NUR] QL]
FLOMDQLK L PRGHULUDQLK UDGLRQLFD RIRUPLOL QDFUW
VWUDWHãNRJ SODQD L SODQD DNWLYQRVWL NRMH EL 1H/3
NDR UHJLRQDOQD PUHåD PRJDR GD VSURYHGH NDNR EL
VHSREROMãDRRGJRYRUQD+,9LSRGUåDOHDNWLYQRVWLX
]HPOMDPDþODQLFDPDPUHåH
$NWLYQRVWLNRMHVXXNOMXþHQHXRYDMSODQVXGH¿QLVDQH
VDQDURþLWLPRVYUWRPQDVSHFL¿þQRVWLVLWXDFLMHYH]DQH
]D+,9X]HPOMDPDVDQLVNRPSUHYDOHQFLMRPJGHMH
ZZZKLYELOWHQLQIR
NDR MHGQD RG NOMXþQLK VHJPHQDWD XVSHãQRJ L HIHN
WLYQRJ ]DJRYDUDQMD SUHSR]QDW XWLFDM PHÿXQDURGQLK
RUJDQL]DFLMD L PUHåD X þHPX 1H/3 LJUD ]QDþDMQX
XORJX
3ODQLUDQH DNWLYQRVWL X VWUDWHãNRP SODQX 0UHåH ]H
PDOMD VD QLVNRP SUHYDOHQFLMRP +,9D &HQWUDOQH L
-XJRLVWRþQH(YURSHVHRGQRVHQDWULREODVWLSUHYHQ
FLMDLWHVWLUDQMHQD+,9SULVWXSWHUDSLML]DNRQVNL L
UHJXODWLYQLRNYLUL]DJRYDUDQMH=QDþDMQHWHPHNRMH
VXXUDGXSUHSR]QDWHNDRNOMXþQHXVYHWULSRPHQXWH
REODVWL VX UHJLRQDOQD ERUED SURWLY VWLJPH YH]DQH
]D +,9 VYHREXKYDWQD SRGUãND ]D REH]EHÿLYDQMH
VUHGVWDYDIXQGUDLVLQJLSRGL]DQMHNDSDFLWHWDRUJD
QL]DFLMD þODQLFD ± JGH MH SUHSR]QDWD NOMXþQD XORJD
1H/3DXUD]PHQL]QDQMDL]PHÿXRUJDQL]DFLMDLLQ
IRUPDFLMDYH]DQLK]D+,9
1DSUDYOMHQLQDFUWVWUDWHJLMHRGQRVLVHQDSHULRGRG
QDUHGQLKSHWJRGLQDUDGDPUHåH8VWYDUDQMXQDFUWD
VWUDWHJLMH SRPRJOL VX LVNXVQL WUHQHUL L PRGHUDWRUL
L]UHJLRQDL(YURSHNDRãWRVXELOLSULVXWQLþODQRYL
($7*D
7RNRP VDVWDQND DNWLYLVWL PDÿDUVNH RUJDQL]DFL
MH +&/8 VX QDSUDYLOL NUDWDN ¿OP Ä.HHS LW ORZ³
2GUåLPRMH>[email protected]
OMDUDGPUHåHWRNRPSUHWKRGQLKJRGLQDDOLLQHNHRG
DVSHNDWDUDGDQDRYRPVDVWDQNX2YDM¿OPVHPRåH
SRJOHGDWL QD <RX7XEHX SUDWHüL OLQN KWWSZZZ
\RXWXEHFRPZDWFK"Y =IX7H*'6<
6DVWDQDN1H/3,,,RUJDQL]RYDOLVX4NOXE±&HQWDU
]DD¿UPDFLMXSR]LWLYQRJåLYRWDL]%HRJUDGDL+(5$
±8GUXåHQMD]D]GUDYVWYHQXHGXNDFLMXLLVWUDåLYDQMD
L]6NRSOMDDX]SRGUãNX7$6&2DL($7*D
*RGLQD,EURM
+,9%,/7(1+7%
0DUN'\EXOüHELWLQDUHGQLL]YUãQLGLUHNWRU*OREDOQRJIRQGD
%HUQDUG5LYHUV1DG]RU*OREDOQRJIRQGD
*OREDOQL IRQG MH L]DEUDR GU 0DUND '\EXOD ]D
SR]LFLMXQDUHGQRJL]YUãQRJGLUHNWRUD*OREDOQRJ
IRQGD1MHJRYDSUHWKRGQDSR]LFLMDELODMHQDþHOX
3URJUDPD 3UHGVHGQLND 6$'D ]D ERUEX SURWLY
$,'6D3(3)$5D
2GOXNXMHGRQHR8SUDYQLRGERU*OREDOQRJIRQGD
QRYHPEUDQDVDVWDQNXXäHQHYLDLPHQRYDQMHüH
VHRGLJUDWLSRþHWNRPIHEUXDUD*DEULHO-DUDPLOORüH
NDNRMHELORRþHNLYDQRJRGLQHSUHGDWL
IXQNFLMX JHQHUDOQRJ PHQDGåHUD NDGD üH GU '\EXO
SUHX]HWLIXQNFLMX
,]ERU GU '\EXOD MH ELR SRVOHGQML NRUDN GXJRJ L
SDåOMLYR SODQLUDQRJ SURFHVD NDGURYVNRJ RGDELUD
$GKRF NRPLWHW ]D QRPLQDFLMH 8SUDYQRJ RGERUD
*OREDOQRJIRQGD±þLMLUDGVXPQRJLþODQRYLRGERUD
SRKYDOLOL±MHREDYLRL]ERULSURFHVIRUPLUDQMDXåHJ
NUXJD NDQGLGDWD SD QMLKRYD LPHQD SUHGDR RGERUX
1DWRMOLVWLVXELOL0LQLTXH%DUEXWþHOQLNXRGODVNX
*OREDOQH RUJDQL]DFLMH ]D RþXYDQMH åLYRWQH VUHGLQH
81D0DUN'\EXO5REHUW*UHHQKLOO.DQDÿDQLQL
'LUHNWRU6YHWVNRJHNRQRPVNRJIRUXPDLELYãLSUHG
VHGQLN .DQDGVNH DJHQFLMH ]D PHÿXQDURGQL UD]YRM
&,'$L%DUEDUD6WRFNLQJ%ULWDQNDNRMDMHþHOQLN
XRGODVNX2[IDUPD
*RGLQD,EURM
'U'\EXOMHSRPRJDRXRVQLYDQMX3(3)$5DDNDV
QLMH YRGLR RYDM ELODWHUDOQL $,'6 SURJUDP 6$'D
NRMLVHSRYHOLþLQLPRåHSRUHGLWLVD*OREDOQLPIRQ
GRP L SUHGVWDYOMD QDMYHüX ]GUDYVWYHQX LQLFLMDWLYX
NRMDELVHEDYLODMHGQRPEROHãüXQDJOREDOQRPQLYRX
LNDGDRIRUPOMHQXâNRORYDRVHNDROHNDULVSHFLMDOL
]RYDRLPXQORJLMXSRVWDRMHVWUXþQMDN]D$,'6NDR
NOLQLþDUQDXþQLNLþHOQLNRUJDQL]DFLMDLSURMHNDWD'U
'\EXOMHURÿHQJRGLQHLRWYRUHQRMHJHM
'U '\EXO MDNR GREUR UD]XPH SURJUDPH YH]DQH ]D
WHUDSLMXLSUHYHQFLMX$,'6DWXEHUNXOR]HLPDODULMH
X]HPOMDPDXUD]YRMXDLPDLVNXVWYDXUDGXVDDG
PLQLVWUDWLYQLP ]GUDYVWYHQLP VOXåEDPD QD PQRJLP
QLYRLPD QDURþLWR X $IULFL 7RNRP JRGLQD UDGD VD
3(3)$5RP EOLVNR MH VDUDÿLYDR VD *OREDOQLP
IRQGRP D X SHULRGX JRGLQH ELR MH
SUHGVHGDYDMXüL.RPLWHWD]D¿QDQVLMHLUHYL]LMX
2YDYHVWMHSUHX]HWDLL]PHQMHQDL]þODQND*)2D
EURML]GDWRJQRYHPEUD
KWWSZZZDLGVSDQRUJ
,]MDYD ]D ãWDPSX *OREDOQRJ IRQGD *OREDOQL IRQG
L]DEUDR0DUND'\EXODNDRQDUHGQRJL]YUãQRJGLUHN
WRUDREMDYOMHQDQRYHPEUD
KWWSZZZWKHJOREDOIXQGRUJHQPHGLDFHQWHU
QHZVUHOHDVHV
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
),/0
.DNRSUHåLYHWLSRãDVW±SUYHJRGLQHUDGD$&783DX1MXMRUNX
6LPRQ&ROOLQV+,9LEDVH
8SRQHGHOMDNXYHþHSDUXOLFDLVWRþQRRGNRQIHUHQ
FLMVNRJ FHQWUD RGUåDOR VH SUHPLMHUQR SULND]LYDQMH
¿OPD NRML SUDWL UDG RUJDQL]DFLMH $&783 >@ MRã
RG QMLKRYRJ SUYRJ VDVWDQND NDGD VX SRþHOL UDG QD
SUDüHQMXUD]YRMDSUYLKHIHNWLYQLKWHUDSLMD)LOPSUL
SRYHGDRWRPHNDNRVXVHOMXGLRNXSLOLLRUJDQL]RYDOL
GD SURPHQH IXQNFLRQLVDQMH LVWUDåLYDQMD X 6$'X
UHJXODWLYH OHNRYD PHGLFLQH L QDXNH L GD VH ERUH
SURWLYQH]QDQMDUDYQRGXãQRVWLLSUHGUDVXGD)LOPMH
XMHGQRODNLGUDPDWLþDQ1RPQRJLNRMLVXVHNDV
QLMHXNOMXþLOLX+,9DNWLYL]DPL]RYRJ¿OPDPRJX
XYLGHWL GD EH] WDGDãQMLK GRVWLJQXüD $&783D PL
GDQDVQHELVPRPRJOLGDUDGLPRYHüLQXVWYDULNRMH
UDGLPR
)LOPMHUHåLUDR'DYLG)UDQFHNRMLMHSURQDãDRYLãHRG
VDWLDUKLYVNLKVQLPDNDL]UD]OLþLWLKNROHNFL
MDLXNRPSRQRYDRLKVDVNRUDãQMLPLQWHUYMXLPDVD
DNWLYLVWLPD NRML VX VH ELOL XNOMXþLOL MRã QD SRþHWNX
PHÿXNRMLPDVX3HWHU6WDOH\0DUN+DUULQJWRQ'D
YLG%DUU*DUDQFH)UDQNH5XWD6SHQFHU&R[/DUU\
.UDPHU*UHJJ%RUGRZLW]L*UHJJ*RQVDOYHV0QR
JLGUXJLNRMLVXELOLMHGQDNRYDåQLXRYRMERUELQLVX
SUHåLYHOL.DNRSULþDXYODþLJOHGDRFHXSR]QDMHLKVD
OMXGLPDNRMLLKWRNRP¿OPDQDSXãWDMXLRVWDYOMDLK
GDSXWRYDQMH]DYUãHEH]WLKOMXGL
2UJDQL]DFLMD$&783 QDVWDOD MH XVOHG NUL]H NDNYX
üHWHãNR]DPLVOLWLVYDNRNRMHQLMHSUHåLYHR±DOLQLMH
QDVWDODVDSUYLPUHJLVWURYDQLPVOXþDMHYLPDþDNQL
WRNRP SUYLK JRGLQD 0HÿXWLP GR RVQLYDQMD JUXSH
X 1MXMRUNX JRGLQH ãHVW JRGLQD QDNRQ SUYLK
SUHPLQXOLK RG$,'6D X 6$'X MH XPUOR QMLK OMXGLDXVYHWX
0HÿXWLPLVWRJPHVHFDNDGDMHRIRUPOMHQDRYDJUX
SDRGREUHQMHOHN$=7NRPELQDFLMDNRMDMHUDQLMH
UD]YLMHQD X] NRULãüHQMH ]QDþDMQRJ MDYQRJ ¿QDQVLU
DQMD3URL]YRÿDþLVX]DOHNWUDåLOLYHüXFHQXRGELOR
NRJGUXJRJSRVWRMHüHJOHND±GRODUDJRGLãQMH
.DGDVX]ERJWRJDGHPRQVWUDFLMH$&783D]DWYRU
LOH WUJRYDQMH QD QMXMRUãNRM EHU]L %RURXJKV:HOO
ZZZKLYELOWHQLQIR
FRPHVXELOLSULVLOMHQLGDVPDQMHFHQX]D
'UXJH DNFLMH NRMH VX NRULVWLOH PHGLMVNX SDåQMX GD
L]GHMVWYXMX SROLWLþNH SURPHQH ELOH VX QDYODþHQMH
GåLQRYVNHUHSOLNHNRQGRPDQDNXüXKRPRIRELþQRJ
UHSXEOLNDQVNRJ VHQDWRUD -HVVH +HOPVD ]DWLP
EORNLUDQMH)'$>@KLOMDGDPDGHPRQVWUDQDWDNDNR
EL VH SURPHQLOL PHKDQL]PL UHJXODWLYH RGREUDYDQ
MD OHNRYD ]D VWDQMD NRMD XJURåDYDMX åLYRWH ]DWLP
RGUåDYDQMH VLPXODFLMH XPLUDQMD X NDWHGUDOL 6Y 3D
WULNDNDRRGJRYRUQDGLUHNWLYXNDWROLþNHFUNYHSUR
WLY NRULãüHQMD NRQGRPD L WRNRP JRGLQH UD
VLSDQMHSHSHODSUHPLQXOLKSULMDWHOMDLOMXEDYQLNDSR
WUDYQMDNX%HOH.XüHX]QDNSURWHVWD
0HÿXWLPSURPHQHQLVXQDVWDOHVDPRNDRSRVOHGLFD
YLNDQMDLSURWHVWYRYDQMD±LDNRMHWDMSRWHQFLMDOGDR
WHåLQX ]DKWHYLPD JUXSH ,]D NXOLVD þODQRYL $&7
83DVXSRVWDOLGRYROMQRVWUXþQLLVWUDåLWHOMLLQDXþQLFL
GDVXPRJOLGDQDSUDYHQDFUWSUYRJVWUDWHãNRJSODQD
]DLVWUDåLYDQMDQDWHPX+,9DL]DQHNHRGSUYLKLQ
GXVWULMVNLK LVSLWLYDQMD VD NRMLP VX PRJOL GD L]DÿX
QDVFHQHPHÿXQDURGQLKNRQIHUHQFLMDLSODVLUDMXRYX
VWUDWHJLMX 0RJOL VX GD QDWHUDMX )'$ GD SURPHQL
RGOXNXRRGELMDQMXOHND]YDQRJ'+3*NRMLGRND
]DQR RþXYDYD YLG OMXGL NRML LPDMX FLWRPHJDORYLUXV
UHWLQLWLVNRMLMHNDVQLMHQD]YDQJDQFLFORYLU7DNRÿH
VX SULPRUDOL RWYDUDQMH WDMQRYLWRJ VYHWD NRPLWHWD
)'$SRGSDURORPÄ]DãWRELQDXNDWUHEDORGDEXGH
RNUXåHQD YHORP WDMQL"³ NDNR EL MDYQRVW PRJOD GD
VHXNOMXþLXSRVWDYOMDQMHQRYLKVWDQGDUGDýDNLNDG
VXQDXþQLFLELOLYUORQHVLJXUQLXUDGXLQWHUDNFLMHVD
DNWLYLVWLPDVXSRPRJOHGDUD]YLMXOLþQXRGJRYRUQRVW
LPRWLYDFLMXWLSDÄQHPDPRSUDYDGDNDåHPRNDNRQH
PRåHPR³
2YL SULPHUL SRND]XMX NDNR MH NRPELQDFLMD MDYQRJ
SURWHVWD $&783D L SULVLOMDYDQMH ]YDQLþQLND X
]GUDYVWYX QD GLMDORJ NDR L PRWLYLVDQMH QDXþQLND L
IDUPDFHXWVNLK NRPSDQLMD GD UDGH EUåH GRYHOR GR
HIHNWLYQLMLKLSULVWXSDþQLKWHUDSLMD/MXGLVXVHRUJD
QL]RYDOLNDNRELVNUHQXOLSDåQMXGDVLWXDFLMDXYH]L
*RGLQD,EURM
+,9%,/7(1+7%
+,9DQLMHGRYROMQRGREUD
8SDQHOGLVNXVLMLQDNRQSULND]LYDQMDUHåLVHU'DYLG
)UDQFHMHJRYRULRNDNRVHUHDNFLMHQD¿OPUD]OLNXMX
Ä=DPODÿHRGJRGLQDVYHRYRMHELORQRYRD]D
VWDULMHMHELORNDRGDJOHGDMXVYRMHVQLPNH³6QLPLR
MH¿OPÄGDLVSUDYLSRJUHãQRVKYDWDQMHGDMHVYHELOR
XJXELFLPD%LRMHWRSHULRGRJURPQHNUHDWLYQRVWL
DNWLYL]PD L SURPHQD³ 8SUNRV VYRM JDODPL L PHGL
MVNRMSDåQMLRYLDNWLYLVWLVXELOLLWLKLSURPLãOMHQL
WDNWLþQLLUDGLOLVWUDWHãNL
-HGDQDNWLYLVWDMHQDJODVLRGDMHLDNRVHSULþD¿OPD
]DYUãDYDJRGLQHRQRãWRVHGHVLORQDNRQWRJD
MRã]QDþDMQLMHDRGQRVLVHQDDNWLYLVWHNRMLVXVHERULOL
]DSULVWXSWHUDSLMLLNRMLVXSURPHQLOLVYHWSRGPQRJR
WHåLP XVORYLPD 'DYLG %DUU MH ELR MHGDQ RG ãDþLFH
þODQRYD$&783DNRMLVXUDGLOLVD$&783JUXSRP
]DWHUDSLMXLNRMLMHNDVQLMHRVQRYDR*UXSX]D7HUDS
LMXL$NFLMX7UHDWPHQW$FWLRQ*URXS±JUXSXNRMD
MH GR GDQDV MHGQD RG YRGHüLK RUJDQL]DFLMD NRMH VH
EDYHSROLWLNRPYH]DQRP]D+,9X6$'
1DNRQ YLãHJRGLãQMHJ UD]YLMDQMD SRGUãNH ]D
PHÿXQDURGQH SURMHNWH YH]DQH ]D +,9 D RSHW YLG
OMLYR GLUQXW QDNRQ JOHGDQMD ¿OPD X NRPH VH L VDP
SRMDYOMXMH 'DYLG %DUU VPDWUD RYRJRGLãQMX ,$6
RYXNRQIHUHQFLMXWHãNRPÄ1DVDVWDQNXMHSXQRGR-
EULKOMXGLNRMLJRYRUHSUDYHVWYDULDOLQHPDVWUDVWL 1DXþQD RWNULüD WRNRP SUHWKRGQH GYH JRGLQH VX
YHRPDGUDPDWLþQD³7HUDSLMDNDRSUHYHQFLMD]DWYDUD
SXQ NUXJ DOL UHWRULND R Ä6YHWX EH] $,'6D³ QHüH
SRVWLüL QLãWD Ä6YH VH QDSURVWR UDVSDGD D DNR VH
UDVSDGQH VDG QLNDG JD YLãH QHüHPR VDVWDYLWL $NWLYLVWLPDWUHEDSRGUãNDLQRYDF8NROLNRKRüHPRGD
WHUDSLMD NDR SUHYHQFLMD XVSH WUHED QDP GUXãWYHQL
DNWLYL]DPDOLLSDNLPDPRPDORLOLQLPDORQRYDFD
6DPR SXVWLWH UXVNH DNWLYLVWH GD JRYRUH R WRPH VD
þLPHVHVXRþDYDMXVYDNRJGDQD±RQRãWRRQLUDGH
VDGDMHMHGQDNREULOLMDQWQRNROLNRLELORãWDãWRVPR
PLSRVWLJOL³
1DWRVHRSHWYUDüDÄ7UHEDQDPDNWLYL]DPNRMLQLMH
VDPRSRVOHGLFDUHYROWDYHüNRMLMHVWUDWHãNLXWROLNR
GD XVSHPR X QDãLP QDVWRMDQMLPD =D PQRJH OMXGH
VDGD+,9SUHGVWDYOMDNDULMHUX0LVPRWDGDVYHRYR
UDGLOLL]OLþQLKUD]ORJD±QHGDSRPRJQHPRGUXJLPD
,PDOL VPR OLþQH FLOMHYH /LþQD PRWLYDFLMD MH SRNUHWDODVYH³
*OHGDQMHRYRJ¿OPDSRPDåHXUD]XPHYDQMXVRSVW
YHQHLVWRULMH3RJOHGDMWHJDGDQDXþLWHQHãWRGDEX
GHWHLQVSLULVDQLLYLGLWHNDNRVHSURPHQHGHãDYDMXL
QDNUDMXGDL]QMHJDPRåHWHGDUD]YLMDWHVRSVWYHQX
LVWRULMX
.DNRSUHåLYHWLSRãDVWHow to Survive a Plague,
RGUHåLVHUD'DYLGD)UDQFHD
KWWSZZZKRZWRVXUYLYHDSODJXHFRP
'UXJL ¿OP NRML SULND]XMH LVWRULMX $&783D SRG
QD]LYRP Ä8MHGLQMHQL X EHVX ,VWRULMD RUJDQL]DFLMH
$&783³VXSURL]YHOL-LP+XEEDUGL6DUDK6FKXO
PDQ SUHPD LVWRULML$&783D L QD RVQRYX PQRJLK
RSVHåQLK LQWHUYMXD VD YLãH RG DNWLYLVWD 7UDQ
VNULSWL RYLK LQWHUYMXD VH PRJX QDüL QD ,QWHUQHWX D
PHÿX QMLPD VX LQWHUYMXL DNWLYLVWD LQWHUYMXLVDQLK X
RED¿OPD
KWWSZZZDFWXSRUDOKLVWRU\RUJLQWHUYLHZVLQGH[
KWPO
KWWSZZZXQLWHGLQDQJHUFRP
5HIHUHQFH
$&783±$,'6&RDOLWLRQWR8QOHDVK3RZHU$,'6NRDOLFLMD]DRVOREDÿDQMHVQDJHMHPHÿXQDURGQDJUXSD]D]DJRYDUDQMHSXWHPGLUHNWQH
DNFLMHNRMDåHOLGDXWLþHQDåLYRWHRVREDNRMHåLYHVD$,'6RPLQDSDQGHPLMX$,'6DWDNRãWRELXQDSUHGLOL]DNRQHPHGLFLQVNDLVWUDåLYDQMDL
WHUDSLMXGDELVHVWDORQDNUDMRYRMEROHVWLNRMDMHSURX]URNRYDODJXELWNH]GUDYOMDLåLYRWDPQRJLK$&783MHIRUPDOQRRIRUPOMHQDX0DUWX
JRGLQHX1MXMRUNXDDNWLYQDMHLGDQDVSULPSUHY
)'$±)RRGDQG'UXJ$GPLQLVWUDWLRQ8SUDYD]DKUDQXLOHNRYHMHIHGHUDOQDDJHQFLMD'LUHNFLMH]D]GUDYOMH6$']DGXåHQD]D]DãWLWXLSURPR
YLVDQMHMDYQRJ]GUDYOMDNUR]UHJXOLVDQMHLQDG]RUEH]EHGQRVWLKUDQHSURL]YRGDRGGXYDQDGRGDWDNDLVKUDQLOHNRYDVDSR]LWLYQLKOLVWLYDNFLQD
ELRIDUPDFHXWLNHWUDQVIX]LMDNUYLPHGLFLQVNLKXUHÿDMDHOHNWURPDJQHWQLKXUHÿDMDLYHWHULQDUVNLKSURL]YRGDSULPSUHY
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%
ƒ”—«‹–‡•˜‘Œ
,ƒ•‘’‹•Œ‡„‡•’Žƒ–ƒǤ‘’”‹Œ‡—ƒ”—†ā„‡‹…‡«ƒ•‘’‹•©‡ƒ•‡”‡†‘˜‘•Žƒ–‹ƒ†ƒ–—ƒ†”‡•—Ǥƒ”—†ā„‹—
–ƒ‘¯‡‘ā‡–‡‹œ˜”æ‹–‹‘Ž‹‡ƒƒ†”‡•‹™™™ǤŠ‹˜Ǧ„‹Ž–‡Ǥ‹ˆ‘
‹–—Žƒǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴‡ǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴”‡œ‹‡ǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
•–ƒ‘˜ƒǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
†”‡•ƒ—•–ƒ‘˜‡ǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴‘æ–ƒ•‹„”‘Œǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
‡•–‘ǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
ƒ‹Žǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̷̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
”‘Œ–‡Ž‡ˆ‘ƒǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
~‡Ž‹†ƒ†‘„‹Œƒǣ
†‹‰‹–ƒŽ‘‹œ†ƒŒ‡’—–‡‡Ž‡–”‘•‡’‘æ–‡
斃’ƒ‘‹œ†ƒŒ‡ƒƒ†”‡•——•–ƒ‘˜‡
ƒ”—†ā„‡‹…—’‘惎Œ‹–‡ƒƒ†”‡•—ǣǦŽ—„ǡeƒˆƒ”‹‘˜ƒ͸ǡͳͳͲͲͲ‡‘‰”ƒ†ǡ”„‹Œƒǡ‹Ž‹ƒˆƒ•ǣ
+381(0)113345852
˜ƒŽƒæ–‘•–‡’‘•–ƒŽ‹ƒæ’”‡–’Žƒ–‹Ǥ
‘Ž‹‘ā‡Ž‹–‡†ƒ’‘‘‰‡–‡‹œ†ƒ˜ƒŒ‡„‹Ž–‡«ƒ•‘’‹•ƒǡ–‘‘ā‡–‡—”ƒ†‹–‹—’Žƒ–‘†‘ƒ…‹Œ‡Ǥ
'RQDFLMHL]6UELMH
3ULPDODF4NOXE
âDIDULNRYD%HRJUDG
6YUKD
'RQDFLMD]D+7%þDVRSLV
5DþXQ
'RQDFLMHL]RVWDOLK]HPDOMD
&RUUHVSRGHQWLV$*5,)533&UHGLW$JULFROH3DULV
0(%$56
&5(',7$*5,&2/(65%,-$$'1RYL6DG
,%$156
4&OXE
'MXUGMHYGDQVND$%HRJUDG
5HSXEOLFRI6HUELD
‘‹ƒ–‡‡‹Š’‹–ƒŒƒ‹Ž‹ƒŒ‡’‘–”‡„ƒ’‘‘©—˜‡œ‹•ƒ—’Žƒ–‘‘–ƒ–‹”ƒŒ–‡ƒ•Ǥ
‡ŽǣΪ͵ͺͳȋͲȌͳͳ͵͵Ͷͷͺͷʹ
Ǧƒ‹Žǣ‘ˆϐ‹…‡̷“Ǧ…Ž—„Ǥ‘”‰Ǥ”•
†”‡•ƒǣeƒˆƒ”‹‘˜ƒ͸ǡ‡‘‰”ƒ†
ZZZKLYELOWHQLQIR
*RGLQD,EURM
HIV i-­‐Base «‹‹ ‰”—’ƒ ƒ–‹˜‹•–ƒǡ —‰Žƒ˜‘ ’‘œ‹Ǧ
–‹˜‹Šǡ‘Œ‹•‡„ƒ˜‡–‡”ƒ’‹Œ‘‹ˆ‡…‹Œ‡‹’‘•˜‡©‡‹
•—‘„‡œ„‡¯‹˜ƒŒ—’”ƒ˜‘˜”‡‡‹Š‹ˆ‘”ƒ…‹Œƒ‘–‡”ƒ’‹Œ‹
‘•‘„ƒƒ‘Œ‡ā‹˜‡•ƒǦ‘‹’”—āƒ‘…‹ƒœ†”ƒ˜•–˜‡‡
‡‰‡Ǥ
‹Ǧƒ•‡Œ‡‘•‘˜ƒʹͲͲͲǤ‰‘†‹‡‘†•–”ƒ‡ƒ–‹˜‹•–ƒ’”‡Ǧ
–Š‘†‘ƒ‰ƒā‘˜ƒ‹Šƒ—”‡¯‹˜ƒŒ—‹‹œ†ƒ˜ƒæ–˜——•Ž‘’—
”‡ƒ–‡–”‘Œ‡…–‹œ‘†‘ƒǤ
˜‹Œ‹Š‘˜‹ƒ–‡”‹ŒƒŽ‹•—’”‘‹œ˜‡†‡‹—œ—«‡æ©‡’‘œ‹Ǧ
–‹˜‹Š‘•‘„ƒ‹’”‡‰Ž‡†ƒ‹‘†•–”ƒ‡Ž‡ƒ”ƒ ‹ •–”—«‹Š
•ƒ”ƒ†‹ƒǤ‡†‹…‹•‹•ƒ˜‡–‹…‹•—’‘•‡„‘ƒ˜‡†‡‹œƒ
•˜ƒ—’—„Ž‹ƒ…‹Œ—Ǥ˜‡ƒ–‡”‹ŒƒŽ‡ǡ—ŽŒ—«—Œ—©‹‹•ƒ†”āƒŒ
™‡„•ƒŒ–ƒǡ•—’”‡‰Ž‡†ƒŽ‹‡†‹…‹•‹•ƒ˜‡–‹…‹‹‘•‘„‡
‘Œ‡ā‹˜‡•ƒǦ‘Ǥ
HIV Treatment Bulletin – HTBŒ‡‡’”‘ϐ‹–‹ā—”ƒŽ
‘Œ‹‹œ˜‡æ–ƒ˜ƒ‘ƒŒ˜ƒā‹Œ‹ƒ’”‡†…‹ƒ—‡†‹…‹‹
‹’”‹•–—’—–‡”ƒ’‹Œ‹Ǥ
”‡†‹ǣ Simon Collins
‡Š‹«‹—”‡†‹ǣ‘ŽŽ›Žƒ›†‡
‡†‹…‹•‹•ƒ˜‡–‹…‹ǣ
”ƒ”‡‡…‡”ƒǡAlbert Einstein College of Medi-­‐
cine, NYC.
”ƒŒƒ›Šƒ‰ƒ‹ǡRoyal Free Hospital, London.
ƒ—ŽŽƒ…Šƒ”†ǡBritish School of Osteopathy, London.
”ƒ”–‹‹•Š‡”ǡBrighton & Sussex University Hospi-­‐
tals.
”‘ˆǤ‹ƒƒ
‹„„ǡMedical Research Council, London.
”‡‰‰
‘•ƒŽ˜‡•ǡAIntl Treatment Preparedess Coali-­‐
tion (ITPC).
”
ƒ”‡–Šƒ”†›ǡCase Western Reserve Univ. Cleve-­‐
land.
”ƒ›‡Š‘‘ǡUniversity of Liverpool Hospital.
”‘ˆǤŽ‹˜‡‘˜‡†ƒ›ǡInternational Laboratory Virology Centre.
”‘ˆǤƒ‡•…–›”‡ǡChris Hani Baragwanath Hosp. South Africa
”
”ƒ‡‡‘›Ž‡ǡChelsea & Westminster Hosp, Lon-­‐
don. ”–‡ˆƒƒ—••ǡDüsseldorf.
”‘ˆƒ”‘Ž‹‡ƒ„‹ǡUCL Medical School, London.
”
”ƒŠƒƒ›Ž‘”ǡImperial College, London.
”–‡’Š‡ƒ›Ž‘”ǡBirmingham Heartlands Hospital.
”
ƒ”‡–Š—†‘”Ǧ‹ŽŽ‹ƒ•ǡImperial College, London.
”†—†‹Ž‹•ǡManchester General Hospital, Manchester.
‹Ǧƒ•‡Ȉ͘–ŠŽ‘‘”ǡ͙͛
”‡ƒ–—ơ‘Ž–”‡‡–ǡ‘†‘ǡ͕‘Ǥ
ǣΪ͘͘ȋ͔Ȍ͖͔͔͛͛͘͘͜͜͜ȈǣΪ͘͘ȋ͔Ȍ͖͔͔͛͛͘͘͜͜͝
Š––’ǣȀȀ™™™Ǥ‹Ǧƒ•‡Ǥ‹ˆ‘
Download

HIV bilten HTB - HIV i-Base