,661
*RGLQD,EURM
+,9ELOWHQ
H
%,+_&51$*25$_+59$76.$_65%,-$
2012.
ƒ†”āƒŒǣ
UVODNIK 3
HIV BILTEN DODATAK 3 IZVEŠTAJI SA KONFERENCIJA 4
ͳͻǤ˜‡–•ƒ‘ˆ‡”‡…‹Œƒ4
Ȉ
Uvod
Ȉ
”—æ–˜‡‹‹’‘Ž‹–‹«‹‰‘˜‘”‹
ȂͳͻǤ‘ˆ‡”‡…‹Œƒ‘”‡–”‘˜‹”—•‹ƒ‹‘’‘”–—‹•–‹«‹‹ˆ‡…‹Œƒƒ6
Ȉ
Uvod
Ȉ
•–”ƒā‹˜ƒŒ‡Ž‡ƒ’”‡—œ‹ƒ‰Žƒ˜—”‡«ǣ†‘ƒœ‘…‡’–ƒœƒƒ–‹˜‹”ƒŒ‡
•”‹˜‡‘‰”‡œ‡”˜‘ƒ”ƒ
Ȉ
—ƒ†ϐ‹•ƒ†‘œƒ‘„‹ƒ…‹Œ‡‹–‡‰”ƒœ‡ǣˆƒœƒ•–—†‹Œ‡ǦͶͺ–Œ‡†ƒ
Ȉ
”‡‹†–”‡–ƒƒƒ‘”ƒ‘‰Ǧƒ‘†‘†‘Œ«ƒ†‹
Ȉ
’‘–”‡„ƒƒ”—ƒ˜‹”Ǧƒ–‘‘–”—†‘©‡
Ȉ
–—†‹Œ‡†‘Ž—–‡‰”ƒ˜‹”ƒ‹†ƒŽŒ‡†ƒŒ—ƒ†—
Ȉ
”‘ǦŽ‡–‡‘ˆ‘˜‹”ǣͳͲǦ†‡˜ƒ•–—†‹Œƒ‘‘–‡”ƒ’‹Œ‡’‘•–ƒ˜ŽŒƒ†‘œ—ƒ
ʹͷ‰œƒŽƒæ—‘ˆ‘”—Žƒ…‹Œ—
Ȉ
”ǣ‘†‡Ž‹”ƒŒ‡•˜ƒ‘†‡˜‘‰‘”‹æ©‡ŒƒȀȋ”—˜ƒ†ƒȌ
’”—āƒ•‘”‘ͳͲͲ؜ƒæ–‹–—‘†‹ˆ‡…‹Œ‡
Ȉ
‡ƒ‹ƒ˜‡˜‡œ‡‹œ‡¯—ƒ–ƒœƒƒ˜‹”ƒ‹‹Ž‹æŽ‘‰ƒ—ǣǣ•–—†‹Œ‹
Ȉ
–—†‹Œ‡‘‹ˆ‡…‹Œ‡‡’ƒ–‹–‹•‘
Ȉ
‡”’‡•‘•–‡”˜ƒ…‹ƒŒ‡„‡œ„‡†ƒ‹‡ˆ‡–‹˜ƒ‘†’‘œ‹–‹˜‹Š‘•Ǧ
‘„ƒ
Ȉ
‹•‘ƒ †‘œƒ ˜ƒ…‹‡ ’”‘–‹˜ ‰”‹’ƒ ’‘„‘ŽŒæƒ˜ƒ ƒ–‹–‡Ž‡ ”‡ƒ…‹Œ‡ ‘†
’‘œ‹–‹˜‹Š‘•‘„ƒ
Ǧͳ͵Ǥ˜”‘’•ƒ‘ˆ‡”‡…‹Œƒ‘ȀǦ—27
Ȉ
Uvod
Ȉ
˜”‘’•‹˜‘†‹«ȋȌȂʹͲͳͳƒā—”‹”ƒƒ˜‡”œ‹Œƒ
Ȉ
ƒŽ–‡‰”ƒ˜‹”’‘•–ƒŒ‡•—’‡”‹‘”ƒ—‘†‘•—ƒ‡ˆƒ˜‹”‡œƒ‘«‡–‹”‹‰‘Ǧ
dine Ȉ
‹æ‹‹˜‘‹–‡‘ˆ‘˜‹”ƒ‹†ƒ”—ƒ˜‹”ƒ—’Žƒœ‹ƒŽ‹‡‹‡ˆƒ˜‹”‡œƒ‘†•–ƒ”Ǧ
‹Œ‹Š’ƒ…‹Œ‡ƒ–ƒ
Ȉ
‹˜‘‹”‹–‘ƒ˜‹”ƒ•ƒŒ‡‹˜‹•‘‘Ǧƒ•‹‘„”‘‘
Ȉ
”ƒ•’Žƒ…‡–ƒŽ‹’”‡‘•”ƒŽ–‡‰”ƒ˜‹”ƒ‹‘†Ž‘ā‡‹Ž‹”‡•Ž‡ƒ—’Žƒœ‹
‘†’”‡”ƒ‘”‘¯‡‹Š„‡„ƒ
,32
Ȉ
‘†‹«˜‡–•‡œ†”ƒ˜•–˜‡‡‘”‰ƒ‹œƒ…‹Œ‡ȋȌœƒ–‡•–‹”ƒŒ‡ǡ•ƒ˜Œ‡–‘Ǧ
˜ƒŒ‡‹Ž‹Œ‡«‡Œ‡‘†•‡”‘Ǧ†‹•‘”†ƒ–‹Š’ƒ”‘˜ƒǣ’”‹Ͷε͵ͷͲœƒ
•ƒŒ‡Œ‡”‹œ‹ƒ’”‹Œ‡‘•ƒ
,ȋȌ 34
Ȉ
‡ƒ’‘˜‡©ƒ‹Š”‹œ‹ƒ‘†’‘Œƒ˜‡•”–‹Š‹•Š‘†ƒ‡˜‡œƒ‹Šœƒ
—•Ž‡†——Žƒ–‹˜‡’”‹‡‡Ǧƒ——”‘‘Š‘”–‹
Ȉ
‘˜‡•–—†‹Œ‡‘Ǧ—‹„‘Ž‡•–‹ƒ•–ƒ”‡Œƒ
Ȉ
‹‘œƒǣŽ‘‰‹–—†‹ƒŽ‹”‡œ—Ž–ƒ–‹‹œǦƒ‹†”—‰‹Š•–—†‹Œƒ
SPOREDNI EFEKTI 40
Ȉ
‡œ‡ ‹œ‡¯— —’‘–”‡„‡ –‡‘ˆ‘˜‹”ƒ ‹ „—„”‡ā‹Š ‘’Ž‹ƒ…‹Œƒ ‘† ‘Š‘”–‡
PEDIJATRIJSKA NEGA 43
Ȉ
†Žƒ‰ƒŒ‡ȋƒ–‹”‡–”‘˜‹”ƒŽ‡–‡”ƒ’‹Œ‡Ȍ—†Œ‡–‹Œ•–˜—‘ā‡•ƒŒ‹–‹
†—‰‘”‘«‹Ͷ„”‘Œ—‘†”ƒ•Ž‘Œ†‘„‹
LOKALNE STRANE 44
Ȉ
‘•–—’‘•––‡”ƒ’‹Œ‡ǣ‘Œ‡ŽŒ‡‘˜‡‹ƒ‘—”‡‰‹Œ‹ǫ
Ȉ
ƒŽ‹͵Ͳ‰‘†‹ƒƒ•‹Œ‡ƒœ‹”‡‘•˜‡–Ž‘•–ƒ”ƒŒ—–—‡Žƒǫ
Ȉ
—„Ž‹‹«ƒ ƒ”‘–‹†ƒ ƒ–‡”‘•Ž‡”‘œƒ ’‘˜‡œƒƒ Œ‡ • Ǧ‹ˆ‡…‹Œ‘ ‹
‹•‹•–—’Œ‡’”‹†”āƒ˜ƒŒƒ‡†‹–‡”ƒ•‘Œ’”‡Š”ƒ‹
Ȉ
”‡‰Ž‡†ƒ—«‹Š”ƒ†‘˜ƒ‹œ”‡‰‹Œ‡—ʹͲͳʹǤ‰‘†‹‹’”‡ƒ„ƒœ‹—„‡†
INTERVJU 51
Ȉ
‡Œƒ‹‘ŽŽ‹•Ȃ—‰‘‹•–‘«ƒ˜”‘’ƒ–”‡„ƒ˜‹æ‡’‘œ‹–‹˜‡’ƒāŒ‡Ǩ
53
Ȉ
‹•‘„‹Ž‹–—
0 54
~Ȁ55
+,9%,/7(1+7%H
+,9ELOWHQ
H
%,+_&51$*25$_+59$76.$_65%,-$
HIV bilten HTB
za Bosnu i Hercegovinu, Crnu Goru, Hrvatsku i Srbiju
‘†‹ƒʹͲͳʹȀ„”‘Œ’”˜‹
ͳͲͲͲ’”‹‡”ƒƒ
Urednik:‡ƒ†‡–‘˜‹©
‡Š‹«‹—”‡†‹ǣƒ†‡—œƒ‘˜‹©
”‡†‹ Ž‘ƒŽ‹Š •–”ƒƒǣ ‘‹•Žƒ˜
—”—æ‹©
‹œƒŒ‡”ǣ”‡ƒƒ”‘˜‹©
œ†ƒ˜ƒ«ǣǦŽ—„
ƒ‹œ†ƒ˜ƒ«ƒǣƒ†ƒ‹©‹©
eƒˆƒ”‹‘˜ƒ͸ǡͳͳͲͲͲ‡‘‰”ƒ†ǡ”„‹Œƒ
ȀǣΪ͵ͺͳͳͳ͵͵Ͷͷͺͷʹ
ǣ‹ˆ‘̷“Ǧ…Ž—„Ǥ‘”‰Ǥ”•
ǣŠ––’ǣȀȀ“Ǧ…Ž—„Ǥ‘”‰Ǥ”•
e–ƒ’ƒ”‹Œƒǣ”’•‹
—–‡„‡”‰
”‡¯‹˜ƒ«‹‘†„‘”ǣ
Ž‡•ƒ†”ƒƒ”Œƒ‘˜‹©ǡPodgorica
‡•ƒƒ†ā‹‘•ƒ‘˜‹©ǡMedicinski fakultet, Univerzitet u Sarajevu
0‘”¯‡‡˜–‘˜‹©ǡMedicinski fakultet, Univerzitet u Beogradu
‘•‹’‡‰‘˜ƒ…ǡMedicinski fakultet, Univerzitet u Zagrebu
ƒ†ƒ‹©‹©ǡBeograd
ƒƒeƒ„‘˜‹©ǡTuzla
‡āƒƒ”‹©ǡMedicinski fakultet, Univerzitet u Novom Sadu
‘‹•Žƒ˜—”—æ‹©ǡPula
HIV bilten HTB je besplatni,
SHULRGLþQL åXUQDO NRML L]YHãWDYD
R QDMQRYLMLP L QDMYDåQLMLP
PHGLFLQVNLP LVWUDåLYDQMLPD L
QDSUHGFLPD L] REODVWL +,9D L
VURGQLKVWDQMDNDRLRGRVWXSQR
VWLWHUDSLMHLSULSUHPDVH]D%RV
QX L +HUFHJRYLQX &UQX *RUX
+UYDWVNX L 6UELMX 1DPHQMHQ MH
]GUDYVWYHQLPUDGQLFLPDGUXJLP
SURIHVLRQDOFLPD L RVREDPD
SRJRÿHQLP+,9RPDOLLRVWDOLP
]DLQWHUHVRYDQLPD]DWHPX+,9D
*ODYQL FLOM L]GDYDQMD ELOWHQD MH
REH]EHÿLYDQMH SRX]GDQLK LQIRU
PDFLMD NDR SODWIRUPH ]D SULVWXS
NYDOLWHWQRM ]GUDYVWYHQRM ]DãWLWL
RVRED NRMH åLYH VD +,9RP X
VYLP]HPOMDPDUHJLMH
+,9ELOWHQVHL]GDMHXãWDPSDQRM
IRUPL NRMD MH GRVWXSQD X YHüLQL
]GUDYVWYHQLKXVWDQRYDXUHJLRQX
D PRåH VH QDUXþLWL L QD NXüQX
DGUHVX HOHNWURQVNL X 3')IRU
PL NRMX PRåHWH GRELMDWL SXWHP
HPHMODLXRQOLQHYHU]LMLQDLQ
WHUQHWVDMWX
HIV bilten HTB je nastao je na
LQLFLMDWLYX4NOXEDL,QWHUQDWLRQ
DO+,93DUWQHUVKLSV9HüLQDWHN
VWRYDX+,9ELOWHQXMHSUHYHGHQD
L]HQJOHVNRJþDVRSLVD+,97UHDW
PHQW %XOOHWLQ X] SRGUãNX RUJD
QL]DFLMH L%DVH NRMD WDM þDVRSLV
L]GDMH8VYRPXUHGQLþNRPWLPX
+,9ELOWHQRNXSOMDOHNDUHDNWLY
LVWHLRVREHNRMHåLYHVD+,9RP
L] %RVQH L +HUFHJRYLQH &UQH
*RUH+UYDWVNHL6UELMH
Izdavanje HIV biltena HTB za Bosnu i Hercegovinu, Crnu Goru, Hrvatsku i Srbiju su grantovima pomogli Gilead Sciences Europe i Merck Sharp & Dohme.
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
892'1,.
'UDJLþLWDRFL
+,9HSLGHPLMDMHMRãXYHNXSXQRP]DPDKXãLURPVYHWD
L LPD RþLJOHGDQ XWLFDM L QD QDãH EOLVNR RNUXåHQMH ,DNR
VHXVYLP]HPOMDPDQDãHUHJLMHEHOHåLQLVNDVWRSD+,9
LQIHNFLMH EURM QRYRGLMDJQRVWLNRYDQLK VOXþDMHYD SRND
]XMH VWDOQR SRYHüDQMH 3UHWKRGQLK QHNROLNR JRGLQD VYH
YLãHOMXGLVHMDYOMDUDGLOHþHQMD+,9$,'6DãWRL]XVNXMH
SRYHüDQMH EURMD PHVWD X NRMLPD VH SUXåD ]GUDYVWYHQD
QHJD YLãH REXþHQRJ RVREOMD L SRGVWLþH YHüH LQWHUHVR
YDQMH0HGLFLQDVHXREODVWL+,9DL$,'6DUD]YLMDEU]R
L QHSUHVWDQR 5D]OLþLWL DVSHNWL EROHVWL SRVWDMX SUHGPHW
EURMQLKLVWUDåLYDQMDRNRMLPDL]YHãWDYDQHNROLNRXJOHGQLK
QDXþQLK þDVRSLVD 6XRþHQL VPR VD PQRJLP L]D]RYLPD
0QRJL VDVWDQFL L NRQIHUHQFLMH RGUåDYDMX VH ãLURP VYHWD
XSRNXãDMXGDSRQXGHRGJRYRUHQDQHNDSLWDQMD3UH]D
SRVOHQLPOHNDULPDQLMHODNRGDSUDWHVYDRYDGHãDYDQMD
=ERJWRJDMHYHRPDYDåQRGDVHRVREDPDNRMHåLYHVD
+,9RP L ]GUDYVWYHQLP UDGQLFLPD REH]EHGH SRWSXQH L
SUHFL]QHLQIRUPDFLMHRQRYLPLVWUDåLYDQMLPDLQDOD]LPD
6D ]DGRYROMVWYRP YDP SUHGVWDYOMDPR SUYR VSHFLMDOQR
L]GDQMH+,9ELOWHQD+7%]D%RVQXL+HUFHJRYLQX&UQX
*RUX+UYDWVNX6UELMXLGUXJH]HPOMHXUHJLRQX8SU
YRPEURMXQDSUDYLüHPRRVYUWQDQDMYDåQLMHLQIRUPDFLMH
NRMHVXVHSRMDYLOHWRNRPJRGLQH]ERJþHJDMHRYR
L]GDQMHSRVHEQRLVDYHüLPRELPRPVDGUåDMD3UHVYHJD
SUHGVWDYLüHPR L]YHãWDMH VD QDM]QDþDMQLMLK NRQIHUHQFLMD
NRMHVXRGUåDQHWRNRPRYHJRGLQH6OHGHUXEULNHRDNWX
HOQLPYRGLþLPD]DNOLQLþNXSUDNVXVSRUHGQLPHIHNWLPD
WHUDSLMH RSRUWXQLVWLþNLP LQIHNFLMDPD L NRPSOLNDFLMDPD
L R SHGLMDWULMVNRM QH]L 7UXGLüHPR VH GD VDGUåDM VYDNRJ
EURMDRGJRYRUL]DKWHYLPDDNWXHOQRVWLLLQWHUHVRYDQMD
3RVHEQL GHR QDãH YHU]LMH +7%D þLQH ORNDOQH VWUDQH X
NRMLPDPRåHWHSURQDüLLQIRUPDFLMHRQRYRVWLPDL]UHJLR
QD GRPDüLP VWXGLMDPD L WHNVWRYH ORNDOQLK DXWRUD 'HR
VDGUåDMD SRVYHüXMHPR GUXãWYHQLP WHPDPD YH]DQLP ]D
+,9$,'63ULSUHPLOLVPRLQWHUYMXVDSR]QDWLP+,9DN
WLYLVWRPLSUHGVWDYOMDQMHGRNXPHQWDUQRJ¿OPDÄ0LVPR
ELOLWX³'RGDWDNRYRPEURMXMHUHJLVWDULVWRULMHEROHVWL
GåHSQD VYHVND NRMD üH ELWL RG YHOLNH SRPRüL SDFLMHQWL
PD
1DGDPRVHGDüH+,9ELOWHQ+7%GRSUHWLGRVYRMHSXE
OLNH D RG þLWDRFD RþHNXMHPR GD QDP SRãDOMX VYRMH NR
PHQWDUH VXJHVWLMH L åHOMH äHOLPR GD ]DMHGQR GDPR GR
SULQRVXQDSUHÿLYDQMX]GUDYVWYHQHQHJHLXVORYD]DRVREH
NRMHåLYHVD+,9RPLPHGLFLQVNRRVREOMHNRMHYRGLEULJX
RQMLPD
3RVHEX]DKYDOQRVWXSXüXMHPRRUJDQL]DFLML+,9L%DVHL]
/RQGRQDXUHÿLYDþNRPRGERUXLGRQDWRULPDNRMLVXSUH
SR]QDOLYDåQRVWRYRJSURMHNWD
8]VYHSRãWRYDQMH
1HQDG3HWNRYLü
XUHGQLN
+,9%,/7(1'2'$7$.
6YHVND LVWRULMH EROHVWL MH XNOMXþHQD NDR GRGDWDN RYRP
EURMX+,9ELOWHQD
.QMLåLFD]DSUDüHQMHLVWRULMHEROHVWLPRåHYDPSRPRüLGD
YRGLWHHYLGHQFLMXRVYRMLPUH]XOWDWLPDLOHþHQMX6DGUåL
VWUDQLFH ]D &' L EURM YLUXVQLK NRSLMD 3&5 WHVWRYH
UH]LVWHQFLMHLVWRULMXEROHVWLEHOHãNHRYDãLPQHåHOMHQLP
ZZZKLYELOWHQLQIR
HIHNWLPDLDOHUJLMDPDGUXJH]DUD]QHEROHVWLYDNFLQDFLMH
QHNHGUXJHQHYROMHXNRMLPDVWHXþHVWYRYDOLNDRLNRQ
WDNWSRGDWNHYDãHNOLQLNH1DURþLWRMHNRULVQRDNRSURPH
QLWHOHNDUDLOLSRVHWLWHGUXJXEROQLFX$NRåHOLWH]DSLV$
YHOLþLQH3')YHU]LMX]DãWDPSXPRåHWHQDüLQDZHEVD
MWXwww.hiv-bilten.info
*RGLQD,EURM
+,9%,/7(1+7%H
,=9(â7$-,6$.21)(5(1&,-$
19. Svetska AIDS konferencija
22. – 25. 7. 2012. Vašington DC, SAD
Simon Collins, HIV i-Base
Uvod
7RNRPSUHWKRGQHGHFHQLMH6YHWVND$,'6.RQIHUHQFLMD
0HÿXQDURGQRJ 'UXãWYD ]D $,'6 ,$6 ,QWHUQDWLRQDO
$,'6 6RFLHW\ MH SRUHG QDXþQLK VYH YLãH XSXüHQD QD
GUXãWYHQHDVSHNWH+,9DDWDMWUHQGVHQDVWDYLRLRYHJR
GLQH2GRNRVWXGLMDLSUH]HQWDFLMDRNRMHNDR
WHPX LPDOR OMXGVND SUDYD ¿QDQVLUDQMH SULVWXS OHþHQMX
SROLWLNXSUHYHQFLMXLSULVWXSQH]LNDRLSUREOHPVWLJPH,
RYHJRGLQHYHüLQDNOLQLþNLKVWXGLMDELORMHSUHGVWDYOMHQR
SRVWHULPDSUHJOHGSUHGVWDYOMHQQDSULND]XYHOLþLQH[
PHWDUJGHMHIRNXVVYHJDSRVWHUDELRQDUDQXLOLRV
QRYQXQDXNXDPDQMHRGQDNOLQLþNHVWXGLMH2G
SUHGDYDQMDVYHJDQMLKSHWMHELORIRNXVLUDQRQDOHþHQMH
,DNRVXNOLQLþNHVWXGLMHNRMHüHPRSUHGVWDYLWLXPDJD]LQX
YHRPDYDåQHNRQWHNVW]DJODYQLVDVWDQDNR+,9$,'6X
RYHJRGLQHGDODVXSUHGDYDQMDQD,QWHUQHWXRGUXãWYHQLP
LSROLWLþNLPDVSHNWLPDLROMXGVNLPSUDYLPD3UH]HQWHULL
SUHGDYDþLVXDQYHüLQLSUHGDYDQMDGDOLEROMLXYLGXQHNH
GUXãWYHQHVLWXDFLMHQHJRXHSUXYHWHLOLVWDWLVWLNH
,DNR MH NRQIHUHQFLML SULVXVWYRYDOR YLãH RG GHO
HJDWD WRNRP SDU VDWL ]DYUãQRJ SUHGDYDQMD VDOD MH ELOD
SUD]QDLSURVWRUVHSULSUHPDR]DNRPSMXWHUVNHLJUHLOL]D
Ä6WLFDQMHNRQWUROHQDGVYRMLPåLYRWRP³GRJDÿDMNRMLMH
ELR ]DND]DQ ]D VOHGHüX QHGHOMX 1R WDNR MH ELOR ODNãH
RGYRMLWLWDþNHDNWLYL]PDLWURãHQMD
1D RYRM NRQIHUHQFLML VH YLãH QHJR QD GUXJLP PHGLFLQ
VNLP NRQIHUHQFLMDPD SDåQMD SRVYHüXMH RGUHÿHQLP
GUXãWYHQLP WHPDPD QHJR LVWLFDQMX UH]XOWDWD QRYLK
QDXþQLKPHGLFLQVNLKQDSUHGDND2YDNRQIHUHQFLMDMHSUH
EDFLODIRNXVQDGRVWXSQRVWOHþHQMDSDVHX]SRGVHüDQMD
QD QHPRJXüH VSRU SURFHV ³[´ NDPSDQMH PLOLRQD
OMXGLXNOMXþHQRXOHþHQMHGRJRGLQHVDPRGRWDNOD
QHNDGD]DVWUDãXMXüHJFLOMD
7DNR GD RYH JRGLQH NRQIHUHQFLMD REHOHåDYD GRED NDGD
YLãHRGRVDPPLOLRQDOMXGLX]HPOMDPDVDQLVNLPLVUHG
QMLP SULKRGLPD LPD PRJXüQRVW GD SULVWXSL L RVWDQH QD
OHþHQMX ,DNR MH SDåQMX PHGLMD SULYXNOD WHPD NDPSDQMH
³=DMHGQR SUHXVPHUDYDPR SOLPX´ 7XUQLQJ WKH WLGH WR
JHWKHUGDOHNRYDåQLMLIRNXVMH]DVOXåLYDRRVWYDUHQLFLOM
RGPLOLRQDOMXGLQDWHUDSLML
*RGLQD,EURM
3URJUDPRYHJRGLQHMHXNOMXþLYDR
Platforma za govore
2SROLWLFLLSULVWXSXWHUDSLML+,9SR]LWLYQLPOMXGLPDL
DNWLYLVWLPDNRMLYRGHPQRJHRGRUJDQL]DFLMDX]DMHGQL
FDPDGDWDMHSULOLNDGDL]ORåHVYRMHVWDYRYHQDVYHWVNRM
VFHQL
Usmeravanje fokusa ka leku
0QRJD SUHGDYDQMD XNOMXþLYDOD VX UDQD LVWUDåLYDQMD YH
]DQD]DOHNXNOMXþXMXüLUDGLRQLFHSUHVDVWDQND
.OLQLþNLSRGDFL
$NFHQDWMHVWDYOMHQQDQRYHOHNRYH]D+,9L7%]GUDYOMH
GHFHLGUXJHVWXGLMH
Prevencija HIV-a
2YH JRGLQH MH LVWDNQXWR GD MH IRNXV XVPHUHQ QD SROLWL
NX L LPSOHPHQWDFLMX XPHVWR QD QRYH NOLQLþNH SRGDWNH
3RVHEQDSDåQMDGDWDMHÄ/HþHQMXNDRSUHYHQFLML³7DV3
3U(3X REUH]LYDQMX UD]PHQL LJDOD L PRJXüQRVWLPD
OHþHQMDPDMNLLQRYRURÿHQþDGL
+,9LGXJRURþQR]GUDYOMH
9HüLIRNXVQDLQÀDPDFLMXNDRSUREOHP]DMHGQRVDVWDUHQ
MHPLXSRWUHERPUDQHWHUDSLMH
/DQVLUDQMHSXEOLNDFLMDLL]YHãWDMD
0QRJHSXEOLNDFLMHVXVDGUåDOHYLãHGHWDOMDLSODQRYHNRML
VX PRJOL GD VH XNORSH X MHGDQ VLPSR]LMXP LOL SRVWHU L
YHüLQDLKMHELODGRVWXSQDEHVSODWQRSUHNR,QWHUQHWD
'UXJLGRJDÿDMLL]]DMHGQLFH
.RQIHUHQFLMDMHXNOMXþLYDOD³*OREDOQRVHOR´NRMHMHELOR
]ELUQR PHVWR PQRJLK GRJDÿDMD D NRMH MH RUJDQL]RYDOD
]DMHGQLFD2YHJRGLQHYLãHRGSURVWLUNLQDOD]LOR
VHXVDODPD]DNRQIHUHQFLMHLELORSURVWUWRGXå3DUNDQD
FLRQDOQRJ FHQWUD EOL]X :DVKLQJWRQ PHPRULMDOD L QD GUXJLKORNDFLMDXJUDGX
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
,$6GUXãWYHQLLSROLWLþNLJRYRUL
1HNLRGQDMMDþLKSROLWLþNLKJRYRUQLNDVXQDVWXSLOLQDRYRM
NRQIHUHQFLMLLPQRJDQMLKRYDSUHGDYDQMDVXGRVWXSQDQD
,QWHUHQWX
$NR PRåHWH ELWL GLUQXWL SDåOMLYR ELUDQLP UHþLPD NRMH
LVWLþX OMXGVND SUDYD VD ]DVOXåHQLP GRVWRMDQVWYRP X]
IRNXVQDVWUDWHJLMHSURPHQHRQGDRGYRMLWHYUHPHGDLK
þXMHWHLOLSRJOHGDWHVQLPDNSUHNR,QWHUQHWD
.DGDVXGRVWXSQL,$6OLQNRYLQDLQWHUQHWXSRVYHüHQLVX
SRMHGLQDþQLPJRYRULPDXPHVWRFHORPSUHGDYDQMXRYR
MHVOXþDMVDVQLPFLPD.DLVHU)RQGDFLMH9LãHRGSUH
GDYDQMDVHPRåHQDüL9HüLQDVHIRNXVLUDQDVRFLMDOQDSL
WDQMDSROLWLNXLOMXGVNDSUDYDLWUDMDQMHYDULUDL]PHÿX
VDWLSRSUHGDYDQMXLL]PHÿXLPLQXWD]DSRMHGLQDþQH
JRYRUH
/LQNRYL]DQHNHRGSUH]HQWDFLMDQD,QWHUHWXVHPRJXQDüL
XGDOMHPWHNVWX
Program otvaranja
KWWSSDJDLGVRUJVHVVLRQDVS["V $XGLWRULMXP MH ELR SRSXQMHQ WRNRP RYRJ UD]QRYUVQRJ
L GLUOMLYRJ SURJUDPD 2Q MH XNOMXþLYDR (OO\ .DWDELra RGOD]HüHJ ,$6 SUHGVHGQLND L Diane Havlir NR
SUHGVHGDYDMXüLNRQIHUHQFLMH+RUJHMRVRED9DãLQJWRQL
RJRGLãQMXAnnah Sango L]=LPEDEYHDNRMDMHJRYR
ULODRVYRMLPQDGDQMLPDNDR+,9SR]LWLYQDåHQH
Jim Yong Kim WUHQXWQL SUHGVHGQLN 6YHWVNH %DQNH L
SUYLNRMLMHSULVXVWYRYDR$,'6NRQIHUHQFLMLLELYãLGLUHN
WRU+,9$,'6RGHOMHQMDX6=2XJRYRULOLVX]DãWRVX
]ELMDQMH$,'6DWUHEDGDSUHGVWDYOMDYHüXUHDOQRVWVDGD
QHJRãWRMH³[´ELRXLNDNR6YHWVND%DQNDLPD
REDYH]XGDVWDQHQDSXW$,'6XLVLURPDãWYX
³.DGD SRJOHGDPR LVWRULMX RYH HSLGHPLMH WHãNR MH UHüL
XELORNRPWUHQXWNXNDGDMHWRNSRþHRGDVHPHQMDMHU
je istina da smo je okretali, korak za bolnim korakom,
tokom 30 godina. I pri skoro svakom pokretu aktivisti i
njihove zajednice su utabavali taj put. Aktivisti i njihove
]DMHGQLFH VX LVWLFDOL YDåQRVW VLJXUQLMHJ VHNVD XSRWUHEX
NRQGRPD UD]PHQX LJDOD L SUDNWLþQR VYH ELKHYLRUDOQH
prevencije koje koristimo danas.´
³Aktivisti su transformisali razvoj leka i zakonsku politiku
LXNOMXþLOLSDFLMHQWHXNOLQLþNDLVWUDåLYDQMDSUHSRORORYLOL
period odobravanja leka na globalnom severu. Aktivisti
X'XUEDQXNRMLVXJRGLQHSRþHOLGDYUãHSULWLVDN
za pristup antiretrovirusnim terapijama u zemljama u
UD]YRMXLNRMLNRMLLGDQDVQDVWDYOMDMXGDNUþHSXWNDNR
ELSULXãWLOLVHELDXþLQLOLVYLPDGRVWXSQRRQRãWRLPMH
potrebno, bilo gde.´
³,RSHWVXDNWLYLVWLWLþLMHMHGXERNRUD]XPHYDQMH]DMHGQLFHQDMYLãHSRJRÿHQLK$,'6RPSRGVWDNORSURPRYLVDQMH
]GUDYOMDLGRVWRMDQVWYDKRPRVHNVXDODFDSUXåDODFDVHNsualnih usluga, korisnika droga, što je sada stiglo u svaki
XJDR VYHWD 7$62 X 8JDQGL$&783 X 6$'X 7$& X
-XåQRM$IULFL *UXSR GH OD 9LGD X %UD]LOX /D\HUV &ROZZZKLYELOWHQLQIR
OHFWLYHX,QGLML7KDLPUHåDNRULVQLNDGURJDLEH]EURMQH
VOLþQHRUJDQL]DFLMHVWRSLOHVXVHMHGDQRGQDMXVSHãQLMLK
pokreta koje je svet ikada video.´
0LFKHO6LGLEH81$,'6
³.RQIHUHQFLMDMHRGUåDQDSRSUYLSXW]DJRGLQHQDNRQ
ãWRVX6$'XNLQXOH]DEUDQXXODVNDRVREDPDVD+,9RP
8NROLNR OHþHQMH NDR SUHYHQFLMX QH SRGLJQHPR QD
viši nivo, ako ne dostignemo broj od 15 miliona ljudi na
terapiji do 2015. godine, ako ne eliminišemo nove inIHNFLMHNRGGHFHDNRQH]DWYRULPR¿QDQVLMVNXSXNRWLQX
LVWRULMD QDP QLNDGD QHüH RSURVWLWL 0DQMDN RG milijardi dolara godišnje ubija ljude. (...) Zaustavljanje
$,'6DQLMHEHVSODWQRQHSURFHQMLYRMH´
)UDQFRLVH%DUUH6LQRXVVL,$6
KWWSSDJDLGVRUJÀDVKDVS["SLG 9LURORJDGYRNDWLSUHGVHGQLN,$6DXJRGLQLNRMD
MH QD VYRMRP SULPDQMX 1REHORYH QDJUDGH ]D PHGLFLQX
JRGLQHJRYRULODRRWNULYDQMX+,9DUHNOD³QDJUDGD
QHSULSDGDPHQLYHüVYLPDQDPD´
,VWDNODMHNOMXþQDSLWDQMD]DQDUHGQXJRGLQX
³.DRQDXþQLNVPDWUDPGDMHXJRGLQLQHSULKYDWOMLYRGDYLãHRGEHEDEXGHURÿHQRVD+,9LQIHNFLMRP
svake godine kada, od devedesetih, imamo instrumente
]D VSUHþDYDQMH SUHQRVD VD PDMNH QD GHWH VWUDWHJLMH ]D
VPDQMHQMHUL]LNDNRMHXNOMXþXMXSURJUDPHUD]PHQHLJDOD
se ne primenjuju svuda iako se zna da je ovo jedna od naMHIHNWLYQLMLKQDXþQLKLQWHUYHQFLMD]DVSUHþDYDQMH+,9LQIHNFLMHNRGLQWUDYHQVNLKNRULVQLNDGURJHLGDSUDYDQDG
intelektualnom svojinom narušavaju pristup lekovima viVRNRJNYDOLWHWDLGLMDJQRVWLFLXGUXãWYLPDVDRJUDQLþHQLP
resursima.´
Bill Clinton
5D]XPOMLYRSUHGVWDYOMHQRXYHUHQMHGDMHRGUåDYDQMHNRQ
WLQXLUDQHWHUDSLMHGRVWLåQRLSULXãWLYRRGVWUDQHMHGQRJRG
NOMXþQLKSRNUHWDþDVPDQMHQMDFHQD]DSUYXLGUXJXOLQLMX
$57D
KWWSSDJDLGVRUJÀDVKDVS["SLG Phill Wilson
+,9 SR]LWLYQL DNWLYLVWD L] 6$'D MH LVWDNDR NRPSOHN
VQRVW+,9SR]LWLYQLDNWLYLVWDL]6$'DLVWDNDRMHNRP
SOHNVQRVW]GUDYVWYHQHQHJHYH]DQH]D+,9X6$'JGH
VHNRGPODGLKKRPRVHNVXDODFDQDURþLWRDNRVXFUQFLL
GDOMH]DGUåDYDYLVRNQLYRQRYLKLQIHNFLMDDQMLKRYLåLYRWL
VX L GDOMH VNUDüHQL Ä FUQLK 060 üH YHURYDWQR ELWL
+,9SR]LWLYQRGRJRGLQH³
KWWSSDJDLGVRUJÀDVKDVS["SLG $,'6DNWLYL]DPGDQDVSRQRYQRSDOMHQMHLVNUH
KWWSJOREDOKHDOWKNIIRUJHQ$,'6-XO\$,'6
$FWLYLVP7RGD\DVS[
6QLPFL QD ,QWHUQHWX XNOMXþXMX SUHGDYDQMD DNWLYLVWD RG
NRMLKVXPQRJL+,9SR]LWLYQLLJRYRUHROMXGVNLP
*RGLQD,EURM
+,9%,/7(1+7%H
SUDYLPDLDNWLYL]PXXYUORUD]OLþLWLPRNROQRVWLPDAlexei
Kurmanaevskii govori o korisnicima narkotika i borbi
]DSULVWXSOHþHQMXX5XVLML.KDYWLQD6ODPDKX,QWHUQHW
SUHQRVX L] 0DOH]LMH MHU VX 6$' RGELOH GD RGREUH YL]X
SUXåDRFLPD VHNVXDOQLK XVOXJD JRYRULOD MH R VWDYX DNWLYLVWDL]JUXSHSUXåDODFDVHNVXDOQLKXVOXJD*LQD%URZQ
JRYRULODMHR$,'6DNWLYL]PXX6$'XLLVWLSRYH]DODVD
JUDÿDQVNLPSUDYLPDLåHQVNLPSRNUHWRP
medicinske sestre i savetnici - bake i majke i sestre i ljudi
NRMLQDSXãWDMXãNROXNDNRELEULQXOLRURÿDFLPDQDVDPrti.´
3UHGDYDQMH R åHQDPD NDR YRÿDPD NRMH MH XNOMXþLYDOR
YLGHRSRUXNXSRGUãNHRG$XQJ6DQ6XX.\LLREUDüDQMH
/DXUD%XVKXWUDMDQMXRGPLQXWDQHWUHEDSURSXVWLWL
KWWSJOREDOKHDOWKNIIRUJ$,'6-XO\OHDGHU
VKLSDVS[
Anthony Fauci
3UHJOHGQDXþQLKQDSUHGDNDLSULPHQMHQLKJOREDOQLKSUR
JUDPD]DOHþHQMHLSUHYHQFLMXNRMLVXGDOLQDGX]DHOLP
LQLVDQMH+,9DPLQXWDSUHGDYDQMD
KWWSSDJDLGVRUJÀDVKDVS["SLG 1DRPL$NHUV
3HWRPLQXWQLOLþQLGRSULQRVRWRPH]DãWRMHSRVDRSUXåDQMD
VHNVXDOQLK XVOXJD SRVDR UD]OLFL L]PHÿX OHJDOQLK L QHO
HJDOQLKXUHÿHQMDLQHGRVWDWNXSUDYD
KWWSSDJDLGVRUJÀDVKDVS["SLG Hilary Clinton
*RYRURSURWHVWXSURWLYDPHULþNLKSUHNRRNHDQVNLKWUJRY
LQVNLK VSRUD]XPD NRML RJUDQLþDYDMX SULVWXS JHQHULþNLP
OHNRYLPD ³âWD EL $,'6 NRQIHUHQFLMD ELOD EH] PDOR
SURWHVWD"'HOLPLþQLUD]ORJ]ERJNRMHJVPRGRãOLQDMGDOMH
do sada jeste taj što mnogo ljudi širom sveta nije zadoYROMQRRQLPãWRVPRXþLQLOLLMDVDPRYGHGDSRVWDYLP
FLOM]DJHQHUDFLMXVORERGQXRG$,'6D´
.DRRVQRYQLJRYRU]DUD]XPHYDQMHSURPHQHSROLWLþNRJ
SULVWXSD6$'SUHPD+,9XSULPHWQRGUXJDþLMLRG³KLWQH´
UHDNFLMH³(´X3(3)$5X³$NRåHOLPRGDVSDVHPRYLãH
åLYRWDPRUDPRLüLWDPRJGHVHYLUXVQDOD]L$WR]QDþL
da nauka treba da upravlja našim naporima´3ROLWLþNLL
OLþQRPLQXWDSUHGDYDQMDR3URPHQLSOLPH
KWWSJOREDOKHDOWKNIIRUJ$,'6-XO\HQGLQJ
WKHHSLGHPLF
Anna Zakowicz i Ian McKnight
$NWLYLVWLL]3ROMVNHLVD-DPDMNHGDOLVXVYRMVWDYQD]D
WYRUHQRP SUHGDYDQMX 8 SR]LYX QD XQLYHU]DOQR OHþHQMH
L]D]YDOLVXIDUPDFHXWVNHNRPSDQLMH³Zašto niste u grupi
3DWHQW3RRO"=DãWRRJUDQLþDYDWHSULVWXSJHQHULþNLPOHNRYLPD"=DãWRL]GUåDYDWHGRNWRUHQDRYRMNRQIHUHQFLMLNDGD
OMXGL XPLUX RG $,'6D QD XOLFDPD +DUDUH 6RZHWRD L
Islamabad-.´L6$'³=DãWRVMHGQHVWUDQHRPRJXüDYDWH
OHþHQMHSUHNR3(3)$5DGRNVGUXJHVWUDQHXVNUDüXMHWH
OHþHQMHSRGUåDYDMXüLWUJRYLQVNHVSRUD]XPHNRMLEORNLUDMX
SULVWXSMHIWLQLPJHQHULþNLPOHNRYLPD´
KWWSSDJDLGVRUJÀDVKDVS["SLG 5RODNH2GHWR\LQER
³äHQHVD+,9RPVXSUHãOHGDOHNLSXWRGQXOHPDQMH
RGVPHüDGRWRJDGDVHQDÿX]DSUHJRYDUDþNLPVWRORP
PRUDOH VPR GD ]DVOXåLPR QDãH PHVWR %RULOH VPR
VH]DRYRDOLWDNRÿHSR]GUDYOMDPRRQHOMXGHNRMLVXQDP
SRPRJOL GD RWYRULPR YUDWD 1LVPR WUDåLOH GD EXGHPR
OLFH+,9DDOL+,9SR]LWLYQLKOMXGLX$IULFLVXåHQH
äHQHVXWDNRÿHSUXåDRFLQHJHXVOXþDMHYDGRNWRUL
Sharon Lewin
1D ]DWYRUHQRP SUHGDYDQMX 6KDURQ /HZLQ MH REHüDOD
VYLPGHOHJDWLPDGDüHELWLGREURGRãOLX0HOEXUQX
JRGLQH XNOMXþXMXüL L ELYãH L WUHQXWQH UDGQLNH X VHNWRUX
SUXåDQMDVHNVXDOQLKXVOXJDLNRULVQLNHLQMHNWDELOQLKGUR
JD =DEUDQD SULVWXSD 6$'D VSUHþLOD MH RYH GHOHJDWH L]
]HPDOMDYDQ6$'DGDRWYRUHQRSULVXVWYXMXNRQIHUHQFLML
LRYRMHLVWDNQXWRXPQRJLPSUH]HQWDFLMDPD
KWWSJOREDOKHDOWKNIIRUJ$,'6-XO\&ORVLQJ
6HVVLRQDVS[
&52,±.RQIHUHQFLMDRUHWURYLUXVLPDLRSRUWXQLVWLþNLPLQIHNFLMDPD
5. – 8. 3. 2012. Sijetl, SAD
Uvod
.RQIHUHQFLMD R UHWURYLUXVLPD L RSRUWXQLVWLþNLP LQIHNFL
MDPD&52,MHYHURYDWQRQDM]QDþDMQLMLJRGLãQMLQDXþQL
VDVWDQDNQDWHPX+,9DLMHGDQRGQDMGRVWXSQLMLK]DVYH
RQH NRML QLVX ELOL X PRJXüQRVWL GD SULVXVWYXMX 9HüLQD
SUH]HQWDFLMDVHQDOD]LQDLQWHUHQHWXEHVSODWQRLEH]UHJLV
*RGLQD,EURM
WURYDQMD$SVNWUDNWLL3')IDMORYLPQRJLKSRVWHUSUH]HQ
WDFLMDVXWDNRÿHGRVWXSQLQDLQWHUQHWX
KWWSUHWURFRQIHUHQFHRUJ
1DNRQIHUHQFLMLMHELORSUH]HQWRYDQRYLãHRGVWXGL
MDRGNRMLKVPRRGDEUDOLQHNHLSUHGVWDYOMDPRLKXRYRP
EURMX
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
,VWUDåLYDQMHOHNDSUHX]LPDJODYQXUHþ
GRND]NRQFHSWD]DDNWLYLUDQMHVNULYHQRJUH]HUYRDUD
Simon Collins, HIV i-Base
7RNRPSUHWKRGQHGYHJRGLQHQDQDMYHüLPNRQIHUHQFLMDPDR+,9XXNOMXþXMXüL&52,L,$60HÿXQDURGQR
$,'6GUXãWYRLVWUDåLYDQMDROHNXSURWLY$,'6DGRELOD VX LVWDNQXWR PHVWR X JODYQRP SURJUDPX 2YR
SUHGVWDYOMDQRYLQXLYHRPD]QDþDMQXSURPHQX
1D&52,NRQIHUHQFLMLJRGLQH$QWKRQ\)DXFLãHI
DPHULþNRJ1DFLRQDOQRJLQVWLWXWD]DDOHUJLMVNHLLQIHNWLYQH
EROHVWL1,$,'MHREMDYLRGDüHYODGD6$'DSRNUHQXWL
QRYHIRQGRYH]DLVWUDåLYDQMHOHNDSURWLY$,'6D>@
0QRJLLVWUDåLYDþLL]RYHQDXþQHREODVWLVXUDGLOLQDOHNX
JRGLQDPDQHNLþDNLGHFHQLMDPD$OLQRYLPRWLY]DRYD
LVWUDåLYDQMDXYLGXYHüLK¿QDQVLMVNLKVUHGVWDYDVYDNDNR
SUHGVWDYOMDYDåDQIDNWRUSRSLWDQMXEU]LQHQDSUHGRYDQMD
LVWUDåLYDQMDXEXGXüQRVWL
1RYLL]YRUL¿QDQVLUDQMDVXVHPRåGDPDNDUGHOLPLþQR
MDYLOL]DKYDOMXMXüLRGJRYRUQRVWLNRMXMH$PHULNDSUHX]H
OD QD VHEH NDR QDMYHüL GRQDWRU ]D JOREDOQH SURJUDPH
OHþHQMD +,9D 7RNRP SURWHNOLK GHVHW JRGLQD SULVWXS
$59X X ]HPOMDPD VD QLVNLP L VUHGQMLP SULKRGRP VH
SRYHüDR VD PDQMH RG PLOLRQD OMXGL GR SUHNR
PLOLRQDOMXGLJRGLQH'XJRURþQDDOWHUQDWLYD]D
GXJRWUDMQR OHþHQMH üH VWRJD YHURYDWQR SRVWDWL HNRQRP
VNLDOLLPHGLFLQVNLQHRSKRGQD,DNRWUHQXWQDLVWUDåLYDQMD
OHND NRULVWH VSHFLMDOL]RYDQH L VNXSH SURFHGXUH NDR ãWR
MHVOXþDMNRGVYLKQRYLKUD]YRMDNDRãWRMHELRVOXþDML
VD DQWLUHWURYLUXVQRPWHUDSLMRPRþHNXMHPRGDüH VH YL
VRNLLQLFLMDOQLWURãNRYLVPDQMLWLNDNRELOHNQDLVWLQDþLQ
SRVWDRãLUHGRVWXSDQ
,$6MHWDNRÿH]DX]LPDROLGHUVNXXORJX]DNRRUGLQLVDQMH
JOREDOQRJ ¿QDQVLUDQMD LVWUDåLYDQMD OHND L QDGDPR VH
]DIRNXVLUDQMHQDPDSHLVWUDåLYDQMDNRMHüHSRQDYOMDQMH
LVWLKLVWUDåLYDQMDVYHVWLQDPLQLPXP>@,$6MHRUJDQL
]RYDR UDGLRQLFH SUH VYRMH GYH SRVOHGQMH NRQIHUHQFLMH D
MRãMHGQDVHSODQLUDSUHVDVWDQNDX9DãLQJWRQXMXOD
>@1HNROLNRUDGLRQLFDX]DMHGQLFDPDXNOMXþXMXüLLRQX
SUH&52,NRQIHUHQFLMHRGUåDQHRYHJRGLQHVXWDNRÿHGR
SULQHOHãLUHQMXVYHVWLRSRWHQFLMDOX]DSURQDODåHQMHOHND
SURWLY$,'6D>@
3RUHGSURWRNRODXVPHQRJNUDWNRJSUHJOHGDRYHJRGLQH
&52,MHREXKYDWLODLQHNROLNRSRPRüQLKSUH]HQWDFLMDR
WUHQXWQRPLVWUDåLYDQMXWRNRPSUHGNRQIHUHQFLMVNLKUDGL
RQLFD]DPODGHLVWUDåLYDþHSRVHEQRL]ODJDQMHRGVWUDQH
-RKQ0HOORUVDLJRYRURåLYRWLQMVNLPPRGHOLPDXYH]LVD
ODWHQWQRãüXRGVWUDQH9LQFHQWH3ODQHOOHVD>@
ZZZKLYELOWHQLQIR
Berlinski lek
%LOR SXWHP SRVUHGRYDQRJ LPXQLWHWD MRã VH QD]LYD L
IXQNFLRQDOQL OHN LOL HUDGLNDFLMRP LVNRUHQMLYDQMHP
VWHULOLãXüL OHN PRJXüQRVW SUHYD]LODåHQMD GRåLYRWQRJ
WUHWPDQD RGXYHN MH SUHGVWDYOMDOD NRQDþQL FLOM LDNR VH
IRNXVSURWHNOLKJRGLQDSRPHULRNDGRVWL]DQMXHIHNWLYQL
MLKSRGQRãOMLYLMLKLGXJRWUDMQLMLKWUHWPDQD
3UYL L]YHãWDM R OHNX NRML MH RSLVLYDR WUDQVSODQWDFLMX
PDWLþQLKüHOLMDVDGRQRUDNRMLMHELRSULURGQRUH]LVWHQWDQ
QD +,9 LQIHNFLMX RQ MH ELR KRPR]LJRWQL QRVLODF GHOWD
GHOHFLMH SRUFLMH &&5 JHQD MH SUHGVWDYOMHQ WRNRP
&52,NRQIHUHQFLMHH>@DVYHYHüDSRNULYHQRVWX
PHGLMLPDRGWDGDMHXþLQLODGDRYREXGHYHRPDSXEOLNR
YDQVOXþDMNRMLMHGRQHRRSWLPL]DPXREODVWLVWUDåLYDQMD
OHND
0HKDQL]DP ]DVOXåDQ ]D L]OHþHQMH 7LPRWK\ %URZQD
SR]QDWRJSRGQD]LYRP%HUOLQVNLSDFLMHQWNRMLMHSUHVWDR
VDWUHWPDQLPDLNRGNRJDYHüYLãHRGþHWLULJRGLQHQHPD
WUDJRYD+,9DQLMHL]RORYDQQDSRMHGLQDþQRMNRPSRQHQWL
L]NRPSOHNVQRJLUL]LþQRJVNXSDSURFHGXUD
3RUHGPLMHORDEODWLYQHKHPRWHUDSLMHL]UDþHQMDþLWDYRJWHOD
NRMHXELMDMXXMHGQRL+,9LQ¿FLUDQHLQHLQ¿FLUDQHLPXQH
üHOLMH SULPLR MH L DQWLWLPRFLWQH JOREXOLQH FLNORVSRULQ
PLNRIHQROQXNLVHOLQX00)LJHPWX]XPDEDQWL&'
NRML WDNRÿH XELMDMX +,9LQ¿FLUDQH L QHLQ¿FLUDQH üHOLMH
SUDüHQRDORJHQLþQLPüHOLMVNLPWUDQVSODQWLPDRGGRQRUD
KRPR]LJRWQRJ QRVLRFD GHOWD PXWDFLMH NRML VX WUHED
OL GD XVSRVWDYH LPXQL VLVWHP UH]LVWHQWDQ QD &&5 +,9
LQIHNFLMX .RG QMHJD VD UD]YLOD EROHVW PDWLþQHSURWLY
GRPDüLQD JUDIW YV KRVW GLVHDVH *9+' XND]XMXüL
QD SULKYDWDQMH LPXQRJ VLVWHPD GRQRUD 2YH SURFHGXUH
VDGUåH UL]LN RG VPUWQRJ LVKRGD D RQ MH VYDNRM RG
SURFHGXUD ELR SRGYUJDYDQ GYD SXWD SRãWR MH SRVWXSDN
SRQRYOMHQ
8VPHQDSUH]HQWDFLMDQD&52,MHL]YHVWLODRGHVHWSDFL
MHQDWDQDVXSUHVLYQRM$57NRMLVXELOLSRGYUJQXWLDXWR
ORJQRM WUDQVSODQWDFLML VDPRGRQLUDQRM KHPDWRSRHWVNLK
PDWLþQH üHOLMD ]D OHþHQMH OLPIRPD SRYH]DQRJ VD$,'6
ãWRMHPDQMHUL]LþQDSURFHGXUDRGRQHNRULãüHQHNRG7LP
%URZQD 1D åDORVW +,9 YLUHPLMD MH L GDOMH ELOD GHWHN
WRYDQD NRG RG SDFLMHQDWD QDNRQ WUDQVSODQWDFLMH
VD SURVHþQLP EURMHP YLUXVQLK NRSLMD RG NRSLMDP/
RSVHJWRLSURVHþQRXNXSQR+,9'1.RG
NRSLMDPLOOLRQ3%0&RYDRSVHJWR/75
VHNYHQFH VX VH PRJOH GHWHNWRYDWL SRVOH WUDQVSODQWDFLMH
VDPRNRGRGSDFLMHQDWDRSVHJGRNRSLMDPLOLRQ
3%0&RYD-HGLQLSDFLMHQWNRGNRJDQLMHELORPRJXüH
GHWHNWRYDWLEURMYLUXVQLKNRSLMDXSOD]PLMHLPDRQDMYLãH
*RGLQD,EURM
+,9%,/7(1+7%H
QLYRH +,9 '1. L /75 VHNYHQFL 3RUHG WRJD YLUH
PLMDXSOD]PLMHRSVWDODNRGSDFLMHQWDNRGNRJDVHQLMH
PRJODGHWHNWRYDWL+,9'1.X3%0&,DNRVXDXWRUL
]DNOMXþLOLGDMHRYRSRND]DORGDMH&&5GHOWDGRQRU
ELRRGVXãWLQVNHYDåQRVWLX%HUOLQVNRPVOXþDMXSDFLMHQWL
XQMLKRYRMVWXGLMLWDNRÿHQLVXELOLSRGYUJDYDQL]UDþHQMX
þLWDYRJWHODEROHVWLPDWLþQHSURWLYGRPDüLQDLSRQRYR
VXLPXEUL]JDQHQMLKRYHVRSVWYHQHPDWLþQHüHOLMHNRMHVX
PRJOHVDGUåDWL+,9LQ¿FLUDQH7üHOLMH>@
'RGDWQD VWXGLMD üH ELWL SRNUHQXWD X 6$' D EDYLüH VH
DORJHQLþQRP WUDQVSODQWDFLMRP PDWLþQLK üHOLMD NRG +,9
SR]LWLYQLKRVREDVDREROMHQMHPNRãWDQHVUåLX]QDGXGDüH
LOLRGSDFLMHQDWDWDNRÿHELWLXVWDQMXGDVHXVNODGL
VDGHOWDGRQRURPNDNRELVPRYLGHOLGDOLVH%HUOLQVNL
VOXþDMPRåHSRQRYLWL>@
2YRüHREXKYDWLWLSUHYD]LODåHQMHSRWHãNRüDSURQDODåHQMD
LSRNODSDQMDGHOWDGRQRUDNRMLMHWDNRÿHNRPSDWLELODQ
SR SLWDQMX +/$ WLSRYD 1D VDVWDQNX R OHNX X RNYLUX
]DMHGQLFHSUHRGUåDYDQMD&52,-RKQ=DLDL]&HQWUD]D
NDQFHUÄ*UDGQDGH³EOL]X/RV$QÿHOHVDRSLVDRMHLQLFL
MDWLYX]DNUHLUDQMHVSLVNDGRQRUDPDWLþQLKüHOLMDXYLGX
PHÿXQDURGQRJUHVXUVDDGRGDQDVRGWHVWLUDQLK
GRQRUDQMLKMHLGHQWL¿NRYDQRNDRKRPR]LJRWQLQRVL
RFL]D&&5GHOWDGHOHFLMX>@
3UYD DNWLYDFLMD ODWHQWQR LQ¿FLUDQRJ UH]HUYRDUD
7üHOLMDXPLURYDQMXLQYLYR
0DGD VX PQRJL DVSHNWL RYRJ LVWUDåLYDQMD NRQWURYHU
]QL SRVWRML ãLURNL NRQVHQ]XV R SRWUHEL ]D VWUDWHJLMRP
SUHYD]LODåHQMD UH]HUYRDUD GXJRYHþQLK ODWHQWQR LQ
¿FLUDQLK&'üHOLMDXPLURYDQMXNRMHVDGUåHLQWHJULVDQL
+,9LGRNRMLKQHGRSLUHWUHQXWQD$57
9UHGLLVWDüLWRGDMHXVPHQDSUH]HQWDFLMDQD&52,REXK
YDWLODUH]XOWDWHL]VWXGLMHGRND]DNRQFHSWDGDVHYLUDOQD
ODWHQWQRVW PRåH SUHYD]LüL 'DYLG 0DUJROLV VD 8QLYHU
]LWHWD6HYHUQD.DUROLQDMHSUHGVWDYLRUH]XOWDWHXRNYLUX
XVPHQHSUH]HQWDFLMHGDMHXSRWUHEDMHGQHGR]HLQKLELWRUD
KLVWRQ GHDFHWLOD]H +'$& YRULQRVWDWD VXEHURLODQLOLG
KLGURNVDPLþQDNLVHOLQD6$+$XVWDQMXGDDNWLYLUDOD
WHQWQR LQ¿FLUDQH &' üHOLMH X PLURYDQMX >@ H
JRGLQH 0DUJROLV MH SUHGVWDYLR UH]XOWDWH NRULãüHQMD MRã
MHGQRJ+'$&LQKLELWRUDYDOSURLQVNHNLVHOLQHSULVWLPX
ODFLMLODWHQWQRJUH]HUYRDUD
2GKXPDQLKKLVWRQGHDFHWLOD]D+$'&LSUHG
VWDYOMDMX SULPDUQH HQ]LPH NRML RJUDQLþDYDMX DNWLYDFLMX
+,9YLUXVDLQWHJULVDQLKXüHOLMDPDSURL]YRGQMRPSUHSUH
NDNRMH]DGUåDYDMXODWHQWQRVW9RULQRVWDWMHVHOHNWLYQLLQ
KLELWRU+'$&L]DNRMLMHSRND]DQRGDLQGXNXMH
+,9HNVSUHVLMXL]ODWHQWQRLQ¿FLUDQLKüHOLMDXPLURYDQMX
H[YLYR0HÿXWLPYRULQRVWDWPDGDSRWYUÿHQXWUHWPDQX
NDQFHUDWDNRÿHLPDLPXWDJHQDVYRMVWYD
8RYRMVWXGLMLGRND]DNRQFHSWDSURPHQDODWHQWQRJUH]HU
YRDUD MH RGUHÿHQD PHUHQMHP EURMD üHOLMD SRYH]DQLK VD
+,9 51. SRVHEQR NRG SRSXODFLMH üHOLMD X PLURYDQMX
2YRREXKYDWDXNODQMDQMHRWSULOLNHþHWLULPLOLMDUGLOLPIR
FLWDSXWHPOHXNRIHUH]HL]VYDNRJDYLUHPLþQRJSDFLMHQWD
*RGLQD,EURM
NRML VH WUHWLUDMX PDJQHWVNLP ]UQLPD DQWLWHOD NDNR EL VH
RVWDYLOR&'üHOLMDXPLURYDQMXNRMHVHPRJX
WHVWLUDWLSRPRüX51.3&5
âHVWXþHVQLNDVWXGLMHMHSRGYUJQXWRSRþHWQLPPHUDPDDN
WLYDFLMHLWHVWLUDQLVXH[YLYRQDNRQL]ODJDQMDYRULQRVWDWX
ãWRMHGHPRQVWULUDORGDMHSURPHQDELODPHUOMLYDNRGVYLK
SDFLMHQDWD6YDNLSDFLMHQWMHWDNRÿHELRSRGYUJQXWMHGQRM
VLJXUQRVQRMGR]LRGPJLRGYRMHQRMGR]LRGPJ
YRULQRVWDWDUDGL3.GRND]NRQFHSWDVWXGLMHNDNRELVH
RGUHGLRWDMPLQJ]DGUXJXOHXNRIHUH]XNRMDMHNRULãüHQD
]DRGUHÿLYDQMHH¿NDVQRVWL
1DNRQGUXJHWHUDSHXWVNHGR]HRGPJVYLKãHVWSDFL
MHQDWD MH UHDJRYDOR YHRPD YHOLNLP SURVHþQLP VWUX
NLP SRYHüDQMHP RSVHJ VWUXNR 51. HNVSUHVLMH
NRG&'üHOLMDXPLURYDQMXS7UHWPDQMHGREUR
SRGQHVHQEH]SULMDYOMHQLKVSRUHGQLKHIHNDWDSRYH]DQLKVD
YRULQRVWDWRPLQLMHGDQQLMHLPDRYHüXRFHQXRG9UHGL
QDSRPHQXWLãWRMHPRåGDLL]QHQDÿXMXüHWRGDQLVXGH
WHNWRYDQDSRYHüDQMD+,951.XSOD]PLSULPHQRPWHVWD
SRMHGLQDþQHNRSLMHXP/VLQJOHFRS\P/WHVW
6WXGLMDMH]DNOMXþLODGDMHRYRELODSUYDGHPRQVWUDFLMDDN
WLYDFLMHODWHQWQLK+,9LQ¿FLUDQLK&'üHOLMDXPLURYDQMX
LQYLYR0HÿXWLPRYLUH]XOWDWLVXMRãXYHNSUHOLPLQDUQL
0DGD MH GRND]NRQFHSWD X]EXGOMLY 0DUJROLV MH XND]DR
QD WR GD VH RYR PRåH SRVPDWUDWL NDR HNYLYDOHQW ÄGG&
PRPHQWDXYH]LVD+$$57RP³
3RUHGWRJDRVWDOLPROHNXOLPRJXSUHGVWDYOMDWLHIHNWLYQL
MD MHGLQMHQMD ]D DNWLYDFLMX ODWHQWQRVWL D LQ YLYR SRGDFL
XND]XMXQDWRGDMHSDQRELQRVWDWDNWLYQLMLRGYRULQRVWDWD
>@
5DQLMH WRNRP LVWRJ NRQIHUHQFLMVNRJ SURWRNROD /LDQJ
6KDQ MH L]MDYLOD GD VX ODWHQWQR LQ¿FLUDQH &' üHOLMH X
PLURYDQMX NRMH VX WUHWLUDQH YRULQRVWDWRP SUHåLYHOH
XSUNRV YLUDOQRP FLWRSDWVNRP GHMVWYX þDN L X SULVXVWYX
DXWRORJQLK &' üHOLMD NRG YHüLQH SDFLMHQDWD QD$57X
]DNOMXþXMXüL ÄGD VWLPXOLVDQMH +,9VSHFL¿þQLK &7/
UHDNFLMD SUH UHDNWLYDFLMH ODWHQWQRJ +,9 PRåH ELWL RG
VXãWLQVNHYDåQRVWL]DXVSHãQHQDSRUHHUDGLNDFLMHLWUHED
JDX]HWLXRE]LUXEXGXüLPNOLQLþNLPWHVWLUDQMLPD³>@
Tretman tokom rane infekcije
7HRUHWVNL QDMODNãH PHWH ]D LVWUDåLYDQMH OHND PRJX ELWL
RQLSDFLMHQWLNRGNRMLKMHQDMUDQLMHGLMDJQRVWLNRYDQDLQ
IHNFLMDNRMLEU]RSRþQXVDWUHWPDQRPLNRML]DGUåDYDMX
VXSUHVRYDQXYLUHPLMXWRNRPPQRJRJRGLQD
,DNR VH ODWHQWQL UH]HUYRDU üHOLMD XVSRVWDYOMD X URNX RG
QHNROLNR QHGHOMD RG LQ¿FLUDQMD L YHURYDWQR üH VH VSRUR
VPDQMLYDWL SRVOH GXJRJ QL]D JRGLQD SULPHQH HIHNWLYQH
$57NRGVNRURVYLKSDFLMHQDWDYLUHPLMDVHEU]RYUDüD
XURNXRGQHNROLNRQHGHOMDXNROLNRVHWUHWPDQSUHNLQH
ýDNLXNROLNRVH+,9VPDQMLXWRMPHULGDMHSULVXWDQNRG
PDQMHRGXPLOLMDUGLüHOLMDWRMHGRYROMQR]DEU]R
YUDüDQMH VLVWHPDWLþQH LQIHNFLMH X URNX RG GYD PHVHFD
XNROLNRVHWUHWPDQ]DXVWDYL>@
0DGDRYDNRQLVNLQLYRLPRJXGRYHVWLXSLWDQMHYDåQRVW
WUHWPDQDNRMLFLOMDYLUXVQLUH]HUYRDURQLVH]DVDGDPRJX
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
GRVWLüL LVNOMXþLYR YHRPD UDQLP SRþHWNRP WUHWPDQD LLOL
GXJRJRGLãQMRP YLUXVQRP VXSUHVLMRP 3RWUHED ]D EUåLP
VPDQMHQMHP YLUXVQRJ UH]HUYRDUD üH SUHGVWDYOMDWL EULJX
]DVYDNRJNRMH]DSRþHRVD$57RPWRNRPKURQLþQHLQ
IHNFLMH
%U]L RSRUDYDN YLUXVD EH] WUHWPDQD MH ãLURNR SUHSR]QDW
X EURMQLP VWXGLMDPD SUHNLGD WUHWPDQD 0HÿXWLP NRG
QHNROLNRPDOLKNRKRUWLMHWDNRÿHSULMDYOMHQDYLUXVQDNRQ
WUROD NRG PDORJ EURMD SDFLMHQDWD RELþQR NRG RQLK NRML
VX ]DSRþHOL WUHWPDQ WRNRP DNXWQH LQIHNFLMH L RGUåDYDOL
EURMYLUXVQLKNRSLMDNRMHVHQHPRåHGHWHNWRYDWLWRNRP
QHNROLNRJRGLQD
3RVOHGQMHJRGLQHQD&52,NRQIHUHQFLML$1569LVFRQWL
VWXGLMDMHRWNULODPDOLEURMSDFLMHQDWDNRMLVX]DSRþHOLVD
WUHWPDQRP WRNRP UDQLK ID]D LQIHNFLMH QDNRQ VHURNRQ
YHU]LMH SURVHþQL EURM YLUXVQLK NRSLMD! NRSLMD
P/RGUåDYDOLYLUXVQXVXSUHVLMXYLãHRGJRGLQHQDWUHW
PDQXLNRMLVXNDVQLMHVWDYLOLYLUHPLMXSRGNRQWUROXYDQ
WUHWPDQD WRNRP YLãH RG JRGLQD >@ 2YH JRGLQH QD
&52,NRQIHUHQFLMLVXSULMDYOMHQLVOLþQLVOXþDMHYLNRGMRã
GYHJUXSH
0DULD 6DOJDGR L NROHJH VX SULMDYLOL SRMHGLQDþQL VOXþDM
SDFLMHQWDNRMLMHSRþHRVDWUHWPDQRPWRNRPVHURNRQYHU
]LMHEURMYLUXVQLKNRSLMD!NRSLMDP/QHRGUHÿHQ
UH]XOWDWZHVWHUQEORWDQDOL]RPWRNRPWULJRGLQHDQDNRQ
SUHNLGD$57DMHRGUåDYDREURMYLUXVQLKNRSLMDVXSUHVR
YDQLP QD PDQMH RG NRSLMDP/ YDQ WUHWPDQD WRNRP
YLãHRGGHYHWJRGLQD3RþHWQLLWUHQXWQLYLUXVQLL]RODWLVX
GYRVWUXNL&&5&;&5WURSVNLLSRWSXQRVHPRJXUH
SOLFLUDWLLQYLWUR0LQLPDOQDHYROXFLMDYLUXVDMHELODGH
WHNWRYDQDWRNRPJRGLQD
.RG WRJ SDFLMHQWD VX WUHQXWQR SULMDYOMHQL QLVNL WLWUL
QHXWUDOL]XMXüLKDQWLWHOD]DKHWHURORJQHLDXWRORJQH+,9
L]RODWH D QMHJRYH &'7 üHOLMH QH SRVHGXMX SRWHQWQX
+,9VXSUHVLYQXDNWLYQRVWãWRXND]XMHQDPHKDQL]DPNRML
VH UD]OLNXMH RG &7/SRVUHGRYDQH VXSUHVLMH SULMDYOMHQH
NRGNRQWUROQHJUXSH>@
$ODLQ/DIHXLOODGHL]2SãWHEROQLFH7RXORQNRMLMHWDNRÿH
LMHGDQRGNOMXþQLKRUJDQL]DWRUD0HÿXQDURGQHUDGLRQLFH
]DRWSRUQRVWQD+,9NRMDVHRGUåDYDODQDVYDNHGYHJRGLQH
RGHMHRWNULRGDMHL]NRKRUWHSDFLMHQD
WDWUHWLUDQLKWRNRPVHURNRQYHU]LMHXSURVHNXJRGLQH
RSVHJGRRVWDORYDQWUHWPDQDWRNRPYLãHRG
JRGLQDDGYRMHSDFLMHQDWDMHRGUåDORVXSUHVLMXQDPDQMH
RGNRSLMDP/SURVHNNRSLMDP/NRGSUHRVWDOLK
ãHVWSDFLMHQDWDRVREDNRMHVXSRQRYRSRþHOHVDWUHW
PDQRP]ERJSRWYUÿHQRJSDGDEURMD&'üHOLMDQDPDQ
MHRGüHOLMDPPWRVXXUDGLOHQDNRQSURVHþQR
JRGLQDRSVHJSURYHGHQLKYDQWUHWPDQD6WXGLMD
MHXND]DODQDWRGD]DãWLWQLPHKDQL]DPPRåHELWLSRYH]DQ
VDUDQRP$57NRMDVPDQMXMH+,9UH]HUYRDUDOLMHWDNRÿH
QDJODVLODGDVXWDNYHUHDNFLMHL]JOHGDUHWNH>@
,]YHãWDM-RVHSK0DUJROLFNDLNROHJDMHRWNULRPDOHUD]
OLNHXYLUHPLMLL]PHÿXRVREDVDUDQRGLMDJQRVWLNRYDQRP
LQIHNFLMRP X URNX RG JRGLQX GDQD RG LQ¿FLUDQMD SRV
ODWLK QD KLWDQ WUHWPDQ Q L RQLK NRML QLVX SRþHOL VD
ZZZKLYELOWHQLQIR
UDQLPWUHWPDQRPQ 0HÿXWLPEURMNHL]VWXGLMHVX
ELOH YHRPD QLVNH X WUHQXWNX SURFHQH PHVHFL QDNRQ
SUHNLGD WUHWPDQD LOL PHVHFL QDNRQ GLMDJQR]H ]ERJ
aJXELWNDSRSLWDQMXQDVWDYNDSUDüHQMDSDFLMHQDWDL
]ERJLVNOMXþHQMDRVREDNRMHVXSRQRYR]DSRþHOHWUHWPDQ
L]GUXJLKUD]ORJD>@
*HQHUDOQR PDOH UD]OLNH VX WDNRÿH SULMDYOMHQH ]D UDQL
SRþHWDN WUHWPDQD X RNYLUX YHüH 63$57$& VWXGLMH NRMD
MHVOXþDMQLPX]RUNRPSRGYUJODVNRURRVREDVDSRVW
DYOMHQRPGLMDJQR]RPXURNXRGPHVHFLRGLQ¿FLUDQMD
RGORåHQRM $57 LOL KLWQRP WUHWPDQX X WUDMDQMX RG LOL PHVHFDLOLPHVHFLDSRWRPMHWUHWPDQSUHNLQXW>@
0HÿXWLP X NRQWHNVWX LVWUDåLYDQMD HUDGLNDFLMH GYH XV
PHQHSUH]HQWDFLMHVXXND]DOHQDWRGDUDQLWUHWPDQPDGD
SUHNDVQR ]D VSUHþDYDQMH XVSRVWDYOMDQMD YLUXVQRJ UH]HU
YRDUDPRåHVPDQMLWLEURMODWHQWQRLQ¿FLUDQLKüHOLMD
0DULD %X]RQ L NROHJH VX SURFHQLOL YHOLþLQX YLUXVQRJ
UH]HUYRDUDNRGSDFLMHQDWDWUHWLUDQLKYLãHRGGHVHWJRGLQD
NRG NRMLK MH ]DSRþHWD$57 X URNX RG PHVHFD RG LQ
IHNFLMH Q L XSRUHGLOL VX QMLKRYH QLYRH LQWHJULVDQH L
XNXSQH+,9'1.VDRVREDPDNRMHVX]DSRþHOHWUHWPDQ
WRNRP KURQLþQH LQIHNFLMH Q L VD RVREDPD L] NRQ
WUROQHJUXSHQ >@
1LYRL LQWHJULVDQH L XNXSQH '1. VX ELOL ]QDþDMQR QLåL
XMHGQRLNRGSULPDUQRWUHWLUDQHS LS UHV
SHNWLYQRLNRQWUROQHJUXSHS LSUHVSHN
WLYQRXSRUHÿHQMXVDRVREDPDWUHWLUDQLPWRNRPKURQLþQH
LQIHNFLMH3RUHGWRJDRGQRVL]PHÿXXNXSQHLLQWHJULVDQH
+,9'1.MHELR]QDþDMQRQLåLNRGUDQRWUHWLUDQLKLNRQ
WUROQLKRVREDNRGREHS XRGQRVXQDKURQLþQHEH]
UD]OLNDL]PHÿXDNXWQHLNRQWUROQHJUXSH
,DNRMHEURMSDFLMHQDWDELRPDOLSULPHüHQHVXUD]OLNHSUL
SRUHÿHQMXHIHNDWDVDUD]OLþLWLPSHULRGLPDSRþHWNDWHUDSL
MHNRGSDFLMHQDWDWRNRP)LHELJVWDGLMXPD,,,L,9VSUDP
VWDGLMXPD9 GYH JRGLQH NDVQLMH NDGD VX LPDOL ]QDþDMQL
QLåHQLYRHLXNXSQRJLLQWHUJLVDQRJ'1.+,9D
8VPHQD SUH]HQWDFLMD $ODQD 3HUHOVRQD L] /RV $ODPRV
1DFLRQDOQHODERUDWRULMHXNOMXþLYDODMHPDWHPDWLþNRPRG
HOLUDQMH ]D VDJOHGDYDQMH XWLFDMD UDQRJ WUHWPDQD NRG RVRED WUHWLUDQLK WRNRP DNXWQH LQIHNFLMH QD YHOLþLQX OD
WHQWQRJUH]HUYRDUDLYH]HXMHGQRLVDLQLFLMDOQLPEURMHP
YLUXVQLKNRSLMDLVDVSRVREQRãüXFLOMDQHüHOLMH>@
2YDVWXGLMDMHWDNRÿHL]YHVWLODGDUDQLMLSRþHWDN$57D
XNOMXþXMXüL L UDQLML SRþHWDN WRNRP SULPDUQH LQIHNFLMH
LPDYHOLNLXWLFDMSRSLWDQMXLQLFLMDOQHYHOLþLQHUH]HUYRDUD
JGHSDFLMHQWLNRMLVXYHüSRþHOLVDYHRPDQLVNLPQLYRLPD
LQIHNFLMH üHOLMD X PLURYDQMX NRML VX WDNRÿH LPDOL QLVNH
QLYRHPDNVLPDOQLKEURMHYDYLUXVQLKNRSLMDGRåLYOMDYDMX
PDQMH SURPHQH X VPDQMHQMX EURMD üHOLMD X PLURYDQMX
0RGHOMHWDNRÿHXND]DRQDWRGDSRYHüDQMHEURMD&'7
üHOLMDXRNYLUXRGJRYRUDQDXVSHãQX$57QLMHSRYHüDOR
YLUXVQLUH]HUYRDU
,VWUDåLYDQMHIXQNFLRQDOQRJOHND
2VWDOH JUXSH VH IRNXVLUDMX QD LPXQRORãNH LQWHUYHQFLMH
NRMHELSRGUåDOHIXQNFLRQDOQLDQHHUDGLNDFLRQLOHN
*RGLQD,EURM
+,9%,/7(1+7%H
3DEOR 7HEDV VD 8QLYHU]LWHWD 3HQVLOYDQLMD MH SUHGVWDYLR
GRGDWQH UH]XOWDWH R EH]EHGQRVWL L H¿NDVQRVWL XSRWUHEH
FLQNRYSUVWQXNOHD]D=)1PRGL¿NDFLMH&'üHOLMDSUL
PHQRP 6% QD &&5L]EULVDQL GHOHWLUDQL IHQRWLS
XVDUDGQMLVD6DQJDPR%LR6FLHQFHV>@
2YDMSURFHVREXKYDWDXNODQMDQMHüHOLMDDIHUH]RPQMLKR
YRWUHWLUDQMHVD6%NDNRELVHGRELORüHOLMD
VD &&5GHOHFLMDPD LQ YLWUR ûHOLMH VH ]DWLP SURãLUXMX
REDYOMDVHNULRSUH]HUYDFLMDDPLOLMDUGLüHOLMDVHSRQ
RYRXEUL]JDYDXGRQRUVNRJSDFLMHQWD
5H]XOWDWLVXLVNRPELQRYDQLL]WULVWXGLMHMHGQDQDGSDFL
MHQWLPD VD UHDNFLMRP QD$57 SRþHWQL EURM &' !
üHOLMDPPNRGNRMLKMHNDVQLMHSUHNLQXWWUHWPDQJUXSD
Q LGYHQDGSDFLMHQWLPDEH]LPXQHUHDNFLMHSRþHWQL
EURM&'üHOLMDPPNRGNRMLKQLMHSUHNLGDQWUHW
PDQJUXSD]DMHGQRQ ,QLFLMDOQLUH]XOWDWLL]RYLK
VWXGLMD VX SUHGVWDYOMHQL QD &52, L ,&$$& NRQIHUHQFL
MDPDSURãOHJRGLQH
9HüLQDSDFLMHQDWDVXELOLPXãNDUFLEHOFLSURVHþQHVWDURV
WLJRGLQDVDGXJRPLVWRULMRP+,9LQIHNFLMHSURVHþQR
LJRGLQDXJUXSLLUHVSHNWLYQR3URVHþDQEURM
&'üHOLMDLRGQRV&'&'MHL]QRVLRüHOLMD
PPLNRGJUXSHLüHOLMDPPL
NRGJUXSH
7UDMDQMH QDVWDYND SUDüHQMD SDFLMHQDWD VDGD L]QRVL X
SURVHNXGDQDRSVHJ±GDQD
1DNRQLQIX]LMHEURM&'üHOLMDVHSRYHüDR]DRNR
üHOLMDPPNRGJUXSHQ D]DWLPMHVPDQMHQWRNRP
SUHNLGDWUHWPDQDDOLMHWRNRPQDVWDYNDSUDüHQMDSDFLMH
QDWDRVWDR]QDþDMQRL]QDGSRþHWQRJQLYRD5HDNFLMH&'
üHOLMDNRGJUXSHVXREXKYDWLOHSRYHüDQMHRGRNR
üHOLMDPPãWRMHNDVQLMHRSDOR]DRNRüHOLMDD
]DWLPVHEURMVWDELOL]RYDRWRNRPJRGLQHGDQDNRGSDFLMH
QDWDNRMLQLVXSUHNLGDOLWUHWPDQ3URãLUHQMH&'üHOLMDMH
ELORSRYH]DQRVDSRYHüDQMLPDQLYRD,/,/L,/
&'&'RGQRVVH]QDþDMQRSRYHüDRNRGREHJUXSH]D
WLPVHQRUPDOL]RYDRL]DGUåDRQDRWSULOLNHWRNRPSH
ULRGDSUDüHQMDNRGJUXSHDSRYHüDRVHQDRWSULOLNH
NRGãHVWSDFLMHQDWDXJUXSLX]VPDQMHQMHWRNRPSUHNLGD
WUHWPDQDDOLVH]DWLPVWDELOL]RYDR
0RGL¿NRYDQH üHOLMH VX QDVWDYLOH GD EXGX GHWHNWR
YDQH WRNRP SHULRGD SUDüHQMD QD QLYRX RG RG EURMD
FLUNXOLãXüLK&'üHOLMDXRMQHGHOMLNRGYHüLQHSDFLMH
QDWD1LYRLVXELOLYLãLWRNRPSUHNLGDWUHWPDQD]DJUXSX
D]DWLPVXRSDOLQD&LUNXODFLMDüHOLMDGRORNDFLMDX
RVWDOLPWNLYLPDMHSRWYUÿHQDNRGYLãHUHNWDOQLKELRSVLMD
NRMLPD VX RWNULYHQL QLYRL &&5PRGL¿NRYDQLK üHOLMD
NRMLVXVHPRJOLXSRUHGLWLVDRQLPDXNUYLLOLþDNLYLãL
WRNRPSHULRGDSUDüHQMD
7RNRPSUHNLGDWUHWPDQDEURMYLUXVQLKNRSLMDVHSRQRYR
SRYHüDR WRNRP SUYLK QHGHOMD QD RNR NRSLMD
P/QDVOLþDQQDþLQNDRLXRVWDOLPVWXGLMDPDSUHNLGDWUHW
PDQDRSDGDMXüLWRNRPSRVOHGQMHQHGHOMHYDQWUHWPDQD
GRQLYRDNRMLVXELOLJHQHUDOQRYLãLQHJRSUH$571DNRQ
WULPHVHFDNDGDMHWUHWPDQSRQRYR]DSRþHWEURMYLUXVQLK
NRSLMD VH SRQRYR QLMH PRJDR GHWHNWRYDWL NRG VYLK ãHVW
SDFLMHQDWD-HGQDRVRED]DNRMXMHNDVQLMHRWNULYHQRGD
MH KHWHUR]LJRWQL QRVLODF GHOWD PXWDFLMHMH LPDODQLåL
VNRNEURMDYLUXVQLKNRSLMDGRFP/D]DWLPMH
SRQRYRVXSUHVRYDODEURMYLUXVQLKNRSLMDGRQLYRDNRMLVH
QH PRåH GHWHNWRYDWL GR H QHGHOMH L ]DGUåDOD WDM QLYR
YDQWUHWPDQDVYHGRSRQRYQRJSRþHWNDWUHWPDQDSUHPD
SURWRNROXXRMQHGHOML
2YDJUXSDMHNRULVWLODQRYXPHWRGXPHUHQMDSURPHQDX
YLUXVQRP UH]HUYRDUX ]DVQRYDQX QD QLYRLPD +,9 '1.
RVHWOMLYXQDPDOLEURMNRSLMDPDGDQLMHELODXVWDQMXGD
UD]OLNXMHLQWHJULVDQX'1.L/75VHNYHQFH2QLQLVX
RWNULOLQLNDNYHGHWHNWDELOQHSURPHQHNRGSDFLMHQDWD
JGH MH MHGQD RVRED LPDOD SUROD]QD VWUXND SRYHüDQMD
X RM L RM QHGHOML WRNRP SUHNLGD WUHWPDQD DOL X]
YUDüDQMH QD SRþHWQH QLYRH D MHGQD RVRED MH GRåLYHOD
VWUXNRSRYHüDQMHNRMHVHYUDWLORQDSRþHWQLQLYRQH
GHOMDQDNRQSRQRYQRJSRþHWNDWUHWPDQD
6SRUHGQLHIHNWLVXELOLEODJLLSUROD]QLXJODYQRPXSH
ULRGXRGþDVDRGLQIX]LMHEODJHGUKWDYLFHJUR]QLFH
JODYREROMHXPRUDOLMHSULMDYOMHQLMHGDQVOXþDMDUWULWLVD
NRMLMHWUDMDRQHNROLNRGDQDNDRLDEQRUPDOQLWHOHVQLPLULV
VOLþDQPLULVXEHORJOXND
1DUHGQL NRUDFL REXKYDWDMX NRULãüHQMH LPXQRPRGXOD
WRUQLK OHNRYD NDR ãWR MH FLNORIRVIDPLG UDGL SREROMãDQMD
SULMHPDPDWLþQLKüHOLMDWUDQVSODQWDLSRYHüDQMDSURFHQWD
PRGL¿NRYDQLKüHOLMDNDRLSURXþDYDQMHRVWDOLKSDFLMHQDWD
NRMLVXKHWHUR]LJRWQLQRVLRFLGHOWDGHOHFLMH
1HNROLNRVWXGLMDMHSUHGVWDYLORSRVWXSNHXNRMLPDMHSH
JLORYDQLLQWHUIHURQSHJ,)1ELRGRGDW$57XSUHSUHNL
GDQMD+,9WUHWPDQDDQDVWDYDNMHREDYOMDQSHJ,)1RP
5H]XOWDWLVXXND]DOLQDWRGDMHSRYHüDQMHEURMDYLUXVQLK
NRSLMDELORRGORåHQRSHJ,)1RPSXWHPLPXQRSRVUHGR
YDQRJDQHDQWLYLUXVQRJPHKDQL]PDDOLVXRYRELOHYHR
PDPDOHVWXGLMHVDNUDWNLPSHULRGRPSUDüHQMDSDFLMHQDWD
LQHGHOMD>@
Komentar
9UHPHQVNLRSVHJ]DOHNMHQDRYRMNRQIHUHQFLMLRSWLPLVWLþQRSURFHQMHQQDQDMPDQMHGHVHWJRGLQD+,9MHOXNDYD
]DJRQHWNDYLUXVMHYHRPDRWSRUDQDRSVHJLPXQRORãNLKUHDNFLMDMHNRPSOHNVDQ,SDNRYDQDSUHGRYDQMDXQHNROLNRNOMXþQLKLPHÿXVREQRSRYH]DQLKREODVWLSUHGVWDYOMDMXQDSUHGDNRGNUXFLMDOQRJ]QDþDMD
1HNROLNRPUHåDRKUDEUXMHNRODERUDWLYQDLVWUDåLYDQMDNDNRELVPRELOLXVWDQMXGDXSRUHGLPRLSURFHQLPRUD]OLþLWH
SULVWXSH>@
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
%URMQL SUHSDUDWL NRML VX YHü OLFHQFLUDQL VH YHü UD]PDWUDMX SR SLWDQMX QMLKRYRJ SRWHQFLMDOD ]D SUHYD]LODåHQMH
ODWHQWQRVWL2YLSUHSDUDWLREXKYDWDMXSURVWUDWLQORQRPLFLQWDSVLJDUJLQLQKLELWRUNDOFLMXPRYHSXPSH30$
W\SKRVWLQ$QHVHOHNWLYQLW\SKRVLQIRVIDWLQKLELWRU&'&'DQWLWHOD]D7&5VLJQDOL]LUDQMH3/$WROOOLNHUHFHSWRU7/5XNOMXþXMXüL*6LDJRQLVWHSURWHLQNLQD]H&3.&1HNROLNRNRPSDQLMDXNOMXþXMXüL*LOHDG
L0HUFNYHüREDYOMDMXVNULQLQJLLGHQWL¿NRYDOLVXRVWDOHSRWHQFLMDOQH+'$&LQKLELWRUH
8þHãüHLQIRUPLVDQH]DMHGQLFHXYLGXSDUWQHUDXRYRPLVWUDåLYDQMXMHSRVHEQRYDåQRVRE]LURPQDHWLþNHRE]LUH
YRORQWHUDXVWXGLMDPD8NROLNRVHRWNULMHGDPHKDQL]DPOHþL+,9QDãLURMRVQRYLWRLSDNLGDOMHPRåH]QDþLWL
XVSHãQRVWVDPRNRGQHNLKSDFLMHQDWD
6DWUHQXWQLPWUHWPDQRPNRMLMHXVWDQMXGDVNRURQRUPDOL]XMHRþHNLYDQLåLYRWQLYHNOHNSUHGVWDYOMDYHRPDYLVRNXSUHSUHNXNRMXWUHEDSUHVNRþLWL1HNDLVWUDåLYDQMDüHREXKYDWLWLLPROMHQMHRVREDXVWDELOQLPWUHWPDQLPDGD
SUHNLQXWHUDSLMXDQHNHRGLQWHUYHQFLMDüHLPDWLSRWHQFLMDOQRYHüXWRNVLþQRVWRGQMLKRYHWUHQXWQH$570DNDU
ãWRVHWLþHEOLVNHEXGXüQRVWLSRWHQFLMDOQLUL]LFLXRYLPLQLFLMDOQLPVWXGLMDPDüHYHURYDWQRQDGPDãLWLELORNDNYH
OLþQHNRULVWL
5DQLWUHWPDQWRNRPSULPDUQHLQIHNFLMHPRåHVWDYLWLQHNHRVREHXVLWXDFLMXSUHIHULUDQX]DXþHãüHXGHORYLPD
VWUDWHJLMHOHþHQMD+,9DDQHNHRVREHVDUDQRSRVWDYOMHQRPGLMDJQR]RPPRJXSULKYDWLWLRYXRGOXNX=ERJWRJD
ãWRMHODWHQWQLSRWHQFLMDOQLåLNRGWDNYLKSDFLMHQDWDRQLNRMLVX]DSRþHOLVD$57WRNRPDNXWQHID]H+,9LQIHNFLMH
PRJXELWLQDMEROMLNDQGLGDWL]DSLORWVWXGLMHNRMHLPDMX]DFLOMHUDGLNDFLMX+,9D
5HIHUHQFH
8NROLNRGUXJDþLMHQLMHQD]QDþHQRVYHUHIHUHQFHVXL]3URJUDPDLDEVWUDNWD]DX.RQIHUHQFLMXRUHWURYLUXVLPDLRSRUWXQLVWLþNLPLQIHNFLMDPD
&52,RGUåDQRMXWUHüHPPHVHFXJRGLQHX6LMHWOX6$'
)DXFL$$)DXFL7KH+,9$,'6UHVHDUFKDJHQGDDYLHZIURP1,$,'WK&52,)HEUXDU\6DQ)UDQFLVFR3OHQDU\VHVVLRQ
)HEUXDU\
KWWSUHWURFRQIHUHQFHRUJGDWD¿OHVZHEFDVWBKWP
,QWHUQDWLRQDO$,'66RFLHW\,$67RZDUGVDFXUHJOREDOVFLHQWL¿FVWUDWHJ\)HEUXDU\
KWWSZZZLDVRFLHW\RUJ'HIDXOWDVS["SDJH,G ,QWHUQDWLRQDO$,'66RFLHW\,$67RZDUGVDFXUHJOREDOVFLHQWL¿FVWUDWHJ\:DVKLQJWRQPHHWLQJ
KWWSZZZLDVRFLHW\RUJ'HIDXOWDVS["SDJH,G 7UHDWPHQW$FWLRQ*URXS5HSRUW+,9FXUHUHODWHGFOLQLFDOUHVHDUFKZRUNVKRS2FWREHU
KWWSZZZWUHDWPHQWDFWLRQJURXSRUJFXUHZRUNVKRSUHSRUW
$7$&&XUH5HVHDUFK:RUNVKRS0DUFK0HOORUV-+,95HVHUYRLUVDQG&XUH5HVHDUFK:RUNVKRS3URJUDP&RPPLWWHH:RUNVKRSIRU
1HZ,QYHVWLJDWRUVDQG7UDLQHHV3DUW0RQGD\0DUFK$06HDWWOH
KWWSUHWURFRQIHUHQFHRUJVWDWLFZHEFDVWV
3ODQHOOHV90RGHOVIRUWKH6WXG\RI/DWHQF\:RUNVKRS)URQWLHUVLQ/DERUDWRU\6FLHQFH:RUNVKRS0RQGD\0DUFK306HDWWOH
KWWSUHWURFRQIHUHQFHRUJVWDWLFZHEFDVWV
+XWWHU*HWDO7UHDWPHQWRI+,9LQIHFWLRQE\DOORJHQHLF&&5''VWHPFHOOWUDQVSODQWDWLRQDSURPLVLQJDSSURDFK3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJ$EVWUDFWVKWP
&LOOR$HWDO3ODVPDYLUHPLDDQGFHOOXODU+,9'1$SHUVLVWGHVSLWHDXWRORJRXVKHPDWRSRLHWLFVWHPFHOOWUDQVSODQWDWLRQIRU$,'6UHODWHGO\P
SKRPD2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
$OORJHQHLF7UDQVSODQWLQ+,93DWLHQWV%07&71
KWWSFOLQLFDOWULDOVJRYFWVKRZ1&7
0DUJROLV'HWDO$GPLQLVWUDWLRQRIYRULQRVWDWGLVUXSWV+,9ODWHQF\LQSDWLHQWVRQ$572UDOODWHEUHDNHU/%
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
5DVPXVVHQ7HWDO7KHKLVWRQHGHDFHW\ODVHLQKLELWRU+'$&LSDQRELQRVWDW/%+VWLPXODWHV+,9H[SUHVVLRQPRUHSRWHQWO\WKDQRWKHU
+'$&LLQFOLQLFDOXVHDQGGLVUXSWV+,9ODWHQF\DWFOLQLFDOO\DFKLHYDEOHFRQFHQWUDWLRQV3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
6KDQHWDO(OLPLQDWLRQRIWKHODWHQWUHVHUYRLUIRU+,9UHTXLUHVLQGXFWLRQRIF\WRO\WLF7O\PSKRF\WHUHVSRQVHV2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
&KXQ7:HWDO5HERXQGRISODVPDYLUHPLDIROORZLQJFHVVDWLRQRIDQWLUHWURYLUDOWKHUDS\GHVSLWHSURIRXQGO\ORZOHYHOVRI+,9UHVHUYRLULP
SOLFDWLRQVIRUHUDGLFDWLRQ$,'6S±1RYHPEHU
KWWSMRXUQDOVOZZFRPDLGVRQOLQH)XOOWH[W5HERXQGBRIBSODVPDBYLUHPLDBIROORZLQJBFHVVDWLRQBRIDVS[
6DH]&LULRQ$HWDO/RQJWHUP+,9&RQWURODIWHULQWHUUXSWLRQRIDWUHDWPHQWLQLWLDWHGDWWKHWLPHRISULPDU\LQIHFWLRQLVDVVRFLDWHGWRORZ
FHOODVVRFLDWHG+,9'1$OHYHOV$1569,6&217,6WXG\3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJ$EVWUDFWVKWP
6DOJDGR0HWDO7LWOH3URORQJHG&RQWURORI5HSOLFDWLRQFRPSHWHQW'XDOWURSLF+,9IROORZLQJ&HVVDWLRQRI+$$573RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
/DIHXLOODGH$HWDO/RQJWHUPFRQWURORI+,9UHVHUYRLUDIWHUD\HDU$57FRXUVHDWDFXWHLQIHFWLRQ3RVWHUDEVWUDFWKWWSZZZUHWURFRQ
IHUHQFHRUJE$EVWUDFWVKWPKWWSZZZUHWURFRQIHUHQFHRUJE3')VSGI3')
0DUJROLFN-HWDO(IIHFWRIUDQGRPL]HG+$$57RQYLUDOVXSSUHVVLRQRIIWKHUDS\LQSDWLHQWVZLWKDFXWHHDUO\+,9LQIHFWLRQ3RVWHUDEVWUDFW
ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%H
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
KWWSZZZUHWURFRQIHUHQFHRUJE3')VSGI3')
)LGOHU 6 HW DO 7KH HIIHFW RI VKRUWFRXUVH DQWLUHWURYLUDO WKHUDS\ LQ SULPDU\ +,9 LQIHFWLRQ ¿QDO UHVXOWV IURP DQ LQWHUQDWLRQDO UDQGRPLVHG
FRQWUROOHG WULDO 63$57$& WK ,$6 &RQIHUHQFH RQ +,9 SDWKRJHQHVLV WUHDWPHQW DQG SUHYHQWLRQ -XO\ 5RPH ,WDO\ 2UDO DEVWUDFW
:(/%;6HH
KWWSLEDVHLQIRKWEVRXWK
%X]RQ0HWDO7UHDWPHQWRIHDUO\+,9LQIHFWLRQUHGXFHVYLUDOUHVHUYRLUWROHYHOVIRXQGLQHOLWHFRQWUROOHUV2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
3HUHOVRQHWDO,PPHGLDWHDQWLYLUDOWKHUDS\UHVWULFWVUHVWLQJ&'LQIHFWLRQEXWGRHVQRWDFFHOHUDWHWKHGHFD\RIODWHQWLQIHFWLRQ2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
7HEDVHWDO,QGXFWLRQRIDFTXLUHG&&5GH¿FLHQF\ZLWK]LQF¿QJHUQXFOHDVHPRGL¿HGDXWRORJRXV&'7FHOOV6%7FRUUHODWHVZLWKLQ
FUHDVHVLQ&'FRXQWDQGHIIHFWVRQYLUDOORDGLQ+,9LQIHFWHGVXEMHFWV2UDODEVWUDFWKWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWV
KWP
0H[DV$HWDO&RQFXUUHQW0HDVXUHPHQWVRI7RWDODQG,QWHJUDWHG+,9'1$3URYLGH,QVLJKWLQWRWKH0HFKDQLVPRI5HGXFHG5HVHUYRLU6L]HLQ
DQ,QWHUIHURQDOSKDIROORZHGE\6WUXFWXUHG7UHDWPHQW,QWHUUXSWLRQ7ULDO3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
3DSDVDYYDV(HWDO,PPXQH&RUUHODWHVRI6XVWDLQHG,)1DOSKDPHGLDWHG6XSSUHVVLRQRI+,95HSOLFDWLRQ$VVRFLDWLRQZLWK,)1DOSKDPHGL
DWHG6LJQDOLQJDQG,QFUHDVHG1.&HOO5HVSRQVHV2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
$]]RQ/HWDO3HJ\ODWHGLQWHUIHURQDOSKD$PRQRWKHUDS\LQGXFHVGXUDEOHVXSSUHVVLRQRI+,9UHSOLFDWLRQDQGGHFUHDVHG+,9'1$LQWHJUD
WLRQIROORZLQJ$57LQWHUUXSWLRQ3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
&ROODERUDWRU\RI$,'65HVHDUFKHUVIRU(UDGLFDWLRQ&$5(DQGWKH'HODQH\$,'65HVHDUFK(QWHUSULVH'$5(
KWWSVZZZGHODQH\FDUHRUJ
'HIHDW+,9±7KH'HODQH\&HOODQG*HQRPH(QJLQHHULQJ,QLWLDWLYH)UHG+XWFKLQVRQ&DQFHU5HVHDUFK&HQWHU8QLYHUVLW\RI:DVKLQJWRQ
6HDWWOH
KWWSGHIHDWKLYRUJ
4XDG¿NVQDGR]DNRPELQDFLMHLQWHJUD]H,,,ID]DVWXGLMHWMHGDQ
Simon Collins, HIV i-Base
)LNVQD GR]D MHGQD WDEOHWD IRUPXODFLMD OLMHND HOYLWH
JUDYLUFRELFLVWDWWHQRIRYLU)7& UD]YLMHQD SRG LPHQRP
4XDGQDMEOLåDMHUHJXODWRUQRPRGREUHQMX4XDGMHRGR
EUHQ NUDMHP PMHVHFD JRGLQH RG )'$ RSDVND
XUHGQLND
1D PHÿXQDURGQRM NRQIHUHQFLML &52, SULND]DQL VX UH
]XOWDWL L] GYLMH UDQGRPL]LUDQH GYRVWUXNR VOLMHSH SODFH
ERNRQWUROLUDQHVWXGLMHID]H-HGQDVWXGLMDXVSRUHÿXMH
4XDGVNRPELQDFLMRP$WULSOHHIDYLUHQ]WHQRIRYLU)7&
NRMD MH ELOD X REOLNX SUHGDYDQMD GRN GUXJD XVSRUHÿXMH
4XDG V NRPELQDFLMRP DWD]DQDYLUULWRQDYLU SOXV WHQRIR
YLU)7&NRMDMHELODXREOLNXSRVWHUD>@
3ULPDUQLFLOMRELMXVWXGLMDELODMHSURSRUFLMDEROHVQLNDV
QHGHWHNWDELOQRPYLUHPLMRPNRSLMDP/XWMHGQX
VDQDOL]RPQDPMHUHOLMHþHQMDVQHLQIHULRUQRãüXGH¿QLUD
QRP QLåRP PDUJLQRP RG L NRMD MH XNOMXþLYDOD
VDWLVIDNFLMX EROHVQLND SR RVQRYL YLUHPLMH L]QDG L LVSRG
NRSLMDP/ 9LURORãND H¿NDVQRVW MH ELOD RNR
SRGQRãOMLYRVW MH ELOD GREUD D SUHNLG WHUDSLMH RVR
ELWRQL]DNXVYLPVWXGLMDPDGRNMH4XDGELRQHLQIHULRUDQ
XVSRUHGLYãLJDVNRPELQDFLMDPDGUXJLKOLMHNRYDXREMH
VWXGLMH
*RGLQD,EURM
6WXGLMD XVSRUHGLOD MH 4XDG V $WULSORP WH
XNOMXþLOD EROHVQLND NRML VX WHUDSLMVNL QDLYQL QLNDG
QLVXX]LPDOLWHUDSLMX]D+,9X6MHGLQMHQLP'UåDYDPD
3RUWR5LNXDUH]XOWDWHMHSULND]DR3DXO6D[L]%ULJKDP
DQG:RPHQ¶V+RVSLWDOX%RVWRQX>@
2VQRYQD RELOMHåMD VX XNOMXþLYDOD SURVMHþQD GRE RG JRGLQD WH QLVND VUHGQMD YLUHPLMD NRSLMDP/
LDNRMHWUHüLQDXNOMXþHQLKNUHQXODV!NRSLMDP/
3URVMHþDQEURM&'MHELRLVSRGVWDQLFDPPV
EROHVQLNDNRMLVXVWDUWDOLVLVSRGQMLKMHVWDUWDOR
]DMHGQRRGGRLGRWHQMLKVWDUWDOR
MHVYLãHRGVWDQLFDPPSRVWRFLVX]D4XDGDOLVX
VOLþQL L$WULSOL 6WXGLMD MH XNOMXþLOD YHþLQRP PXãNDUFH
VEMHODFDDIURDPHULNDQDFDLRVWDOLK
0DQMHRGVXGLRQLNDXREMHJUXSHLPDODMHLOL+%9LOL
+&9NRLQIHNFLMX
3UHNLG WHUDSLMH SULMH WMHGQD ELR MH VOLþDQ X QDSUHPD NRG 4XDGD QDSUHPD$WULSOL ]ERJ JRWRYR
LGHQWLþQLKUD]ORJD
9LUHPLMDMHVXVSUHJQXWDGRQHPMHUOMLYRVWLXQDVSUDP
EROHVQLNDUD]OLND&,WRãWR
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
GRND]XMH NULWHULM QHLQIHULRUQRVWL V EROHVQLND X VYD
NRMJUXSLNRMLVXLPDOLYLURORãNLQHXVSMHKWHQDVSUDP
NRMLPDVXQHGRVWDMDOLSRGDFLVYH4XDGYV$WULSOD
2GJRYRULSRSRGJXSDPDYLUHPLMD&'UDVDVSROJR
GLQHLQLYRDGKHUHQFLMHQLVXELOL]QDþDMQRUD]OLþLWLDOLVX
UDVOLXNRULVW4XDGD&'SRYHüDQMHELORMHXNRULVW4XDG
JUXSHVYVVWDQLFDPPS 2WSULOLNHSRORYLFDEROHVQLNDXVYDNRMJUXSLQLMHXVSMHOR
]ERJPXWDFLMDSRYH]DQLKVUH]LVWHQFLMRPLOLQDLQKLELWRUH
LQWHJUD]H XJODYQRP (4 LOL QD 1157, XJODYQRP
.1XYV
9HüLQD QXVSRMDYD SULMDYOMHQD MH NDR EODJH VWXSDQM V
VWDWLVWLþNL]QDþDMQLPUD]OLNDPDXNOMXþXMXüLYLãHPXþQLQH
X 4XDG JUXSL YV L YLãH DEQRUPDOQLK VQRYD
YVQHVDQLFDYVYUWRJODYLFHYV
WHRVLSYVX$WULSODJUXSL
3UHNLGL SRYH]DQL V QXVSRMDYDPD GRJRGLOL VX VH ]ERJ
RVLSD YV EXEUHåQLK DEQRUPDOQRVWL YV
GHSUHVLMHYVDEQRUPDOQLKVQRYDYV
X4XDGJUXSLQDVSUDP$WULSODJUXSHRGQRVQRV
XVYDNRMJUXSLSUHNLGWHUDSLMH]ERJ]DPRUDLSDUDQRMH
1DMþHãüHODERUDWRULMVNHDEQRUPDOQRVWLLOLVWXSQMDSR
MDYLOHVXVHXYLãHRGEROHVQLNDXVYDNRMJUXSLNRMHVX
ELOHXJODYQRPVOLþQHLJHQHUDOQRQLVNHXNOMXþXMXüLNUHD
WLQLQNLQD]HYV$67YV$/7YV
**7YVQHXWUR¿OLYVDPLOD]H
VYDNDJUXSDLKDHPDWXULMDYVVYHX4XDG
QDVSUDP$WULSODJUXSL
6HUXP NUHDWLQLQD SRYHüDR VH ]D RWSULOLNH PJ
G/GRGUXJRJWMHGQDX4XDGJUXSLãWRVHRGUåDORGR
WMHGQDXVSRUHÿXMXüLVQLNDNYLPSURPMHQDPDNRG$WULSOH
S
3RYHüDQMHGLMHWHMHWRWDOQLNROHVWHURO/'/L+'/NROHV
WHUROXþLQLOR]QDþDMQRYHüLPX$WULSODJUXSLXVSRUHÿXMXüL
V4XDGJUXSRPDOLQLMHELORQLNDNYHUD]OLNHPHÿXJUX
SDPDXNOLQLþNL]QDþDMQLMHPRPMHUX7&+'/LOLXWULJOLF
HULGLPDPJG/XVYDNRMJUXSL
'UXJD 4XDG VWXGLMD QD]YDQD XVSRUHÿXMH
4XDGVDWD]DQDYLUULWRQDYLURPSOXVWHQRIRYLU)7&7UX
YDGD 8NOMXþLOD MH WUHWPDQVNL QDLYQLK EROHVQLND D
UH]XOWDWL VX SUH]HQWLUDQL RG VWUDQH (GZLQD 'H-HVXVD X
REOLNXSRVWHUD>@%D]LþQHNDUDNWHULVWLNHELOHVXXYHOLNH
VOLþQH VWXGLML SURVMHþQD GRE JRGLQD PXãNDUFL ELMHOFL &' YLUHPLMD WH KHSDWLWLV NRLQ
IHNFLMD ELOH VX WDNRÿHU VOLþQH V EROHVQLND NRML VX
LPDOLYLUHPLMX•NRSLMDP/.ULWHULMLQH]DGRYRO
MDYDQMDXWRMVWXGLMLXNOMXþXMXH*)5P/PLQ
9LURORãNDH¿NDVQRVWFRSLHVP/MHXWMHGQXELOD
YV UD]OLND &, ± WR X NRULVW 4XDGD NRMD VXVUHüH FULWHULM QHLQIHULRUQRVWL 8
EROHVQLND V ED]LþQRP YLUHPLMRP • NRSLMDP/
VWRSDRGJRYRUDELODMHYV169LURORãNLQHXV
SMHK ELR MH X REMH JUXSH 6UHGQMD YULMHGQRVW &'
SRYHüDQMD ELOD MH VOLþQD V YV VWDQLFDPP D
SUHNLGWHUDSLMH]ERJQXVSRMDYDELRMHYVREDX
4XDGYVDWD]DQDYLUUJUXSDPD
1XVSRMDYHVXVHSRMDYLOHX•EROHVQLNDELOHVXVOLþQH
XREMHJUXSHRVLPSRYLãHQLKYULMHGQRVWLELOLUXELQDNRMH
VXELOH]QDþDMQRYLãHXDWD]DQDYLUULWRQDYLUJUXSL3UHNLG
WHUDSLMHXVOLMHGLRMH]ERJSUROMHYDYVSRYLãHQH
WMHOHVQHWHPSHUDWXUHYVPXþQLQHYV
SRYUDþDQMD L XPRUD VYDNL YV WH åXWLFH YU
WRJODYLFH RþQRJ LNWHUXVD WH HUXSFLMH OLMHND VYDND YV
1DMIUHNYHQWQLMH ODERUDWRULMVNH DEQRUPDOQRVWL LVWXSQMDSRMDYLOHVXVHXQDMPDQMHXREMHJUXSH
ELOH VX YUOR VOLþQH XNOMXþXMXüL NUHDWLQLQ NLQD]X YV
KHPDWXULMXYV$67YV$/7
YVDPLOD]XVYDNDJUXSDWHSRYHüDQLELOLUXELQ
YVVYHX4XDGYVDWD]DQDYLUULWRQDYLUJUXSD
PD 6HUXP NUHDWLQLQD SRYHþDR VH ]D RWSULOLNH PJ
G/GRGUXJRJWMHGQDX4XDGJUXSLãWRMHELORPJG/
X WMHGQX XVSRUHÿXMXüL V DWD]DQDYLUULWRQDYLURP
S6UHGQMDSURPMHQDX&/&URGRVQRYQRJSUDYFD
ELODMH±P/PLQX4XDGL±P/PLQS
3RYHþDQMHOLSLGDELORMHVOLþQL]D7&/'/L+'/NROHV
WHUROVYLS 16DOLWULJOLFHULGLVXSRUDVOLPDQMHX4XDG
JUXSLYVPJG/S 6UHGQMD SURPMHQD X PLQHUDOQRM JXVWRüL NRVWLMX ELOD MH
VOLþQDXVYDNRMJUXSL3URPMHQHNUDOMHåQLFHVPDQMHQHVX
]DRNRXWMHGQXWHVXRVWDOHVWDELOQHVVPDQMHQMHP
XWKHGQX]DYVS ]DXVSRUHGEX
L]PHÿXJUXSD6PDQMHQMHNRGNXNRYDNRQWLQXLUDQRMH
SDGDORXREMHPDNRPELQDFLMDPD]DRNRYVX
WMHGQXLYVWMHGQXS 8 RGJRYRUX QD SLWDQMH R NOLQLþNRP PHQDGåPHQWX
SRYLãHQRJ VHUXPD NUHDWLQLQD X UHIHUHQFL R SRYHüDQMX
XREMH4XDGVWXGLMH3DXO6D[MHQDJODVLRGDVWDWLVWLþND
DQDOL]DSRGDWDNDVXJHULUDGDSRYHþDQMHRGPJG/LOL
YLãHMHELOR³FXWRII´]D]DEULQXWRVWRNRPRJXüHUHQDOQH
WXEXODUQHWRNVLþQRVWLWHQRIRYLUD
.DGDMHXSLWDQGDOLVSDUHQLFLVWDWLQ&XVHUXPXUD]OLN
RYDR L]PHÿX WHQRIRYLU L FRELFLWDW SRYH]DQLK SURPMHQD
6D[ MH UHNDR GD MH WR PRJXüQRVW DOL GD PRåH ELWL XWMH
FDQRLGUXJLPIDNWRULPDSRYH]DQLPDV+,9RP3LWDQMH
FLMHQH MH WDNRÿHU SRVWDYOMHQR X NRQWHNVWX UH]XOWDWD NRML
QLVXGHPRQVWULUDOLVXSHULRUQRVWãWRMHPRåGDSRYH]DQRV
YHOLþLQRPVWXGLMH
Komentar
4XDGMHRGREUHQNUDMHPPMHVHFDJRGLQHRGVWUDQH)'$
ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%H
5HIHUHQFH
6D[3HWDO(OYLWHJUDYLUFRELFLVWDWHPWULFLWDELQHWHQRIRYLU4XDGKDVQRQLQIHULRUHI¿FDF\DQGIDYRUDEOHVDIHW\FRPSDUHGWRHIDYLUHQ]HPWULF
LWDELQHWHQRIRYLULQWUHDWPHQWQDwYH+,9VXEMHFWVWK&52,±0DUFK6HDWWOH2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
:HEFDVW6WDWHRIWKH³$57´DQG'UXJ5HVLVWDQFH7XHVGD\DP
KWWSUHWURFRQIHUHQFHRUJVWDWLFZHEFDVWV
'H-HVXVHWDO:HHNUHVXOWVRIDQRQJRLQJJOREDOSKDVHVWXG\FRPSDULQJHOYLWHJUDYLUFRELFLVWDWHPWULFLWDELQHWHQRIRYLU4XDGZLWKDWD]D
QDYLUULWRQDYLUSOXVHPWULFLWDELQHWHQRIRYLULQWUHDWPHQWQDwYH+,9VXEMHFWVVKRZLQJHI¿FDF\VDIHW\DQGSKDUPDFRNLQHWLFVWK&52,±
0DUFK6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
3UHNLGWUHWPDQDQDNRQUDQRJ$57DNRGRGRMþDGL
Polly Clayden, HIV i-Base
8XYRGQRPXVPHQRPL]ODJDQMX0DUN&RWWRQMHSUHGVWDYLR NRQDþQH UH]XOWDWH L] LVWUDåLYDQMD ³5DQD SULmena antiretrovirusnih lekova kod dece sa HIV-om”
&KLOGUHQZLWK+,9(DUO\$QWLUHWURYLUDOV&+(5
3UHWKRGQL UH]XOWDWL L] &+(5D REMDYOMHQL H VX
GHPRQVWULUDOL SRWUHEX ]D UDQLP $57RP NRG +,9LQ
¿FLUDQH RGRMþDGL L XWLFDOL VX QD VPHUQLFH OHþHQMD ãLURP
VYHWD 6WDQGDUG ]GUDYVWYHQH QHJH VDGD SUHGVWDYOMD XQL
YHU]DOQL WUHWPDQ ]D RGRMþDG GR MHGQH JRGLQH VWDURVWL D
SUHPD:+2YRGLOMDPD]DGHFXGRGYHJRGLQHVWDURVWLL
SRNUHüHVHãWRMHUDQLMHPRJXüH
8 VWXGLML RGRMþDG GR QHGHOMD VWDURVWL VD &' SUR
FHQWRP • VX ELOD VOXþDMQR RGDEUDQD ]D SULPDQMH
RGORåHQH$57$57'HIKLWQH$57NRMDVHSUHNLGDQD
NRQQHGHOMD$57:LOLKLWQH$57NRMDVHSUHNLGD
QDNRQQHGHOMD$57:3UHSRUXNDGDVHSUHNLQH
SULPHQD$57'HILGDVHNRGVYHGHFH]DSRþQH$57MH
ELODGRQHWDRGVWUDQH'60%MXQDHSRãWRMHSRþHWDN
SULPHQH $57 RGPDK QDNRQ URÿHQMD VPDQMLYDR SRMDYX
VPUWQLKLVKRGD]D6YDGHFDVXSULPLODWUHWPDQNRML
VDGUåLORSLQDYLUULWRQDYLU/39U7&$=7
3RþHWDNWUHWPDQDXVOXþDMXVDRGORåHQRPSULPHQRPLUH
LQLFLMDFLMDXGUXJDGYDVOXþDMDVXELOLXVNODGXVDSUHWKRG
QRP :+2 VPHUQLFRP ]D JUDQLþQL SUDJ &' SURFHQWD
NRGRGRMþDGLLQDNRQSHULRGDGRMHQMDLOLVD
QDSUHGRYDQMHP NOLQLþNH EROHVWL 3ULPDUQD NUDMQMD WDþND
MHELRVPUWQLLVKRGLOLQDSUHGRYDQMHGR&'&R]ELOMQH%
LOL&'&&EROHVWL6YHDQDOL]HVXELOHWLSDQDPHUDWUHW
PDQD LQWHQWWRWUHDW L NRULVWLOH VX YUHPHGRGRJDÿDMD
PHWRGH
8NXSQR RGRMþDGL MH REXKYDüHQR X &+(5 L]PHÿX
HLH1MLKRYDSURVHþQDVWDURVWELODMHQH
GHOMDVD&'SURFHQWRPRGQDSRþHWNXDQMLK
*RGLQD,EURM
MHNRPSOHWLUDORVWXGLMX3URVHþQRYUHPHSUDüHQMD
EROHVWLMHL]QRVLORQHGHOMDJRGLQDDPDNVLPXP
MH ELR QHGHOMD JRGLQD 8NXSQL XGHR YUHPHQD
QDNQDGQRJSUDüHQMDEROHVWLQD$57XXWULVOXþDMDVWXGL
MHMHL]QRVLRL]D$57'HI$57:L
$57:UHVSHNWLYQR
$SURNVLPDWLYQR X RNYLUX $57: L X RN
YLUX$57: VOXþDMD MH SRQRYR SRþHOR VD WUHWPDQRP
GRHQHGHOMH3URVHþQRYUHPHGRSRþHWND$57NRG
$57'HIMHL]QRVLOR,45QHGHOMDDGRSRþHWND
$57QDNRQSUHNLGDX$57:L$57:MHL]QRVLOR
,45L,45QHGHOMDUHVSHNWLYQR
5D]OLNDL]PHÿXGYDRGORåHQDVOXþDMDMHL]QRVLOD
&,GRQHGHOMDS 'RNUDMDLVWUDåLYDQMDVDPR
GHFHMHSUHãORQDGUXJLQLYRDQWLUHWURYLUDOQHWHUDSLMH
.DGDVXLVWUDåLYDþLXVPHULOLSDåQMXQDXNXSQHSULPDUQH
NUDMQMHWDþNHXVWXGLMLRWNULOLVXXRNYLUX$57
'HIXRNYLUX$57:LXRNYLUX
$57:2YRMHXJODYQRPELRVOXþDMXVOHGQDMPDQMH
GYRVWUXNRJ EURMD VPUWQLK LVKRGD X $57'HI VOXþDMX X
RGQRVXQDGUXJDGYDVOXþDMDL
X RNYLUX$57'HI$57: L$57: UHVSHNWLYQR
'U&RWWRQMHSULPHWLRGDQLMHELORVOXþDMHYDWRNVLþQRVWL
NRMDRJUDQLþDYDUHåLP
9UHPHGRSULPDUQRJLVKRGDXSRUHÿHQMXVD$57'HIMH
SRND]DORPDQMHJEURMDVOXþDMHYDX$57:
PDQMHJEURMDX$57:LPDQMDXRYDGYDVOXþDMD
]DMHGQR 2GQRVL UL]LND +5 X RGQRVX QD $57'HI VX
L]QRVLOL]D$57:&,S ]D$57:&,S D]D$57
:$57:±S 1DSUHGRYDQMHEROHVWLGR&'&%LOL&LOLVPUWQRJLVKRGD
MH WDNRÿH VPDQMHQR ]D L UHVSHNWLYQR +5 X
RGQRVXQD$57'HIVXL]QRVLOL]D$57:
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
&,S D]D$57:DQG&,
S %LORMHLSRMDYDEROHVWLXRNYLUX
$57'HI$57:L$57VOXþDMHYDUHVSHNWLYQR=D
HQFHIDORSDWLMXMHELORLSRMDYHEROHVWL
.DGDVXLVWUDåLYDþLXSRUHGLOL$57:L$57VOXþDM
±XNOMXþXMXüLGRGDWQHGHFHREXKYDüHQHQDNRQSUHNLGD
$57'HIVOXþDMDQ XVYDNRPRGVOXþDMHYD±RWNULOL
VXGDQLMHELORUD]OLNHL]PHÿXRYDGYDVOXþDMDSRSLWDQMX
YUHPHQD GR SULPDUQRJ LVKRGD +5 &, ± S 9HüLQD VPUWQLK LVKRGD X RED VOXþDMD VH
GRJRGLODUDQRWRNRPLQLFLMDOQRJSHULRGD$57D
1DNUDMXLVWUDåLYDQMDGHFHXRNYLUX$57:
L X RNYLUX $57: QLNDGD QLMH ]DSRþHOR
QHSUHNLGQX$57D&'SURFHQDWMHLPDRSURVHþQXYUHG
QRVWRGDSURNVLPDWLYQRXREDVOXþDMD
'U&RWWRQMH]DNOMXþLRGDWUHWPDQWRNRPUDQRJSHULRGD
LQIDQWLOQRVWLãWLWLRG+,9SRYH]DQRJYLVRNRJPRUWDOLWHWD
LPRUELGLWHWDDL]JOHGDGDMHSUHNLG$57DQDNRQSHULRGD
LQIDQWLOQRVWLEH]EHGDQ$OLLGDOMHSRVWRMLSRWUHED]DGR
GDWQRPDQDOL]RPYLURORãNHVXSUHVLMHLUHVLVWHQFLMHNDRL
LPXQRORãNRJ RGJRYRUD QD SRQRYQR SRNUHWDQMH L SUHNL
GDQMHWUHWPDQD
Komentar
3UHNLGDQMHWUHWPDQDNRGRGRMþDGLNRMDSULPDMX$57WRNRPDNXWQHLQIHNFLMHVHSRND]DOREH]EHGQLPXRNYLUX
&+(5,SDN$QG\3UHQGHJDVWMHGRYHRXSLWDQMHYUHGQRVWNUDWNRJSUHNLGDWUHWPDQDSUHQMHJRYRJSRQRYQRJ
SRþHWNDLQHGHOMDQDNRQLQHGHOMDUDQHSULPHQH$57UHVSHNWLYQRXVYRPRGOLþQRPSUHJOHGXNRML
LVWUDåXMHÄNRQWURYHU]HLSRVOHGLFHUDQRJSRþHWNDSULPHQH³$57DNRGRGRMþDGL>@
5H]XOWDWLVXSURWQLRQLPDL]&+(5VXSULMDYOMHQLXRNYLUX6WXGLMHRSWLPL]LUDQMDSHGLMDWULMVNH+,9WHUDSLMH
23+±UDQGRPL]LUDQLWHVWNRQWLQXLUDQRJQDVSUDPSUHNLGDQRJWUHWPDQDNRGRGRMþDGLVD&'!QDNRQ
QDMPDQMHPHVHFL$57DLVDSRQRYQLPSRþHWNRPWUHWPDQDXNROLNR&'SDGQHGRãWRMH]DXVWDYOMDQR
SXWHP'60%]ERJYLVRNRJXGHODGHFHNRMDVXSRQRYRSRþLQMDODWUHWPDQ]DWULPHVHFD>@8RYRMVWXGLML
VOXþDMQRL]DEUDQHGHFHSRXVYDNRPRGVOXþDMDLXVOXþDMXVDSUHNLGRPMHSRQRYRSRþHORVD
WUHWPDQRPLWRYHOLNDYHüLQDSUHLVWHNDSHULRGDRGPHVHFD'HFDX23+VXVHUD]OLNRYDODRGRQLKX
&+(5SRWRPHãWRVXELODSRGYUJQXWDWUHWPDQX$57XSURVHNXVDPHVHFLVWDURVWLX]QLåL&'SURFHQDWSUH
SULPHQH$57D0HÿXWLPLDNRMHQLåL&'SURFHQDWSULUDQGRPL]DFLMLSUHGYLÿDRSRþHWDNWUHWPDQDQDNRQPDQMHRGPHVHFDVWDURVWLS XRGQRVXQD!PHVHFLQLX]UDVWSUL$57QLWL&'SUH$57DQLVXWRSUHGYLÿDOL
]DREDMHYDåLORS 'U3UHQGHJDVWMHSRVWDYLRSLWDQMHGDOLMHMHGQDLOLGYHJRGLQHUDQRJWUHWPDQDGRYROMQRLQDJODVLRMHGDQLMHSRVWRMDORSRUHÿHQMHVDUDQLPQHSUHNLGQLP$57RP
1DJODãDYDMXüLNRQWURYHU]HMHGDQRGJRYRUQLNDMHL]MDYLRGDMHELRÄãRNLUDQ³GDVXSUHNLGLWUHWPDQDþDNELOLL
UD]PDWUDQLNRGGHFHLXND]DRQDWRGDWDNYLSULVWXSLSULSDGDMXSHULRGXÄPUDþQRJVUHGQMHJYHND³
5HIHUHQFH
&RWWRQ0HWDO(DUO\$57IROORZHGE\LQWHUUXSWLRQLVVDIHDQGLVDVVRFLDWHGZLWKEHWWHURXWFRPHVWKDQGHIHUUHG$57LQ+,9LQIDQWV¿QDO
UHVXOWVIURPWKH<HDUUDQGRPLVHG&+(5WULDO6RXWK$IULFDWK&52,±0DUFK6HDWWOH2UDODEVWUDFW/%
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
3UHQGHUJDVW$$57IRUWKH+,9LQIDQWFRQWURYHUVLHVDQGFRQVHTXHQFHVRIHDUO\LQLWLDWLRQ6\PSRVLXPDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
:DPDOZD'HWDO7UHDWPHQWLQWHUUXSWLRQLQLQIDQWVIROORZLQJPRQWKVRIHPSLULF$57.HQ\D2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
8SRWUHED'DUXQDYLUDWRNRPWUXGQRüH
Polly Clayden
6PHUQLFH ]DVQRYDQH QD GRND]LPD ]D XSRWUHEX SURWHD]HLQKLELWRUD3,XWUXGQRüLVXRVNXGQHSRVHEQR
]DQRYLMHOHNRYH7ULSRVWHUDX&52,XSRND]DOL
ZZZKLYELOWHQLQIR
VX UH]XOWDWH L] VWXGLMD NRMH VX LVSLWLYDOH EH]EHGQRVW
H¿NDVQRVW L IDUPDNRNLQHWLNX 3. GXUDQDYLUDULWRQDYLUD'59UNRGWUXGQLFD
*RGLQD,EURM
+,9%,/7(1+7%H
3URVSHNWLYQD PXOWLFHQWUDOQD VWXGLMD YUãHQD X 3DUL]X RG
strane (YH&RXUERQLNROHJDXNOMXþLYDODMH+,9SR]L
WLYQLK WUXGQLFD NRMH VX ELOH SRGYUJQXWH UHåLPX '59U
äHQHVXXSURVHNXELOHVWDURVWLRGJRGLQDVDSURVHþQLP
QLYRRP&'RGüHOLMDPP6NRURWUHüLQDQ MH
ELODLQ¿FLUDQDLOLYLUXVRPKHSDWLWLVD%+%9LOLYLUXVRP
KHSDWLWLVD&+&9LYHüLQDMHQ ELODSRGYUJQXWD
OHþHQMX
1MLKRYL RVQRYQL UHåLPL ELOL VX 157, Q 157,UDOWHJUDYLU 5$/ Q 157,HQIXYLUWLG
7Q 157,Q 1HNLVXSULPDOLPJ
'59U MHGQRP GQHYQR Q D GUXJL PJ GYD
SXWD GQHYQR Q 'D EL VH SRVWLJOD YHüD L]ORåHQRVW
'59UXPDOLEURMMHSUHãDRVDX]LPDQMDWUHWPDQDMHG
QRPGQHYQRQDGYDSXWDGQHYQRXGUXJRPQ LWUHüHP
WURPHVHþMXQ 2G WUXGQLFD ELOR MH åLYR URÿHQLK RG NRMLK MH SUHYUHPHQR VHOHNWLYQL DERUWXV L LQWUDXWHULQD VPUW
2VWDWDNåHQDELORMHWUXGQRLGDOMHWRNRPDQDOL]D
,VWUDåLYDþLVXSULMDYOMLYDOL'59NUR]NRQFHQWUDFLMHXSOD]
PL RG QJP/ QJP/ Q X SUYRP
WURPHVHþMX QJP/ Q X GUXJRP
WURPHVHþMX QJP/ Q X WUHüHP
WURPHVHþMXQJP/Q SULSRURÿDMX
6YHåHQHRVLPMHGQH]DNRMXVHYHUXMHGDQLMHSRãWRYDOD
XSXWVWYDLPDOHVXSURVHþQXNRQFHQWUDFLMXXSOD]PLYHüX
RG'59RPRWDQRJVD(&]DUH]LVWHQWQL+,9RNR
QJP/ ELOR GD VX SULPDOH WUHWPDQ MHGQRP LOL GYD
SXWDGQHYQR
3URVHþQLRGQRVNRQFHQWUDFLMH'59DL]PHÿXNUYQHYH]H
LPDMNHELRMH,:5GRQ 5HGXNFLMD
NRQFHQWUDFLMH '59D X SOD]PL ELOD MH L]PHÿX SU
YRJ L GUXJRJ WURPHVHþMD L L]PHÿX SUYRJ L WUHüHJ
WURPHVHþMD]DåHQHNRMHVXRVWDOHQDLVWRMGR]L'59U
3ULSRURÿDMXLåHQDSULPDORMH'59UMHGQRP
LGYDSXWDGQHYQRUHVSHNWLYQRLLPDOHVXYLUDOQLVDGUåDM
NRSLMD P/ L ELOR MH NRSLMPDP/
6YHEHEH]DNRMHVXSRGDFLELOLGRVWXSQLELOHVX
+,9QHJDWLYQH
'UXJDVWXGLMDNRMXMHVSURYHR&DUPDQ=RUULODLLVWUDåLYDþL
X3RUWR5LNXL6$'XXNRULVWSURL]YRÿDþDYUãLODMHSUR
FHQX3.XNXSQRJLQHYH]DQRJ'59DNRGWUXGQLFDNRMH
VXSULPDOHPJ'59UVDGUåDMGYDSXWDGQHYQR
2YDPXOWLFHQWUDOQDID]DEVWXGLMHXNOMXþLYDODMHåHQHX
GUXJRP WURPHVHþMX L NRQFHQWUDFLMD X SOD]PL MH PHUHQD
SUHGR]LUDQMDLLVDWLQDNRQX]LPDQMD
GR]HLXGUXJRPLXWUHüHPWURPHVHþMXLRQGDRSHW
QHGHOMDQDNRQSRURÿDMD
8NXSQH NRQFHQWUDFLMH '59D L ULWRQDYLUD 579D X
SOD]PLPHUHQHVXXSRWUHERP+3/&060VVDPDQMRP
JUDQLFRPNYDQWL¿NDFLMHQJP/L]D'59L]D579
,VWUDåLYDþL VX PHULOL QHYH]DQL '59 REH]EHÿLYDQMHP
X]RUDND SOD]PH VD & '59 L RGYDMDQMHP XNXSQRJ L
QHYH]DQRJ '59D XSRWUHERP XOWUD¿OWUDFLMH 8NXSQL L
QHYH]DQL&'59MHPHUHQXSRWUHERPWHþQRJVFLQWLOD
FLRQRJEURMDþD
*RGLQD,EURM
6WXGLMDMHXNOMXþLYDODåHQDSURVHþQHVWDURVWLRGJR
GLQH L QLYRRP &' RG üHOLMDPP 2G RYLK MH
LPDOR3.SRGDWNHSRJRGQH]DSURFHQX
,VWUDåLYDþLVX]DNOMXþLOLGDMHXNXSQL'59&PD[ELR
LPDQMLWRNRPGUXJRJLWUHüHJWURPHVHþMDUHVSHN
WLYQRXSRUHÿHQMXVDSHULRGRPSRVOHSRURÿDMDDOLXNX
SDQ '59 &PLQ VH SRYHüDR UHVSHNWLYQR ]D L X SRUHÿHQMX VD SHULRGRP QDNRQ SRURÿDMD $8&K MH
ELR L PDQML X GUXJRP L WUHüHP WURPHVHþMX X
SRUHÿHQMXVDSHULRGRPSRVOHSRURÿDMD
6ORERGQLGHR'59DMHELRPDORYHüLXSRUHÿHQMXVDSHUL
RGRP SRVOH SRURÿDMD ]D RED WURPHVHþMD 2YR ]QDþL GD
MHUD]OLNDNRGQHYH]DQRJ&PD[DL$8&KELODPDQMD
QHJR]DXNXSQL'59
,VWUDåLYDþLVPDWUDMXGDL]ORåHQRVWOHNX'59DXWUXGQRüL
NRG SUHPLQXOLK PRåH ELWL GHOLPLþQR ]DPHQMHQD RYLP
SRYHüDQLP XGHORP VORERGQRJ OHND MHU VX NRQFHQWUDFLMH
DOEXPLQD L DNLVHORJ JOLNRSURWHLQD $$* XPDQMHQH
]DGRWRNRPWUXGQRüH1HYH]DQL'59MHELR
!(&QJP/]DVYHåHQHUH]LVWHQWQHQDLQKLEL
WRUH+,9SURWHD]H
8NXSQL&PD[]D579MHELRLPDQMLXNXSQL
&PLQMHELRLYHüLL$8&KMHELRL
PDQMLUHVSHNWLYQR]DGUXJRLWUHüHWURPHVHþMHXRGQRVX
QDSRVWSRURÿDMQLSHULRG
.DNR VX NRQFHQWUDFLMH QHYH]DQRJ '59D ELOH UHOD
WLYQR QHSURPHQMHQH WRNRP WUXGQRüH L QDNRQ SRURÿDMD
LVWUDåLYDþLVPDWUDMXGDSULODJRÿDYDQMHGR]HQLMHSRWUHEQR
VDGR]RPRGPJGYDSXWDGQHYQR
*HQHUDOQR VH YLUDOQD NRQFHQWUDFLMD NRG åHQD VPDQ
MLOD WRNRP YUHPHQD VD üHOLMDPP X WUHüHP
WURPHVHþMX üHOLMDPP ,VWUDåLYDþL SUL
MDYOMXMX MHGDQ R]ELOMDQ QHåHOMHQL GRJDÿDM SRYHüDQX
WUDQVDPLQD]X 2G QRYRURÿHQþDGL MH URÿHQR SUH
YUHPHQRLVYDVXELOD+,9QHJDWLYQDSUHPDVWDQGDUGQRP
3&5WHVWLUDQMX
2YRLVSLWLYDQMHXWRNXüHWDNRÿHSURFHQLWLHIHNDWWUXGQRüH
QD'59UPJMHGQRPGQHYQRHWUDYLULQLULOSLYL
ULQ3.
7UHüL SRVWHU MH SRND]LYDR SRGDWNH L] 3$11$D (YURS
VNHPUHåHXWYUÿHQH]DLVSLWLYDQMH3.QRYLK$59OHNRYD
WRNRP WUXGQRüH $QJHOD &ROEHUV L NROHJH VX LVSLWLYDOL
L]ORåHQRVW'59XXWUHüHPWURPHVHþMXL]ORåHQRVWDWD]D
QDYLUX$79L579XNRULãHüHQRPNDRSRMDþLYDþX
8 RYRM ID]L LVSLWLYDQLK åHQD MH SULPDOR '59U PJPJGYDSXWDGQHYQRLOLPJPJMHGQRP
GQHYQRLOL$79UPJPJMHGQRPGQHYQRWRNRP
WUXGQRüH.RQFHQWUDFLMHXSOD]PLPHUHQHVXSUHGR]LUDQ
MDLþDVDXWUHüHPWURPHVHþMXL
QDMPDQMHQHGHOMHQDNRQSRURÿDMD7DPRJGHMHPRJXüH
X]LPDQMHX]RUDNL]SXSþDQHYUSFHLRGJRYDUDMXüLX]RUDN
NUYLPDMNHSULSRURÿDMX.RQFHQWUDFLMHXSOD]PLRGUHÿHQH
VXXSRWUHERPSRWYUÿHQH83/&PHWRGH
äHQHVXELOHXSURVHNXJRGLQDVWDUH1MLKRYLRVQRY
QL UHåLPL ELOL VX 7')7& Q $=77& Q $%&7&Q $=77&7')Q LMHGQDåHQDMH
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
SULPDOD'59UPRQRWHUDSLMX
3RGDFLVXELOLGRVWXSQL]DåHQDNRMHVXSULPDOH'59U
PJMHGQRPGQHYQRQLVXLPDOHNRQFHQWUDFLMH
QDNRQSRURÿDMDLNRMHVXSULPDOHPJGYDSXWD
GQHYQR =D$79U PJ MHGQRP GQHYQR SRGDFL
VXELOLGRVWXSQL]DåHQD8]RUFLSXSþDQHYUSFHLNUYL
PDMNHGRVWXSQLVX]DåHQDNRMHVXSULPDOH'59UL
$79U
2YDVWXGLMDMH]DNOMXþLODGDMHL]ORåHQRVW$8&WDXWRNRP
WUXGQRüH'59X$79XL579XELODVPDQMHQD]DUHVSHN
WLYQR L X SRUHÿHQMX VD SRVWSRURÿDMQLP
SHULRGRP ,VWUDåLYDþL VPDWUDMX GD SRYHüDQL RELP GLV
WULEXFLMH LOL VPDQMHQD DSVRUSFLMD REMDãQMDYDMX RYX SR
MDYX'RGDMXGDMHSRYHüDQDHOLPLQDFLMDPDORYHURYDWQR
UD]ORJ ]D RYX SRMDYX MHU MH SROXYUHPH VOLþQR WRNRP L
QDNRQWUXGQRüH
,VWLþXGDSUDWHüDXSRWUHEDWHQRIRYLUDNRULãüHQRJNRG
SDFLMHQDWDQHXWLþHQDL]ORåHQRVW'59XLOL$79X
8 RYRM VWXGLML åHQD NRMH VX SULPDOH '59 LPDOR
MH NRQFHQWUDFLMX LVSRG FLOMQH NRQFHQWUDFLMH X WUHüHP
WURPHVHþMX
2GQRVNRQFHQWUDFLMHXSXSþDQRMYUSFLNUYLPDMNHNUHWDR
VHRGQ LELRMH]D'59Q 6YDGHFDVXELOD+,9QHJDWLYQDLQLVXSULMDYOMHQLGHIHNWL
SULURÿHQMX
Komentar
3RGDFLL]RYLKVWXGLMDSUHGODåXGDGR]LUDQMHGYDSXWDGQHYQRGDUXQDYLURPRGPJULWRQDYLURPPJ
RPRJXüDYDDGHNYDWQXL]ORåHQRVWOHNXWRNRPWUXGQRüH
0HÿXWLPSRGDFLL]3$11$VWXGLMH]DPDOLX]RUDNåHQDNRMHVXMHGQRPGQHYQRX]LPDOHGDUXQDYLUPJULWRQDYLUPJLSRGDFL&DSSDUHOOLDSUHGVWDYOMHQLVXQDSHGLMDWULMVNRMUDGLRQLFLX5LPXSURãOHJRGLQHSRND]XMX
PQRJRPDQMXNRQFHQWUDFLMXNRMDMHXQHNLPVOXþDMHYLPDLVSRGSUHSRUXþHQH]DSRVWL]DQMHYLUDOQHVXSUHVLMH
'RNQHEXGHGRVWXSQRYLãHSRGDWDNDWUHEDSUHSLVLYDWLGDUXQDYLUGYDSXWDGQHYQRXVWDQGDUGQRMGR]LLWUHED
NRULVWLWL7'0]DSUDüHQMHXSRWUHEHGDUXQDYLUDMHGQRPGQHYQRWRNRPWUXGQRüH
5HIHUHQFH
&RXUERQ(HWDO6DIHW\HI¿FDF\DQGSKDUPDFRNLQHWLFRIGDUXQDYLUULWRQDYLUFRQWDLQLQJUHJLPHQLQSUHJQDQW+,9ZRPHQWK&RQIHUHQFHRQ
5HWURYLUXVHVDQG2SSRUWXQLVWLF,QIHFWLRQV0DUFK6HDWWOH3RVWHUDEVWUDFW
=RUULOOD&HWDO7RWDODQGXQERXQGGDUXQDYLUSKDUPDFRNLQHWLFVLQ+,9SUHJQDQWZRPHQWK&RQIHUHQFHRQ5HWURYLUXVHVDQG2SSRUWXQLVWLF
,QIHFWLRQV0DUFK6HDWWOH3RVWHUDEVWUDFW
&ROEHUV$HWDO$FRPSDULVRQRIWKHSKDUPDFRNLQHWLFVRIGDUXQDYLUDWD]DQDYLUDQGULWRQDYLUGXULQJSUHJQDQF\DQGSRVWSDUWXPWK&RQIHU
HQFHRQ5HWURYLUXVHVDQG2SSRUWXQLVWLF,QIHFWLRQV0DUFK6HDWWOH3RVWHUDEVWUDFW
&DSSDUHOOL(HWDO3KDUPDFRNLQHWLFVRI'DUXQDYLU2QFHRU7ZLFH'DLO\'XULQJDQG$IWHU3UHJQDQF\UG,QWHUQDWLRQDO:RUNVKRSRQ+,93HGL
DWULFV-XO\5RPH,WDO\3RVWHUDEVWUDFW3B
+7%3KDUPDFRNLQHWLFVRIGDUXQDYLUDQGIRVDPSUHQDYLULQSUHJQDQF\
KWWSLEDVHLQIRKWE
3U(33.PRGHOLUDQMHVYDNRGQHYQRJNRULãüHQMD7'))7&7UXYDGD
SUXåDVNRUR]DãWLWXRG+,9LQIHNFLMH
Simon Collins, HIV i-Base
Uvod
1RYRLVWUDåLYDQMHSUHGVWDYOMHQRQD&52,MHXND]DOR
QD WR GD EL ]DãWLWD RG +,9D PRJOD ELWL EOL]X VYDNRGQHYQRPSULPMHQRP7'))7&7UXYDGDLWR
ELWUHEDORGDSURPLMHQLUDQLMXUH]HUYLVDQRVWSRSLWDQMX3U(3NDRLQWHUYHQFLMH>@
8 QHNLP VWXGLMDPD VYDNRGQHYQD SULPMHQD 7UXYDGH MH
ZZZKLYELOWHQLQIR
GUDPDWLþQRVPDQMLODSRMDYX+,9LQIHNFLMHSRVHEQRNRG
YLVRNRUL]LþQLKSRMHGLQDFD]DNRG060XL3U(;
VWXGLMLDOLMHXRVWDOLPVWXGLMDPDGRYHODGRNRQÀLNWQLK
UH]XOWDWD QDSRPLQMHPR )(03U(3 VWXGLMX NRG KHW
HURVHNVXDOQLKDIULþNLKåHQD
6YH VWXGLMH VX VH SRND]DOH NRPSOLNRYDQLP ]D LQWHUSUH
*RGLQD,EURM
+,9%,/7(1+7%H
WLUDQMH ]ERJ YLVRNLK VWRSD VDPRSULMDYOMHQH DGKHUHQFLMH
DOL YMHURYDWQR YHRPD QLVNLK VWRSD VWYDUQH DGKHUHQFLMH
GHPRQVWULUDQH X 3. SRGVWXGLMDPD NRMH VX RWNULOH QL
VNH QLYRH WHQRIRYLUD L )7&D XMHGQR L X DNWLYQRP L X
SODFHER GLMHOX VWXGLMH 3URMHNWRYDQD H¿NDVQRVW 3U(3 VH
GUDPDWLþQR SRYHüDOD NDGD VX 3. UH]XOWDWL X]HWL X RE]LU
GRNRGL3U(;>@
2YDGRND]DQD]DãWLWDELSRWHQFLMDOQRPRJODSRYHüDWLDG
KHUHQFLMX X VWYDUQRP åLYRWX X RGQRVX QD RQX YLÿHQX X
UDQLMLPVWXGLMDPD8NROLNRQHNR]QDGDüHELWL]DãWLüHQ
DQHGDMHVDPRXþHVQLNXSODFHERNRQWUROLVDQRPWHVWL
UDQMX L GD MH RYD ]DãWLWD WDNR HIHNWLYQD GD PRåH HOLP
LQLVDWLUL]LNRGGRELMDQMD+,9DWRELPRJORSURPLMHQLWL
REUD]DFQLVNHXSRWUHEHþDNLNRGSDFLMHQDWDVDPDQMRP
DGKHUHQFLMRP
3U(3 VWXGLMH VX GRGDWQR ]DNRPSOLNRYDQH UD]OLNDPD X
IDUPDNRNLQHWLþNLPVYRMVWYLPDSRMHGLQDþQLKOMHNRYDUD
]OLNDPDXDSVRUSFLMLVYDNRJOLMHNDNRGPXãNRJLåHQVNRJ
JHQLWDOQRJWUDNWDNDRLUHNWDOQRJWNLYDLLQWUDFHOXODUQRM
NRQFHQWUDFLML DNWLYQLK PHWDEROLWD QD RELMH RYH ORNDFLMH
5D]OLNH L]PHÿX DSVRUSFLMH OLMHND NRG OMXGL L åLYRWLQMD
PRJX RJUDQLþLWL VWHSHQ PRJXüHJ SRYH]LYDQMD H¿NDV
QRVWLSURWLYYDJLQDOQHLUHNWDOQHL]ORåHQRVWLL]VWXGLMDQDG
PDNDNLPDMPXQLPD
1D &52, QRYL SRGDFL R PRGHOLUDQMX VX SRND]DOL GD
]DãWLWDNRMXSUXåD3U(3PRåHELWLþDNLYHüDQHJRãWRVHWR
UDQLMHPLVOLOR,]YHãWDMGDVH]DãWLWDSULEOLåDYDYULMHGQRVWL
RG SUHGVWDYOMD PRWLY ]D QRYD UD]PDWUDQMD QDþLQD
QDNRMLEL3U(3PRJDRELWLLQNRURSRULUDQNDR]GUDYVWYHQD
LQWHUYHQFLMD
2VWDOHVWXGLMHSUHGVWDYOMHQHQDNRQIHUHQFLMLVXDGUHVLUDOH
QHNHRGEULJDRNRWRJD]ERJþHJD3U(3QLMHXQLYHU]DOQR
SUXåDR]DãWLWXXQHNLPGUXJLPVWXGLMDPD
L3U(;PRGHOLUDQDSUHGLNFLMD]DãWLWHX]VYDNRGnevnu adherenciju
3HWHU$QGHUVRQLNROHJHVXSUHGVWDYLOLXVPHQX3.DQDOL
]X LQWUDFHOXODUQLK NRQFHQWUDFLMD OLMHND X L3U(; VWXGLML L
SRYH]DOLLKVDQLYRLPDDGKHUHQFLMHX6WUDQGVWXGLML>@
2YD JUXSD MH NRULVWLOD UHJUHVLRQL PRGHO ]D SURFMHQX
H¿NDVQRVWL 3U(3 QD RVQRYX LQWUDFHOXODUQLK QLYRD WHQR
IRYLU GLIRVIDWD 7')'3 X RGUåLYLP 3%0&RYLPD L]
VOXþDMHYD XSDUHQLK VD QHLQ¿FLUDQLK NRQWUROQLK
VOXþDMHYD,VWUDåLYDþLVX]DWLPXVWDQRYLOL7')'3QLYRH
GRVWLJQXWH ]DEHOHåHQRP WHUDSLMRP WRNRP L GDQD
QHGMHOMQRXRGYRMHQRM3.VWXGLMLQDG+,9QHJDWLYQD
YRORQWHUD 6WUDQG VWXGLMD .RQDþQR NRULVWLOL VX L3U(;
UHJUHVLRQH PRGHOH L] L3U(; QD SRGDFLPD L] 6WUDQG
VWXGLMH]DSURFMHQMLYDQMH3U(3H¿NDVQRVWL]DVQRYDQHQD
GR]LUDQMXLGDQDQHGMHOMQR
8 L3U(; GHWHNWDELOQL QLYRL WHQRIRYLUD L X SOD]PL L X
üHOLMDPD VX VH SRVWHSHQR VPDQMLYDOL RG SRþHWND GR WUH
QXWND LQIHNFLMH QD VDPR VOXþDMHYD X WUHQXWNX LQ
IHNFLMH X RGQRVX QD DSURNVLPDWLYQR QHLQ¿FLUDQLK
VXEMHNDWDL]NRQWUROQHJUXSH8PMHVHFXNRMLMHSUHWKRGLR
LQIHNFLMDPDRYHVWRSHVXELOHQDVSUDPUHVSHN
WLYQRXND]XMXüLQDWRGDVXVHLQIHNFLMHGRJRGLOHWRNRP
SHULRGDQLVNHL]ORåHQRVWLOLMHNX
86WUDQGVWXGLMLGR]LUDQMHLGDQDQHGMHOMQRMHGRYHOR
GRSURVMHþQLK,45QLYRDIPROPLOLRQüHOLMD7')'3
RGLUHVSHNWLYQR2YR
XSRUHÿHQRVDQLYRLPDRGIPRO0XRGL3
U(;VOXþDMHYDVDGHWHNWDELOQLP7')LIPRO0
X NRQWUROQLK VOXþDMHYD VD GHWHNWDELOQLP QLYRLPD
6YDNRGQHYQR GR]LUDQMH EL PRJOR ELWL X]HWR X RE]LU L]
QLYRD OMHNRYD NRG L3U(; NRQWUROD GRN NRQ
WURODYMHURYDWQRQLMHX]LPDORVYDNRGQHYQXGR]X
5HJUHVLRQR PRGHOLUDQMH MH GRELOR L SURFLMHQLOR (&
RG IPRO0 RGUåLYLK üHOLMD &, VD SURFMH
QDPD RVMHWOMLYRVWL PDQMH RG IPRO0 GDMXüL SURFMHQH
]DVPDQMHQMHUL]LNDRG!L
!]DGR]LUDQMHLGDQDQHGHOMQRYL
GMHWL7DEHOX
7DEHOD3URFMHQH]DVPDQMHQMHUL]LNDXL3U(;
'R]DQHGHOMQR
QHGMHOMQR
QHGMHOMQR
QHGMHOMQR
7')'3IPRO0RGUåLYLKüHOLMD
&,
6PDQMHQMHUL]LND&,
!
!
Komentar
2YD VWXGLMD MH REXKYDWLOD Y3%0& D SOD]PD X]RUDND MH WHVWLUDQR L] YUHPHQVNLK WDþDND VOXþDMHYD NRQWUROD DOL RJUDQLþHQMD REXKDYDWDMX L WR GD VX QLYRL OLMHND ELOL VDPR SURNVLPDOQL ]D YUHPH
L]ORåHQRVWLLGDXWLFDM)7&QLYRDQLMHLVSLWLYDQ
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
,QWHUYDOLSRX]GDQRVWL]DFLOMDQR,&RG•IPRO0RGUåLYLKüHOLMD&,GRGMHOXMXãLURNLDWREL
VHWUHEDORSRWYUGLWLXEXGXüLPVWXGLMDPD
PrEP Partnera: zaštita kod sero-diskordantnih hetHURVHNVXDOQLKSDURYD
-DUHG%HDWHQLNROHJHVXSUHGVWDYLOLDåXULUDQHUH]XOWDWHL]
UDQGRPL]LUDQHVWXGLMH3U(3SDUWQHUDUDQGRPL]LUDQHSOD
FHERNRQWUROLVDQHVWXGLMHXMHGQRL7'))7&LVDPR7')
NRGQHJDWLYQLKSDUWQHUD+,9SR]LWLYQLKRVREDNRML
MRãXYLMHNQLVXELOLSRGYUJQXWL$59WHUDSLML>@
6WXGLMDMHELODREDYOMHQDXGHYHWJUDGVNLKLUXUDOQLKPHVWD
X .HQLML L 8JDQGL +,9 QHJDWLYQL SDUWQHUL VX PMHVHþQR
GROD]LOLUDGLWHVWLUDQMDQD+,9LVDYMHWRYDQMDRDGKHUHQ
FLMLLSUHYHQFLMLD+,9SR]LWLYQLSDUWQHULVXGROD]LOLMHG
QRPXWULPMHVHFDDDSURNVLPDWLYQRXVYDNRPGLMHOX
VWXGLMHMHSRþHORVD$59WUHWPDQRPXVNODGXVDSUHSRUX
NDPDL]QDFLRQDOQLKYRGLþD
3ODFHERGLRVWXGLMHMHQDVWDYOMHQMXODHQDNRQSUH
SRUXNHRGVWUDQHVWXGLMH'60%DWLSUHOLPLQDUQLUH]XOWDWL
VXYHüSUHGVWDYOMHQL8þHVQLFLL]SODFHERGLMHODVWXGLMHVX
]DWLPVOXþDMQLPSXWHPVYUVWDQLXMHGDQRGDNWLYQLKGMHOR
YDVWXGLMHDSUDüHQMHVHQDVWDYOMDGRGHFHPEUDH
$SURNVLPDWLYQH SRþHWQH NDUDNWHULVWLNH ]D QHJDWLYQRJ
SDUWQHUDVXREXKYDWLOHWHNQHãWRYLãHRGPXãNDUDFD
SURVMHþQDVWDURVW,45JRGLQHVDPODÿLK
RGJRGLQD,DNRMHSURVMHþQRWUDMDQMH,45SDUWQHU
VNLKRGQRVDL]QRVLORJRGLQDYULMHPHRGXSR]
QDYDQMD VD +,9VWDWXVRP QMLKRYLK SDUWQHUD MH L]QRVLOR
VYHJDPMHVHFLJRGLQH3URVMHþDQEURM&'
üHOLMD SR]LWLYQRJ SDUWQHUD MH ELR VNRUR üHOLMDPP
,45
=DGUåDYDQMH UHWHQFLMD VWXGLMH MH ELOR YHüH RG VD
SURVMHþQLP WUDMDQMHP SUDüHQMD RG PMHVHFD ,45 RSVHJ2YRMHREXKYDWLORYLãHRGRVR
EDJRGLQD SUDüHQMD 3<)8 L ! SRVMHWD X RNYLUX
VWXGLMHVD!UDVSRGMHOHPHGLNDPHQDWDVWXGLMH
2G QRYLK +,9 GLMDJQRVWLNRYDQLK RVRED NRG QHJD
WLYQLKSDUWQHUDNRGMHRWNULYHQRGDVHQDOD]HXVWDQMX
DNXWQHLQIHNFLMHQDSRþHWNXSXWHPUHWURVSHNWLYQRJ3&5
WHVWLUDQMD QDNRQ +,9 VHURNRQYHU]LMH RVWDYOMDMXüL VOXþDMD VWLFDQMD EROHVWL X SULPDUQRM VWXGLML 2G QMLK VHSRMDYLORX7')GHOXVWXGLMHQDVSUDPX7'))7&
GLMHOXX]XSODFHERGLMHOXVWXGLMHGDMXüLVWRSHSRMDYH
3<)8RVREDJRGLQDSUDüHQMDRGL
UHVSHNWLYQR 2YR MH GRYHOR GR YHRPD ]QDþDMQLK VWRSD
]DãWLWHRG&,L&,
X RGQRVX QD SODFHER X 7') L 7'))7& GLMHOX VWXGLMH
UHVSHNWLYQRXREDVOXþDMDS1LMHELOR]QDþDMQLK
UD]OLNDL]PHÿXGYDDNWLYQDGLMHODVWXGLMHS DRED
GLMHOD VX RGEDFLOD SUHWKRGQR GH¿QLVDQX QLåX H¿NDVQRVW
RG
,DNR VX QHJDWLYQLKSDUWQHUD þLQLOLPXãNDUFL
LQIHNFLMDVHGHVLORNRGåHQDQ QDVSUDPQDVSUDP
VWRSDSRMDYHNRGåHQD]DQ LVWRSDSRMDYH
NRGPXãNDUDFD]DSRMHGLQDþDQOLMNQDVSUDPNRP
ELQDFLMHOMHNRYDQDVSUDPSODFHERGLMHODVWXGLMHUHVSHN
WLYQR=DãWLWDMH]DEHOMHåHQDXMHGQRL]DPXãNDUFHLåHQH
X]VWDWLVWLþNHQH]QDþDMQHUD]OLNHL]PHÿXUD]OLNDXUH]XO
WDWLPDXRþHQLKNRGPXãNDUDFDRGQRVQRåHQDS ]D
MHGDQ OLMHN L S ]D GYRVWUXNX 3U(3 YLGMHWL 7DEHOX
7DEHOD(¿NDVQRVWSRSRORYLPD
(¿NDVQRVW&,
SYULMHGQRVW
,QWHUDNFLMD
7')
äHQH
0XãNDUFL
S S S S S S
S S 7'))7&
äHQH
0XãNDUFL
1LVX RWNULYHQH QLNDNYH UD]OLNH L]PHÿX R]ELOMQLK
QHSRåHOMQLK VOXþDMHYD L]PHÿX UD]OLþLWLK GMHORYD VWXGLMH
XNOMXþXMXüL SODFHER ]D VYDNL GLR VWXGLMH QLWL VX
SRWYUÿHQHODERUDWRULMVNHDEQRUPDOQRVWLVYDNLGLRVWXGL
MH MH LPDR RFMHQH LOL YHüH SRYHüDQMH NUHDWLQLQD
SRYHüDQMH IRVIRUD 7RNRP SUYRJ PMHVHFD ELOR MH
]QDþDMQR YLãH VOXþDMHYD EODJH PXþQLQH LOL XPRUD X DN
ZZZKLYELOWHQLQIR
WLYQLPGMHORYLPDVWXGLMHDOLVXXNDVQLMLPWDþNDPDVWXGLMH
SRVWDOLVOLþQLNDRLXSODFHERGLMHOXVWXGLMH
0DGD MH SRVWRMDOD MHGQD RVRED VD .5 PXWDFLMRP X]
WHQRIRYLULMHGQDRVREDVD09)7&PXWDFLMRPPHÿX
RVREDPDVDSRWYUÿHQRPDNXWQRPLQIHNFLMRPQDSRþHWNX
VWXGLMHQLNDNYHPXWDFLMHQLVXGHWHNWRYDQHXLQIHNFLMDPD
L] JODYQH VWXGLMH .RG þHWLUL VOXþDMD UH]LVWHQWQRVWL QD
*RGLQD,EURM
+,9%,/7(1+7%H
1157,MH]DELOMHåHQSULMHQRVUH]LVWHQWQRJYLUXVD
2NR MHGQH WUHüLQH XþHVQLND MH SULMDYLOR YLãH VHNVXDOQLK
SDUWQHUDPXãNDUDFDåHQD
3. UH]XOWDWL ]D QLYRH OLMND WHQRIRYLUD X VYDNRP RG DN
WLYQLKGMHORYDXVWXGLML3DUWQHULX3U(3VXSUHGVWDYOMHQLX
GUXJRMXVPHQRMSUH]HQWDFLMLRGVWUDQH'HERUDK'RQQHOO
>@
2YDVWXGLMDMHNRULVWLODVOXþDMHYDQ ]DGLRVWXGLMH
VDMHGQLPOLMHNRPQ ]DGLRVWXGLMHVDNRPELQDFLMRP
GYDOLMHNDLXSRUHGLODQLYRHOLMHNDNRGQHLQ¿FLUDQLK
RVREDL]NRQWUROQHJUXSHXVYDNRPGLMHOXVWXGLMHNRULVWHüL
YLãHX]RUDNDãLURPVWXGLMHXPMHVHFLPD
L1LYRLOLMHNDVXWHVWLUDQLNRULãüHQMHP/&06
VD GRQMRP JUDQLFRP NYDQWL¿NDFLMH RG QJP/ 1D
RVQRYXRVWDOLKVWXGLMDWHQRIRYLUELELRGHWHNWRYDQGHYHW
GDQDQDNRQMHGQHGR]HDQLYRLWHQRIRYLUDXUDYQRPHUQRP
VWDQMXXVOMHGGQHYQRJGR]LUDQMDELL]QRVLOL!QJP/
7HQRIRYLUMHELRGHWHNWRYDQNRG!QHLQ¿FLUDQLKRVR
EDL]NRQWUROQHJUXSHXRGQRVXQDX]RUDNDVOXþDMHYD
LNRGVDPRL]GLMHODVWXGLMHVDMHGQLPOLMHNRP
LX]RUDNDL]GLMHODVWXGLMHVDNRPELQDFLMRP
OMHNRYDSULSRVMHWLUDGLLVSLWLYDQMDVHURNRQYHU]LMH2YLP
VHGRELORUHODWLYQRVPDQMHQMHUL]LNDSRYH]DQRVDGHWHN
WDELOQLP OLMHNRP RG &, S
L &, S X GLMHOX VWXGLMH VD
MHGQLP OLMHNRP L GLMHOX VD NRPELQDFLMRP UHVSHNWLYQR
6DPRVOXþDMHYDLQIHNFLMHVDGHWHNWDELOQLPOLMHNRPMH
LPDORQLYRH!QJP/NRQ]LVWHQWQHVDYLVRNRPDGKHU
HQFLMRP
2EUDVFL DGKHUHQFLMH NRG NRQWUROQH JUXSH VX XND]DOL QD
WR GD SDFLMHQWL NRML VH QLMHVX LOL VX VH VODER SULGUåDYDOL
SURSLVDQH WHUDSLMH QLMHVX SURPLMHQLOL VYRMH DGKHUHQFLMX
WRNRP VWXGLMH 1DVXSURW WRPH RNR SDFLMHQDWD VD
YLVRNRPDGKHUHQFLMRPMH]DGUåDORLVWLQLYRDGKHUHQFLMH
WRNRPVWXGLMHGRNMHQMLKSUHãORQDQLåXDGKHUHQFLMX
DVHQLMHXRSãWHSULGUåDYDORSURSLVDQHWHUDSLMH
1HNROLNRGUXJLKDQDOL]DMHSUHGVWDYOMHQRL]VWXGLMH3DUW
QHULX3U(3WRNRP&52,2QHVXREXKYDWLOH
‡,]YHãWDMRVNRURWUXGQRüDWRNRPVWXGLMHVDVOLþQLP
VWRSDPDSRMDYHXVYDNRPRGWULGLMHODVWXGLMHLEH]EH]
EMHGQRVQLKEULJDNRMLMHSULMHGODJDRVSHFL¿þQXXSRWUHEX
]D3U(3NRGVHURGLVNRUGDQWQLKSDURYDNRMLåHOHGDLPDMX
EHEX>@
‡ 'HWDOML R DåXULUDQMX $59 NRG SR]LWLYQLK SDFLMH
QDWDþLMLMHEURM&'üHOLMDRSDRWRNRPVWXGLMHþLQHüLLK
SRJRGQLP ]D SRþHWDN WUHWPDQD JGMH MH VDPR QMLK ]DSRþHORWUHWPDQ)DNWRULVXREXKYDWLOLRNOLMHYDQ
MHSRSLWDQMXSRþHWNDJXELWDNSDFLMHQDWDWRNRPSUDüHQMD
LQHGRVWXSQRVWWUHWPDQD>@
‡9LVRND ! SR]LWLYQD SULKYDüHQRVW XSRWUHEH 3U(3
NRG QHJDWLYQLK SDUWQHUD X] QLåH DOL MRã XYHN YLVRNR
LQWHUHVRYDQMHNRGSR]LWLYQLKSDUWQHUD]DUDQLWUHW
PDQNDRSUHYHQFLMX>@
‡,PSOLNDFLMHL]3U(3]DãWLWHQDVWRSXQHWDþQLKSR]LWLYQLK
UH]XOWDWDL]EU]LKWHVWRYD2GSUHNRWHVWRYD
QMLKMHGDORSR]LWLYDQUH]XOWDWQDGYRVWUXNHEU]HWHVWRYH
*RGLQD,EURM
2GQMLKMHSRWYUÿHQRNDR]DLVWDSR]LWLYQR
SULPMHQRP (/,6$ QMLK MH ELOR QHWDþQR
SR]LWLYQR ãWR MH WDNRÿH XWYUÿHQR SULPMHQRP (/,6$ D
NRG VH QLMH PRJOR WDþQR XWYUGLWL /DåQL
SR]LWLYQL UH]XOWDWL VX ELOL þHãüL X DNWLYQLP GMHORYLPD
VWXGLMHQDVSUDPXSODFHER
GLMHOXVWXGLMHXVOMHGQLåHSRMDYH+,9D>@
‡ 0RGHOLUDQMH IDNWRUD ]D RFMHQX UL]LND UDGL RGUHÿLYDQMD
NDUDNWHULVWLNDSRSXODFLMHXFLOMXRWNULYDQMDHIHNWLYQHXS
RWUHEH3U(3NDRLQWHUYHQFLMH>@
Zašto PrEP nije funkcionisao kod FEM-PrEP
-RãMHGQDXVPHQDSUH]HQWDFLMDMHSUHGVWDYLODUH]XOWDWHL]
)(03U(3VWXGLMHXNRMRMVYDNRGQHYQRNRULãüHQMH7)'
)7&7UXYDGDNDR3U(3QLMHELORHIHNWLYQR)(03U(3
VWXGLMDNRMDMHREXKYDWLODQHãWRSUHNRRGSODQLUDQLK
XþHVQLNDMHRNRQþDQDDSULODHXVOMHGQHGRVWDW
NDH¿NDVQRVWLVYDNRGQHYQHSULPMHQH7'))7&XRGQRVX
QDSODFHERNRGSUHNRFUQLKKHWHURVHNVXDOQLKåHQD
'60%MHSUHSRUXþLRSUHNLGVWXGLMHNDGDMHREDYOMHQDWHN
SRORYLQD VWXGLMH NDGD MH SR LQIHNFLMD ]DELOMHåHQR X
VYDNRPGLMHOXVWXGLMH9LãHWUXGQRüDVHGHVLORDVSRUHGQL
HIHNWLVXWDNRÿHELOLYHüLXDNWLYQRPGLMHOXVWXGLMH
.RQDþQL UH]XOWDWL L] VWXGLMH VX SUHGVWDYOMHQL QD &52,
NRQIHUHQFLMLRGVWUDQH/XW9DQ'DPPHLNROHJD>@
3RþHWQHNDUDNWHULVWLNHVXREXKYDWLOHDSURNVLPDWLYQR
PODÿLKRGJRGLQDVDXSRWUHERPNRQGRPD
MHLPDORSODüHQLVHNVVDGUXJLPSDUWQHULPDSRUHGSULPDU
QRJ 0HÿXWLP XþHVQLND MH PLVOLOR GD VX L]ORåHQL
PDORPUL]LNXRGGRELMDQMD+,9DDOLMHLPDOR+O
DPLGLMX D JRQRUHMX WRNRP SUHJOHGD äHQH VX LPDOH
VHNV SURVMHþQR þHWLUL SXWD QHGHOMQR SURVMHN RSVHJ
2GLQIHNFLMDNRMHVXVHGHVLOHWRNRPJODYQHVWXGLMH
LQIHNFLMHVXVHGHVLOHXDNWLYQRPGLMHOXVWXGLMHVWRSD
LQFLGHQFLMHRVREDJRGLQDDXSODFHERJUXSL
,5 RVREDJRGLQD VD SURFLMHQMHQLP RSVHJRP
LQGHNVRPRSDVQRVWL+5]DLQIHNFLMXRG&,
GRS ,DNRMHVHGDPLQIHNFLMDRGEDþHQR
]ERJQHGRVWDWNDSURL]YRGDQDNOLQLFLREDYOMDQMDVWXGLMH
DQDOL]DVHQ]LWLYQRVWLNRMDMHFHQ]XULVDODåHQH]DSRVOHGQML
GDWXPXSRWUHEHSURL]YRGDQLMHSURPLMHQLODJODYQHUH]XO
WDWH+5&,S 7ROHUDELOQRVWJHQHUDOQRGREUDEH]VOXþDMHYDRFMHQHDOL
MHREXKYDWLODYLãHPXþQLQHXDNWLYQRMJUXSL
%LORMHSHWVOXþDMHYD)7&SRYH]DQHUH]LVWHQWQRVWLMHGDQ
XSODFHERGLMHOXVWXGLMHDOLEH]VOXþDMHYDUH]LVWHQWQRVWL
QD7')
.DRLNRGRVWDOLK3U(3VWXGLMDVWRSHDGKHUHQFLMHVXELOH
YHRPDYLVRNHSUHPDVDPRSULMDYOMLYDQMX!LEURMX
SLOXOD a DOL MH IDUPDNRNLQHWLþND DQDOL]D X SRG
VWXGLMLVOXþDMNRQWURODXND]DODQDWRGDMHRYDMQLYRXQD
MEROMHPVOXþDMXELRRNRXREDGLMHODVWXGLMHJGMH
MHGHWHNFLMDELODQLåDNRGVOXþDMHYDXRGQRVXQDNRQWUROH
1LYRLDGKHUHQFLMHLVSRGXVYDNRPGLMHOXVWXGLMHVX
WDNRÿH HOLPLQLVDOL PRü RYH VWXGLMH GD GHWHNWXMH VWYDUQL
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
XWLFDMXRNYLUXDNWLYQRJGLMHODVWXGLMH
2QRãWRPRåHELWLLQWHUHVDQWQRPLãOMHQMHRGVWUDQH$Q
QHNH *UREOHU L NROHJD X L]GDQMX RG RJ PDUWD X YH]L
VD$,'6RPRL]D]RYLPDGL]DMQD]DEXGXüHVWXGLMHSUH
YHQFLMHREXKYDWDLWDEHOXNRMDL]UDþXQDYDSURMHNWRYDQX
HIHNWLYQRVW RWNULYHQX ]D UD]OLþLWH QLYRH VWYDUQH H¿NDV
QRVWL NRPSDUDWRUD L QRYH LQWHUYHQFLMH X NRPELQDFLML VD
UD]OLþLWLPQLYRLPDDGKHUHQFLMH>@
Komentar
,DNRMHQHGRVWDWDN]DãWLWHXRYRMVWXGLMLSULSLVDQQLVNRMDGKHUHQFLMLRYRPRåHELWLNRPSOHNVQLMHSLWDQMHSRãWRMH
DGKHUHQFLMDWDNRÿHELODQLVNDXL3U(;2YRWDNRÿHPRåHREXKYDWLWLSRþHWQLUL]LNXþHVQLNDLSHUFHSFLMXUL]LNDãWR
PRåGDREMDãQMDYDUD]OLNHXRþHQHXRVWDOLPKHWHURVHNVXDOQLPVWXGLMDPDNDRãWRMH7')
7DNRÿHPRJXSRVWRMDWLLPSOLNDFLMHSRSRORYLPDSRYH]DQHVDIDUPDNRNLQHWLþNRPLLQWHUPLWHQWQRPDGKHUHQFLMRP
LVWDNQXWRPXVWXGLMDPDQDGPDNDNLPDMPXQLPDXNOMXþXMXüLLL]YMHãWDMXGDOMHPWHNVWX
,QWHUPLWHQWQL7'))7& 7UXYDGD NRG PDNDNL PDjmuna: PK vaginalnog, cervikalnog i rektalnog tkiva
LüHOLMD
-HVVLFD5DG]LRLNROHJHVD&'$X$WODQWLVXSUHGVWDYLOL
UH]XOWDWHL]IDUPDNRNLQHWLþNHVWXGLMHNRGPDNDNLPDMPX
QD>@
2YDVWXGLMDMHELODYDåQD]DLVSLWLYDQMHXMHGQRLWHQRIR
YLUDL)7&XWNLYXNDRLLQWUDFHOXODUQLKQLYRD2EDOLMHND
VXGRVWLJODYUKXQDF±]DGYDVDWDXSOD]PLL]DþHWLULVDWD
XYDJLQDOQRPVHNUHWX±D]DWLPVXRSDODGRQLVNLKQLYRD
]DþDVD8UHNWDOQRPVHNUHWXQLYRLVXVHSRYHüDYDOL
VSRULMH L UDYQRPHUQLMH GRVWLåXüL PDNVLPXP QDNRQ þDVDD]DWLPVXRVWDOLQDYLVRNLPQLYRLPDWRNRPQDMPDQ
MHMRãþDVD
2YDMDVSHNW3.SUR¿ODNRGPDNDNLPDMPXQDMHXSRUHGLY
VD RQLP XRþHQLP NRG åHQD *UXSD MH ]DWLP SRVPDWUDOD
DNWLYQHLQWUDFHOXODUQHQLYRHDNWLYQLKPHWDEROLWDVYDNRJ
RGOLMHNRYD)7&73L7)9'3
1LYRL ]D OLMHN )7& VX ELOL YHRPD VOLþQL X YDJLQDOQRP
FHUYLNDOQRPUHNWDOQRPLOLPIRLGQRPWNLYXXSRUHÿHQMX
VD üHOLMDPD X] YDJLQDOQLUHNWDOQL RGQRV RG X
üHOLMDPDLXWNLYXQDNRQþDVD2YRMHELORVOLþQR
L ]D FHUYLNDOQLUHNWDOQL RGQRV 0HÿXWLP QLYRL WHQRIRYL
UD X YDJLQDOQRP FHUYLNDOQRP L OLPIRLGQRP WNLYX NDR
L X üHOLMDPDVX ELOLGUDPDWLþQRQLåLGRNVX RVWDOL YLVR
NL X UHNWDOQRP WNLYX L üHOLMDPD VD RGQRVLPD NRQFHQ
WUDFLMDXYDJLQDOQRPUHNWDOQRPWNLYXRG]DLQWUDF
HOXODUQH QLYRH L X WNLYX VD VOLþQLP UH]XOWDWLPD ]D
FHUYLNDOQRUHNWDOQLRGQRVLUHVSHNWLYQR
*UXSDMH]DWLPSRVPDWUDODGDOLELRYLQLYRLELOLGRYROMQL
]DYDJLQDOQXL]ORåHQRVW6,9XNRGãHVWPDNDNLMDQDNRQ
RUDOQRJ GR]LUDQMD L SRQDYOMDOD MH L]ORåHQRVW QLVNLP GR
]DPDVYDNHQHGMHOMHGRQHGMHOMDNUR]þHWLULPHQVWUX
DOQD FLNOXVD NDNR EL DSURNVLPLUDOL OMXGVNX VHNVXDOQX
L]ORåHQRVW VD ãHVW PDNDNL NRQWUROQLK VOXþDMHYD 7')
)7&LOLSODFHERMHELRGDWþDVDSULMHLOLGYDVDWDQDNRQ
L]ORåHQRVWL6YHNRQWUROQHåLYRWLQMHVXVHEU]RLQ¿FLUDOH
XJODYQRPXSUYRPPHQVWUXDOQRPFLNOXVXDOLVHQLMHGDQ
DNWLYQL PDNDNL NRML MH SULPDR 7'))7& VD SUHNLGLPD
QLMH LQ¿FLUDR WRNRP QHGHOMD XND]XMXüL QD WR GD QLåD
3. PRåH ELWL ]DãWLWQD þDN L NRG 3U(3 VD SUHNLGLPD ]D
VSUHþDYDQMHYDJLQDOQRJSULMHQRVDLQIHNFLMH
2YD VWXGLMD MH RWNULOD REUD]DF RGQRVD XPMHVWR DSVR
OXWQLK NRQFHQWUDFLMD XND]XMXüL QD WR GD RYR SRWYUÿXMH
PRGHO PDNDNLMD ]D EXGXüH VWXGLMH ,DNR MH RYD VWXGLMD
SRVPDWUDODVDPRSOXVVDWDGR]LUDQMH]DYDJLQDOQX
L]ORåHQRVWUHNWDOQHVWXGLMHQDGPDNDNLMLPDVXQDJODVLOH
GD MH VDWD GR]D RG VXãWLQVNH YDåQRVWL D ]DãWLWD NRMX
SUXåDGR]DSULMHL]ORåHQRVWLVHSURGXåXMHRGGRVHGDP
GDQD0HÿXWLPGR]LUDQMHVDPRVDWDQDNRQL]ORåHQRVWL
MH ELOR SRYH]DQR VD ]QDþDMQR QLåRP ]DãWLWRP PDGD MH
LRQDELODRSHWYHüDQHJRXVOXþDMXNDGDQLMHGDWDGR]D
SULMHL]ORåHQRVWL
Komentar
3RWHQFLMDO]DVNRUR]DãWLWHRG+,9LQIHNFLMDX]QDL]PMHQLþQRLOLVYDNRGQHYQRGR]LUDQMHELWUHEDRGDSRNUHQH
SLORWSURJUDPHNRMLREXKYDWDMXSULVWXSRYRMRSFLMLNRGSRMHGLQDFDNRMLVXL]ORåHQLQDMYLãHPUL]LNX]DVWLFDQMH
HIV-a.
=DPQRJHOMXGHUL]LþQLMHSRQDãDQMHLYXOQHUDELOQRVWQDLQIHNFLMXPRåHELWLSRYH]DQDVDUHODWLYQRNUDWNLPSHULRGRPåLYRWDWLKRVRED%LORGDRYDMSHULRGWUDMHQHGMHOMDPDPMHVHFLPDLOLQHNROLNRJRGLQDRSFLMDGDVHNRULVWL
ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%H
RUDOQDSUR¿ODNVDNDGDMHPDODYMHURYDWQRüDNRULãüHQMDRVWDOLKPHWRGDSUHYHQFLMHPRåHVSULMHþLWLNRPSOLNDFLMH
NRMHQDVWDMXXVOMHGGRåLYRWQHLQIHNFLMHLWUHWPDQD
7'))7&7UXYDGDMHYHüSRGQLMHW)'$XUDGLRGREUHQMD]DXSRWUHEXNDR3U(3DRGOXNDVHRþHNXMHNDVQLMH
tokom ove godine.
5HIHUHQFH
$QGHUVRQ3HWDO,QWUDFHOOXODUWHQRIRYLU'3FRQFHQWUDWLRQVDVVRFLDWHGZLWK3U(3HI¿FDF\LQ060IURPL3U([WK&52,6HDWWOH2UDO
ODWHEUHDNHUDEVWUDFW/%
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
*UDQW50HWDO3UHH[SRVXUHFKHPRSURSK\OD[LVIRU+,9SUHYHQWLRQLQPHQZKRKDYHVH[ZLWKPHQ1(-01RYHPEHU1(-
0RD)UHHDFFHVV
KWWSZZZQHMPRUJGRLIXOO1(-0RD
%DHWHQ-HWDO$593U(3IRU+,9SUHYHQWLRQDPRQJKHWHURVH[XDOPHQDQGZRPHQWK&52,6HDWWOH2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
'RQQHOO'HWDO7HQRIRYLUGLVRSUR[LOIXPDUDWHGUXJOHYHOVLQGLFDWH3U(3XVHLVVWURQJO\FRUUHODWHGZLWK+,9SURWHFWLYHHIIHFWV.HQ\DDQG
8JDQGDWK&52,6HDWWOH2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
0XJR1HWDO3UHJQDQF\,QFLGHQFHDQGELUWKRXWFRPHVDPRQJLQDFOLQLFDOWULDORI3U(38JDQGDDQG.HQ\DWK&52,6HDWWOH3RVWHU
DEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
0XMXJLUD$HWDO%DUULHUVWR$57LQLWLDWLRQDPRQJ+,9LQGLYLGXDOV(DVW$IULFDWK&52,6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
+HIIURQ5HWDO3UHIHUHQFHVIRUDQGZLOOLQJQHVVWRXVH$59EDVHG+,9SUHYHQWLRQVWUDWHJLHVDPRQJ+,9VHURGLVFRUGDQWFRXSOHV.HQ\D
WK&52,6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
1GDVH3HWDO)UHTXHQF\RIIDOVHSRVLWLYH+,9UDSLGWHVWVLQDFRKRUWRIPHQDQGZRPHQUHFHLYLQJ3U(3²LPSOLFDWLRQVIRUSURJUDPPDWLFUROO
RXW.HQ\DDQG8JDQGDWK&52,6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
.DKOH(HWDO$QHPSLULFULVNVFRULQJWRROIRULGHQWLI\LQJKLJKULVNKHWHURVH[XDO+,9VHURGLVFRUGDQWFRXSOHVIRUWDUJHWHG+,9SUHYHQWLRQ
WK&52,6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
9DQ'DPPH/HWDO7KH)(03U(3WULDORIHPWULFLWDELQHWHQRIRYLUGLVRSUR[LOIXPDUDWH7UXYDGDDPRQJ$IULFDQZRPHQWK&52,
6HDWWOH2UDOODWHEUHDNHUDEVWUDFW/%
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
*UREOHU$&$EGRRO.DULP66$,'60DUFK9ROXPH,VVXHS±
KWWSMRXUQDOVOZZFRPDLGVRQOLQH)XOOWH[W'HVLJQBFKDOOHQJHVBIDFLQJBFOLQLFDOBWULDOVBRIBWKHDVS[
5DG]L-HWDO,QWHUPLWWHQWRUDO3U(3ZLWK7UXYDGDSUHYHQWVYDJLQDO6+,9WUDQVPLVVLRQLQPDFDTXHVWK&52,6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
1HPDQLNDNYHYH]HL]PHÿXDWD]DQDYLUDL0,LOLãORJDX'$'VWXGLML
Simon Collins, HIV i-Base
$åXULUDQH LQIRUPDFLMH L] '$' NRKRUWH R UL]LNX SR
MDYHNDUGLYDVNXODUQLKREROMHQMDVXSUHGVWDYOMHQHXYLGX
SRVWHUD'$'SUHGVWDYOMDYHOLNXNRKRUWXNRMDREXKYDWD
YLãHRG+,9SR]LWLYQLKRVREDL](YURSH$XVWUDOL
MHL6$'NRMHVXXSRVOHGQMHYUHPHSRVWDOHGRYROMQRVSR
VREQHGDVDJOHGDMXYH]HL]PHÿXEH]EHGQRVQLKUH]XOWDWDL
SRMHGLQDþQLK+,9OHNRYD
.RKRUWDVDGDREXKYDWDVOXþDMHYDLQIDUNWDPLRNDUGD
0, L ãORJD NRG SUHNR SDFLMHQWJRGLQD
SUDüHQMD3<)8DRYDJRGLQDMHGRQHODGRYROMQRSRGD
*RGLQD,EURM
WDNDRDWD]DQDYLUX!3<)8]DSUHGVWDYOMDQMHRYH
DQDOL]H5DQLMHYH]HVDRYLPVOXþDMHYLPDVXSULMDYOMHQH
]DNXPXODWLYQXL]ORåHQRVWLQGLQDYLUXLORSLQDYLUXUDOLQH
L]DVDNYLQDYLULOLIRVDPSUHQDYLU
6WRSDLQFLGHQFLMH0,MHL]QRVLOD3<)<&,
GRNRGRQLKNRMLQLVXELOLL]ORåHQLDWD]DQDYLUX
LGRNRGRQLKVD!JRGLQHL]ORåHQRVWL
6WRSDLQFLGHQFLMHãORJDMHL]QRVLODGRL
GR]DLVWHJUXSHUHVSHNWLYQR
5HODWLYQH VWRSH LQFLGHQFLMH 55 ]D 0, L VWURNH VX
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
L]QRVLOH&,S L&,
S QDNRQ SULODJRÿDYDQMD ]D NOLQLþNH L
GHPRJUDIVNHIDNWRUHXNOMXþXMXüL$59XSRWUHEX1LNDNYD
YH]D QLMH RWNULYHQD VD NXPXODWLYQRP L]ORåHQRãüX ! JRGLQH LOL QDNRQ GRGDWQRJ SULODJRÿDYDQMD
]DELOLUXELQ6WRSHLQFLGHQFLMHVXELOHVOLþQH]DDWD]DQDYLU
NRULãüHQVDLEH]ULWRQDYLUD
7DEHOD6WRSDLQFLGHQFLMH&,]D0,LOLãORJLL]ORåHQRVWDWD]DQDYLUX
0,
âORJ
%H]$79
!JRGLQH
GR
GR
GR
GR
5HIHUHQFH
G¶$UPLQLR0RQIRUWH$HWDO$79FRQWDLQLQJ$57LVQRWDVVRFLDWHGZLWKDQLQFUHDVHGULVNRIFDUGLRRUFHUHEURYDVFXODUHYHQWVLQWKH'$'
VWXG\WK&RQIHUHQFHRI5HWURYLUXVHVDQG2SSRUWXQLVWLF,QIHFWLRQV±0DUFK6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
6WXGLMHNRLQIHNFLMH+HSDWLWLVRP&
Simon Collins, HIV i-Base
.RQIHUHQFLMDMHREXKYDWLODYHRPDRKUDEUXMXüHUH]XOWDWHL]SUYLKVWXGLMDRWHODSUHYLUX,QFLYHN9HUWH[L
ERFHSUHYLUX 9LFWUHOLV 0HUFN NRG RVRED VD +,9
HCV koinfekcijom.
2EHVWXGLMHVXJHQHUDOQRSRND]DOHVOLþQHVWRSHUHDNFLMD
NRG+,9+&9NRLQIHNFLMHRQLPD]DEHOHåHQLPNRG+&9
PRQRLQIHNFLMH =DGUåDQL UH]XOWDWL YLURORãNH UHDNFLMH
695 X RM QHGHOML VX YLVRNRSUHGLNWLYQL ]D 695 X
RMQHGHOML
7HODSUHYLU 695 UH]XOWDWL NRG +,9+&9 NRLQfekcije
695UH]XOWDWLXRMQHGHOMLQDNRQWUHWPDQDL]GYRVWUX
NRVOHSHSODFHERNRQWUROLVDQH)D]DVWXGLMHWHODSUHYLUD
XNRPELQDFLMLVDSHJLORYDQLPLQWHUIHURQRPSHJ,)1
ULEDYLULQ5%9NRGSDFLMHQDWDVD+,9L+&9JHQR
WLS NRLQIHNFLMRP VX SUHGVWDYOMHQL RG VWUDQH Douglas
Dieterich>@
3DFLMHQWL VX VOXþDMQLP SXWHP UDVSRUHÿHQL ]D WHODSUHYLU
PJQDVYDNLKVDWLLOLSODFHERSOXV3(*,)1DOID
D3HJ\V\V5%9PJGQHYQRWRNRPQHGHOMD
SUDüHQLK VD QHGHOMD SULPHQH SHJ,)15%9 2YR MH
ZZZKLYELOWHQLQIR
ELODGYRGHOQDVWXGLMDNRMDMH]DYLVLODRGWRJDGDOLVXSDFL
MHQWLNRULVWLOL$57'HR%Q LOLQH'HR$Q 8
$57GHOXGR]YROMHQLVXUHåLPL]DVQRYDQLQDDWD]DQDYLU
ULWRQDYLUQ LOLHIDYLUHQ]Q VDSRYHüDQRPGR
]RPWHODSUHYLUD]DHIDYLUHQ]SDFLMHQWH
3RþHWQHNDUDNWHULVWLNHVXREXKYDWLOHSURVHþQDVWDURVWRG
JRGLQDPXãNDUFLFUQFLVDSRGWLSRP
DDMHLPDORFLUR]X+&951.MHELOR!,8
P/NRGLXEH]$57L$57JUXSLUHVSHNWLYQR
SURVHþDQEURM&'üHOLMDMHL]QRVLRDSURNVLPDWLYQR
üHOLMDPPRSVHJ!
1HGHWHNWDELOQL +&9 51. NRPELQRYDQR X DNWLYQRM
QDVSUDPSODFHERJUXSHVXGRVWLJQXWLVDQDVSUDP
QDVSUDP QDVSUDP L QDVSUDP
XQHGHOMDPDQHGHOMDPDLLQHGHOMLUH
VSHNWLYQRYLGHWL7DEHOX.RULãüHQMH$57QLMHXWLFDOR
QDVWRSHUHDNFLMD5H]XOWDWLSRSRþHWQRM+&951.QLVX
SUHGVWDYOMHQL
8MHGQRLEH]EHGQRVWLWROHUDELOQRVWWHODSUHYLUDXNRPEL
QDFLMLVDSHJ,)15%9VXELOHXSRUHGLYHVDRQLPSUH
WKRGQR ]DEHOHåHQLP NRG +&9PRQRLQ¿FLUDQLK SDFLMH
QDWD1LVXSULMDYOMHQLR]ELOMQLRVLSL
*RGLQD,EURM
+,9%,/7(1+7%H
7DEHOD3ULYUHPHQH+&951.%/4VWRSHUHDNFLMDVDWHODSUHYLURPNRG+,9+&9NRLQIHNFLMH
1
1
1HGHOMD
595
1HGHOMD
R595
1HGHOMHL
H595
1HGHOMD
%H]$57
()97'))7&
$7=U7'))7&
735
35
735
35
735
35
7WHODSUHYLU3SHJ,)15ULEDYLULQ%/4QHGHNWDELOQRGRQMDJUDQLFDNYDQWL¿NDFLMH,8OP/JUDQLFDGHWHNFLMH
,8P/
,QWHUDNFLMHL]PHÿXWHODSUHYLUDLDQWLUHWURYLUDOD
3RGDFLRLQWHUDNFLMLL]PHÿXWHODSUHYLUDL+,9OHNRYDVX
WDNRÿHREXKYDüHQLXLVWRMSUH]HQWDFLML.RQFHQWUDFLMHWH
ODSUHYLUDVXELOHVOLþQHXNRPELQDFLMLVDHIDYLUHQ]RPL
DWD]DQDYLURPUHIHUHQWQLPNRQFHQWUDFLMDPDVDSURVHNRP
&,&PLQ&DYJL&PD[RGQJP/
QJP/LQJP/VDHIDYLUHQ]RP
LQJP/QJP/LQJP/
VDDWD]DQDYLURPUHVSHNWLYQR
2GQRVLSURVHþQHNRQFHQWUDFLMHLUHIHUHQWQLKQLYRDVXELOL
EOL]X]DQLYRHHIDYLUHQ]DLDWDYDQDYLUDXND]XMXüL
QDWRGDMHYLãDGR]DHIDYLUHQ]DGRYROMQD]DSUHYD]LODåHQMH
RYHLQWHUDNFLMH
7HODSUHYLUVHPRåHNRULVWLWLLVNOMXþLYRVDSRYHüDQLPDWD
]DQDYLURP HIHYLUHQ]RP VD YHüRP GR]RP WHODSUHYLUD
± PJ WLG QDVSUDP PJ WLG LOL UDOWHJUDYLURP
3UDWHüLQXNOHR]LGLVXWHQRIRYLUSOXV)7&LOL7&
%RFHSUHYLU 695 UH]XOWDWL NRG +,9+&9 NRLQfekcije
695UH]XOWDWLXRMQHGHOMLQDNRQWUHWPDQDL]UDQGRP
L]LUDQH GYRVWUXNRVOHSH SODFHER NRQWUROLVDQH VWXGLMH
0HUFNRYRJERFHSUHYLUD%2&VDSHJLORYDQLPLQWHUIHU
RQRPSHJ,)1ULEDYLULQ5%9NRGSDFLMHQDWDVD
+,9L+&9JHQRWLSNRLQIHNFLMRPVXSUHGVWDYOMHQLRG
*RGLQD,EURM
strane 0DUN6XONRZVNL>@
8RYRMVWXGLMLVYLSDFLMHQWLVXELOLQDVWDELOQRPDQWLUHW
URYLUXVQRP WUHWPDQX EH] 1157,RYD$=7 LOL GGO VD
VXSUHVRYDQLP EURMHP YLUXVQLK NRSLMD NRSLMDP/
$57UHåLPMHREXKYDWLRDWD]DQDYLUUQ ORSLQDYLUU
Q GDUXQDYLUU Q RVWDOH 3, Q UDOWHJUDYLU
Q LGUXJHQ 3DFLMHQWLVXVOXþDMQLPSXWHPRGUHÿHQLXUD]PHULGD
SULPDMXERFHSUHYLUPJQDVYDNLKRVDPVDWLQ LOL SODFHER Q SOXV SHJLORYDQL LQWHUIHURQDOIDE
SHJ,QWURQL5%9]DVQRYDQQDWHåLQLGRPJ
GQHYQR6YLSDFLMHQWLVXWDNRÿHSURãOLþHWYRURQHGHOMQX
XYRGQXID]XVDSHJ,)15%9
3RþHWQH NDUDNWHULVWLNH VX REXKYDWLOH SURVHþQD VWDURVW
JRGLQD PXãNDUFL EHOFL MH LPDOR
+&951.!,8P/DMHLPDORJHQRWLSD
3URVHþQL EURMHYL &' üHOLMD VX DSURNVLPDWLYQR L]QRVLOL
üHOLMDPPRSVHJ!6DPRSDFLMHQWD
VXLPDODFLUR]X
+&951.QLYRLVXELOLQHGHWHNWDELOQLNRGQDVSUDP
SDFLMHQDWDXRMQHGHOMLLQDVSUDPX
RMQHGHOML]DJUXSXVDERFHSUHYLURPQDVSUDPNRQWUROQH
JUXSHVD695VWRSDPDQHGHOMDQDNRQSUHNLGDWUHWPD
QDRGQDVSUDPYLGHWL7DEHOX
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
7DEHOD3ULYUHPHQH+&951.%/4VWRSHUHDNFLMDVDERFHSUHYLURPNRG+,9+&9NRLQIHNFLMH
1
'LVNRQWLQXLWHW
QHGHOMDSHJ,)15%9OHDGLQ
QHGHOMD
QHGHOMD
QHGHOMD
QHGHOMD(27
695
%35
35
%ERFHSUHYLU3SHJ,)15ULEDYLULQ
9DåQH LQWHUDNFLMH L]PHÿX +,9 SURWHD]H LQKLELWRUD L
ERFHSUDYLUD
3UHGVWDYOMHQ MH SRVWHU RG VWUDQH LVWUDåLYDþD L] 0HUFND
RWNULYDMXüL ]QDþDMQH LQWHUDNFLMH L]PHÿX ERFHSUHYLUD L
+,9LQKLELWRUDSURWHD]HDWD]DQDYLUORSLQDYLULGDUXQD
YLUNRG+,9QHJDWLYQLKYRORQWHUD>@2YRMHLVWDNORQH
VDPRNRPSOHNVQRVW]DEXGXüL+&9WUHWPDQNRGRVRED
NRMH VX YHü QD$57 YHü WDNRÿH L YDåQRVW VSURYRÿHQMD
YHOLNLKVWXGLMDOHNOHNLQWHUDNFLMHSUHNRDGPLQLVWULUDQMD
XQRYLPVWXGLMDPD
%RFHSUHYLU MH ]QDþDMQR VQL]LR L]ORåHQRVW 3,RYD þDN GR
]D$8&ODVW&PD[L&PLQ>*05&,@
.RDGPLQLVWULUDQMH VD ERFHSUHYLURP MH WDNRÿH VPDQMLOR
L]ORåHQRVWULWRQDYLU$8&W]DLXJUXSDPD
VD DWD]DQDYLURP ORSLQDYLURP L GDUXQDYLURP UHVSHN
WLYQR.RDGPLQLVWULUDQMHVDDWD]DQDYLUUQLMHSURPHQLOR
ERFHSUHYLU$8&WDOLMHNRDGPLQLVWULUDQMHVDORSLQDYLUU
LGDUXQDYLUUVPDQMLORERFHSUHYLU$8&WLUHV
SHNWLYQR
7DEHOD,QGHNVJHRPHWULMVNHVUHGLQH&,]DLQWHUDNFLMXL]PHÿXERFHSUHYLUDL+,93,RYD
$7=
/39U
'59
$8&ODVW
&PD[
&PLQ
Komentar
2YLUH]XOWDWLVXYDåQL]DRVREHVD+&9JHQRWLSNRMLPDMHQHRSKRGDQKLWDQWUHWPDQ
3RGDFLRLQWHUDNFLMLL]PHÿXRYLK+&9OHNRYDLDQWLUHWURYLUDODXRYLPVWXGLMDPDVUHüRPQLVXELOLSRYH]DQLVD
YLVRNLPVWRSDPDQHXVSHKDWUHWPDQD
=D GRGDWQH LQIRUPDFLMH R LQWHUDNFLMDPD +&9 OHNRYD PROLPR SRJOHGDMWH RGOLþDQ RQODMQ L]YRU GDW RG VWUDQH
IDUPDNRORãNRJWLPDQD/LYHUSXO8QLYHU]LWHWX
KWWSZZZKHSGUXJLQWHUDFWLRQVRUJ
8.YRGLOMHRXSRWUHELRYLKQRYLK+&9OHNRYDRNRNRMLKMHSRVWLJQXWNRQVHQ]XVVXQHGDYQRREMDYOMHQHRQODMQX]
EHVSODWDQSULVWXSDLDNRQLVX+,9VSHFL¿þQHRQHREXKYDWDMXLUHIHUHQFHNDNRLQIHNFLMDPDNDRGRPHQXXNRP
VHQMLKRYDXSRWUHEDWUHEDUD]PRWULWL>
5HIHUHQFH
'LHWHULFK'HWDO7HODSUHYLULQFRPELQDWLRQZLWKSHJ\ODWHGLQWHUIHURQDOIDD5%9LQ+&9+,9FRLQIHFWHGSDWLHQWVDZHHNWUHDWPHQW
LQWHULPDQDO\VLV2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
6XONRZVNL0HWDO%RFHSUHYLUSHJ\ODWHGLQWHUIHURQULEDYLULQIRUWKHWUHDWPHQWRI+&9+,9FRLQIHFWHGSDWLHQWVHQGRIWUHDWPHQWZHHN
ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%H
LQWHULPUHVXOWV2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
+XOVNRWWH(HWDO3KDUPDFRNLQHWLFLQWHUDFWLRQEHWZHHQWKH+&9SURWHDVHLQKLELWRUERFHSUHYLUDQGULWRQDYLUERRVWHG+,9SURWHDVHLQKLELWRUV
DWD]DQDYLUORSLQDYLUDQGGDUXQDYLU3RVWHUODWHEUHDNHU/%
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
5DPDFKDQGUDQ3HWDO8.FRQVHQVXVJXLGHOLQHVIRUWKHXVHRIWKHSURWHDVHLQKLELWRUVERFHSUHYLUDQGWHODSUHYLULQJHQRW\SHFKURQLFKHSDWLWLV
&LQIHFWHGSDWLHQWV$OLPHQW3KDUPDFRO7KHU)UHHIXOODFFHVV
KWWSRQOLQHOLEUDU\ZLOH\FRPGRLM[IXOO
+HUSHV=RVWHUYDNFLQDMHEH]EHGQDLHIHNWLYQDNRG+,9SR]LWLYQLKRVRED
Simon Collins, HIV i-Base
2KUDEUXMXüL UH]XOWDWL VX SUHGVWDYOMHQL L] $&7* $
VWXGLMHRXSRWUHELGYHGR]HYDNFLQHåLYRJYDULþHOD]RVWHU
YLUXVD 9=9 =RVWDYD[ 0HUFN NRG VNRUR +,9
SR]LWLYQLKRVREDNRMHVXELOH9=9SR]LWLYQHLOLNRMHVX
LPDOH KHUSHV ]RVWHU +=SRMDVQL KHUSHV PDNDU MHGQX
JRGLQXSUHXODVNDXVWXGLMXDNRMLMHYLUXVQRVXSUHVRYDQ
GRVWDELOQRJ$57>@
,QFLGHQFLMD L R]ELOMQRVW += L SRVWKHUSHWLþND QHXUDOJLMD
3+1VXYLãHNRG+,9SR]LWLYQLKRVREDDUDQDXSRWUHED
WUHWPDQDDFLNORYLURPQLMHXYHNHIHNWLYQD.DNRVXVFHS
WLELOQRVWQD+=UDVWHVDVPDQMHQRPLPXQRPIXQNFLMRP
SRYH]DQRP VD VWDURãüX RGJRYRU ]DãWLWQH YDNFLQH YHü
GHPRQWULUDQNRG+,9QHJDWLYQLKRVREDVWDULMLKRGJR
GLQD>@ELELRSRVHEQRYDåDQ]D+,9SR]LWLYQHRVREH
8þHVQLFL L] SUHNR PHVWD X 6$' VX UDQGRPL]LUDQL
RGQRVRPQDDNWLYQHLOLSODFHERGHORYHVWXGLMHLNDW
HJRUL]RYDQLSUHPDEURMX&'üHOLMDSULSUHJOHGX!
YLVRNQLYRQDVSUDPQL]DNQLYRüHOLMDPP
9DNFLQDFLMDMHREDYOMHQDQDGDQLXãHVWRMQHGHOMLDLP
XQH UHDNFLMH VX SURFHQMLYDQH X QHGHOMDPD L
3ULPDUQHNUDMQMHWDþNHVXELOHEH]EHGQRVWXNROLNR”
SDFLMHQDWDXDNWLYQRPGHOXVWXGLMHLPDSULPDUQHEH]EHG
QRVQHNUDMQMHWDþNHLH¿NDVQRVWSURPHQDX9=9JS(/,
6$WLWHUXQHGHOMDQDNRQVYDNHYDNFLQDFLMH
3RþHWQH NDUDNWHULVWLNH VX REXKYDWLOH VOHGHüH PXãNDUDFDEHODFDFUQDFDKLVSDQRSRUH
NODSURVHþQDVWDURVWJRGLQD3URVHþDQEURM&'üHOLMD
L&'QDGLUQDMQLåLQLYRXJUXSLVDYLVRNLPQ L
QLVNLPQ QLYRRPMHL]QRVLRQDGLUL
QDGLU üHOLMDPP UHVSHNWLYQR 6NRUR VYL XþHVQLFL
VX UDQLMH LPDOL $,'6 PDQLIHVWDFLMX ! JGH MH LPDORPDQLIHVWDFLMXSUH9=9D+=!JRGLQHSUH
XODVNDXVWXGLMX
8EH]EHGQRVQRMDQDOL]LQLMHELOR]QDþDMQLKUD]OLNDL]PHÿX
DNWLYQHLSODFHERJUXSHDQLMHGQDRGSULPDUQLKNUDMQ
MLKWDþDNDXDNWLYQRPGHOXVWXGLMHQLMHELODSRYH]DQDVD
YDNFLQRP5HDNFLMHQDPHVWXXERGDVXþHãüH]DEHOHåHQH
NRGDNWLYQHJUXSHQDVSUDPS9=9
RVLSLVX]DEHOHåHQLNRGSDFLMHQWDL]DNWLYQHJUXSHL
SDFLMHQWDL]SODFHERJUXSHX]3&5NRMLMHSRND]DRQHJD
WLYQHLOLQHSRYH]DQHVDYDNFLQRPUH]XOWDWH
*HRPHWULMVND VUHGLQD SRYHüDQMD WLWHUD 9=9 DQWLWHOD VH
SRYHüDODVD=9QDVSUDP]DSODFHERRGSRþHWND
GR ãHVWH QHGHOMH S D WDNR MH RVWDOR GR H QH
GHOMHXND]XMXüLGDQHPDQLNDNYHSURPHQHXVOHGGUXJH
GR]H3DFLMHQWLVDYLãLPEURMHP&'üHOLMDQDSRþHWNX
VXLPDOLEODJRYLãLWLWHUDQWLWHODYUHPHQRPS 2YHUHDNFLMHVXELOHVOLþQHRQLPD]DEHOHåHQLPNRG+,9
QHJDWLYQLKSDFLMHQDWDVWDULMLKRGJRGLQD0HÿXWLPRYD
VWXGLMD QLMH PRJOD GD GHWHNWXMH UD]OLNX X += LVKRGX D
SUDüHQMHQDNRQVWXGLMHQLMHXSODQX
5HIHUHQFH
%HQVRQ&HWDO=RVWDYD[LVJHQHUDOO\VDIHDQGLPPXQRJHQLFLQ+,9DGXOWVYLURORJLFDOO\VXSSUHVVHGRQ$57UHVXOWVRID3KDVHUDQGRPL]HG
GRXEOHEOLQGSODFHERFRQWUROOHGWULDOWK&52,±0DUFK6HDWWOH2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
2[PDQ01HWDO$YDFFLQHWRSUHYHQWKHUSHV]RVWHUDQGSRVWKHUSHWLFQHXUDOJLDLQROGHUDGXOWV1(-0
KWWSZZZQHMPRUJGRLIXOO1(-0RD
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
($&6(YURSVNDNRQIHUHQFLMDR+,9$,'6X
±%HRJUDG6UELMD
Uvod
($&6 (YURSVND NRQIHUHQFLMD R +,9$,'6X MH
RGUåDQD X %HRJUDGX RG RNWREUD JRGLQH
6DRNRWULKLOMDGHGHOHJDWDRYRMHQDMYHüDNRQIHUHQFLMDR
+,9$,'6XLNDGDRGUåDQDXRYRPUHJLRQX=ERJWRJD
VPRRGOXþLOLGDYDPSUHGVWDYLPRQHNHQDMLQWHUHVDQWQLMH
SUH]HQWDFLMHVDQMH
3UHJOHGLL]YHãWDMDLRVWDOLVDGUåDMVDNRQIHUHQFLMHMHGRVWX
SDQ QD LQWHUQHWX ZHEFDVW SRGFDVW L 3RZHU3RLQW VODM
GRYL=DQMHJRYRSUHJOHGDYDQMHMHSRWUHEQRNRULVQLþNR
LPHLOR]LQNDNRMLVHPRJXGRELWLHPDLORPRG($&6
VHNUHWDULMDWD
ZZZDEVWUDFWVHUYHUFRPHDFVDEVWUDFWDUFKLYH OLQN ]D DE
VWUDNWHVDNRQIHUHQFLMH
ZZZPXOWLZHEFDVWFRPHDFV OLQN ]D VYH SUH]HQWDFLMH
ZHEFDVWDQG337VODMGRYL
,VWL SRGDFL ]D ORJRYDQMH VH WDNRÿH PRJX LVNRULVWLWL ]D
SULVWXS SRGDFLPD R REXFL ]D GRNWRUH NRMD MH REDYOMHQD
SUHNRQIHUHQFLMHNDRLRVWDOLPUHVXUVLPDL3KRQHLL3DG
YHU]LMHVXGRVWXSQHX]NRULãüHQMHEHVSODWQH7DONV2Q7KH
*RDSOLNDFLMH
KWWSZZZHXURSHDQDLGVFOLQLFDOVRFLHW\RUJ
(YURSVNLYRGLþ($&6±DåXULUDQDYHU]LMD
Simon Collins, HIV i-Base
(YURSVNRNOLQLþNRGUXãWYD]D$,'6(XURSHDQ$,'6
&OLQLFDO6RFLHW\MHREMDYLORQRYLYRGLþVYHREXKYDWDQLVSUDYOMHQLDåXULUDQãWRMHYHURYDWQRELORMHGQR
RGJODYQLKQDXþQLKWDþDNDQDNRQIHUHQFLML
7UL SUHWKRGQR RGYRMHQR REMDYOMHQD YRGLþD VX VDGD
JUXSLVDQDXYHüHPIRUPDWXSDMHRYRãWDPSDQRL]GDQMH
VYHREXKYDWQLMHLODNãH]DXSRWUHEXLUHIHUHQFH
9RGLþLVXED]LUDQLQDOLVWDPDNOMXþQLKSLWDQMDDOJRULWPL
PDOHþHQMDLWDEOLFDPDUHIHUHQFLDSUHGVWDYOMDMXRGOLþDQ
IRUPDW ]D EU]L SUHJOHG WUHQXWQR QDMEROMHJ VWDQGDUGD SR
SLWDQMX]GUDYVWYHQHQHJHXWULNOMXþQHREODVWLXSUDYOMDQMD
+,9RP
L 3URFHQD L SUDüHQMH WRNRP SRþHWQH L NDVQLMLK SRVHWD
OHNDUX
LL$59WUHWPDQNRGRGUDVOLKRVRED
LLL 3UHYHQFLMD L XSUDYOMDQMH QHLQIHNWLYQLP NRPRUELG
LWHWLPD
LY .OLQLþNR XSUDYOMDQMH L OHþHQMH KHSDWLWLVD % L & NRG
+,9SR]LWLYQLKSDFLMHQDWD
9RGLþYHU]LMDVHPRåHEHVSODWQRVNLQXWLXYLGX3')
IDMODDãWDPSDQLSULPHUFLVHPRJXQDUXþLWLQD($&6ZHE
VDMWX
KWWSZZZHXURSHDQDLGVFOLQLFDOVRFLHW\RUJ
âWDPSDQDYHU]LMDVHPRåHQDUXþLWLRG($&6D
LQIR#HDFVSDULVRUJ
5DOWHJUDYLUSRVWDMHVXSHULRUDQXRGQRVXQDHIDYLUHQ]QDNRQþHWLULJRGLQH
Simon Collins, HIV i-Base
5H]XOWDWL GRELMHQL WRNRP þHWLUL JRGLQH REDYOMDQMD
SHWRJRGLãQMH GYRVWUXNRVOHSH GRXEOHEOLQG UDQGRPL]LUDQHVWXGLMHQHLQIHULRUQRVWLNRMDMHXSRUHÿLYDOD
UDOWHJUDYLUVDHIDYLUHQ]RPVYDNLVDWHQRIRYLURPSOXV
ZZZKLYELOWHQLQIR
)7& NRG QDLYQLK SDFLMHQDWD NRG NRMLK VH SUYL SXW
SULPHQMXMHWDNYDWHUDSLMDVXSUHGVWDYOMHQLRGVWUDQH
Jurgen Rockstroh-a.
*RGLQD,EURM
+,9%,/7(1+7%H
3ODQVWXGLMHXVNODÿHQHSRþHWQHNDUDNWHULVWLNHLUH]XOWDWL
EH]EHGQRVWLLH¿NDVQRVWLL]UDQLMLKDQDOL]DVXYHüSUHGVWDY
OMHQLQDUDQLMLPNRQIHUHQFLMDPD1RYDDQDOL]DSRGJUXSH
XNOMXþXMXüL SRþHWQH YUHGQRVWL &' NRSLMDPP
EURMYLUXVQLKNRSLMD!NRSLMDP/KHSDWLWLVLGH
PRJUDIVNL RGJRYRUL VH IRNXVLUDOD QD YLURORãNX H¿NDV
QRVWX]REXKYDWDQMHGLVNRQWLQXLWHWDYH]DQLP]DYLURORãNL
QHXVSHK DOL EH] GLVNRQWLQXWLWHWD L] RVWDOLK UD]ORJD L X]
NRULãüHQMHSULVWXSDXRþHQRJQHXVSHKDREVHUYHGIDLOXUH
DSSURDFK
2GDSURNVLPDWLYQRSDFLMHQDWDXVYDNRPGHOXVWXGLMH
QD SRþHWNX L MH GRYUãLOR DQDOL]X
NRMDMHWUDMDODQHGHOMHXGHOXVDUDOWHJUDYLURPRGQRV
QRHIDYLUHQ]RP'LVNRQWLQXLWHWLVXELOLUHÿLXGHOXVWXGLMH
VD UDOWHJUDYLURP YLURORãNL QHXVSHK Q NRG VYLK VX ELOL
UHÿL X GHOX VWXGLMH VD UDOWHJUDYLURP YLURORãNL QHXVSHK
Q QDVSUDP VSRUHGQL HIHNWL Q QDVSUDP L
L]JXEOMHQLSDFLMHQWLQ QDVSUDP
8 RM QHGHOML SULPDUQD DQDOL]D YLUXVQH VXSUHVLMH QD
NRSLMDP/QHNRPSOHWLUDQR QHXVSHKMHRWNULODGD
MHUDOWHJUDYLUGRVWLJDRVWDWLVWLþNXVXSHULRUQRVWXRGQRVX
QDHIDYLUHQ]>QDVSUDPUD]OLND &,
S VD GRQMRP JUDQLFRP ]D QHLQIHUL
RUQRVW SRVWDYOMHQRP QD ± D VXSHULRUQRVW VH GRVWLåH
NDGDREDLQWHUYDODSRX]GDQRVWLSRVWDQXYHüDRG@
3RYHüDQMD&'üHOLMDVXL]QRVLODüHOLMDPPYLãHX
GHOXVWXGLMHVDUDOWHJUDYLURP&,
8NXSQLNOLQLþNLVOXþDMHYLQDVSUDPS GLVNRQWLQXLWHWLXVOHGVOXþDMHYDSRYH]DQLKVDGURJRP
QDVSUDPS LR]ELOMQRQHSRYROMQLVOXþDMHYL
XREDGHODVWXGLMHS ELOLVXVOLþQLL]PHÿX
GYHLVSLWLYDQHJUXSHGRNMHUDOWHJUDYLUELR]QDWQRUHÿH
SRYH]DQ VD VOXþDMHYLPD SRYH]DQLK VD GURJRP QDVSUDPS
1LMHELORQLNDNYLKVWDWLVWLþNL]QDþDMQLKUD]OLNHSRSLWDQMX
UHDNFLMHL]PHÿXRYHGYHJUXSHXRGQRVXQDSROX]UDVW
UDVXHWQLþNXSULSDGQRVWEURMYLUXVQLKNRSLMD!ü
P/&'!üHOLMDPPNRLQIHNFLMXKHSDWLWLVRPLOL
SRGYUVWX +,9D 5DOWHJUDYLU MH SRND]DR ]QDþDMQR YHüX
YLURORãNX UHDNFLMX NRG JUXSH VD üP/ QDVSUDPUD]OLND&,7XPDþHQMHUD
]OLNHXNRULVWUDOWHJUDYLUDNDGDMHSRþHWQLEURM&'üHOLMD
L]QRVLRüHOLMDPPMHNRPSOLNRYDQRXVOHGWUHQ
GDXNRULVWHIDLUHQ]DNDGDVXEURMHYL&'üHOLMDELOL
üHOLMDPP
Komentar
2YLUH]XOWDWLSRGUåDYDMXGXJRWUDMQRVWLEH]EHGQRVWUDOWHJUDYLUD7DNRÿHSRND]XMXGDQDNRQQHGHOMHUDOWHJUDYLUSRVWLåHVXSHULRUQRVWXRGQRVXQDHIDYLUHQ]VDUD]OLNRPNRMXXYHOLNRMPHULRGUHÿXMXVSRUHGQLHIHNWLSRYezani sa efavirenzom.
5D]OLNDXEURMX&'üHOLMDPRåHWDNRÿHELWLYDåQD]DSDFLMHQWHVDVXERSWLPDOQLP&'UHDNFLMDPDQD+$$57NRPEL
QDFLMH
5HIHUHQFH
5RFNVWURK-.HWDO/RQJWHUPHI¿FDF\RIUDOWHJUDYLURUHIDYLUHQ]FRPELQHGZLWK7'))7&LQWUHDWPHQWQDwYH+,9LQIHFWHGSDWLHQWVZHHN
VXEJURXSDQDO\VHVIURP67$5705.WK($&6±2FWREHU%HOJUDGH$EVWUDFW36
9LãLQLYRLWHQRIRYLUDLGDUXQDYLUDXSOD]PLDOLQHLHIDYLUHQ]DNRGVWDULMLKSDFLMHQDWD
Simon Collins, HIV i-Base
1HNROLNR VWXGLMD MH LVWUDåLYDOR YH]X L]PHÿX VWDULMHJ
uzrasta i farmakokinetike antiretrovirusnih lekova
3.
Tenofovir
0XJH&HYLNL]&KHOVHDDQG:HVWPLQVWHU%ROQLFHX/RQ
GRQX MH SUHGVWDYLR UH]XOWDWH L] 3. VWXGLMH NRML XND]X
MX QD WR GD VH NOLUHQV WHQRIRYLUD ]QDþDMQR VPDQMXMH VD
SRYHüDQMHP VWDURVWL L UH]XOWXMH YLãLP QLYRLPD OHNRYD
$8&L&WURXJK>@
2YL UH]XOWDWL VX REXKYDWLOL VWDELOQH QLYRH X SOD]PL NRG
*RGLQD,EURM
PXãNDUFD L åHQH RG NRMLK MH QMLK ELOR QD 3,U
]DVQRYDQLPNRPELQDFLMDPD3URVHþQDVWDURVWMHL]QRVLOD
JRGLQHRSVHJ±JRGLQDGRNMHVDPRGYRMHOMXGL
ELORPODÿHRGJRGLQD8]RUFLVXRGDELUDOQLVOXþDMQRD
IDUPDNRNLQHWLND SRSXODFLMH MH NRULãüHQD ]D SUHGYLÿDQMH
YUHGQRVWL
3URVHþQLNOLUHQVWHQRIRYLUD&/)$8&KL&WURXJK
& MH L]QRVLR /U ± PJKU/
±LPJ/±UHVSHNWLYQR
9HüDVWDURVWMHELODXYHOLNRMPHULSRYH]DQDVDVSRULMLP
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
NOLUHQVRP S YLãLP $8& S L YLãLP
&WURXJKS /MXGLVWDULMLRGJRGLQDVXLPDOL
]QDþDMQRQLåHNOLUHQVHS LYLãH$8&S RGRVREDPODÿLKRGJRGLQD
1LNDNYH3.UD]OLNHQLVXRWNULYHQHL]PHÿXNRPELQDFLMD
]DVQRYDQLKQD3,L1157,S (IDYLUHQ]LGDUXQDYLUULWRQDYLU
6OLþQD DQDOL]D MH ELOD SUHGVWDYOMHQD RG VWUDQH Ahmeda i
NROHJDL]LVWHJUXSHL]&KHOVHDDQG:HVWPLQVWHUEROQLFH
XYH]LVD3.HIDYLUHQ]DLOLGDUXQDYLUDWHQRIRYLUDNRMHVX
NRULVWLOL VWDULML SDFLMHQWL SURVHþQD VWDURVW MH L]QRVLOD JRGLQHRSVHJLJRGLQDUHVSHNWLYQR
>@
.RG PXãNDUDFD L åHQD NRML VX NRULVWLOL HIDYLUHQ]
QLNDNYHUD]OLNHQLVXRWNULYHQHQL]DMHGDQ3.SDUDPHWDU
SULREDYOMDQMXSRUHÿHQMDL]PHÿXRVREDVWDULMLKLPODÿLK
RGJRGLQDVYHSYUHGQRVWL!]DSRUHÿHQMDL]PHÿX
VWDURVQRJGRED
.RGPXãNDUFDLMHGQHåHQHNRMLVXNRULVWLOLGDUXQDYLU
ULWRQDYLUMHNRULVWLORMHGQRPGQHYQRRUDOQLNOLUHQVMH
ELR]QDþDMQRQLåLNRGRVREDVWDULMLKRGJRGLQD
QDVSUDP/KS VDYLãLP$8&QDVSUDP
PJK/S L&WURXJKQLYRLPDQDVSUDP
PJ/S QHJRNRGRQLKPODÿLKRGJRGLQD
2GQRV L]PHÿX VLWXDFLMD MHGQRPGQHYQR L GYDSXWGQHY
QR QLMH PRJDR ELWL SURFHQMHQ ]ERJ QHMHGQDNH VWDURVQH
UDVSRGHOHL]PHÿXGYDUHåLPDGR]LUDQMD
5HIHUHQFH
&HYLN0HWDO7HQRIRYLU7)9SKDUPDFRNLQHWLFV3.LQ+,9LQIHFWHGLQGLYLGXDOVRYHU\HDUVRIDJHWK($&6±2FWREHU
%HOJUDGH$EVWUDFW36
$KPHG$HWDO(IDYLUHQ]DQG'DUXQDYLU3ODVPD&RQFHQWUDWLRQVLQ+,9LQIHFWHG3DWLHQWV$JHG<HDUVRURYHUWK($&6±2FWREHU
%HOJUDGH$EVWUDFW3(
1LYRLULWRQDYLUDVPDQMHQLYLVRNRPDVQLPREURNRP
Simon Collins, HIV i-Base
,VWUDåLYDþL QD 0DNHUHUH 8QLYHU]LWHWX .DPSDOD L
IDUPDNRORãND JUXSD QD /LYHUSXOVNRP 8QLYHU]LWHWX
VX RWNULOL ]QDþDMQX LQWHUDNFLMX L]PHÿX YLVRNRPDVQLKREURNDLULWRQDYLUDNDRSRMDþLYDþDXORSLQDYLUU
.DOHWUD
,VSLWLYDQHVXVLWXDFLMHVDWULUD]OLþLWDREURNDXRNYLUXRSHQ
ODEHOWURGHOQHFURVVRYHUVWXGLMHNRG+,9SR]LWLYQLK
RVREDPXãNDUDFDåHQDNRMLNRULVWHORSLQDYLUH[
PJ WDEOHWD NDR VHNXQGDUQX WHUDSLMX 3URVHþQD
,45VWDURVWLWHåLQDSDFLMHQDWDMHL]QRVLOD
JRGLQDLNJ
,QWHQ]LYQR X]LPDQMH 3. X]RUND QDNRQ XPHUHQR J
PDVWLLYLVRNRJPDVQRJREURNDQD'DQLUH
VSHNWLYQRMHXSRUHÿHQRVDVWDQMHPSUD]QRJVWRPDNDQD
'DQ
8 SRUHÿHQMX VD JODGRYDQMHP DGPLQLVWULUDQMH YLVRNR
PDVQRJREURNDMHUH]XOWRYDORQLåLP$8&RPULWR
QDYLUDJHRPHWULMVNLSURVHþDQRGQRV&,
L QLåLP &PD[ *0 &, GRN VH & QLMH ]QDþDMQR SRYHüDR ]D *0 &,
5HIHUHQFH
/DPRUGH0HWDO6WHDG\VWDWHH[SRVXUHRIULWRQDYLULVUHGXFHGE\DKLJKIDWPHDOLQ8JDQGDQSDWLHQWVUHFHLYLQJORSL
QDYLUSOXVULWRQDYLUFRIRUPXODWHGWDEOHWVWK($&6±2FWREHU%HOJUDGH$EVWUDFW3(%3'
7UDQVSODFHQWDOQLSUHQRVUDOWHJUDYLUDLRGORåHQLNOLUHQVOHNDXSOD]PL
NRGSUHUDQRURÿHQLKEHED
Polly Clayden, HIV i-Base
3UHUDQL SRURÿDM MH þHVW NRG +,9 SR]LWLYQLK PDMNL
L SRYH]DQ MH VD SRYHüDQLP UL]LNRP SUHQRVD EROHVWL VD PDMNH QD GHWH 2UDOQD DSVRUSFLMD OHND NRG
ZZZKLYELOWHQLQIR
QRYRURÿHQþDGLVHQHPRåHSUHGYLGHWL]ERJQH]UHORVWL
gastro-intestinalnog trakta u ovom uzrastu. U ovakYLPVOXþDMHYLPDVHþHVWRNRULVWLXEUL]JDYDQMHPDWHUQDOQRJQHYLUDSLQD193XIHWXV
*RGLQD,EURM
+,9%,/7(1+7%H
5DOWHJUDYLU 5$/ MH NDWHJRULMH & SR SLWDQMX WUXGQRüH
D SRGDFL NRML EL XSUDYOMDOL QMHJRYRP XSRWUHERP WRNRP
WUXGQRüH VX RJUDQLþHQL 0HÿXWLP NRULãüHQ MH ]D GRVWL
]DQMHEU]RJVPDQMHQMDEURMDYLUXVQLKNRSLMDSUHSRURÿDMD
]DX]EUL]JDYDQMHXIHWXVXVOXþDMHYLPDNDGDVHSUHGYLÿD
ORãDRUDOQDDSVRUSFLMDLXVOXþDMHYLPDNDGDSRVWRMLUHVLVW
HQWQRVW LOL QHWROHUDQFLMD QD RVWDOH DQWLUHWURYLUXVQH OHN
RYH
5$/VHEU]RDSVRUEXMHVD7PD[RGRNRWULVDWDDWUH
ED PX GYD GDQD ]D GRVWL]DQMH VWDELOQLK NRQFHQWUDFLMD
L LPD SROXåLYRW X WUDMDQMX RG VDWL .RULVWL 8*7 $
PHWDEROLþNX SXWDQMX 2NR SRORYLQH RUDOQH GR]H VH
L]OXþXMH X QHL]PHQMHQRP REOLNX SXWHP VWROLFH D SXWHP PRNUDüH RNR WUHüLQH RYRJ GHOD SUHGVWDYOMD
QHSURPHQMHQL5$/DRVWDWDNMHXYLGXPHWDEROLWD3RV
WRML]QDþDMQDYDULMDELOQRVWL]PHÿXSDFLMHQDWDSRSLWDQMX
PHWDEROL]PDRYRJOHND
8 XVPHQRP REUDüDQMX $VHHO +HJD]L VD 6W *HRUJHV
8QLYHU]LWHWVNH EROQLFH /RQGRQ MH SUHGVWDYLR WUL VWXGL
MH VOXþDMD NRG NRMLK VX WUXGQH PDMNH SUHUDQR URÿHQLK
EHED SULPDOH 5$/ NDR GHR UHåLPD SUHYHQFLMH SUHQRVD
VD PDMNH QD GHWH 307&7 >@ ,VWUDåLYDþL VX LVSLWLYDOL
WUDQVSODFHQWDOQLSUHQRVOHNDLNOLUHQVOHNDXSOD]PLNRG
QRYRURÿHQþDGL
,VWD JUXSD MH UDQLMH RSLVDOD XSRWUHEX 5$/ X RNYLUX
307&7 UHåLPD NRG PDMNL WUL SUHUDQR URÿHQH EHEH 8
RYLPVOXþDMHYLPDVXRWNULOLGREDUWUDQVSODFHQWDOQLSUHQRV
VD YLãLP NRQFHQWUDFLMDPD NRG QRYRURÿHQþDGL QHJR NRG
PDMNLDSURNVLPDWLYQRWULVDWDQDNRQSRURÿDMD>@7DNRÿH
VX RWNULOL RGUåDYDQMH NRQFHQWUDFLMD NRG QRYRURÿHQþDGL
WRNRPWULGDQDPDGDLVSRGWHUDSHXWVNRJRSVHJD2QLVX
XND]DOLQDWRGDVHRYRPRåHSULSLVDWLVODELPQHRQDWDOQLP
LIHWDOQLPVD]UHYDQMHP8*7]DYLVQLKSXWDQMD.DRLGDMH
PRJXüHGDMHSRYHüDQDDNWLYQRVW8*7$SRYH]DQDVD
SURJHVWHURQRP ]DEHOHåHQD NRG WUXGQLK åHQD GRSULQHOD
RYRM UD]OLFL 8 WUL VOXþDMD XSRWUHEH 5$/ NRG SUHUDQRJ
SRURÿDMDXSDUHQLX]RUFLNUYLVXX]HWLWLNSUHSRURÿDMDD
]DWLPLWLNSRVOHSRURÿDMD0DWHUQDOQHLQHRQDWDOQHNRQ
FHQWDFLMH5$/DXSOD]PLVXL]PHUHQHNRULãüHQMHPWHþQH
KURPDWRJUD¿MHLPDVHQHVSHNWURPHWULMH7DEHODVXPLUD
RYHVOXþDMHYH
7DEHOD7ULVOXþDMDPDWHUQDOQHXSRWUHEH5$/NRGSUHUDQRJSRURÿDMD
5DQLMD$57LNOLQLþNL
NRQWHNVW
9UHPHSRþHWNDXSRWUHEH
5$/
6OXþDM
1157,L7&UH]LVWHQWQRVW
1HWROHUDQFLMDQDULWRQDYLU
/RãDDGKHUHQFLMD3UHH
NODPSVLMD3ODFHQWDSUDH
YLD%HEDPDOD]DQHGHOMX
WUXGQRüH+LWDQ&DUVNLUH]
QHGHOMHWUXGQRüH
9LUXVQRRSWHUHüHQMHSUL
SRþHWNXNRULãüHQMD5$/D
NRSLMDP/
3UDWHüLUHåLP
5D]GREOMHWUXGQRüHQD
SRURÿDMX
7HåLQDEHEH
9LUXVQRRSWHUHüHQMHSUL
SRURÿDMXNRSLMDP/
0DWHUQDOQHNRQFHQWUDFLMH
5$/DXSOD]PLQJP/
QHGHOMHGDQD
*RGLQD,EURM
7')$79
J
1LMHELORPRJXüHGHWHNWR
YDWL
VDWLQDNRQSULP
OMHQHGR]HQDSRURÿDMX
6OXþDM
/RãDDGKHUHQFLMD%HED
PDOD]DQHGHOMXWUXGQRüH
+LWDQ&DUVNLUH]
VDWLSUHSRURÿDMD%H]
SRQRYOMHQHGR]H]ERJ
X]QDSUHGRYDQLKWUXGRYDL
RSVWHWULþNLKNRPSOLNDFLMD
6OXþDM
$57QDLYQLSDFL
MHQW3RþHWDODVD
$%&$=77&XRP
WURPHVHþMX6SRQWDQD
UXSWXUDPHPEUDQD0XOWLSOL
¿EURLGL+LWDQ&DUVNLUH]
VDWLSUHSRURÿDMD
'R]DSRQRYOMHQDVDWL
SUHSRURÿDMD
1LMHELORPRJXüHGHWHNWR
YDWL
$79U7'))7&193 ()97')7&193
,9$=7QDSRURÿDMX
,9$=7QDSRURÿDMX
QHGHOMDGDQD
QHGHOMDGDQD
J
VDWLQDNRQ
SULPOMHQHGR]HVDWLSUH
SRURÿDMD
VDWDQDNRQSULPOMHQH
GR]HVDWSRVOHSRURÿDMD
J
1LMHELORPRJXüHGHWHNWR
YDWL
VDWLQDNRQSULP
OMHQHGR]HQDSRURÿDMX
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
'U+HJD]LMH]DNOMXþLODGDVHWHUDSHXWVNHNRQFHQWUDFLMH
5$/DXSOD]PL!QJP/PRJX]DGUåDWLGRSHWGDQD
NRGSUHUDQRURÿHQLKEHED2QDMHWDNRÿHQDSRPHQXODGD
MHWRGXåHQHJRNRGSUDYRYUHPHQRURÿHQLKEHEDLYHUR
YDWQRMHSRYH]DQRVDQH]UHORãüX8*7$SRVUHGRYDQRP
JOXNXURQLGDFLMRP 2QD MH XND]DOD QD WR GD PDWHUQDOQR
SUHWKRGQRRSWHUHüLYDQMH5$/RPPRåHELWLGREUDDOWHU
QDWLYD]D193WDNRJGHMHRUDOQDDSVRUSFLMDQHSRX]GDQD
SRVHEQRNRGSUHUDQRURÿHQLKEHEDDPDWHUQDOQHRSFLMH
VXRJUDQLþHQH
Komentar
2YHVWXGLMHVOXþDMDVXLQWHUHVDQWQHDRYDNYDXSRWUHED5$/DVHPRåHSRND]DWLYDåQRP8SRWUHED5$/DQDRYDM
QDþLQüHYHURYDWQRELWLVSRPHQXWDXQDUHGQLP%+,9$YRGLOMDPDPDGDVXSRGDFLYHRPDRVNXGQLSDüHVWRJD
GRND]LELOLVODEL
,03$$&7MHVWXGLMDSUHOD]QRZDVKRXWSDVLYQH3.LVWXGLMDEH]EHGQRVWLSURMHNWRYDQD]DLVSLWLYDQMH
RYRJIHQRPHQDNRGQRYRURÿHQþDGL7RMHSUYRNOLQLþNRWHVWLUDQMHLVWUDåLYDQRJOHNDNRMHVHEDYLQHRQDWDOQRP3.
2YDVWXGLMDUHJUXWXMHPDMNHNRMHYHüSULPDMX5$/XWUXGQRüLDQRYRURÿHQþDGüHELWLX]RUNRYDQDXLQWHUYDOLPD
RGGRVDWLQDNRQGR]LUDQMD
1DNRQSUHJOHGD3.LEH]EHGQRVQLKSRGDWDNDL]RYRJGRNXPHQWDL,03$$&7±NRMLLVSLWXMHRYDMOHNNRG
GHFHXX]UDVWLPDVDGHHVNDOLUDQRPWHUDSLMRPJGHGHFDPODÿDRGGYHJRGLQHSULPDMXJUDQXODUQXIRUPXODFLMX
NRMDVHWUHQXWQRLVSLWXMH±NRPSDQLMDSODQLUDVWXGLMXQRYRURÿHQþDGLURÿHQLRGVWUDQH+,9SR]LWLYQLKPDMNL]D
SHULRGRGPDKQDNRQURÿHQMDGRSRWYUGHQMLKRYRJVWDQMD
5HIHUHQFH
+HJD]L$HWDO5DOWHJUDYLULQWKHSUHYHQWLRQRIPRWKHUWRFKLOGWUDQVPLVVLRQRI+,9HIIHFWLYHWUDQVSODFHQWDOWUDQVIHUDQGGHOD\HGSODVPDFOHDU
DQFHREVHUYHGLQSUHWHUPQHRQDWHVWK($&6±2FWREHU%HOJUDGH2UDODEVWUDFW36
0FNHRZQ'$HWDO+LJKQHRQDWDOFRQFHQWUDWLRQVRIUDOWHJUDYLUIROORZLQJWUDQVSODFHQWDOWUDQVIHULQ+,9SRVLWLYHSUHJQDQWZRPHQ$,'6
6HSWHPEHU9ROXPH,VVXHS±
ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%H
92',ý,
9RGLþ6YHWVNH]GUDYVWYHQHRUJDQL]DFLMH:+2]DWHVWLUDQMHVDYMHWRYDQMHL
OLMHþHQMHNRGVHURGLVNRUGDQWQLKSDURYD$57SUL&'!]DVPDQMHQMH
UL]LNDSULMHQRVD
1DWKDQ*HIIHQ7$&
:+2MHXþHWYUWRPPMHVHFXREMDYLODQRYLYRGLþ
]D+,9WHVWLUDQMHLOLMHþHQMHNRGSDURYD2YDMGRNXPHQWMHYDåDQ]ERJWRJDãWRREXKYDWDãLURNHSUHSRUXNH GD VH$57 WUHED NRULVWLWL NDNR EL VH VSULMHþLOR
SULMHQRãHQMHLQIHNFLMHSULELORNRPEURMX&'üHOLMD
>@
2YDM YRGLþ MH QDMSULMH WUHEDOR ELWL SUHGVWDYOMHQ QD VDV
WDQNX0HÿXQDURGQRJ$,'6GUXãWYD,$6X5LPXVHG
PRJPMHVHFD>@0HÿXWLPL]UD]ORJDNRMLQLNDGD
QLVXELOLMDYQRREMDYOMHQLSXEOLNDFLMDMH]DXVWDYOMHQDD
DNWLYLVWLþNHRUJDQL]DFLMHXNOMXþXMXüLL%DVHVXRGJRYRU
LOHSLVPRPSRVODWLP:+2X>@
0DGD MH YHOLNL GHR WHNVWD SUHUDÿHQ JODYQH SUHSRUXNH
VX VXãWLQVNL RVWDOH QHSURPLMHQMHQH XNOMXþXMXüL L RSFLMX
SULPMHQH$57DSULEURMHYLPD&'üHOLMDYHüLPRG
NDNR EL VH VPDQMLR UL]LN RG SUHQRãHQMD LQIHNFLMH YL
GMHWL7DEHOX.RQDþQLGRNXPHQWVDGDL]YODþLNRULVWLL]
SRVYMHüHQLMH GLVNXVLMH R 3(3X 3U(3X L WUHWPDQX NDR
SUHYHQFLML
,DNRVXVYHSUHSRUXNHRFLMHQMHQHNDRVQDåQHVDPRSUH
SRUXNH L VX ]DVQRYDQH QD YLVRNRNYDOLWHWQLP GRND
]LPDSULMHVYHJD+371>@
7DEHOD6DåHWHSUHSRUXNHLQLYRGRND]D
3UHSRUXND
1LYRGRND]D
6QDåQDSUHSRUXNDQLVNRNYDOLWHWQLGRND]L
3DURYLPDLSDUWQHULPDWUHEDSRQXGLWLGR
EURYROMQR+,9WHVWLUDQMHLVDYHWRYDQMHX]
SRGUãNXX]DMDPQRPRWNULYDQMX
3DURYLPDLSDUWQHULPDXVLWXDFLMDPDDQWH
QDWDOQH]DãWLWHWUHEDSRQXGLWLGREURYROMQR
+,9WHVWLUDQMHLVDYHWRYDQMHX]SRGUãNX
X]DMDPQRPRWNULYDQMX
'REURYROMQR+,9WHVWLUDQMHLVDYHWRYDQMH
X]SRGUãNXX]DMDPQRPRWNULYDQMXWUHED
SRQXGLWLSRMHGLQFLPDVDSRWYUÿHQRP+,9
LQIHNFLMRPNDRLQMLKRYLPSDUWQHULPD
6QDåQDSUHSRUXNDQLVNRNYDOLWHWQLGRND]L
6QDåQDSUHSRUXNDQLVNRNYDOLWHWQLGRND]L]DVYH
OMXGHVD+,9RPXVYLPHSLGHPLMVNLPSRVWDYNDPD
8VORYQDSUHSRUXNDQLVNRNYDOLWHWQDHYLGHQFLMD]D
+,9QHJDWLYQHOMXGHX]DYLVQRVWLRGVSHFL¿þQH+,9
SUHYDOHQFLMH]DGRWLþQX]HPOMX
2VREDPDVD+,9RPXVHURGLVNRUGDQWQLP 6QDåQDSUHSRUXNDYLVRNRNYDOLWHWQLGRND]L
SDURYLPDLRVREDPDNRMHSRþLQMXVDDQWL
UHWURYLUDOQRPWHUDSLMRP$57]DQMLKRYR
VRSVWYHQR]GUDYOMHWUHEDSUHGRþLWLGDVH
$57WDNRÿHSUHSRXþXMHL]DVPDQMHQMH
SUHQRVD+,9DQDQHLQ¿FLUDQRJSDUWQHUD
+,9SR]LWLYQLPSDUWQHULPDVDEURMHP&' 6QDåQDSUHSRUXNDYLVRNRNYDOLWHWQLGRND]L
üHOLMD!üHOLMDPPXVHURGLVNRUGDQW
QLPSDURYLPDWUHEDSRQXGLWL$57NDNREL
VHVPDQMLRSUHQRV+,9DQDQHLQ¿FLUDQH
SDUWQHUH
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
5HIHUHQFH
*XLGDQFHRQFRXSOHV+,9WHVWLQJDQGFRXQVHOOLQJLQFOXGLQJDQWLUHWURYLUDOWKHUDS\IRUWUHDWPHQWDQGSUHYHQWLRQLQVHURGLVFRUGDQWFRXSOHV
5HFRPPHQGDWLRQVIRUDSXEOLFKHDOWKDSSURDFK:+2$SULO
KWWSZKTOLEGRFZKRLQWSXEOLFDWLRQVBHQJSGI
:RUOG +HDOWK 2UJDQLVDWLRQ 8QSXEOLVKHG &RXSOHV +,9 WHVWLQJ DQG FRXQVHOOLQJ DQG DQWLUHWURYLUDO WKHUDS\ IRU WUHDWPHQW DQG SUHYHQWLRQ LQ
VHURGLVFRUGDQWFRXSOHV5HFRPPHQGDWLRQVIRUDSXEOLFKHDOWKDSSURDFK
KWWSGOGURSER[FRPX3ULPDU\'RFXPHQWV:+2:+2JXLGHOLQHV)RU6HUR'LVFRUGDQW&RXSOHVSGI3')
$5$6$HWDO2SHQOHWWHUWR:+2RQGHOD\HGWHVWLQJDQGWUHDWPHQWJXLGHOLQHVIRUGLVFRUGDQWFRXSOHV
KWWSZZZWDFRUJ]DFRPPXQLW\QRGH
&RKHQ063UHYHQWLRQRI+,9LQIHFWLRQZLWKHDUO\DQWLUHWURYLUDOWKHUDS\1(QJO-0HG$XJ
KWWSZZZQFELQOPQLKJRYSXEPHG
ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%H
232581,67,ý.(,1)(.&,-(2,,.203/,.$&,-(
1HPDSRYHüDQLKUL]LNDRGSRMDYHVPUWQLKLVKRGDQHYH]DQLK]D$,'6XVOHG
NXPXODWLYQHSULPHQH$57DX(XUR6,'$NRKRUWL
1DWKDQ*HIIHQ&HQWDU]DLVWUDåLYDQMDGUXãWYHQLKQDXND8&7
'YHSRVWRMHüHEULJHYH]DQH]D+,9SR]LWLYQHRVREHQD
$57XVX'DOLGXJRURþQLVSRUHGQLHIHNWLVNUDüXMX
RþHNLYDQLåLYRWQLYHN"L'DOLMHSUHUDQRVWDUHQMH
SRYH]DQRELORVD$57RPLOLVD+,9RP"
0DGDVXXMHGQRLNUDWNRURþQLLVUHGQMHURþQLUH]XOWDWLGR
VDGD ELOL YHRPD GREUL SRGDFL NRML VX SRWUHEQL ]D RYH
SUREOHPH ]DKWHYDMX SUDüHQMH YHOLNRJ EURMD SDFLMHQD
WD WRNRP GXJRJ QL]D JRGLQD 3RãWR MH QHPRJXüH LPDWL
VOXþDMQH NRQWUROQH JUXSH WXPDþHQMH UH]XOWDWD NRKRUWH
WDNRÿHPRUDX]HWLXRE]LULEURMQHSULVXWQHSURPHQOMLYH
'UXJR SLWDQMH SUHGVWDYOMD SRVHEDQ IRNXV WUHQXWQRJ
LVWUDåLYDQMD $OL QRYD DQDOL]D L] (XUR6,'$ NRKRUWH MH
EOL]XQDODåHQMDRGJRYRUDQDSUYRSLWDQMH8þODQNXRE
MDYOMHQRP SUYRJ PHVHFD L]GDQMH R $,'6X
QLMHELORGRND]DL]RYHRJURPQHNRKRUWHGDVHUL]LNSR
MDYHVPUWQRJLVKRGDXNXSQLPRUWDOLWHWLOLVPUWQRVWXVOHG
$,'6DSRYHüDYDMXVDWUDMDQMHP$57D>@
(XUR6,'$MHMHGQDRGQDMYHüLKRSVHUYDFLRQLK$57NR
KRUWL2QDREXKYDWDVNRURSDFLMHQDWDL](YURSH
,]UDHODL$UJHQWLQH,VWUDåLYDþLRYHNRKRUWHUDQLMHVXRE
MDYLOLYDåQDGRNXPHQWDNRMDSRND]XMXNRULVWLRG$57D
SRSLWDQMXRþHNLYDQRJåLYRWQRJYHND$XWRULREMDãQMDYDMX
GDMHRYRSUYDVWXGLMDÄNRMDMHLVSLWLYDODYH]XL]PHÿXVP
UWQLKLVKRGDQHSRYH]DQLKVD$,'6LYUHPHQDSURYHGHQRJ
QD NRPELQRYDQRM DQWLUHWURYLUDOQRM WHUDSLML F$57 NDR
L GXJRURþQH SHUVSHNWLYH L]ORåHQRVWL WUHWPDQX 5H]XOWDWL
SRWYUÿXMXGD]DVDGDSURORQJLUDQDSULPHQDF$57DQDL]
JOHGQHGRYRGLGRSRYHüDQRJUL]LNDRGVPUWQRJLVKRGD
XVOHG RGUHÿHQRJ SUHWKRGQR LGHQWL¿NRYDQRJ NXPXOD
WLYQRJHIHNWDLOLHIHNWDOHNDLDNRSRVWRMLGXJLSHULRGLQ
GXNFLMHSUHSRMDYHREROMHQMD³
7HNQHãWRYLãHRGSDFLMHQDWDMHSUDüHQRRGSRþHWND
NRML MH GH¿QLVDQ NDR WUHQXWDN ]DSRþLQMDQMD $57D LOL
XNOMXþHQMDX(XUR6,'$QDNRQH7ULþHWYUWLQHNR
KRUWHVXPXãNDUFL2NRMH]DUDGLOR+,9KRPRVHNVX
DOQLPRGQRVLPDþLQH,'8NRULVQLFLLQWUDYHQR]QLK
GURJDDMHGRELOR+,9KHWHURVHNVXDOQLPRGQRVLPD
,QWHUHVDQWQR VNRUR NRKRUWH VX WUHQXWQL LOL UDQLML
SXãDþL D RYDM VWDWXV SXãDþ LOL QHSXãDþ QLMH ELR SR]QDW
NRGYLãHRGRVREDL]NRKRUWH1DSRþHWNXRNR
MHLPDORSRWYUÿHQLKHSDWLWLV&DNRGRNRMHSRWYUÿHQR
GDJDQHPDMX2NRMHLPDORSRWYUÿHQXKLSHUWHQ]LMX
*RGLQD,EURM
DWHNQHãWRYLãHRGMHLPDORSRWYUÿHQLGLMDEHWHV
,VWUDåLYDþLVXL]UDþXQDOLLQFLGHQFLMXVWRSHVPUWQRVWLYH
]DQX]D$,'6LQHYH]DQX]D$,'6QDRVREDJRGLQD
SUDüHQMDEROHVWLNDWHJRUL]RYDQLKSRYUHPHQXL]ORåHQRVWL
F$57XJRGLQHGRJRGLQDGRJRGLQD
GRJRGLQDL!JRGLQD
7RNRP RVREDJRGLQD SUDüHQMD EROHVWL XNXSQR
SDFLMHQDWDMHXPUOR$,'6MHELRX]URNDQH
$,'6 EROHVWL VX ELOH X]URN VPUWQD LVKRGD 6WRSH
LQFLGHQFLMHQDJRGLQDSUDüHQMDEROHVWLVXL]QRVLOH
XNXSQR&,±]DVPUWQHLVKRGH
YH]DQH ]D$,'6 &, ± L ]D VPUWQH
LVKRGHQHYH]DQH]D$,'6&,±
âWRVHWLþHVPUWQLKLVKRGDQHYH]DQLK]D$,'6MHELR
SRYH]DQ VD LQIHNFLMDPD VD REROMHQMHP MHWUH VD NDQFHUD VD NDUGLRYDVNXODUQLP EROHVWLPD VD
QDVLOMHP ãWR XNOMXþXMH L VDPRXELVWYR L YH]DQR ]D
RVWDOLHX]URNH
*ODYQDDQDOL]DMHXSRUHÿLYDODPRUWDOLWHWWRNRPSUHWKRG
QRGH¿QLVDQLKSHULRGDQD$57X,VWUDåLYDþLVXNRULVWLOL
GR JRGLQD QD $57X NDR UHIHUHQWQX NDWHJRULMX
.RG PXOWLYDULMDQWQH DQDOL]H NRMD MH NRQWUROLVDOD SRO
HWQLþNRSRUHNORUHJLRQ(YURSHREROHORVWRGKHSDWLWLVD%
L&GLMDEHWHVKLSHUWHQ]LMXSXãHQMHYLUXVQRRSWHUHüHQMH
EURM&'üHOLMDVWDQMHSUH$,'6DLX]UDVWRWNULYHQLVX
QDUHGQL RSVH]L VWRSH LQFLGHQFLMH RSãWLK VPUWQLK LVKRGD
VPUWQLK LVKRGD SRYH]DQLK VD $,'6 L QH$,'6 VPUWQLK
LVKRGDYLGHWL7DEHOX
7DEHOD2SVH]LVWRSHLQFLGHQFLMH&,]DRSãWH
smrtne ishode, AIDS i ne-AIDS smrtne ishode
9UHPHQD$57
2SãWLVPUWQLK
ishodi
6DPR$,'6
VPUWQLLVKRGL
6DPRQH$,'6
VPUWQLLVKRGL
JRGLQH
±
±
JRGLQD
±
±
JRGLQD
±
±
±
!JRGLQD
±
±
±
'XåH YUHPH SURYHGHQR QD $57X MH ELOR SRYH]DQR VD
VPDQMHQMHPUL]LNDRGVPUWQLKLVKRGDSRYH]DQLKVDMHWURP
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
QDVLOMHP L RG QHSR]QDWLK VPUWQLK LVKRGD $OL MH GXåH
YUHPHQD$57XWDNRÿHELORSRYH]DQRLVDSRYHüDQMHP
PRUWDOLWHWD NRML VH SULSLVXMH QH$,'6 NDQFHULPD
,VWUDåLYDþLXND]XMXQDWRGDRYRÄPRåHRGUD]LWLVWDUHQMH
+,9SRSXODFLMHSRãWRHIHNDWYLãHQLMHELRSULVXWDQQDNRQ
SULODJRÿDYDQMD]DYUHPHQVNLDåXULUDQX]UDVW³
Komentar
2YDMþODQDNMHRKUDEUXMXüL]DOMXGHVDQHGDYQRSRVWDYOMHQRPGLMDJQR]RPNRMLLPDMXSULVWXSPRGHUQLP$59
RYLPDLVDPHGLFLQVNRPLVWRULMRPNRMDQLMH]DNRPSOLNRYDQDNRLQIHNFLMDPDLOLSUHWKRGQRUD]YLMHQRPUH]LVWHQFLMRPQDOHN9DåQRMHGDQHPDVLJQDODGRGDWQRJUL]LNDRGWUHWPDQDNRMLMHLQDþHVWDELODQLHIHNWLYDQ
5L]LNRGSUHUDQRJVWDUHQMDSUHGVWDYOMDIRNXV]DLVWUDåLYDQMDLPXQRJRGJRYRUDLLQÀDPDFLMH7DNRÿH RG +,9
QHJDWLYQLKNRQWUROQLKJUXSD]DYLVLVKYDWDQMHXWLFDMDUH]LGXDOQHLQÀDPDFLMHNRGOMXGLSRWLVQXWH+$$57RP8
XYRGQRPL]ODJDQMXX7UHQXWQRPPLãOMHQMXRLQIHNWLYQLPEROHVWLPD0DUWLQ)LVKHUL9DQHVVD&RRSHUXND]XMXQD
RSUH]SRSLWDQMXYH]DL]PHÿX+,9L$57LVWDUHQMD2QL]DNOMXþXMXÄLDNREH]VXPQMHSRVWRMHYLVRNHVWRSHNRPRUELGLWHWDNRG+,9SR]LWLYQHSRSXODFLMH>@QHRSKRGQDVXGRGDWQDLVWUDåLYDQMDNDNRELVHLVSLWDOLPHKDQL]PL
NRMLPD+,9+$$57PRJXGRSULQHWLUD]YRMXVWDURVQRSRYH]DQLKEROHVWLGRSULQRVRVWDOLKYDåQLKLSRWHQFLMDOQR
SURPHQOMLYLKIDNWRUDUL]LNDXNOMXþXMXüLSXãHQMHXSRWUHEXDONRKRODLGURJHNDRLXORJDNRPRUELGQLKEROHVWL³
>@
5HIHUHQFH
.RZDOVND-'HWDOIRU(XUR6,'$/RQJWHUPH[SRVXUHWRFRPELQDWLRQDQWLUHWURYLUDOWKHUDS\DQGULVNRIGHDWKIURPVSHFL¿FFDXVHVQRHYLGHQFH
IRUDQ\SUHYLRXVO\XQLGHQWL¿HGLQFUHDVHGULVNGXHWRDQWLUHWURYLUDOWKHUDS\$,'6±-DQXDU\)UHHIXOOWH[WRQOLQH
KWWSMRXUQDOVOZZFRPDLGVRQOLQH)XOOWH[W/RQJBWHUPBH[SRVXUHBWRBFRPELQDWLRQBDQWLUHWURYLUDODVS[
)LVKHU0DQG&RRSHU9+,9DQGDJHLQJSUHPDWXUHDJHLQJRUSUHPDWXUHFRQFOXVLRQV"&XUU2SLQ,QIHFW'LV±)UHHIXOOWH[WRQ
OLQH
KWWSMRXUQDOVOZZFRPFRLQIHFWLRXVGLVHDVHV)XOOWH[W+,9BDQGBDJHLQJBBBSUHPDWXUHBDJHLQJBRUBSUHPDWXUHDVS[
1RYHVWXGLMHR+,9XLEROHVWLPDVWDUHQMD
5LFKDUG-HIIHU\V7$*
Izdanje Clinical Infectious Diseases iz 12. meseca
SURãOHJRGLQHVDGUåLSXQRGRNXPHQDWDNRMLDGUHVLUDMXSUREOHPH+,9DLVWDUHQMD
,]YHãWDM L] 6WXGLMH ãYDMFDUVNH +,9 NRKRUWH GRNXPHQWX
MHGDEROHVWLNRMHVHRELþQRSRYH]XMXVDVWDUHQMHPVDGD
SUHGVWDYOMDMXQDMþHãüHX]URNHPRUELGLWHWDXQMLKRYRMNR
KRUWLNRMDVDGUåLUDVWXüLXGHRSRMHGLQDFDVWDURVWLJR
GLQD L YLãH >@ 1DVXSURW WRPH RSRUWXQLVWLþNH LQIHNFLMH
GDMXWHNPDOLGRSULQRVXVDYUHPHQRMHULHIHNWLYQHDQWL
UHWURYLUDOQHWHUDSLMH$578YRGQLþODQDN0LNH6DDJD,
WRJL]GDQMDLVWLþHLPSOLNDFLMHQDSUXåDQMHRGJRYDUDMXüH
PXOWLGLVFLSOLQDUQHQHJHOMXGLPDVD+,9RPWRNRPQMLKR
YRJVWDUHQMD>@
,DNRVXXWRNXGHEDWHRWRPHGDOLMH+,9LQIHNFLMDSRY
H]DQDVDSUHUDQLPVWDUHQMHP±QHNHRGVWXGLMDVXXND]DOH
QDWRGDMHUL]LNRGSRMDYHEROHVWLSRYH]DQLKVDVWDUHQMHP
YHüLNRG+,9SR]LWLYQLKOMXGLQHJRNRG+,9QHJDWLYQLK
SRMHGLQDFD LVWRJ X]UDVWD GRN VX QHNH GUXJH VWXGLMH RV
ZZZKLYELOWHQLQIR
SRULOH RYH QDOD]H ± 6WXGLMD ãYDMFDUVNH +,9 NRKRUWH
QDJODãDYDGDELORGDVHRYLPRUELGLWHWLSRMDYOMXMXUDQLMH
LOLQHRQLVDGDSUHGVWDYOMDMXJODYQXEULJXXGXJRURþQRM
QH]LRVREDVD+,9RP3ULGLVNXWRYDQMXRYLKQDOD]DDX
WRULQDSRPLQMXGDMHSRMDYDNDQFHUDVUþDQLKXGDUDLGL
MDEHWHVD NRG þODQRYD LVWUDåLYDQH NRKRUWH X]UDVWD JRGLQDELODYLãDRGSRMDYHLVWLKREROMHQMDSULMDYOMHQHX
VWXGLMDPD GRQHNOH XSRUHGLYLK +,9QHJDWLYQLK NRKRUWL
DOLDXWRULWDNRÿHQDJODãDYDMXÄGDMHSRUHÿHQMHQDãLKUH]XOWDWDVD+,9QHLQ¿FLUDQRPSRSXODFLMRPLVWRJX]UDVWD
VDVOLþQLPNRPRUELWHWRPLOLSRQDãDQMHPWHãNR]ERJWRJD
ãWRQHPDPRSRJRGQXNRQWUROQXJUXSX+,9QHLQ¿FLUDQLK
osoba u našoj zemlji³
*LRYDQQL*XDUDOGLLNROHJHVD8QLYHU]LWHWDX0RGHQLL
5HÿR(PLOLMLX,WDOLMLVXSRNXãDOLGDREUDGHRYDMSUREOHP
XVYRMRMVWXGLMLNRMDMHXSRUHÿLYDODSRMDYXQHLQIHNWLYQLK
NRPRUELWLGLWHWD1,&0RYDLSROLSDWRORJLMHSULVXVWYR
YLãH RG MHGQRJ 1,&0D NRG +,9SR]LWLYQLK RVRED QD
$57X L VOLþQH +,9QHJDWLYQH NRQWUROQH JUXSH L] RSãWH
*RGLQD,EURM
+,9%,/7(1+7%H
SRSXODFLMHRGHGRH>@
1,&0RYL ]DEHOHåHQL X VWXGLML VX REXKYDWLOL NDUGLR
YDVNXODUQX EROHVW KLSHUWHQ]LMX GLMDEHWHV PHOOLWXV SUH
ORPH NRVWLMX L SUHVWDQDN UDGD EXEUHJD 5H]XOWDWL VX RW
NULOL GD VX SUHYDOHQFLMD 1,&0RYD L SROLSDWRORJLMD ELOH
YLãH NRG +,9SR]LWLYQLK SRMHGLQDFD X VYLP VWDURVQLP
NDWHJRULMDPD3UHYDOHQFLMDSROLSDWRORJLMHPHÿXRVREDPD
VD+,9RPX]UDVWDMHELODVOLþQDSUHYDOHQFLMLNRG
+,9QHJDWLYQHNRQWUROQHJUXSHVWDURVWL
7XPDþHQMH UH]XOWDWD MH ]DNRPSOLNRYDQR þLQMHQLFRP GD
VX VYL SRGDFL ]D +,9SR]LWLYQH SRMHGLQFH ELOL GRELMHQL
RG PHWDEROLþNH NOLQLNH X 0RGHQL 'HR RYH SRSXODFLMH
þLQH ORNDOQH RVREH L] JODYQH NOLQLNH ]D +,9 X 0RGHQL
NRMHVXDXWRPDWVNLSRVODWHQDPHWDEROLþNXNOLQLNXXNR
OLNRVXQD$57X0HÿXWLPSRSXODFLMDWDNRÿHREXKYDWD
LYHOLNLXGHR+,9SR]LWLYQLKSRMHGLQDFDNRMLVXSRVODWLX
PHWDEROLþNXNOLQLNXX0RGHQLL]VXVHGQLKFHQWDUD]ERJ
PHWDEROLþNLK SUREOHPD NDR ãWR MH OLSRGLVWUR¿MD D WR MH
L]JOHGD XWLFDOR QD QHRELþQR YLVRNX SUHYDOHQFLMX RYRJ
VWDQMDXLVSLWLYDQRMNRKRUWL.DNRELSURFHQLOLGDOL
MHRYDSUHNRPHUQD]DVWXSOMHQRVWRVREDVDPHWDEROLþNLP
SUREOHPLPD XWLFDOD QD QMLKRYH UH]XOWDWH DXWRUL VWXGLMH
VXXSRUHGLOLLQFLGHQFLMX1,&0RYDLSROLSDWRORJLMHNRG
ORNDOQLKSDFLMHQDWDSRVODWLKQDRYXNOLQLNXVDLQFLGHQFL
MRPNRGRQLKSDFLMHQDWDL]VXVHGQLKFHQWDUDDOL±PRåGD
L]QHQDÿXMXüH NDNR -DFTXHOLQH &DSHDX QDSRPLQMH X
XYRGQRPNRPHQWDUX±QLVXRWNULOLQLNDNYHUD]OLNH>@
$XWRUL ]DNOMXþXMX Änaši nalazi ukazuju na to da je
DJUHVLYQLSULVWXSSUDüHQMXVNULQLQJXGLMDJQRVWLNRYDQMX
LOHþHQMX1,&0RYD]DJDUDQWRYDQNDRGHRUXWLQVNHQHJH
+,9LQ¿FLUDQLKSDFLMHQDWD3RUHGWRJDQDãLSRGDFLXND]XMXQDWRGDELSRþHWDNWDNYRJVNULQLQJDWUHEDRQDVWXSLWL
X]QDþDMQRUDQLMHPX]UDVWXNRG+,9LQ¿FLUDQLKRVREDX
RGQRVX QD +,9QHLQ¿FLUDQH RVREH YHURYDWQR QDMPDQMH
deset godina ranije. Dodatne studije su potrebne kako
bi se dalje procenio uticaj konvergentnih starosno-povH]DQLK 1,&0RYD QD VWDURVQRSRYH]DQD IXQNFLRQDOQD
VWDQMD VODERVW L LQYDOLGLWHWH NRG +,9LQ¿FLUDQLK RVRED
L]ORåHQLK$57X L NDNR EL VH RPRJXüLOL XYLGL X SURFHVH
XEU]DQRJVWDUHQMDNRMLPRJXELWLSRYH]DQLVDKURQLþQRP
+,9LQIHNFLMRP³
5HIHUHQFH
+DVVH%HWDOIRUWKH6ZLVV+,9&RKRUW6WXG\0RUELGLW\DQGDJHLQJLQ+,9LQIHFWHGSHUVRQVWKH6ZLVV+,9&RKRUW6WXG\&OLQ,QIHFW'LV
2FW
KWWSFLGR[IRUGMRXUQDOVRUJFRQWHQW
6DDJ06(GLWRULDOFRPPHQWDU\+,9QRZ¿UPO\HVWDEOLVKHGLQWKH0LGGOH$JHV&OLQ,QIHFW'LV2FW
KWWSFLGR[IRUGMRXUQDOVRUJFRQWHQW
*XDUDOGL*HWDO3UHPDWXUHDJHHODWHGFRPRUELGLWLHVDPRQJ+,9LQIHFWHGSHUVRQVFRPSDUHGZLWKWKHJHQHUDOSRSXODWLRQ&OLQ,QIHFW'LV
2FW
KWWSFLGR[IRUGMRXUQDOVRUJFRQWHQW
HIV i mozak: Longitudinalni rezultati iz CHARTER-a i drugih studija
1DWKDQ*HIIHQ&665
6YUKD VWXGLMH ,VWUDåLYDQMH HIHNDWD &16 +,9 DQWLUHWUR
YLUXVQH WHUDSLMH &+$57(5 MHVWH GD LVSLWD NDNR$57
XVOHG+,9DXWLþHQDNRPSOLNDFLMHXFHQWUDOQRPLSHULIHU
QRPQHUYQRPVLVWHPX6WXGLMDMHSRNUHQXWDJRGLQH
QDQHNROLNRPHVWDX6$'LVDVWRMDODVHRGSDFLMH
QDWD &+$57(5 JUXSD MH SUHGVWDYLOD EURMQH VWXGLMH QD
&52,X%LOHVXUD]PDWUDQHVWXGLMHNRMHVXLPDOH
QDMGLUHNWQLMLXWLFDMQDGLMDJQRVWLNRYDQMHSUHGYLÿDQMHLOL
SUHYHQFLMXSDGDQHXURNRJQLWLYQLKIXQNFLMDUD]PDWUDQH
$VLPSWRPDWVNL SDG QHXURNRJQLWLYQLK IXQNFLMD $1, MH
YH]DQ ]D QDMJRUL IXQNFLRQDOQL LVKRG %ODFNVWRQH MH VD
VYRMLP NROHJDPD YUãLR SURFHQX XþHVQLND SRPRüX
QDSUHGQHQHXURSVLKRORãNHEDWHULMHXSLWQLNDQDPHQMHQLK
]DVDPRVWDOQRSULMDYOMLYDQMHNRJQLWLYQLKSUREOHPDLVYD
NRGQHYQRJIXQNFLRQLVDQMDNDRLSRPRüX]DGDWDNDQDED]L
*RGLQD,EURM
XþLQND]DPHUHQMHLVNRULãüHQRVWLNDSDFLWHWDLXSUDYOMDQMD
OHNRYLPD2GVYLKSDFLMHQDWDQMLKMHNODVL¿NRYDQR
NDRQRUPDOQRDNDRPHWNULWHULMXP]D$1,'DOMHMH
GH¿QLVDQRNDRPHWNULWHULMXP]DVLPSWRPDWLþQLQHX
URNRJQLWLYQLSRUHPHüDMYH]DQ]D+,9+$1'RGNRMLK
MHLPDORGHPHQFLMXX]URNRYDQX+,9RP
6LPSWRPDWVND +$1' JUXSD SRND]DOD MH ]QDþDMQR YLãH
VLPSWRPDGHSUHVLMHLPDQMLWUHQXWQLQLYR&'üHOLMD1D
NRQNRQWUROHWUHQXWQRJQLYRD&'LVLPSWRPDGHSUHVLMH
$1, XþHVQLFL LPDMX JRUX LVNRULãüHQRVW NDSDFLWHWD RG
QRUPDOQLKXþHVQLNDDOLVXXSRUHGLYLVD+$1'JUXSRP
S ]D RED SRUHÿHQMD 1LMH ELOR UD]OLND L]PHÿX
JUXSD X WHVWLUDQMX XSUDYOMDQMD OHNRYLPD ,VWUDåLYDþL VX
]DNOMXþLOLNDNRVWXGLMDJRYRULGDMH$1,PDQMHEHQLJQR
VWDQMHQHJRãWRVHJHQHUDOQRPLVOL,VWDNOLVXGDVXQMLKRYL
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
QDOD]LNRQ]LVWHQWQLVDLVWUDåLYDQMHPNRMHSRND]XMHGDMH
EODJLSDGQHXURSVLKRORãNLKIXQNFLMDYH]DQ]DJRUHIXQN
FLRQDOQH LVKRGH 'DOMH SUHGODåX GD EL WHVW QD ED]L SHU
IRUPDQVLXVYDNRGQHYQRPIXQNFLRQLVDQMXWUHEDRELWLGHR
GLMDJQRVWLNH+$1'D
/RQJLWXGLQDOQDVWXGLMD]DLVSLWLYDQMHSDGDQHXURNRJnitivnih funkcija
+HDWRQ MH VD VYRMLP NROHJDPD SUDWLR QHXURNRJQLWLYQH
IXQNFLMHNRG+,9SR]LWLYQLKSDFLMHQDWDPHUHQHSRPRüX
QDSUHGQLK ODERUDWRULMVNLK QHXURPHGLFLQVNLK L QHXUREL
KHYLRUDOQLKSURFHQDVYDNLKPHVHFLWRNRPSHULRGDRG
GRPHVHFD
6WXGLMD MH SRND]DOD GD MH XþHVQLND LVNXVLOR
SDGQHXURNRJQLWLYQLKIXQNFLMDMHRVWDORVWD
ELOQRDMHSRND]DORQDSUHGDNWRNRPGR
PHVHFD 0HÿXWLP MHGLQL SURJQR]HUL X PXOWLYDULMDQWQRM
&RUHJUHVLRQRMDQDOL]LLPDOLVX]EXQMXMXüXNRPRUELGQRVW
55 &, S YDQ$57D 55
&,S LPDOLQLYR&'55
&,S 8GUXJRM+HDWRQRYRMVWXGLMLRRQRPHãWRVHþLQLGDMHLV
WRJWLSDSDFLMHQWLVD$1,HPQ LEODJLPQHXURNRJ
QLWLYQLPSRUHPHüDMHP01'Q üHYLãHYHURYDWQR
LVNXVLWLVWDWLVWLþNL]QDþDMQLMLSDGXRGQRVXQDSDFLMHQWHVD
QRUPDOQLPQHXURNRJQLWLYQLPIXQNFLMDPDQ YV S 7DNRÿH MH PDQMH YHURYDWQR GD
üH$1, SDFLMHQWL SREROMãDWL VYRMH VWDQMH X SRUHÿHQMX VD
JUXSRP SDFLMHQDWD VD QRUPDOQLP QHXURNRJQLWLYQLP
IXQNFLMDPD YV S 2YL UH]XOWDWL VX
NRULãüHQLGDVH$1,L01'SRWYUGHNDRNOLQLþNL]QDþDMQL
IDNWRULYH]DQL]DVPDQMHQMHNRJQLWLYQLKIXQNFLMDWRNRP
YUHPHQDLXVNODGXVXVD%ODFNZHOORYLPQDOD]LPD
%LRPDUNHUL]DSUHGYLÿDQMHQHXURNRJQLWLYQLKSHUIRUmansi
&+$57(5 LVWUDåLYDþL VX WUDåLOL ELRPDUNHUH NRML
SUHGYLÿDMX SDG NRJQLWLYQLK IXQNFLMD &HUHEURVSLQDOQD
WHþQRVW &6) MH SULNXSOMHQD RG VNRUR XþHVQLND X
VWXGLMLRGNRMLKMHELORQD$57X3UDWHüLX]RUFLVX
SULNXSOMHQL XQXWDU SHULRGD RG RNR JRGLQX GDQD ]D VXEMHNDWD 8 RVQRYL QLMH ELOR YH]H L]PHÿX ELRPDUNHUD
L SDGD QHXURNRJQLWLYQLK IXQNFLMD 0HÿXWLP SURQDÿHQH
VX ]DQLPOMLYH DVRFLMDFH QDNRQ SULNXSOMDQMD SUDWHüLK
X]RUDND0DQMLRVQRYQLRGQRVV¿QJRPLHOLQDLFHUDPLGD
SUHGYLGHR MH SDG X QHXURNRJQLWLYQLP SHUIRUPDQVDPD
S 6¿QJRPLHOLQMHOLSLGNRMLVHXJODYQRPMDYOMD
XQHUYQRPWNLYX&HUDPLGMHOLSLGNRMLVHMDYOMDXYHOL
NLPNRQFHQWUDFLMDPDXüHOLMDPDLMHGDQMHRGNRPSRQHQWL
V¿QJRPLHOLQD$XWRULLVWLþXGDMHSRWHQFLMDOSUHGYLÿDQMD
RYRJRGQRVDYRÿHQSRYHüDQMHPRGUHÿHQLKYUVWDFHUDPL
GD WRNRP YUHPHQD 0DQML QLYRL QHNLK YLãHVWUXNLK HVWUD
KROHVWHORUD WDNRÿH VX YH]DQL ]D SDG QHXURNRJQLWLYQLK
IXQNFLMDSVHNUHüHRGGRX]DYLVQRVWLRG
YUVWH
6GUXJHVWUDQHYLVRNLQLYRLGYDWULJOLFHULGDXRVQRYLSUHG
ZZZKLYELOWHQLQIR
YLGHOLVXSREROMãDQMHQHXURNRJQLWLYQLKIXQNFLMDS L S ]D GYH YUVWH 1DNRQ SRQDYOMDQMD RQL VX ELOL
PDQMLãWRXND]XMHQDQRUPDOL]RYDQMHWRNRPYUHPHQD
-Rã MHGQD VWXGLMD NRMX VX YUãLOL &+$57(5 LVWUDåLYDþL
WHVWLUDOD MH SDQHO ELRPDUNHUD ]D SUHGYLÿDQMH SDGD NRJ
QLWLYQLKIXQNFLMD0DORPDQMHRGRVREDVD+,9RP
MH NDWHJRUL]RYDQR X þHWLUL JUXSH VWDELOQR QRUPDOQR
VWDELOQR XPDQMHQMH SRX]GDQR SRJRUãDQMH L SRX]GDQR
SREROMãDQMH 6YL VX SRGYUJQXWL QHXURNRJQLWLYQRP WHVWL
UDQMXÀHERWRPLMLLOXPEDOQRMSXQNFLMLXGYHYUHPHQVNH
WDþNH RGYRMHQH PHGLMDQRP PDOR GXåRP RG PHVHFL
,45GR,VWUDåLYDþLVXPHULOL&&/&;&/
&;&/&;&/,/71)DOIDUDVWYRUOMLYH71)UH
FHSWRUH V71)5 S L V&' SDFLMHQDWD NRML VX
QD$57XXSUYRPYUHPHQVNRPWUHQXWNXWUHQXWQDPHGL
MDQD &' RG üHOLMDPP L GRQMD PHGLMDQD RG üHOLMDPPRGNRMLKMHLPDORQHGHWHNWLELOQLYLUDOQL
VDGUåDM X SOD]PL L &6)X .RPELQDFLMD V&' &&/
&;&/V71)571)DOIDSUHGYLGHODMHQHXURNRJQLWLY
QLVWDWXVNRGSDFLMHQDWD'R]YROMDYDQMHYHüHVWRSH
SRJUHãQHNODVL¿NDFLMH]QDþLGD71)DOIDPRåHELWL
XNORQMHQRL]SDQHOD
=DSDFLMHQWHVDQRUPDOQLPSHUIRUPDQVDPDXSUYRPYUH
PHQVNRPWUHQXWNXNRPELQDFLMDV&',/&;&/
&&/LV71)5MHNRUHNWQRNODVL¿NRYDODNRJQLWLYQLVWDWXV
]DXGUXJRPYUHPHQVNRPWUHQXWNX8]GR]YROMHQX
VWRSXJUHãNHRGV&'&;&/L,/NRUHNWQR
VXNODVL¿NRYDOLXNOMXþXMXüLVYHVXEMHNWHXVWDELOQR
QRUPDOQRMJUXSL=DVXEMHNWHVDVPDQMHQLPSHUIRUPDQVD
PD X SUYRP YUHPHQVNRP WUHQXWNX &&/ 71)DOID
V&'L&;&/NODVL¿NRYDOLVXLVSUDYQR&&/L
71)DOIDLVSUDYQRVXNODVL¿NRYDOLXNOMXþXMXüLVYH
OMXGHXJUXSLVWDELOQRJXPDQMHQMD
'YD QDMþHãüH LGHQWL¿NRYDQD ELRPDUNHUD ELOL VX V&'
L &&/ 2QL VX LQGLNDWRUL DNWLYDFLMH PRQRFLWD LOL PDN
URIDJH 6YL VOXþDMHYL QHXURNRJQLWLYQH VWDELOQRVWL ELOL VX
LVSUDYQRNODVL¿NRYDQL
-Rã MHGQD VWXGLMD ELRPDUNHUD SRUHGLOD MH QHXURNRJQL
WLYQLVWDWXVNRG+,9SR]LWLYQLKSDFLMHQDWDNRGNRMLK
MH$57RP VPDQMHQ EURM YLUDOQLK SDUWLNNXOD VD +,9
QHJDWLYQLP NRQWUROQLP SDFLMHQWLPD LVWLK JRGLQD 6YDNL
SDFLMHQW MH LPDR GYH SRVHWH 5D]OLND L]PHÿX þODQRYD X
SDUX QLMH SULPHüHQD DOL MH ]DQLPOMLYR GD MH RG VXE
MHNDWD NRML VX SRND]DOL XPDQMHQMH SUL SUYRM SRVHWL RVWDORXWRPVWDQMXSULGUXJRMSRVHWLLVYLRVLPMHGQRJ
RGQHXURSVLKRORãNLQRUPDOQLKVXEMHNDWDRVWDORMHQRU
PDOQR6XEMHNWLNRMLVXRVWDOLXVWDQMXXPDQMHQMDSRND
]DOLVXPDOXSURPHQXXRVQRYQRPSULODJRÿDYDQMXQLYRD
V&'GRNVXRQLNRMLVXRVWDOLQRUPDOQLSRND]DOLSDG
X RVQRYQRP SULODJRÿDYDQMX V&' VUHGQMD YUHGQRVW
QDMPDQMHJNYDGUDWDQDVSUDPS 8ORJDFHQWUDOQHJRMD]QRVWLLGLMDEHWHVD
-RãMHGQD&+$57(5SRGVWXGLMDNRMXMHL]YHR$OOHQ0F
&XWFKDQVDVYRMLPNROHJDPDLVSLWLYDODMHRGQRVL]PHÿX
GLMDEHWHVD JRMD]DQRVWL L SDGD NRJQLWLYQLK IXQNFLMD NRG
*RGLQD,EURM
+,9%,/7(1+7%H
+,9SR]LWLYQLKSDFLMHQDWD
8PDQMHQMH QHXURNRJQLWLYQLK IXQNFLMD GLMDJQRVWLNRYDQR
MH NRG XþHVQLND 6WDURVW L GXåH WUDMDQMH LQIHNFLMH
SUHGYLÿDOL VX XPDQMHQMH 7DNRÿH MH X WX VYUKX VOXåLR L
RELPVWUXNDDOLMHPHUHQVDPRNRGXþHVQLND1LMHELOR
SRYH]DQRVWL VD %0, +20$ RFHQRP SURJQR]HU UH]
LVWHQFLMH QD LQVXOLQ L QLYRLPD OHSWLQD 6DPRVWDOQR SUL
MDYOMHQL GLMDEHWHV ELR MH YH]DQ VD XPDQMHQMHP IXQNFLMD
NRG SDFLMHQDWD X RYRM SRGVWXGLML 2YR VH VXSURWVWDYOMD
FHORM&+$57(5VOLþQRMDQDOL]LNRMDMHQDãODSRYH]DQRVW
NRGSDFLMHQDWDVWDULMLKRGJRGLQDDOLQHNRGSDFLMHQDWD
PODÿLKRGJRGLQD
1LYRL FLWRPHJDORYLUXVD &09 L SDG NRJQLWLYQLK
funkcija
/HWHQGUHLNROHJHVXYUãLOLLVSLWLYDQMH+,9SR]LWLYQLK
OMXGL UDGL RGUHÿLYDQMD SRYH]DQRVWL L]PHÿX &09 QLYRD
QHXURNRJQLWLYQLK NDUDNWHULVWLND EROHVWL L GHPRJUD¿MH
.RQFHQWUDFLMH&09DQWLWHODPHUHQHVXSRPRüXHQ]LPVNL
SRYH]DQLPLPXQRVRUEHQWQLPRJOHGRP(/,6$WHVWRP
9LãL QLYRL &09 DQWLWHOD SRYH]DQL VX VWDURãüX U S PDQMRP GRQMRP JUDQLFRP QLRYD &' üHOLMD
U S $57 XSRWUHERP S L QD
MJRURPJOREDOQRPRFHQRPGH¿FLWDU S =D
SDFLMHQWH NRML QLVX NRULVWLOL$57 YHüL QLYRL &09 DQWL
WHODYH]DQLVXWDNRÿH]DYHüHQLYRH+,951$X&6)X
U S DOLQHXSOD]PL0XOWLYDULMDQWQDDQDOL]D
SRND]DODMHGDMHQDMJRUDJOREDOQDRFHQDGH¿FLWDYD]DQD
]DYHüHQLYRH&09DQWLWHODYHüLEURMNRPRUELGQLKXVOR
YDLLQWHUDNFLMXL]PHÿXQLYRD&09DQWLWHODL+,951$
SOD]PHS $QDOL]H LQWHUDNFLMH LGHQWL¿NRYDOH VX GD VX YHüL QLYRL
&09 DQWLWHOD SRYH]DQL VDPR VD QDMJRURP JOREDOQRP
RFHQRP GH¿FLWD NRG VXEMHNDWD NRML VX LPDOL QHGHWHNWD
ELOQL+,951$XSOD]PL
$XWRUL]DNOMXþXMXGDVXYHüLQLYRL&09DQWLWHODYH]DQL
]D QDMJRULP QHXURNRJQLWLYQLP IXQNFLRQLVDQMHP 7YUGH
GD QMLKRYL QDOD]L LPDMX LPSOLNDFLMH ]D UDQLMX LQLFLMDFLMX
$57D ]D VWDUHQMH +,9 SRSXODFLMH L ]D HIHNDW &09D
QD+,9XFHQWUDOQRPQHUYQRPVLVWHPX7DNRÿHJRYRUH
GDVXQMLKRYLQDOD]LGRGDWDNDSRVWRMHüLPSRGDFLPDNRML
XND]XMXQDWRGD&09SUR¿ODNVDPRåHELWLNRULVQD
-Rã MHGDQ ]DNOMXþDN YDåDQ ]D VWDURVW L NRJQLWLYQR IXQN
FLRQLVDQMHNRGOMXGLVD+,9RPGROD]LL]LVSLWLYDQMDYLãH
RG&+$57(5SDFLMHQDWD2YLSDFLMHQWLRPRJXüLOLVX
&6)LX]RUDNDSOD]PH.RQFHQWUDFLMH7HQRIRYLU
&6) Q SRYHüDYDMX VH PQRJR RãWULMH VD JRGLQDPD
VWDURVWLXRGQRVXQDSOD]PXQ .RQFHQWUDFLMHHID
YLUHQ]DSRYHüDQHVXX&6)XQ NRGSDFLMHQDWDVWDUL
MLKRGVDPDQMRPRãWULQRPLVWDELOQLMLPSRYHüDQMHPVD
VWDURãüX]DNRQFHQWUDFLMHXSOD]PLQ .RQFHQWUDFLMD
DWD]DQDYLUDXSOD]PLQ EODJRVHVPDQMXMHVDJRGL
QDPDGRNNRQFHQWUDFLMDX&6)XQ RVWDMHVWDELOQD
9HüH$59NRQFHQWUDFLMHVXWDNRÿHSRYH]DQHVDQDMJRULP
QHXURNRJQLWLYQLPIXQNFLRQLVDQMHPãWRSUHPDVWDYXDX
WRUD PRåH XND]LYDWL QD QHXURWRNVLþQRVW OHND =DNOMXþLOL
VXGDMHSRWUHEQRYLãHSRGDWDND]DVWDULMH+,9SR]LWLYQH
OMXGH]DSRWYUÿLYDQMHRYLKUH]XOWDWD
3UDYLOQLN(YURSVNRJ$,'6.OLQLþNRJ'UXãWYD($&6
]DGLMDJQRVWLNRYDQMHQHGRYROMQRRVHWOMLYRJ+$1'D
,JQDFLR3HUH]9DOHURLNROHJHYUãLOLVXSRUHÿHQMHQHGDYQR
REMDYOMHQRJ($&6YRGLþDL+,9VNDOHGHPHQFLMH+'6
]DGLMDJQRVWLNRYDQMHVLPSWRPDWVNRJLQHVLPSWRPDWVNRJ
+$1'D
&+$57(5RYD QDSUHGYD QHXURELKHYLRUDOQD SURFHQD
NRMDXNOMXþXMHQHNROLNRVDWLGHWDOMQRJWHVWLUDQMDNRULãüHQD
MHNDR]ODWQLVWDQGDUG
7DEHOD6SHFL¿þQRVWLRVHWOMLYRVW($&6DL+'6DXGHWHNWRYDQMXVLPSWRPDWVNRJLDVLPSWRPDWVNRJ+$1'D
2VHWOMLYRVW
($&6LVSLWLYDQMD]DVLPSWRPDWVNL+$1'
($&6LVSLWLYDQMD]D+$1'
+'6LVSLWLYDQMD]DVLPSWRPDWVNL+$1'
+'6LVSLWLYDQMD]D+$1'
,DNRDXWRULWYUGHGDQL($&6QLWL+'6LVSLWLYDQMDQLVX
GRYROMQRRVHWOMLYD]DGHWHNWRYDQMHSRPHQXWLKVOXþDMHYD
]DNOMXþXMXüLGDMH($&6RVHWOMLYRVWSRVHEQRORãDDNRVH
X]PHXRE]LUSXQRELP+$1'DRQLQLVXUD]PRWULOLGD
MH ($&6 YRGLþ XWYUÿHQ GD RPRJXüL SRYHüDQX VYHVW ]D
MHGQRVWDYQHLQWHUYHQFLMHED]LUDQRVDPRQDRJUDQLþHQRP
6SHFL¿þQRVW
YUHPHQVNRPSHULRGXNRMLYHüLQDGRNWRUDLPDVDSDFLMHQ
WLPD D L GD ]D PQRJH GRNWRUH SURFHQD 1&,D QLMH WUH
QXWQR]QDþDMQLDVSHNWXSUDYOMDQMD+,9RP2YDMUH]XOWDW
QHSUHGVWDYOMDMXSURFHQHODNH]DXSRWUHEXNRMHXURNXRG
SDU PLQXWD PRJX UD]MDVQLWL þDN L JUXER KLWQRVW QHNLK
VOXþDMHYDLOLNRMHQHPDMXVYRMSRORåDMXNOLQLþNRMQH]L
Komentar
(IHNDW+,9DQDPR]DNRVWDMHYDåDQDVSHNWQHJHLRYLSRGDFLSRPDåX,DNRQDSUHGQR+,9REROMHQMHX]URNXMH
+$1'LGHPHQFLMXELRORãNLPHKDQL]PLVXVODERVKYDüHQL'DOL+,9LOL$59GRSULQRVLSDGXNRJQLWLYQLKIXQNFLMD
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
NRGDVLPSWRPDWVNLKSDFLMHQDWDSRVHEQRSULYHüHPQLYRX&'LLOLNRQWUROLVDQDYLUDHPLMDVDLOLEH]$57DRVtaje nejasno.
5H]XOWDWL L] &+$57(5D PRJX SRPRüL SUHGYLÿDQMX GLMDJQR]H DOL GRND]L SRGNOLQLþNLK SURPHQD LDNR
]DEULQMDYDMXüLQHSUHGODåXGUXJDþLMHXSUDYOMDQMHRVLPPRåGDSDåOMLYLMHJSRVPDWUDQMD
9HüHVWRSHNRJQLWLYQLKSUREOHPDNRG+,9SR]LWLYQLKRVREDXSRUHÿHQMXVDQHJDWLYQLPþDNLSULVWDELOQRP$57X
þHVWRVX]EXQMXMXüHLSUHGVWDYOMDMXSRWHãNRüXSULNODGQRRGUHÿHQHNRQWUROH
6WXGLMHELRPDUNHUDL]&+$57(5DVX]DQLPOMLYHDOLVRE]LURPQDYHOLNLEURMELRPDUNHUDNRMLVXUD]PDWUDQL
QHNHRGQMLKPRJXSUHGVWDYOMDWLVOXþDMQXSRYH]DQRVWLQMLKRYLUH]XOWDWLLGDOMHPRUDMXELWLSRWYUÿHQL
6WXGLMD NRMD SULMDYOMXMH SRYH]DQRVW L]PHÿX FHQWUDOQH JRMD]QRVWL GLMDEHWHVD L 1&,D QLMH SULMDYLOD PRJXüQRVW
REUQXWHSRVOHGLþQRVWL±GDMH1&,PRåGDGRSULQHRORãRMLVKDUQLDOLMHWR6$'VWXGLMDSDMHLVKUDQDPRJODELWL
UHJLRQDOQRQRUPDOQD±LOLGD]DMHGQLþNLX]URNPRåHELWLRGJRYRUDQ]D1&,LGLMDEHWHV
,DNRVXDXWRULSUHGORåLOLGDÄL]EHJDYDQMH$59OHNRYDNRMLLQGXNXMXFHQWUDOQXJRMD]QRVWPRåH]DãWLWLWLSDFLMHQWH
RGLOLREUQXWQRJXPDQMHQMDQHXURNRJQLWLYQLKIXQNFLMD³WRMHODNRUHüLDOLNRPSOLNRYDQLMHLQWHUSUHWLUDWLVDELOR
NRMLPVWHSHQRPSUHFL]QRVWLVRE]LURPGDMHFHQWUDOQDOLSRKLSHUWUR¿MDSRYH]DQDVDVYLPNODVDPD$59DLQLMH
GRND]DQRGDELORNRML$59SUXåDMDVQX]DãWLWX
7ULNOMXþQDSLWDQMDRVWDMXEH]RGJRYRUD'DOLSUH$,'6+,9LQIHNFLMD]QDþDMQRXWLþHQDNRJQLWLYQRIXQNFLRQLVDQMH".RMLVXGXJRURþQLHIHNWL+,9DQDNRJQLWLYQRIXQNFLRQLVDQMH"'DOLUDQLML$57PRåHSREROMãDYLNRJQLWLYQLLVKRGNRGRVREDNRMHåLYHVD+,9RP"
1DGDPRVHGDüHLVWUDåLYDQMH67$57VWXGLMHNRMLVDGUåLSRGVWXGLMXQHXURORJLMHSUXåLWLSRGDWNHVDYHüLP&'
QLYRLPD!üHOLMDPP]DMHGQRVDELORNRMLPXWLFDMHPUDQLMHJ$57D3RGVWXGLMDüHLPDWLXþHVQLNDX
svakoj grani.
9HüD GRPLQDFLMD XPDQMHQMD NRG +,9 SR]LWLYQLK OMXGL SUHGODåH GD QHXURNRJQLWLYQD SURFHQD WUHED GD EXGH
GH¿QLVDQDXSUDYLOQLFLPDLLQWHJULVDQDXUXWLQVNRMQH]L
5HIHUHQFH
&+$57(5:HOFRPHWR&+$57(5DVDUHVRXUFH
KWWSVZZZFKDUWHUUHVRXUFHXFVGHGXLQGH[SKS
&+$57(5&+$57(5LQYHVWLJDWRUVSUHVHQWDW&52,
KWWSVZZZFKDUWHUUHVRXUFHXFVGHGXLQGH[SKS"RSWLRQ FRPBFRQWHQWYLHZ DUWLFOHLG FKDUWHULQYHVWLJDWRUVSUHVHQWDWFURL
FDWLG FXUUHQWQHZV,WHPLG %ODFNVWRQH.HWDO+RZ³DV\PSWRPDWLF´LV+,9DVVRFLDWHGDV\PSWRPDWLFQHXURFRJQLWLYHLPSDLUPHQW"WK&52,6HDWWOH3RVWHU
DEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
+HDWRQ5HWDO3UHYDOHQFHDQGSUHGLFWRUVRIQHXURFRJQLWLYHGHFOLQHRYHUWR0RQWKVD&+$57(5ORQJLWXGLQDOVWXG\WK&52,
6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
+HDWRQ5HWDO$V\PSWRPDWLFPLOG+,9DVVRFLDWHGQHXURFRJQLWLYHGLVRUGHULQFUHDVHVULVNIRUIXWXUHV\PSWRPDWLFGHFOLQHD&+$57(5
ORQJLWXGLQDOVWXG\WK&52,6HDWWOH
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
+DXJKH\1HWDO$OLSLGRPLFDQDO\VLVRI&6)IURP+,9LQIHFWHGVXEMHFWVLGHQWL¿HVPHWDEROLWHVWKDWSUHGLFWFKDQJHVLQFRJQLWLYHSHUIRU
PDQFHWK&52,6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
/HWHQGUH6HWDO$FRQFLVHSDQHORIELRPDUNHUVGLDJQRVHVDQGSUHGLFWVQHXURFRJQLWLYHVWDWXVLQ+,9LQIHFWHGLQGLYLGXDOVWK&52,
6HDWWOH2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
%XUGR7HWDO(OHYDWHGV&',VDPDUNHURIQHXURFRJQLWLYHLPSDLUPHQWLQ+,9LQIHFWHGLQGLYLGXDOVRQHIIHFWLYH$57WK&52,
6HDWWOH2UDODEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
0F&XWFKDQ-$HWDO5ROHRIFHQWUDOREHVLW\GLDEHWHVDQGPHWDEROLFYDULDEOHVLQ+,9DVVRFLDWHGQHXURFRJQLWLYHGLVRUGHUWK&52,
6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
/HWHQGUHHWDO+LJKHUF\WRPHJDORYLUXV&09DQWLERG\FRQFHQWUDWLRQVDUHDVVRFLDWHGZLWKROGHUDJHORZHUQDGLU&'FHOOFRXQWVDQG
ZRUVHJOREDOQHXURFRJQLWLYH1&IXQFWLRQLQJLQSHRSOHZLWK+,9GLVHDVHWK&52,6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
&URWHDX'HWDO2OGHUDJHLVDVVRFLDWHGZLWKKLJKHUDQWLUHWURYLUDOFRQFHQWUDWLRQVLQFHUHEURVSLQDOÀXLGLQ+,9LQIHFWHGLQGLYLGXDOVWK
&52,6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
3HUH]9DOHUR,HWDO9DOLGDWLRQRIWKH($&6JXLGHOLQHV$OJRULWKPIRUGHWHFWLQJ+$1'LQWKH&+$57(5FRKRUW3DSHUWK&52,
6HDWWOH3RVWHUDEVWUDFW
KWWSZZZUHWURFRQIHUHQFHRUJE$EVWUDFWVKWP
81&6FKRRORI0HGLFLQH6WDUWQHXURORJ\VXEVWXG\
KWWSZZZPHGXQFHGXQHXURORJ\GLYLVLRQVQHXUR$,'6FOLQLFDOUHVHDUFKVWDUW
ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%H
6325('1,()(.7,
9H]HL]PHÿXXSRWUHEHWHQRIRYLUDLEXEUHåQLKNRPSOLNDFLMDNRG9$NRKRUWH
Simon Collins, HIV i-Base
7HQRIRYLUMHMHGDQRGQDMãLUHNRULãüHQLKDQWLUHWURYLUXVQLKOHNRYDNRGNRJDMHSULMDYOMHQJHQHUDOQRQL]DN
UL]LN RG EXEUHåQLK NRPSOLNDFLMD 0HÿXWLP ELOR MH
RGUHÿHQLK NRQWURGLNWRUQLK SRGDWDND R SRWHQFLMDOX
SRMDYHEXEUHåQLKNRPSOLNDFLMDNRGNXPXODWLYQHXSRWUHEH LOL NRG SDFLMHQDWD VD QRUPDOQRP EXEUHåQRP
funkcijom.
$QDOL]DREDYOMHQDQDNRKRUWL8GUXåHQMDUDWQLKYHWHUDQD
6$'D 9$ REMDYOMHQD þHWYUWRJ PHVHFD L]GDQMH
R$,'6XMHRWNULODGDMHNXPXODWLYQDXSRWUHEDWHQRIR
YLUDELODSRYH]DQDVDEXEUHåQLPNRPSOLNDFLMDPDNRMHVH
PRåGDQHPRJXSRQLãWLWL>@
8SHULRGXRGGRJRGLQHNRGYLãHRG
SDFLMHQDWDNRMLVHSRSUYLSXWOHþHW]YQDLYQLSDFLMHQWLMH
RWNULYHQRGDVXSRþHOLVDNRULãüHQMHP$57X9$NRKRUWL
8NROLNRLVNOMXþLPRRQHEH]LMHGQRJNOMXþQRJSDUDPHWUD
&' YLUXVQR RSWHUHüHQMH SRVHWD QHKRVSLWDOL]RYDQRJ
SDFLMHQWD UHQDOQL PDUNHUL LOL RWND] EXEUHJD X]RUDN
RYH VWXGLMH VH VPDQMXMH QD SDFLMHQWD RG NRMLK
MH NRULVWLOR WHQRIRYLU$QDOL]D SHULRGD NRULãüHQMD
SULODJRÿHQD MH ]D WHQRIRYLU NRML QLMH RGREUHQ VYH GR
JRGLQHSDFLMHQDWDMHNRULVWLORWHQRIRYLUXSH
ULRGX X SHULRGX D SUHJRGLQH
3URPHQHEXEUHåQHIXQNFLMHVXRGUHÿLYDQHSULPHQRPMHG
QRJRGQDUHGQDWULNULWHULMXPD
3URWHLQXULMDELRKHPLMVNDWHVWWUDND]DPRNUDüX! PJG/QDGYDX]DVWRSQDWHVWD
%U]RVPDQMHQMHIXQNFLMHEXEUHJD!P/PLQP
JRGLãQMHVPDQMHQMHWRNRPQDMPDQMHGYHJRGLQHL
+URQLþQD EXEUHåQD EROHVW &.' H*)5 P/
PLQPXGYDQDYUDWDVDUD]PDNRPRGQDMPDQMH
PHVHFD
'RGDWQH DQDOL]H RVHWOMLYRVWL VHQ]LWLYQRVWL VX WDNRÿH
REDYOMHQH]DYUHPHGRGRJDÿDMDWLPHWRHYHQWL]DR]
ELOMQLMHEXEUHåQHGLVIXQNFLMH3DFLMHQWLVDSURWHLQXULMRP
*RGLQD,EURM
LOL&.'QDSRþHWNXVXLVNOMXþHQLL]RYLKDQDOL]D2GQRVL
UL]LNDKD]DUGUDWLRVVXL]UDþXQDWLX]SULODJRÿDYDQMHGH
PRJUDIVNLP YUHPHQVNL]DYLVQLP L PDUJLQDOQLP VWUXN
WXUDOQLPPRGHOLPD
3URVHþQD VWDURVW MH L]QRVLOD JRGLQD ,45 L
DSURNVLPDWLYQRXþHVQLNDVXELOLPXãNDUFL.DGDMHX
SLWDQMXHWQLþNDSULSDGQRVWDSURNVLPDWLYQRXþHVQLND
VXELOLFUQFLEHOFLLRVWDOL3URVHþQLEURM&'
L YLUXVQR RSWHUHüHQMH SUH WUHWPDQD VX L]QRVLOL DSURNVL
PDWLYQR ,45 ± üHOLMDPP L ,45
±NRSLMDP/
3UHYDOHQFLMD NRPRUELGQLK VWDQMD QD SRþHWNX X JUX
SL VD 7') L JUXSL EH]7') MH REXKYDWLOD KLSHUWHQ]LMX
L GLMDEHWHV L +&9 L SXãHQMHLLGLVOLSLGHPLMX]DREHJUXSH
%XEUHåQR REROMHQMH NRMH MH ELOR SULVXWQR QD SRþHWNX
WHUDSLMHMHREXKYDWLORDSURNVLPDWLYQRSURVHþQRH*)5
,45 ± P/PLQ QD P VD L ]D
H*5)P/PLQPLLVDSURWHLQXULMRP
!PJG/
3URVHþQR WUDMDQMH SUDüHQMD SDFLMHQWD SR SRMHGLQFX MH
L]QRVLORRGJRGLQD]DSURWHLQXULMXGRJRGLQD]D
&.'WRNRPNRJMH]DEHOHåHQRVOXþDMHYDSURWHL
QXULMH!SDFLMHQDWDJRGLãQMHVDEU]LPSD
GRPIXQNFLMHEXEUHJD!SDFLMHQDWDJRGLãQMHL
&.'VOXþDMHYD!SDFLMHQDWDJRGLãQMH0HÿXWLP
]D XþHVQLNH NRML VX NRULVWLOL WHQRIRYLU ]DEHOHåHQD MH
SURVHþQD L]ORåHQRVW WHUDSLML RG VYHJD JRGLQH ,45
3DMHWDNROMXGLNRMLVXGRVWDYLOLSRGDWNH
NRULVWLORWHQRIRYLUPDQMHRGPHVHFLPDQMHRG
PHVHFLDPDQMHRGJRGLQH0DNVLPDOQDWUDMDQMH
XSRWUHEHWHQRIRYLUDMHL]QRVLORJRGLQH3UHJOHGRYLK
JUXSDSULND]DQX7DEHOLREMDYOMHQXYLGXGRGDWQLKLQ
IRUPDFLMDMHYDåDQ]DSURFHQXVWRSDXJUXSDPDSDFLMH
QDWDNRMLNRULVWHWHQRIRYLULSDFLMHQDWDNRMLQHNRULVWHWHQ
RIRYLUVRE]LURPGDVXUH]XOWDWLXJODYQRPGRNXPHQWX
]DVQRYDQLQDRGQRVLPDUL]LND
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
7DEHOD3UHJOHGEURMDVOXþDMHYDLSDFLMHQDWDJRGLãQMH3<SRL]ORåHQRVWLWHQRIRYLUX
2EROMHQMH
%URMVOXþDMHYD
3<
6WRSDSDFLMHQDWD
JRGLãQMH
3URWHLQXULMD
7HQRIRYLUQLNDGDQLMH
NRULãüHQ
7HQRIRYLUMHNRULãüHQ
%U]RVPDQMHQMHIXQNFLMH
7HQRIRYLUQLNDGDQLMH
NRULãüHQ
7HQRIRYLUMHNRULãüHQ
+URQLþQREXEUHåQRREROMHQMH
7HQRIRYLUQLNDGDQLMH
NRULãüHQ
7HQRIRYLUMHNRULãüHQ
6YL$59OHNRYLELOLVXXNOMXþHQLXDQDOL]XDOLMHVDPR
]DWHQRIRYLURWNULYHQDYHüDYH]DVDVYDWULUHQDOQDPDUN
HUDNRGVYHWULSULODJRÿHQHDQDOL]HYLGHWL7DEHOX.RG
YUHPHQVNL]DYLVQH DQDOL]H SULODJRÿDYDQMH ]D$59 XS
RWUHEX SRUHG SRþHWQLK GHPRJUDIVNLK SRGDWDND VYDND
JRGLQD L]ORåHQRVWL WHQRIRYLUX MH ELOD SRYH]DQD VD YHüLP UL]LNRP RG SURWHLQXULMH &, S YHüLPUL]LNRPRGEU]RJRSDGDQMDEXEUHåQH
IXQNFLMHS LYHüLPUL]LNRPRG
&.' S ,VSLWLYDQMH EODJR þHãüHJ
SUDüHQMD NRG NRULVQLND WHQRIRYLUD QLMH XWLFDOR QD UH]XO
WDWH9HüSRVWRMHüLEXEUHåQLIDNWRULUL]LNDL]JOHGDGDQLVX
SRJRUãDYDOLHIHNWHWHQRIRYLUD
7DEHOD9H]DL]PHÿXL]ORåHQRVWLWHQRIRYLUXLUL]LNDSRMDYHEXEUHåQRJREROMHQMD
'HPRJUDIVNLSULODJRÿHQPRGHO
2GQRVUL]LND&,
9UHPHQVNL]DYLVWDQ&R[PRGHO
2GQRVUL]LND&,
0DUJLQDOQLVWUXNWXUDOQLPRGHO
2GQRVUL]LND&,
.XPXODWLYQDL]ORåHQRVWWHQRIRYLUXJRGLãQMH
3URWHLQXULMD
%U]LSDGIXQNFLMH
&.'
±
±
±
±
±
±
±
±
±
±
±
±
±
±
±
,]ORåHQRVWWHQRIRYLUXELORNDGD
3URWHLQXULMD
%U]LSDGIXQNFLMH
&.'
±
±
±
2VWDOL$5,VXSRND]DOLVODELMHLOLQHNRQ]LVWHQWQHYH]HVD
SRMDYDPDEXEUHåQRJREROMHQMDDYUHGLQDSRPHQXWLULWR
QDYLU L ORSLQDYLUU SRYH]DQ VD SURWHLQXULMRP DWD]DQDYLU
ZZZKLYELOWHQLQIR
SRYH]DQ VD EU]LP SDGRP EXEUHåQH IXQNFLMH L LQGLQDYLU
SRYH]DQVD&.'9LGHWLWDEHOX
*RGLQD,EURM
+,9%,/7(1+7%H
7DEHOD9H]DEXEUHåQLKREROMHQMDVDXSRWUHERP$57D
5H]XOWDWLSULND]DQLVDPR]DDQWLUHWURYLUXVQHOHNRYHVD! VWDWLVWLþNL]QDþDMQLPUH]XOWDWRP
$59
7HQRIRYLU
SRHQDVD
L]ORåHQRãüX
$=7
(IDYLUHQ]
5LWRQDYLU
,QGLQDYLU
$WD]DQDYLU
/RSLQDYLUU
6DTXLQDYLU
SURWHLQXULMD
p
±
±
9H]D VD L]ORåHQRãüX WHQRIRYLUX MH ELOD NRQ]LVWHQWQD ]D
VYHVWDURVQHLUDVQHSRGJUXSHNDRL]DVYHSRþHWQHNR
PRUELGLWHWHRVLPGLMDEHWHVDL&.'YLUDOQRJRSWHUHüHQMD
&'L%0,
0HÿXRQLPDNRMLVPDQMLOLXSRWUHEXWHQRIRYLUDUL]LNRG
%U]LSDG
IXQNFLMH
±
p
&.'
p
±
SRMDYHEXEUHåQLKREROMHQMDVHQLMHSRYHüDYDRQLWLVPDQ
MLYDR WRNRP SURVHþQRJ QDVWDYND SUDüHQMD SDFLMHQWD RG
JRGLQH3UHWKRGQDXSRWUHEDWHQRIRYLUDMHELODSRYH
]DQDVDYLãLPUL]LNRPSRMDYHVYLKNRPSOLNDFLMDXRGQRVX
QDVOXþDMNDGDVHWHQRIRYLUQLMHNRULVWLR
Komentar
2YDVWXGLMDMHãLURNRSULMDYOMHQDQDRVQRYXVWDWLVWLþNL]QDþDMQLKSRYHüDQMDRGSURWHLQXULMDEU]LSDG
EXEUHåQHIXQNFLMHL&.'JRGLãQMHL]ORåHQRVWLWHQRIRYLUXQDNRQSULODJRÿDYDQMD]DWUDGLFLRQDOQHUL]LNH]D
EXEUHåQHNRPSOLNDFLMHVDSRYHüDQMLPDNRGVOXþDMHYDNRULãüHQMDOHNDELORNDGDRGRGQRVQR
.DR L NRG VYLK PHGLFLQVNLK L]YHãWDMD UHODWLYQH VWRSH X RYRP VOXþDMX RGQRVL UL]LND VH PRUDMX WDNRÿH LQWHUSUHWLUDWL ]DMHGQR VD SRGDFLPD NRML SRGUåDYDMX DSVROXWQH UL]LNH SRYH]DQH XMHGQR L VD NRULãüHQMHP WHQRIRYLUD
LVDQHNRULãüHQMHPWHQRIRYLUDýDNLXNROLNRX]PHPRXRE]LUJHQHUDOQRNUDWNRWUDMDQMHXSRWUHEHWHQRIRYLUDL
RJUDQLþHQRWUDMDQMHSUDüHQMDQDNRQSUHNLGDXSRWUHEHLWRãWRMHRYRELODVWXGLMDQDGPXãNDUFLPDRYLUH]XOWDWL
VXYHRPDYDåQLSRVHEQRNDGDLKSRGUåHLRVWDOHVWXGLMHNDRãWRMH'$'DQDOL]DSUHGVWDYOMHQDQD&52,YLGHWL
UDQLMD L]GDQMD +7%D 0DGD RSWLPDOQL QDþLQ GH¿QLVDQMD EU]RJ SDGD EXEUHåQH IXQNFLMH QLMH MDVDQ L]DEUDQL
PDUNHULGHOXMXUD]XPQRLDNRRVWDOHJUXSHXNOMXþXMXüL'$'NRULVWHGUXJDþLMHNULWHULMXPH
,DNRQLMHMDVQRGDOLSRVWRMLQHNDNDYPLQLPDOQLEURMH*5)PHUDSRWUHEDQ]DL]UDþXQDYDQMXVWRSHSDGDEXEUHåQH
IXQNFLMHQDJRGLãQMHPQLYRXHSL]RGHKRVSLWDOL]DFLMHSDFLMHQDWDNDRQLPQRJHGUXJHVWXGLMHQLVXELOHXVWDQMXGD
WRRWNULMX6DRJUDQLþHQLPQDVWDYNRPSUDüHQMDSDFLMHQDWDWHãNRMHUD]GYRMLWLHIHNDWÄL]ORåHQRVWLELORNDGD³RG
ÄNXPXODWLYQHL]ORåHQRVWL³SDþDNLVDGXåLPSUDüHQMHPSDFLMHQWDWRQLMHXYHNMHGQRVWDYQRDOLüHWRSRVWDWL
MDVQLMHXEXGXüLPDQDOL]DPD3RãWREXEUHåQDIXQNFLMDQLMHXYHNSURFHQMLYDQDWRNRPSRþHWND+$$57SHULRGD
SDFLMHQWLVDRYLPUDQLPSRGDFLPDVXPRåGDLPDOLRVWDOHEXEUHåQHNRPSOLNDFLMHNRMHVX]DKWHYDQDG]RU0HÿXWLP
UH]XOWDWLVHQLVXXYHOLNRMPHULSURPHQLOLNDGDVXSDFLMHQWLL]SHULRGDSUHHLVNOMXþHQLL]DQDOL]H
0DGD PHWRGD SRGHãDYDQMD PDUJLQDOQLK VWUXNWXUDOQLK PRGHOD PRåH ELWL QHMDVQD GRQHNOH MH RKUDEUXMXüH WR
ãWR VX VOLþQL UH]XOWDWL RWNULYHQL ]D VYD WUL PRGHOD XND]XMXüL QD WR GD VX UH]XOWDWL VQDåQL SR SLWDQMX RGDELUD
PHWRGRORãNRJSULVWXSD
'RåLYOMHQLUL]LNRGWHQRIRYLUDLEXEUHåQLKNRPSOLNDFLMDMHMDVQRXWLFDRQDL]ERUUDQHSURPHQHOHNDLREMDãQMDYD
QHSRVWRMDQMHYH]DVDX]QDSUHGRYDOLPVWDGLMXPLPD&.'D
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
5HIHUHQFH
6FKHU]HU5HWDO$VVRFLDWLRQRIWHQRIRYLUH[SRVXUHZLWKNLGQH\GLVHDVHULVNLQ+,9LQIHFWLRQ$,'6$SULOGRL
4$'EHII
KWWSMRXUQDOVOZZFRPDLGVRQOLQH)XOOWH[W$VVRFLDWLRQBRIBWHQRIRYLUBH[SRVXUHBZLWKBNLGQH\DVS[
3(',-$75,-6.$1(*$
2GODJDQMH$57DQWLUHWURYLUDOQHWHUDSLMHXGMHWLQMVWYXPRåHVPDQMLWL
GXJRURþQLEURM&'üHOLMDXRGUDVORMGREL
Polly Clayden, HIV i-Base
2GOXND GD VH ]DSRþQH VD $57 NRG GMHFH VH GRQRVL X
RGQRVXQDX]UDVWLSURFHQDWLOLEURM&'üHOLMD3UHSRUXNH
VX ]DVQRYDQH QD SUHWSRVWDYOMHQRP NUDWNRURþQRP UL]LNX
RG PRUELGLWHWD L PRUWDOLWHWD 3RþHWDN SULPMHQH$57 VH
PRåHRGORåLWLNRGGMHFHVD&'YULMHGQRVWLPDL]QDGGR]
YROMHQLKJUDQLþQLKSUDJRYDNDNRELVHL]EMHJODWRNVLþQRVW
UH]LVWHQFLMDLQHNLRGSUDNWLþQLKSUREOHPDSRYH]DQLKVD
SULPMHQRP$57NRGGMHFH
,VWUDåLYDþLL],&+L3(17$JUXSHXND]XMXQDWRGDWUH
QXWQHYRGLOMHSUHWSRVWDYOMDMXGDWDNYRRGODJDQMHSRþHWND
WHUDSLMHQHPDGXJRURþQHãWHWQHSRVOHGLFH8GRNXPHQWX
REMDYOMHQRPSULMHãWDPSHX-,'RJGHFHPEUDQDYRGL
VHGDGRND]LXND]XMXQDSRVWRMDQMHUD]OLNDL]PHÿXGMHFH
L RGUDVOLK X QLYRX UHSRSXODFLMH 7üHOLMD ]ERJ YHüH DN
WLYQRVWL JUXGQH åOLMH]GH 1HNROLNR SHGLMDWULMVNLK VWXGLMD
SRND]XMHGDMHORãLMDREQRYDEURMD&'üHOLMDSUL$57X
SRYH]DQVDVWDULMLPX]UDVWRPLQLåLPEURMHP&'üHOLMD
QD SRþHWNX WUHWPDQD .RULVWHüL ORQJLWXGLQDOQH SRGDWNH
L] 3(17$ VWXGLMH L QHOLQHDUQH PRGHOH VD NRPELQDFL
MRP HIHNDWD JUXSD MH LVSLWDOD RGQRVH L]PHÿX X]UDVWD
EURMD&'üHOLMDQDSRþHWNXWUHWPDQDLUHSRSXODFLMH&'
üHOLMD 3RUHG SRWYUGH SUHWKRGQR RSLVDQLK YH]D QMLKRYL
QDOD]L LOXVWUXMX L YDåQRVW QDLYQH VXESRSXODFLMH ]D RYX
REQRYXLLVSLWXMXSRVOMHGLFHNRG$57QDLYQHGMHFHNRG
NRMLKVHSRSUYLSXWSULPHQMXMH$57UD]OLþLWRJX]UDVWDL
VDUD]OLþLWLPEURMHYLPD&'üHOLMD
3(17$WHVWMHSURFMHQMLYDRUD]OLþLWH$59UHåLPHNRG
SHULQDWDOQR LQ¿FLUDQH GMHFH NRG NRMLK VH SR SUYL SXW
SULPMHQMXMHWUHWPDQ0HÿXGMHFHNRGNRMLKMH]DSRþHW
WUHWPDQSURVMHþQDVWDURVWQDSRþHWNXWUHWPDQDMHELOD
,45GRJRGLQD&'EURMMHL]QRVLR,45
WR üHOLMDPP ]RFMHQD NRMD SRND]XMH QLYR
]DELOMHåHQRJEURMD&'üHOLMDXQXWDURþHNLYDQHUDVSRG
MHOH NRG +,9QHJDWLYQH GMHFH LVWRJ X]UDVWD URÿHQH RG
VWUDQH +,9SR]LWLYQLK PDMNL L]UDåHQD X XVORYLPD VWDQ
GDUGQH QRUPDOQH UDVSRGMHOH MH L]QRVLOD ,45 GR D WUDMDQMH SUDüHQMD MH L]QRVLOR ,45 GR
JRGLQD
.RGPXOWLYDULMDQWQRJPRGHODLVWUDåLYDþLVXSURFLMHQLOLGD
MH]RFMHQDNRGGMHFHSULMHWUHWPDQDELOD]D“
WDþNDVWD SURFMHQD “ VWDQGDUGQD JUHãND QLåD ]D VYDNX
GRGDWQXJRGLQXQDSRþHWNXWUHWPDQDDGDMHGXJRURþQD
]RFMHQDELOD]D“QLåD]DVYDNXGRGDWQXJRGLQX
QDSRþHWNXWUHWPDQDRELMHYULMHGQRVWLX]S3RUHG
RYLKHIHNDWDSRVWRMDODMHVQDåQDSR]LWLYQDYH]DS
L]PHÿX ]RFMHQH SULMH WUHWPDQD L GXJRURþQH ]RFMHQH ±
RGQRVQRGMHFDVD]RFMHQRPLVSRGLOLL]QDGSURVMHND]D
VYRMX]UDVWSULMHWUHWPDQDVXLGDOMHLPDODQLåHLOLYLãH
SURVMHþQHRFMHQHLQDGXJLURN
%URMQDLYQLKLPHPRULMVNLK&'üHOLMDMHEHOMHåHQXSRG
VWXGLML NRMD MH REXKYDWLOD GMHFH 2YD DQDOL]D MH RWN
ULODGDVHUHNRQVWLWXFLMD7üHOLMDREQRYDNRGRYHGMHFH
REDYOMDODSULMHVYHJDL]JUXSHQDLYQLKüHOLMDX]NRPSDUD
WLYQRPDQMHSRYHüDQMHEURMDPHPRULMVNLKüHOLMDPDGDX
EUåHPYUHPHQVNRPRNYLUX0HÿXWLPRYDMSRWHQFLMDO]D
REQRYXSUHNRQDLYQHJUXSHüHOLMDVHRþLJOHGQRVYHYLãH
VPDQMXMHVDX]UDVWRPLLOLWUDMDQMHPLQIHNFLMH,OXVWURYDQL
PRGHOMHXND]DRQDWRGDWUHQXWQRSUHSRUXþHQLJUDQLþQL
SUDJ ]D SRþHWDN WUHWPDQD NRG PODÿH GMHFH UH]XOWXMH X
YHüHP EURMX &' üHOLMD QD GXJL URN QHJR NRG VWDULMH
GMHFH 6WRJD YRGLOMH ]D VWDULMX GMHFX PRåGD QLVX RSWL
PDOQH]DRGUåDYDQMHEURMD&'üHOLMDXRGUDVORMGREL
5HIHUHQFH
/HZLV-HWDO$JHDQG&'FRXQWDWLQLWLDWLRQRIDQWLUHWURYLUDOWKHUDS\LQ+,9LQIHFWHGFKLOGUHQHIIHFWVRQORQJWHUP7FHOOUHFRQVWLWXWLRQ-,'
3XEOLVKHGDKHDGRISULQW'HFHPEHU
ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%H
/2.$/1(675$1(
'RVWXSQRVW$59WHUDSLMHNRMHOMHNRYHLPDPRXUHJLML"
=DXVSMHãQROLMHþHQMH+,9DYUORMHYDåQRLPDWLQDUDVSR
ODJDQMXãWRYLãHOLMHNRYDUD]OLþLWLKNODVDSRPRüXNRMLKVH
UDGHNRPELQDFLMHRGGYDWULLOLþHWLULOLMHND$NRVHVMHWL
PR MRã SULMH DN JRGLQD SDFLMHQW NRML LPD +,9 PRUDR
MHGQHYQRSRSLWLLGRWDEOHWDNDNRELPRJDRVPDQMLWL
YLUHPLMXLSRGLJQXWLEURMOLPIRFLWD&''DQDVXVYLMHWX
SRVWRMLMHGQDSLOXODNRMDXVHELVDGUåLNRPELQDFLMXOLMHND
LX]LPDVHMHGQRPGQHYQR9HüQHNROLNRJRGLQDGRVWXS
QDMHLNRPELQDFLMDRGWULOLMHNDXMHGQRMWDEOHWLNRMDVH
WDNRÿHUX]LPDMHGQRPGQHYQR1R]DQDãXUHJLMXQLMHGQD
QLGUXJDNRPELQDFLMDMHGQHWDEOHWHGQHYQRQLMHGRVWXSQD
=DãWR"1DUD]OLþLWLPPMHVWLPDGRELWLüHWHUD]OLþLWHRGJR
YRUHGDVXWLOLMHNRYLSUHVNXSLGDQHPDSRWUHEH]DQML
PDGDMHUHJLVWUDFLMVNLSURFHVSUHGXJLSUHVSRUNRMLYDV
QDNUDMXGRYHGXGRMHGLQRJORJLþQRJ]DNOMXþNDGDVPR
SUHPDORWUåLãWHWHGDQHNLPDMHGQRVWDYQRQLMHVWDORGDWL
OLMHNRYLGRÿX=ERJþHJD"3DNDGSRQXGLWHVYXSRPRüL
SRGUãNXRNRUHJLVWUDFLMVNRJSURFHVDIDUPDFHXWVNLPWYUW
NDPDREMDVQLWHSRWUHEX]DRGUHÿHQLPOLMHNRPPLQLVWDU
VWYX ]GUDYOMD WH SRMDVQLWH ÄFRVW EHQH¿W³ QRYRJD OLMHND
]GUDYVWYHQRPRVLJXUDQMXQHGRJRGLVHQLãWD6YHVWRMLQD
*RGLQD,EURM
LVWRPPMHVWXDWRMHGDMHOLMHNQHGRVWXSDQRQLPDNRMLPD
MHSRWUHEDQ0RåGDVYLPDQMLPDWUHEDSRQRYQRQDJODVLWL
GDMHGQDLOLGYLMHWDEOHWHGQHYQRQDVXSURWLOLWDEOHWD
GQHYQRQLMHNRPIRUPL]DPRVREDNRMHåLYHV+,9RPQHJR
åLYRWQDSRWUHEDNRMDPHÿXLQLPDX]XVSMHãQRVWOLMHþHQMD
LPD MRã MHGQX GREUX ©QXVSRMDYXª D WR MH SREROMãDQMH
NYDOLWHWH åLYRWD , PL PRUDPR WDNRÿHU ELWL UHDOQL L QD
JODVLWL GD QH PRJX VYL X]LPDWL NRPELQDFLMX OLMHNRYD V
MHGQRP WDEOHWRP GQHYQR 5HDOQRVW MH WDNYD GD QHNLPD
WRQHüHRGJRYDUDWLXJODYQRP]ERJQXVSRMDYDDOLWRQH
]QDþLGDOLMHNPRUDELWLQHGRVWXSDQ8WDEOLFLNRMDVOLMHGL
YLGMHWüHPRNDNYDMH]DVWXSOMHQRVWRGUHÿHQLKOLMHNRYDX
QDãRMUHJLMLýRYMHNELUHNDRGDLPDPRL]ERUDLLPDPR
JD DOL LPDPR OL GRYROMQR" 6YDNDNR LPDPR SRWUHEX ]D
QRYLMLPOLMHNRYLPD1RYLMLOLMHNRYLþHVWR]QDMXELWLÄOLIH
VDYLQJWKHUDS\³LOLWHUDSLMDNRMDVSDãDYDåLYRWLEDã]ERJ
WRJD RQL PRUDMX ELWL GRVWXSQL MHU QDPD MH YDåDQ VYDNL
þRYMHN$OEHUW6FKZHLW]HUQMHPDþNLOLMHþQLNJOD]EHQLN
L WHRORJ WH GRELWQLN 1REHORYH QDJUDGH ]D PLU MHGQRP
MHUHNDRÄ2GJRYRUQLVPR]DVYHãWRPRåHPRXþLQLWL]D
þRYMHNDELRQDPRQSR]QDWLOLQH³
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
*HQHULþNR
ime
$NWLYQDH
VXSVWDQFDH
Ime leka
7&ODPLYX
GLQH
(SLYLU
$EDFDYLU
=LDJHQ
(S]LFRP
$=7]LGRYX
GLQH
5HWURYLU
Zidosan
GG,GLGDQRV
LQH
9LGH[
7HQRIRYLU')
Viread
)7&HPWULFLW (PWULYD
DELQH
$WD]DQDYLU
5H\DWD]
'DUXQDYLU
3UH]LVWD
)RVDPSUHQDYLU 7HO]LU
/HYL[D
,QGLQDYLU
&UL[LYDQ
1HO¿QDYLU
9LUDFHSW
5LWRQDYLU
1RUYLU
6DTXLQDYLU
,QYLUDVH
7LSUDQDYLU
$SWLYXV
(IDYLUHQ]
6XVWLYD
6WRFULQ
(WUDYLULQH
,QWHOHQFH
70&
Vrsta leka
Bosna i
Hercegovina
/LFHQ 1D
FLUDQ listi
QXNOHR]LGQL
LQKLELWRULUHYHU
]QHWUDQVNULSWD]H
157,
QXNOHR]LGQL
LQKLELWRULUHYHU
]QHWUDQVNULSWD]H
157,
QXNOHR]LGQL
LQKLELWRULUHYHU
]QHWUDQVNULSWD]H
157,
QXNOHR]LGQL
LQKLELWRULUHYHU
]QHWUDQVNULSWD]H
157,
QXNOHR]LGQL
LQKLELWRULUHYHU
]QHWUDQVNULSWD]H
157,
QXNOHR]LGQL
LQKLELWRULUHYHU
]QHWUDQVNULSWD]H
157,
,QKLELWRUSURWHD]H
3,
,QKLELWRUSURWHD]H
3,
,QKLELWRUSURWHD]H
3,
,QKLELWRUSURWHD]H
3,
,QKLELWRUSURWHD]H
3,
,QKLELWRUSURWHD]H
3,
,QKLELWRUSURWHD]H
3,
,QKLELWRUSURWHD]H
3,
QHQXNOHR]LGQL
LQKLELWRULUHYHU
]QHWUDQVNULSWD]H
1157,
QHQXNOHR]LGQL
LQKLELWRULUHYHU
]QHWUDQVNULSWD]H
1157,
&UQD*RUD
Hrvatska
6UELMD
/LFHQ 1D
FLUDQ listi
/LFHQ 1D
FLUDQ listi
/LFHQ 1D
FLUDQ listi
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
6DPR]DWHUDSLMX+%9
ZZZKLYELOWHQLQIR
*RGLQD,EURM
+,9%,/7(1+7%H
*HQHULþNR
ime
$NWLYQDH
VXSVWDQFDH
Ime leka
1HYLUDSLQH
9LUDPXQH
5LOSLYLULQH
(GXUDQW
70&
5DOWHJUDYLU
5DOWHJUD
YLU
Zerit
6WDYXGLQH
7HQIX
YLUWLGH
0DUDYLURF
HIDYLUHQ]
WHQRIRYLU
)7&
NRPELQDFLMD
¿NVQLKGR]D
ULOSLYLULQH
WHQRIRYLU
)7&
ORSLQDYLU
ULWRQDYLU
7&DED
FDYLU
7&DED
FDYLU$=7
WHQRIRYLU
)7&
WHQRIRYLU
)7&
HOYLWHJUDYLU
FRELFLVWDW
)X]HRQ
Vrsta leka
QHQXNOHR]
idni inhibi
WRULUHYHU]QH
WUDQVNULSWD]H
1157,
QHQXNOHR]
idni inhibi
WRULUHYHU]QH
WUDQVNULSWD]H
1157,
Inhibitor Inte
JUD]H,1,
QHQXNOHR]LGQL
DNWLYQLLQKLEL
WRULUHYHU]WQH
WUDQVNULSWD]H
1$57,
,QKLELWRUXODVND
Bosna i
Hercegovina
/LFHQ 1D
FLUDQ listi
¥
&UQD*RUD
Hrvatska
6UELMD
/LFHQ 1D
FLUDQ listi
/LFHQ 1D
FLUDQ listi
/LFHQ 1D
FLUDQ listi
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
&HOVHQWUL
6HO]HQWU\
$WULSOD
&&5LQKLELWRU
&RPELYLU
NRPELQDFLMD
¿NVQLKGR]D
NRPELQDFLMD
¿NVQLKGR]D
¥
¥
¥
¥
¥
¥
¥
¥
NRPELQDFLMD
¿NVQLKGR]D
NRPELQDFLMD
¿NVQLKGR]D
7UL]LYLU
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
¥
NRPELQDFLMD
¿NVQLKGR]D
NRPELQDFLMD
¿NVQLKGR]D
¥
¥
¥
(YLSOHUD
.DOHWUD
$OXYLD
.LYH[D
7UL]LYLU
7UXYDGD
4XDG
*RGLQD,EURM
¥
¥
NRPELQDFLMD
¿NVQLKGR]D
¥
¥
¥
¥
¥
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
=DQLPOMLYRMHYLGMHWLNRMHNRPELQDFLMH$59OLMHNRYDVH
QDMþHãüHNRULVWHXSUDNVL,VNXVWYDXUHJLMLVXUD]OLþLWDDOL
QDNUDMXüHYDPVYDNLOLMHþQLNNRMLOLMHþLRVREHNRMHåLYH
V+,9RPUHüLLVWRSRWUHEQLVXQDPQRYLMLXþLQNRYLWLML
OLMHNRYLDOLLVWRYUHPHQRLQHVPHWDQDNRQWLQXLUDQDQDEDY
NDVYLKWUHQXWQRUHJLVWULUDQLKSRWUHEQLKOLMHNRYDNRMLVX
VHQDåDORVWQDãOLQDXGDUXIDPR]QHHNRQRPVNHNUL]H8
WRPHLPMHSRWUHEQDSRPRü]DMHGQLFHDSRVHEQRDNWLYLVWD
GDVHWRLRVWYDUL3DSRJOHGDMPRSREOLåHLSRMHGLQDþQR
]HPOMHXUHJLMLNRMHQDMþHãüHNRPELQDFLMHOHNRYDVHNR
ULVWH
ýHãüHNRPELQDFLMHELOHVX
.RPELQDFLMD
1
.9;()9
.9;/39
&%9/39
&%9()9
&%9193
79'()9
ýHãüHLQLFLMDOQHNRPELQDFLMHELOHVX
.RPELQDFLMD
1
79'()9
.9;/39
.9;()9
&%9193
&%9()9
'77&193
HRVATSKA
3UHPDSRGDFLPDL]JRGLQHX+UYDWVNRMMHEROH
VQLNDX]LPDOR$578NXSQRMHELORSURSLVDQRUD]OLþLWD
NRPELQDFLMD 8 WRNX LVWH JRGLQH RVRED MH ]DSRþHOR
$571MLPDMHELORSURSLVQRUD]OLþLWLKSRþHWQLKNRP
ELQDFLMD
/HJHQGD&%9 NRIRUPXOLUDQL$=77&.9; NRIRUPXOLUDQL$%&7&79' NRIRUPXOLUDQL7'))7&()9±HID
YLUHQ]/39ORSLQDYLUU193±QHYLUDSLQ'7VWDYXGLQ7&±ODPLYXGLQ$%&±DEDFDYLU$=7]LGRYXGLQH
%261$,+(5&(*29,1$
8 %RVQL L +HUFHJRYLQL WUL NOLQLNH SUXåDMX ]GUDYVWYHQX
QMHJXEROHVQLFLPDX6DUDMHYX7X]OLL%DQMD/XFL%ROH
VQLFLNRMLSUYLSXW]DSRþLQMXVWHUDSLMRPQDMþHãüHGRELYD
MX NRPELQDFLMX 79'()9 LOL 79'/39 LOL .9;()9
âWR VH WLþH EROHVQLND NRML LPDMX LVNXVWYD VD X]LPDQMHP
WHUDSLMHWDGDVHRELþQR&%9PLMHQMDVD79'LOL.9;D
XVOXþDMXYLUXVRORãNRJQHXVSMHKD]DPLMHQLVHLWUHüLOLMHN
()9VD/39LOLREUDWQR]DYLVQRNRMLMHOLMHNELRLQLFL
MDOQRXNOMXþHQ
&51$*25$
1DMþHãüD NRPELQDFLMD NRMX SURSLVXMX LQIHNWROR]L X
.OLQLþNRPFHQWUX&UQH*RUHX3RGJRULFLRVREDPDNRMH
LPDMX SRWUHEX ]D DQWLUHWURYLUXVQRP WHUDSLMRP MH .9;
()9
SRBIJA
86UELMLVHOLMHþHQMHSUHNRWLVXüXRVREDNRMHåLYHVD+,9
RP REDYOMD X þHWLUL FHQWUD QD LQIHNWLYQLP NOLQLNDPD X
%HRJUDGX 1RYRP 6DGX .UDJXMHYFX L 1LãX 3RþHWQD
NRPELQDFLMD$57MHQDMþHãüH.9;()9DNRGRQLKNRG
NRMLKVHOLMHþHQMHSRND]DORQHXVSMHãQLPWRMH/39$%&
$=7
'DOLWULGHVHWJRGLQDNDVQLMHQD]LUHPRVYHWORVWQDNUDMXWXQHOD"
ĈRUÿH-HYWRYLü
QDþHOQLNRGHOMHQMD]D+,9$,'6.OLQLNH]DLQIHNWLYQHLWURSVNHEROHVWL
.OLQLþNRJFHQWUD6UELMH
3LVDQD LVWRULMD HSLGHPLMH $,'6D MH ]YDQLþQR SRþHOD X
MXQX JRGLQH NDGD MH X .DOLIRUQLML VDRSãWHQR R
SHWVOXþDMHYD3FDULQLLSQHXPRQLMH'DQDV]QDPRGDMH
RYDHSLGHPLMDSRWPXORWLQMDODLYLãHSUHWKRGQLKGHFHQLMD
7DNRÿH MH VDVYLP L]YHVQR GD üH SRWUDMDWL L X RYRP WHN
]DSRþHWRPYHNXLELüHPRVYHGRFLQRYLKGRVWLJQXüDDOLL
QRYLKVWUDKRYDRGRYHEROHVWLNRMRMMHXLVWRULMLPHGLFLQH
QHVDPRPHWDIRULþNLULYDOMHGLQR³FUQDVPUW´
ZZZKLYELOWHQLQIR
6LQGURP VWHþHQH LPXQRGH¿FLMHQFLMH QD IUDQFXVNRP
³V\QGURPH G¶LPPXQRGH¿FHQFH DFTXLVH ³6,'$ LOL
³DFTXLUHG LPPXQRGH¿FLHQF\ V\QGURPH´$,'6 QD HQ
JOHVNRP MH WHUPLQDOQL VWDGLMXP KURQLþQH LQIHNFLMH YL
UXVRP KXPDQH LPXQRGH¿FLMHQFLMH ³KXPDQ LPPXQRGH
¿FLHQF\ YLUXV´ +,9 2G SURGRUD +,9D X RUJDQL]DP
SDGRUD]YRMD$,'6DRELþQRSURWHNQHYLãHJRGLQDþDN
LSUHNRLDNRMHRSLVDQDLYUORNUDWNDLQNXEDFLMDRG
*RGLQD,EURM
+,9%,/7(1+7%H
QHNROLNRPHVHFL2YHUD]OLNHXGXåLQLWUDMDQMDDVLPSWRP
DWVNHID]HLQIHNFLMHVXQDMYHURYDWQLMHJHQHWVNLXVORYOMHQH
LQGLYLGXDOQH UD]OLND X RGJRYRUX RGEUDPEHQRJ VLVWHPD
þRYHNDQD+,9
7RNRP SURWHNOH WUL GHFHQLMH HSLGHPLMD +,9 LQIHNFLMH
L$,'6D MH QDGPDãLOD VYH SRþHWQH SURJQR]H R QMHQLP
UD]PHUDPD L XWLFDMX QD UD]OLþLWH DVSHNWH åLYRWD KX
PDQH SRSXODFLMH $,'6 QH VDPR GD MH VWHNDR SULPDW
QDM]QDþDMQLMHVWHþHQH LPXQRGH¿FLMHQFLMHYHü MH SRVHE
QR X ]HPOMDPD 7UHüHJ VYHWD GRYHR GR GUDPDWLþQRJ
VNUDüHQMD åLYRWQRJ YHND X] SRJXEQL XWLFDM QD VDGDãQML
L EXGXüL HNRQRPVNL UD]YRM WLK YHü L WDNR VLURPDãQLK
]HPDOMD8]HPOMDPDUD]YLMHQRJ]DSDGDXNRMLPDMHRG
JRGLQH ãLURNR GRVWXSQD YLVRNRDNWLYQD DQWLUHWUR
YLUXVQD WHUDSLMD ³KLJKO\ DFWLYH DQWLUHWURYLUDO WKHUDS\´
+$$57UHJLVWURYDQMH]QDþDMDQSDGPRUELGLWHWDLPRU
WDOLWHWDRG$,'6D0HÿXWLPRYDMSDGMHGRVWLJDRSODWR
NRMLVHSRVOHGQMLKJRGLQDRGUåDYDQDJRYHãWDYDMXüLGDMH
L QDMRSWLPLVWLþNLML VFHQDULMR R H¿NDVQRVWL L GRVWXSQRVWL
DQWLUHWURYLUXVQHWHUDSLMHGRVWLJDRWHåQMHSDFLMHQDWDLQML
KRYLKOHNDUDGDVHVD+,9RP³QRUPDOQR´åLYL
3UHPD SURFHQDPD 6YHWVNH ]GUDYVWYHQH RUJDQL]DFLMH
6=2 NUDMHP JRGLQH MH RNR PLOLRQD OMXGL
ãLURPVYHWDåLYHORVD+,9LQIHNFLMRPRGNRMLKVXPQRJL
YHüREROHOLRG$,'6D2GWRJEURMDGYHWUHüLQHMHX]HP
OMDPD3RGVDKDUVNH$IULNHJGHVHSURFHQMXMHGDVYDNL
VWDQRYQLNLPD+,9LQIHNFLMXLOL$,'67DNRÿHVHSURFHQ
MXMH GD MH RG SRþHWND HSLGHPLMH SUHNR PLOLRQD OMXGL
XPUORRGRYHEROHVWL1RMRãMHSHVLPLVWLþQLMHVD]QDQMH
GD MH X SRSXODFLML OMXGL RG JRGLQD X QDMSURGXN
WLYQLMHP SHULRGX åLYRWD $,'6 YRGHüL X]URN VPUWL 8
]HPOMDPD X UD]YRMX SRVHEQR FHQWUDOQRDIULþNLP HSL
GHPLMD$,'6DYHüLPDRJURPDQXWLFDMQDGHPRJUDIVNH
NDUDNWHULVWLNHVWDQRYQLãWYDDJXELWDNSUHYDVKRGQRUDGQR
VSRVREQLK LPD RJURPDQ XWLFDM QD GDOML HNRQRPVNL UD]
YRMRYLK]HPDOMD,DNRMHXYLVRNRLQGXVWULMVNLUD]YLMHQ
LP ]HPOMDPD ]DSDGQH KHPLVIHUH +,9 LQIHNFLMD L$,'6
]QDþDMQRPDQML]GUDYVWYHQLSUREOHPLSDNMHXPQRJLP
YHOLNLPJUDGRYLPD=DSDGQH(YURSH6HYHUQH$PHULNHL
$XVWUDOLMH$,'6 MH SRVWDR YRGHüL X]URN VPUWL X SRSX
ODFLMLRGUDVOLK,SRUHG]QDþDMQLKQDSRUDNRMLVXXþLQMHQL
GD VH HSLGHPLMD +,9 LQIHNFLMH VX]ELMH VPDWUD VH GD MH
WRNRPXFHORPVYHWXVYDNRGQHYRELORRNR
QRYRLQ¿FLUDQLKDVNRUROMXGLMHGQHYQRXPLUDORRG
$,'6D
$NR VH RVYUQHPR QD KURQRORJLMX GYDGHVHWSHWRJRGLãQMH
ERUEH VD $,'6RP QH PRåHPR D GD QH SUHSR]QDPR
IDVFLQDQWDQ RGJRYRU ED]LþQLK ELRPHGLFLQVNLK QDXND QD
QRYLL]D]RY,PXQRORJLMDLYLUXVRORJLMDVXWDNRSRVWDYLOH
VFHQX ]D NOLQLþNRLVWUDåLYDþNL UDG NRML MH EUåH L H¿NDV
QLMH QHJR LNDGD UDQLMH X LVWRULML IDUPDNRWHUDSLMH GRYHR
GR QDSUHWND RYRJD SXWD DQWLYLUXVQH WHUDSLMH L ELOL VPR
VYHGRFLSREROMãDQMDNYDOLWHWDåLYRWDVYRMLKSDFLMHQDWD6D
XYRÿHQMHP +$$57 X NOLQLþNX SUDNVX SUHG NUDM GHYH
GHVHWLKXUD]YLMHQLP]HPOMDPDEOMHVQXODMHQDGDVSDVD
+$$57 MH SRND]DOD GD MH L PRJXü RSRUDYDN LPXQVNH
*RGLQD,EURM
IXQNFLMHãWRVHRSHWPHWDIRULþNLJRWRYRPRåHSRUHGLWL
VDELEOLMVNRPSULþRPR/D]DUX7HUDSLMDMHXVSHãQDDOL
LSDN GUDPDWLþQL SDG PRUELGLWHWD L PRUWDOLWHWD RG RYH
EROHVWL]DRNRVHUHJLVWUXMHVDPRX]HPOMDPDUD]
YLMHQRJ]DSDGD+$$57MHGRVWXSQDLX6UELMLRG
JRGLQHDSDFLMHQWLMHPRJXGRELWLXVNORSX]GUDYVWYHQRJ
RVLJXUDQMD V WLP ãWR MH L]ERU OHNRYD PDQML QHJR X UD]
YLMHQLP HYURSVNLP ]HPOMDPD 1RYLML L YUOR VNXSL OHNR
YL ]D VDGD QLVX GRVWXSQL WDNR GD MH NRG MHGQRJ PDORJ
SURFHQWDSDFLMHQDWDNRGNRMLKSRVWRMHüLOHNRYLYLãHQLVX
GHORWYRUQLQDVWDYDNOHþHQMDPRJXüVDPRSXWHPVWUDQLK
GRQDFLMD 3RORYLQRP JRGLQH X 6UELML VH OHþL RNR
SDFLMHQDWD VDYUHPHQRP DQWLUHWURYLUXVQRP WHUDSL
MRP$QDOL]LUDMXüLXVSHãQRVW+$$57WRNRPSURWHNOLK
JRGLQD]DNOMXþLOLVPRGDMHYHURYDWQRüDGHVHWRJRGLãQMHJ
SUHåLYOMDYDQMDRNRDVPUWQRVWMHELODRNR2YL
VXUH]XOWDWLNRPSDWLELOQLVDRQLPDL]UD]YLMHQLK]HPDOMD
XSUNRVPQRJLPRJUDQLþHQMLPDVNRMLPDVHVXVUHüXOHNDUL
NRMLX6UELMLOHþH+,9LQIHNFLMX
'DQDVMHL]YHVQRGDMHVYLPDNRMLVXLQ¿FLUDQLQHRSKRGQD
GRåLYRWQD +$$57 DOL V QMRP MH +,9 LQIHNFLMD SRVWDOD
KURQLþDQEROHVWVNRMRPVHåLYLDQHRGNRMHVHVLJXUQR
XPLUH=ERJUD]YRMDUH]LVWHQFLMD+,9DQDOHNRYH³PDJL
MD´ +$$57 NRG PQRJLK YLãH ³QH GHOXMH´ ,SDN RYRJD
SXWDVDYLãHRSWLPL]PDYHUXMHPRGDüHWUNDVD+,9RP
ELWLPDUDWRQNUR]YHNRYRJDSXWDYHüLVDQD]QDNDPD
RPRJXüHPL]OHþHQMX
.RPELQRYDQDDQWLYLUXVQDWHUDSLMDOHNRYLPDL]UD]OLþLWLK
NODVD DQWLUHWURYLUXVQLK OHNRYD NDG MH GRVWXSQD NDNR X
UD]YLMHQLPWDNRLX]HPOMDPDXUD]YRMXXVSHãQDMHNRG
YHüLQHOHþHQLK,DNRVHX6UELMLRSWLPDOQLYLUXVRORãNLXV
SHK+$$57SRVWLåHNRGSUHNROHþHQLKVDPRMHNRG
PRJXüDLLPXQVNDUHNRQVWLWXFLMD-HGQDWUHüLQD+,9
RP LQ¿FLUDQLK NRG NRMLK MH SRVWLJQXW ]DGRYROMDYDMXüL
YLUXVRORãNLWHUDSLMVNLXVSHKLSDNåLYLGXJRVVXENOLQLþNRP
LPXRGH¿FLMHQFLMRPVUL]LNRPGDREROHRGRSRUWXQLVWLþNLK
LQIHNFLMDLLOLWXPRUD=DVDGDQHPD]YDQLþQLKSUHSRUXND
NDNR WHUDSLMVNLLPXQRPRGXODWRUQRXWLFDWL QD LPXQRGH
¿FLMHQFLMX 8 VYLP VOXþDMHYLPD WHDUDSLMVNRJ XVSHKD MH
LSDNQRSKRGQDGRåLYRWQD+$$57EXGXüLGDVHGRVDGD
SR]QDWLP DQWLUHWURYLUXVQLP OHNRYLPD QH PRåH SRVWLüL
HUDGLNDFLMD YLUXVD $57 MH SRYH]DQD VD ]QDþDMQRP
WRNVLþQRãüXNRMDLVDPDSRVHELPRåHXJUR]LWLåLYRW8
FLOMXVPDQMHQMDWRNVLþQRWLMHPRJXüHIDUPDNRJHQHWVNLP
DQDOL]DPDSURFHQLWLNRMLELOHNRYLVDDVSHNWDIDUPDNRNLQH
WLNHELOLRGJRYDUDMXüLLXNRMLPGR]DPD]DSRMHGLQDþQRJ
SDFLMHQWD3RUHGWRNVLþQRVWL]QDþDMQLVXSUREOHPLNRP
SOLMDQVDUD]YRMUH]LVWHQFLMH+,9DQDOHNRYHGRVWXSQRVW
OHNRYD L QMLKRYD YLVRND FHQD 6=2 SURFHQMXMH GD RNR
+,9RP LQ¿FLUDQLK ãLURP VYHWD NRMLPD MH $57
SRWUHEQDLPDLGRVWXSQROHþHQMH=ERJVYHJDQDYHGHQRJ
QDUHGQLMHFLOMXVWUDWHJLMLDQWLUHWURYLUVXQHWHUDSLMHSRVWLüL
HOLPLQDFLMX UH]HUYRDUD SUHRVWDORJ YLUXVD X RUJDQL]PX L
NRQDþQR ]DYUãLWL OHþHQMH , ]DLVWD SRSXW OHþHQMD GUXJLK
LQIHNWLYQLK EROHVWL NRQDþQL FLOM MH L]OHþLWL LQ¿FLUDQH L
SURQDüL SURWHNWLYQX YDNFLQX ]D QHLQ¿FLUDQH =D VDGD MH
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
SR]QDWR GD VX GXJRåLYHüL QHDNWLYLUDQL &' OLPIRFLWL
PHPRULMVNRJIHQRWLSDQDMYDåQLMLUH]HUYRDUYLUXVDDOLMRã
XYHNQHSRVWRMHUH]XODWDWLNOLQLþNLKVWXGLMDNRMLELXND]DOL
NRMLELWRQRYLOHNRYLELOLSRWUHEQLLGRYROMQL]DNRQDþQR
L]OHþHQMH=D VDGD QLMH X SRWSXQRVWL UD]MDãQMHQD SULURGD
SURWHNWLYQRJ LPXQLWHWD ]D +,9 ãWR X] YHOLNX YDULMDELO
QRVW NYD]LVRMHYD YLUXVD MRã XYHN XGDOMDYD QDXþQLNH RG
RWNULüDYDNFLQH
6XENOLQLþNDNDURWLGQDDWHURVNOHUR]DSRYH]DQDMHV+,9LQIHNFLMRPLQLVNLPVWXSQMHP
SULGUåDYDQMDPHGLWHUDQVNRMSUHKUDQL
.ODXGLMD9LãNRYLü*HRUJH:5XWKHUIRUG
*DEULHO6XGDULR/RUQD6WHPEHUJHU-RVLS%HJRYDF
3UHGVWDYOMDPR VWXGLMX L]ORåHQX QD &RQIHUHQFH RQ 5HW
URYLUXVHV DQG 2SSRUWXQLVWLF ,QIHFWLRQ &52, X YLGX
SRVWHUSUH]HQWDFLMHEURMRGVWUDQHQDXþQLKUDGQLND
L]UHJLMH
Uvod
%PRGXOWUD]YXNYLVRNHUH]ROXFLMHRPRJXüDYDSURFMHQX
GHEOMLQHNRPSOHNVDNDURWLGQHLQWLPHPHGLMHHQJO&DUR
WLG,QWLPD0HGLD7KLFNQHVV&,07þLMH]DGHEOMDQMHSUHG
VWDYOMD UDQL PDUNHU DWHURVNOHUR]H L XND]XMH QD SRYHüDQ
UL]LN UD]YRMD NRURQDUQH L FHUHEUDOQH DUWHULMVNH EROHVWL
.DURWLGQLSODN MH SRYH]DQ V WUDGLFLRQDOQLP UL]LþQLP
þLPEHQLFLPDLLPDYHüXSUHGLNWLYQXYULMHGQRVW]DUD]YRM
LQIDUNWD PLRNDUGD QHJR PRåGDQRJ LQIDUNWD 0HGLW
HUDQVND SUHKUDQD SUHGVWDYOMD ]GUDY QDþLQ SUHKUDQH NRML
ãWLWL RG UD]YRMD NDUGLRYDVNXODUQLK EROHVWL .DUDN
WHUL]LUDQD MH SRYHüDQRP SRWURãQMRP PDKXQDUNL YRüD L
SRYUüDWHPDVOLQRYRJXOMDXPMHUHQRPSRWURãQMRPULEHL
FUQRJYLQDWHQLVNRPSRWURãQMRPFUYHQRJPHVDLPHVQLK
SUHUDÿHYLQDYUKQMDLVODWNLãD
&LOMHYLLVWUDåLYDQMD
SURFMHQD XWMHFDMD SUHKUDPEHQLK QDYLND RVRELWR
SULGUåDYDQMD PHGLWHUDQVNRM SUHKUDQL QD YULMHGQRVWL &,
07DXEROHVQLND]DUDåHQLK+,9RPLQH]DUDåHQLKLVSL
WDQLNDNRMLþLQHNRQWUROQXVNXSLQX
SRYH]DQRVWL+,9LQIHNFLMHLVXENOLQLþNHDWHURVNOHUR]H
Metode rada
8LVWUDåLYDQMHMHELRXNOMXþHQLVSLWDQLNLQ¿FLUDQ+,9
RP•JRGLQDEH]UDQLMHSUHEROMHOLKNDUGLRYDVNXODUQLK
EROHVWL L QH]DUDåHQL LVSLWDQLN L] NRQWUROQH VNXSLQH
.ULWHULMLLVNOMXþHQMD]DLVSLWDQLNHREMHVNXSLQHELOLVXGH
PHQFLMDDNXWQDEROHVWWURãHQMHOLMHNRYDNRMLPRGL¿FLUDMX
PHWDEROL]DPOLSLGDLJOXNR]HQSULQ]XOLQLVWDWLQLNDRL
GLXUHWLNDWHNRUWLNRVWHURLGD7DNRÿHUVPRLVNOMXþLOLLVSLWDQ
LNHVSR]QDWRPDOHUJLMRPQDRUDãDVWHSORGRYHPDVOLQRYR
XOMHULEXLPRUVNHSORGRYH&,07VPRPMHULOLXSRUDERP
YLVRNRIUHNYHQWQH OLQHDUQH VRQGH X %PRGX 3ULVXWQRVW
VXENOLQLþNHDWHURVNOHUR]H VPDWUDOL VPR SR]LWLYQRP DNR
MHLVSLWDQLNLPDR&,07•PPLOLMHLPDRYLGOMLYSODN
ZZZKLYELOWHQLQIR
XNDURWLGQRMDUWHULML6WXSDQMSULGUåDYDQMDPHGLWHUDQVNRM
SUHKUDQLXWYUÿLYDOLVPRXSRUDERPXSLWQLNDRGERGRYD
L UH]XOWDW ERGRYDQMD VPR GLKRWRPL]LUDOL SUHPD PHGL
MDQX ,VWUDåLYDOL VPR WDNRÿHU L WUDGLFLRQDOQH UL]LþQH
þLPEHQLNH ]D UD]YRM DWHURVNOHUR]H GRE SXãDþNL VWDWXV
VSRORELWHOMVNXDQDPQH]XNDULRYDVNXODUQLKUL]LNDKLSHU
WHQ]LMXL+,9VWDWXV6YLVXLVSLWDQLFLSULMHXNOXþLYDQMDX
LVWUDåLYDQMHSRWSLVDOLLQIRUPLUDQLSULVWDQDN
5H]XOWDWLLVWUDåLYDQMD
6XENOLQLþNDDWHURVNOHUR]D MH XWYUÿHQD X RG
LVSLWDQLND 8WYUGLOL VPR QLVNL VWXSDQM SULGUåDYDQMD
PHGLWHUDQVNRM SUHKUDQL EURM ERGRYD þHãüH SULVX
WDQ X QH]DUDåHQLK LVSLWDQLND NRQWUROQH VNXSLQH QHJR X LVSLWDQLND ]DUDåHQLK +,9RP S 8 LVSLWDQLND • JRGLQD XWYUGLOL VPR YHüX XþHVWDORVW
VXENOLQLþNH DWHURVNOHUR]H X ]DUDåHQLK +,9RP X XV
SRUHGEL V LVSLWDQLFLPD NRQWUROQH VNXSLQH RG QDVSUDPRGS 8PRGHOXPXOWLYDULMDWQH
DQDOL]H QLVNL VWXSDQM SULGUåDYDQMD PHGLWHUDQVNRM SUHK
UDQL ELR MH ]QDþDMQR XGUXåHQ V UD]YRMHP VXENOLQLþNH
DWHURVNOHUR]H 25 &, S ]D
MHGQRVSXãHQMHP25KLSHUWHQ]LMRPVLVWROLþNLWODN
! PP +J 25 L PXãNLP VSRORP 25 8
GRELRGJRGLQDPXOWLYDULMDWQLPRGHODQDOL]HSRND]DR
QDPMHGDRVREH]DUDåHQH+,9RPLPDMXRPMHUL]JOHGD
UD]YRMD VXENOLQLþNHDWHURVNOHUR]H SXWD YHüL &,
GRXXVSRUHGELVLVSLWDQLFLPDNRQWUROQHVNXSLQH
S =DNOMXþFL
‡1LVNL VWXSDQM SULGUåDYDQMD PHGLWHUDQVNRM SUHK
UDQL SUHGVWDYOMD QHRYLVQL SUHGLNWRU UD]YRMD
VXENOLQLþNHDWHURVNOHUR]H
‡+,9LQIHNFLMD MH ELOD QHRYLVQR XGUXåHQD VD
VXENOLQLþNRPDWHURVNOHRUR]RP X RVRED ]DUDåHQLK +,9
RP
‡3UHKUDPEHQH LQWHUYHQFLMH X VPLVOX SULGUåDYDQMD PHG
LWHUDQVNRM SUHKUDQL PRJX UH]XOWLUDWL X PDQMHP VWXSQMX
VXENOLQLþNHDWHURVNOHUR]H
*RGLQD,EURM
+,9%,/7(1+7%H
3UHJOHGQDXþQLKUDGRYDL]UHJLMHXJRGLQLSUHPDED]L3XE0HG
*UJLü,=LGRYHF/HSHM6/XQDU03ROMDN09LQFH$
%DFD9UDNHOD,3ODQLQLü$6HPH.%HJRYDF-
7KH SUHYDOHQFH RI WUDQVPLWWHG GUXJ UHVLVWDQFH LQ
newly-diagnosed HIV-infected individuals in Croatia:
WKHUROHRIWUDQVPLVVLRQFOXVWHUVRIPHQZKRKDYHVH[
with men carring T215S surveillance drug resistance
mutation.
$,'6 5HV +XP 5HWURYLUXVHV $XJ 3XE0HG
30,'
'DNRYLü5RGH20DUNRWLü$.XMXQGåLü7LOMDN0=L
GRYHF/HSHM6%HJRYDF-
6HUXP DSRSWRVLV PDUNHUV LQ +,9LQIHFWHG SDWLHQWV
ZLWKKXPDQKHUSHVYLUXVW\SHDQGKHUSHVVLPSOH[
YLUXVW\SHFRLQIHFWLRQ
(XU - &OLQ0LFURELRO,QIHFW'LV -XO 3XE0HG
30,'
%RåLüHYLü,/HSHM6=5RGH2'*UJLü,-DQNRYLü3
'RPLQNRYLü=/XNDV'-RKQVWRQ/*%HJRYDF-
3UHYDOHQFHRI+,9DQGVH[XDOO\WUDQVPLWWHGLQIHFWLRQV
DQG SDWWHUQV RI UHFHQW +,9 WHVWLQJ DPRQJ PHQ ZKR
KDYHVH[ZLWKPHQLQ=DJUHE&URDWLD
6H[7UDQVP,QIHFW
0D\
3XE0HG
30,'
'UDJRYLü*-HYWRYLü'
7KH UROH RI QXFOHRVLGH UHYHUVH WUDQVFULSWDVH ,QKLELWRUV XVDJH LQ WKH LQFLGHQFH RI K\SHUODFWDWHPLD DQG
ODFWLFDFLGRVLVLQ+,9$,'6SDWLHQWV
%LRPHG3KDUPDFRWKHU-XQ0D\
3XE0HG30,'
'UDJRYLü*-HYWRYLü'
5HSRUW RQ WKH WK (XURSHDQ $,'6 &RQIHUHQFH
EACS.
9RMQRVDQLWHW3UHJO-DQ3XE0HG30,'
%MHNLü00DUNRYLü0âLSHWLü6
&OLQLFDOPDQLIHVWDWLRQVRISULPDU\V\SKLOLVLQKRPRVH[XDOPHQ
%UD] - ,QIHFW'LV -XO 3XE0HG
30,'
%MHNLü00DUNRYLü06DOHPRYLü'âLSHWLü6
6\SKLOLWLFDORSHFLDLQ +,9 ,QIHFWHG KRPRVH[XDO PHQ
FDVHUHSRUWV
$FWD 'HUPDWRYHQHURO &URDW 3XE0HG
30,'
-DGUDQLQ = âXOMDJLü 9 7RGRURYLü 9 7UNXOMLü 0
9XþHWLü'
+,9$,'6DQGRWKHUVH[XDOO\WUDQVPLWWHGLQIHFWLRQV
DPRQJPLOLWDU\PHPEHUVRIWKH$UPHG)RUFHVRI6HUELD
9RMQRVDQLW3UHJO-DQ6HUELDQ3XE0HG
30,'
&LFFR]]L0/DL$(EUDQDWL(*DEDQHOOL(*DOOL0
0XJRãD%9UDWQLFD=9XMRãHYLF'/DXãHYLF'&LRWWL
0&HOOD(/R3UHVWL$=HKHQGHU*
3K\ORJHRJUDSKLF 5HFRQVWUXFWLRQ RI +,9 7\SH % LQ
Montenegro and the Balkan Region.
$,'6 5HV +XP 5HWURYLUXVHV $SU 3XE0HG
30,'
6WDQRMHYLü 0$OH[LHY , %HVKNRY ' *|NHQJLQ '
0H]HL00LQDURYLWV-2WHOHD
'3DUDVFKLY63ROMDN0=LGRYHF/HSHM63DUDVNHYLV
'
+,9PROHFXODU(SLGHPLRORJ\LQWKH%DONDQVDPHOWLQJSRWIRUKLJKJHQHWLFGLYHUVLW\
$,'65HY-DQ0DU5HYLHZ3XE0HG
30,'
5HIHUHQFH
ZZZQFELQOPQLKJRYSXEPHG
*RGLQD,EURM
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
,17(59-8
%HQMDPLQ&ROOLQV-XJRLVWRþQD(YURSDWUHEDYLãHSR]LWLYQHSDåQMH
%HQ &ROOLQV MH MHGDQ RG SLRQLUD DNWLYL]PD X REODVWL
+,9$,'6D -Rã RG UDQLK RVDPGHVHWLK ± RG SRMDYH
HSLGHPLMH+,9DX6$'X±DNWLYLUDRVHNDNRYRORQWHUSDFLMHQWXVWXGLMDPDVDUDGQLNXQHYODGLQLPRUJDnizacijama i kasnije konsultant.
8 (YURSX GROD]L JRGLQHWDþQLMHVHOLVH X /RQGRQRGDNOHQDVWDYOMDVYRMDNWLYLVWLþNLUDGLRVQLYD]Djedno sa dr Mike Youle-om, HIVTRI – inicijativu za
HIV treninge, a kasnije i International HIV PartnerVKLSV±,+,93
5DGLRMHQDEURMQLPSURMHNWLPDX(YURSL,QGLML7XUVNRML,UDQXDRGJRGLQHVHLQWHQ]LYQRDNWLYLUDR
X &HQWUDOQRM L -XJRLVWRþQRM (YURSL JGH VDUDÿXMH VD
drugim HIV aktivistima, lekarima, organizacijama i
LQVWLWXFLMDPD'RSULQHRMHXVSHKXEURMQLKSURMHNDWD
X QDãHP UHJLRQX L XþHVWYRYDR X RUJDQL]DFLML ($&6
konferencije u Beogradu.
,PDOLVPRSULOLNHGDSRUD]JRYDUDPRVQMLP]DPROLPRJDGDSRGHOLQMHJRYDLVNXVWYDVDQDãLPþLWDRFLPDL
SLWDPRJDNDNRYLGLVLWXDFLMXXQDãHPUHJLRQX
*GLQH&ROOLQVPRåHWHOLQDPUHüLNDGD9DPMHGLMDJQR]LUDQ+,9"
'LMDJQR]DPLMHSRVWDYOMHQDX6DQ)UDQFLVFRXJR
GLQHDOLVDPVHLQ¿FLUDR+,9RPLOL
.DNRVWHVHWDGDRVHüDOL"
/HNDU PH MH QD]YDR GRN VDP ELR QD SRVOX %LR VDP X
ãRNXDOLQLVDPELRL]QHQDÿHQSRãWRVPRYHü]QDOLGDVX
PQRJLRGQDVX6DQ)UDQFLVNX+,9SR]LWLYLQL0DORVDP
SODNDR L QDSXVWLR VDP VYRMH GRWDGDãQMH VQRYH 1DNRQ
WRJDVDPVHYUDWLRQDSRVDR
0RåGD VDGD WR ]YXþL QHRELþQR DOL MH WR ELOR SRWSXQR
RGYUDWQRGRED3RORYLQDJHMOMXGLX6DQ)UDQFLVNXVXVD]
QDYDOLGDVX+,9SR]LWLYQL%LOLVPRQDVPUWSUHSODãHQL
GRVORYFH0QRJLPRMLSULMDWHOMLVXYHüELOLXPUOL3RGUãND
RGGUåDYHVNRURGDQLMHSRVWRMDODSDVXVHPQRJLERULOL
]DJROLåLYRW
3URãOHJRGLQHMHQDIHVWLYDOXJHM¿OPDÄ0HUOLQND³SULND
]DQ ¿OP ³:H :HUH +HUH´ %LOL VPR WX NRML QD GLYDQ
QDþLQJRYRULRWRPGREX9HUXMHPGDVH¿OPPRåHQDüL
QDLQWHUQHWX
.DGDVWHSRþHOLVDNRULãüHQMHPWHUDSLMH"
7RNRPNDVQLKRVDPGHVHWLKLUDQLKGHYHGHVHWLKVDPX]L
ZZZKLYELOWHQLQIR
PDR GRVWD UD]QLK UDQLK VODELK OHNRYD 3RþHR VDP GD
NRULVWLP HIHNWLYQX NRPELQRYDQX WHUDSLMX JRGLQH
NDGDVDPVHR]ELOMQRUD]EROHRLRGWDGDVDPQDWHUDSLML
1DNRQãWRVWHVHSUHVHOLOLX(YURSXNDNR9DPGHOXMX
UD]OLNHXWHUDSLMLX6$'XLX(YURSL"
(YURSDLPDHNLSXOHNDUDNRMLOHþH+,9NRMLVXYUORVSUHP
QLQDVDUDGQMXNDRL($&6RYHYRGLþH]DOHþHQMH+,9D
7RMHRGYHOLNHSRPRüL
7HUDSLMX X /RQGRQX GRELMDP X MDYQRM NOLQLFL ]D +,9
GRNNRGOHNDUDRSãWHSUDNVHRGOD]LPXNOLQLNXXVYRP
NRPãLOXNX=GUDYVWYHQD]DãWLWDMHEROMHRUJDQL]RYDQDX
9HOLNRM%ULWDQLMLQHJRX6$'X6YDNRNRPHWUHEDWHUDSL
MD]D+,9X9HOLNRM%ULWDQLMLMHLGRELMH86$'XQLMH
WDNR
.DGDVWHVHXNOMXþLOLX+,9DNWLYL]DP"
3RþHRVDPNDRYRORQWHUMRãWRNRPRVDPGHVHWLKQD626
WHOHIRQX±GDYDRLQIRUPDFLMHRSRYUJDYDRJODVLQHGDYDR
VDYHWHNDNRLPDWLEH]EHGQLMLVHNV2QGDVDPJR
GLQHSRþHRGDUDGLPNDRNRRUGLQDWRUYRORQWHUDX3URMHFW
,QIRUPMHGQDRGSUYLKRUJDQL]DDFLMDX6$'XNRMDMHUD
GLODQDSRGUãFLRVREDNRMHåLYHVD+,9RPSULPSUHY
1DPHÿXQDURGQRPSODQXVDPDNWLYDQRGVUHGLQHGHYH
GHVWLK 3UHVHOLR VDP VH X (YURSX JRGLQH RGDNOH
VDPQDVWDYLRGDUDGLP
âWDUDGLWHVDGD"
5DGLPNDRSURMHNWQLPHQDGåHUX,QWHUQDWLRQDO+,93DUW
QHUVKLS1DãWLPUDGLVDVYLP]DLQWHUHVRYDQLPVWUDQDPD
L] REODVWL +,9D ± VD OMXGLPD NRML åLYH VD +,9RP VD
SUXåDRFLPD ]GUDYVWYHQH QHJH SUHGVWDYQLFLPD YODGLQRJ
VHNWRUD PHÿXQDURGQLP RUJDQL]DFLMDPD L LQGXVWULMRP
± NDNR ELVPR SRGUåDOL SURPRYLVDOL L UD]YLOL VWUDWHãND
SDUWQHUVWYD]DXVSHãDQRGJRYRUQD+,9LVURGQDSLWDQMD
7UHQXWQR UD]YLMDP SDUWQHUVWYD X 6UELML VD 4NOXERP
L LVWUDåLYDþLPD X 9RMYRGLQL 7XUVNRM ,QGLML ,UDQX L SR
þLWDYRM&HQWUDOQRML-XJRLVWRþQRM(YURSL
.DNYDVXYDãDLVNXVWYDXUHJLRQX"
3R]YDOLVXPHX-XJRLVWRþQX(YURSXGDNRRUGLQLUDPSUR
JUDPREXND]DOHNDUHNRMLUDGHXSROMX+,9DX%HRJUDGX
JRGLQH2GWDGDUDGLPX&HQWUDOQRML-XJRLVWRþQRM
(YURSL2UJDQL]RYDRVDPGRVWDWUHQLQJD]DPHGLFLQVNR
*RGLQD,EURM
+,9%,/7(1+7%H
RVREOMH L ]D QHYODGLQ VHNWRU 7UHQXWQR VDP NRRUGLQDWRU
1H/3D0UHåH]HPDOMDVDQLVNRPSUHYDOHQFLMRP+,9D
X&HQWUDOQRML-XJRLVWRþQRM(YURSL
.DNYDVXYDãDLVNXVWYDVDRVREDPDNRMHåLYHVD+,9
RPLXRSãWH+,9DNWLYL]PRPXUHJLRQX"
8 &HQWUDOQRM L -XJRLVWRþQRM (YURSL OMXGL VX IUXVWULUDQL
UHODWLYQRVODELPRGJRYRURPQDNOMXþQDSLWDQMDXGUXãWYX
NDGD MH +,9 X SLWDQMX ,PD GRVWD VWLJPH WHVWRYD LPD
PDOR0QRJLRWNULMXGDVX+,9SR]LWLYQLNDVQRNDGDVH
LVSROMHRSRUWXQLVWLþNHLQIHNFLMH8VYDNRM]HPOMLLPDMDNR
PDOR DNWLYLVWD 'UåDYH LPDMX VSRU RGJRYDU ,DNR MH JHM
SRSXODFLMDYHRPDYXOQHUDELOQDQD+,9JHMJUXSDFLMHVH
NORQH+,9D
.DG SLWDP OMXGH ]DãWR MH WDNR GDMX PL VODEH RGJRYRUH
±NDåXÄ7DNYLVPRPL7XUFL³LOLÄ7DNYRVPRPL6UEL³
NDRGDüHWLPHGDREMDVQHVYHLOLÄ,PDSUHYLãHVWLJPH³
LOLÄ3UHYLãHVHERULPR³
0HÿXWLP WHQ]LMD L VWLJPD VX XYHN ELOH YLVRNH NDGD MH
+,9 X SLWDQMX MHU VH EROHVW þHVWR SRYH]XMH VD VHNVRP
L GURJRP$PHULþND YODGD MH UHFLPR ELOD VWUDãQR NRQ
WUDSURGXNWLYQD WRNRP RVDPGHVHWLK D PRåHWH ]DPLVOLWL
NROLNRLPDUD]QLKSUREOHPDVDGUåDYQLPXSUDYDPDX$I
ULFL
3RþHPXVHRQGD-XJRLVWRþQD(YURSDUD]OLNXMH"
5D]OLNDQDPMHSUHGQRVRPDQHSULPHüXMHPRMH(SL
GHPLMD +,9D X 3RGVDKDUVNRM $IULFL GHORYLPD $]LMH
SRMHGLQLP]HPOMDPD=DSDGDX5XVLMLLQMHQLPVXVHGQLP
]HPOMDPDQDUDVODMHVDQLVNRSUHYDOHQWQHXYLVRNRSUHY
DOHQWQXUHODWLYQREU]R.DGDSRPLVOLPRQD+,9RELþQR
QDP SDGD QD SDPHW PQRãWYR EROHVQLK OMXGL SXQR XP
UOLK OMXGL VD +,9RP NRML SURWHVWXMX QD XOLFDPD VYL VH
RUJDQL]XMXNDNRELL]YUãLOLSULWLVDNQDYODGXLSREROMãDOL
VLWXDFLMX
0HÿXWLPHSLGHPLMD+,9DX-XJRLVWRþQRM(YURSLL&HQ
WUDOQRM (YURSL &HQWUDOQRM$]LML QD %OLVNRP ,VWRNX L X
6HYHUQRM$IULFLMHRVWDODQDQLYRXUHODWLYQRQLVNHSUHYD
OHQFLMHYHüYLãHJRGLQD-HVWHGDMHSUDYLEURMLQ¿FLUDQLK
MHYHüLRGEURMDUHJLVWURYDQLKDOLVPRVLJXUQLGDMHLGDOMH
SUHYDOHQFLMDQLVND
.DGD PDQMH OMXGL åLYL VD +,9RP PDQMD MH L SRGUãND
PDQML MH L EURM PHGLFLQVNRJ RVREOMD SD MH L NDSDFLWHW
GD VH RGJRYRUL QD +,9 SULJXãHQ 6D PDQMLP XNXSQLP
GUXãWYHQLPXWLFDMHPSHUFLSLUDQDSRWUHED]DUHDJRYDQMHP
GHOXMHNDRPDQMHKLWQD'UåDYQHYODVWLLRSãWDSRSXODFLMD
MRãXYHNQHYLGH+,9NDRYHOLNLSUREOHP,SDNQDUDYQR
]QDPRGDVXPQRJLOMXGLXUHJLRQXLGDOMHLQ¿FLUDQL+,9
RPLOLMH+,9XWLFDRQDQMLKRYHåLYRWH
YDVQLMHWDNRORãD0HÿXWLPWHãNRMH]QDWLNDNRQDSUDYLWL
SURPHQXNRMDVHWLþHWDNRPDORJEURMDOMXGL
âWDPLVOLWHRVLWXDFLMLGRVWXSQRVWLWHUDSLMHXUHJLRQX"
/MXGLL]UHJLRQDVXWUHQXWQRYHRPDQHUYR]QL]ERJQLVNLK
]DOLKDOHNRYD]D+,9LSUREOHPDVDGLMDJQRVWLþNLPVUHG
VWYLPD +RüH OL ELWL OHNRYD NDG LP EXGH WUHEDOR" +RüH
OLPRüLGDXUDGHGLMDJQRVWLþNHWHVWRYHNDNRELPRJOLGD
SUDWHVYRMH]GUDYVWYHQRVWDQMHLGRELMXQDMEROMXQHJX"
âWD PLVOLWH GD EL WUHEDOR XUDGLWL GD EL VH VLWXDFLMD
SREROMãDOD"
3RNUHQXOL VPR 1H/3 0UHåX ]HPDOMD VD QLVNRP SUHYD
OHQFLMRP+,9DX&HQWUDOQRML-XJRLVWRþQRM(YURSLNDNR
ELVPR VH ]DMHGQR ERULOL SURWLY ]DMHGQLþNLK SUREOHPD X
UHJLRQX 7UHEDMX QDP VWUDWHJLMH NRMH üH ELWL GHORYDWL X
RNUXåHQMXVDQLVNRPSUHYDOHQFLMRPNDNRGDSUXåLPR
XVSHãQX]DãWLWXQHJXLWHUDSLMXRQLPDNRMLPDVXSRWUHEQH
DEH]YHOLNLKEURMHYDOMXGLLQ¿FLUDQLK+,9RPLOMXGLQD
þLMHMHåLYRWH+,9XWLFDR
7UHED GD EXGHPR RED]ULYL SULOLNRP XJOHGDQMD QD PRG
HOH L] ]HPDOMD VD YLVRNRP SUHYDOHQFLMRP 7L PRGHOL
IXQNFLRQLãXNDGDLPDSXQRSDFLMHQDWDLNDGDMHHSLGHPL
MDNRQFHQWULVDQD
/LþQRVPDWUDPGDWUHEDGDVHþYUVWRSRYHåHPRVDGUXJLP
JUXSDPD NRMH VX YXOQHUDELOQH SR SLWDQMX ]GUDYOMD LOL
VHNVXDOQRJ L UHSURGXNWLYQRJ åLYRWD 6PDWUDP GD QDP
WUHEDMXQDFLRQDOQHRUJDQL]DFLMHSDFLMHQDWDJGHüHVHOMXGL
PHÿXVREQRSRGUåDYDWLXERUEL]DFHORNXSQRSREROMãDQMH
NYDOLWHWDQHJH1DUDYQRRYDNYRRUJDQL]RYDQMHMHXVORY
OMHQRHNRQRPVNLPVWDQMHP0HÿXWLPGREUDNRRUGLQDFLMD
VPDQMXMHWURãNRYHLSREROMãDYDNYDOLWHWQHJH
0RåHWH OL QDP UHüL QHãWR R SODQRYLPD ,+,93D ]D
EXGXüQRVW"
7UHQXWQRQDPMHQDMYDåQLMLVWUDWHãNLVDVWDQDN1H/3DX
%HRJUDGXNRMLüHVHRGUåDWLRYRJRNWREUD1DGDPVHGD
üHPRUD]YLWLXVSHãQXNRRUGLQDFLMXPHÿX]HPOMDPDXUH
JLRQX1DGXåHVWD]HELKYROHRGDUD]YLMHPRVOLþQHPUHåH
XGUXJLPUHJLRQLPDVDQLVNRPSUHYDOHQFLMRP
9UOR VH UDGXMHP SUYRP EURMX YDãHJ +,9 ELOWHQD +7%
äHOLP PX SXQR XVSHKD 1DGDP VH GD üH SRPRüL
]EOLåDYDQMX OMXGL L SREROMãDQMX VLWXDFLMH X YDãHP UH
JLRQX
,QDþH MD UDGLP QD QRYRP SURMHNWX SURJUDPX UD]PHQH
DNWLYLVWDNRMLPELKGDDNWLYLVWHL]YDãHJUHJLRQDSRYHåHP
VD UHVXUVLPD L] GUXJLK ]HPDOMD 0RåHPR GRVWD WRJD GD
QDXþLPRMHGQLRGGUXJLK
1DGDPVHGDüXELWLGREURLLPDWLSXQRSRVOD
6LWXDFLMDX6UELMLMHYHRPDVOLþQDQDãRMX6DQ)UDQFLVFRX
WRNRP QDMUDQLMLK GDQD HSLGHPLMH +,9D 3XQR VPR VH
UDVSUDYOMDOL1RVLOLVHVDPQRJRSUREOHPDLQHGRVWDWNRP
RUJDQL]DFLMH0HÿXWLPNDGDMHVPUWQRVWSRVWDODMDNRYH
OLNDLSLWDQMD+,9DVHYLãHQLVXPRJODL]EHüL7HNWDGD
VX VWYDUL SRþHOH GD VH PHQMDMX 1D VUHüX VLWXDFLMD NRG
*RGLQD,EURM
%HQåHOLPRWLLVWR
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
),/0
0LVPRELOLWX:HZHUHKHUH
Simon Collins, HIV i-Base
8 RYRP SRWUHVQRP GRNXPHQWDUFX LQWHUYMXLVDQR MH SHW
RVREDNRMHVXWRNRPVHGDPGHVHWLKJRGLQDåLYHOHX6DQ
)UDQFLVNXLNRMHVXSUHåLYHOHSUYLQDOHWHSLGHPLMH+,9D
)LOPQDVYRGLNUR]RQRãWRVXSURãOLLNDNYRJMHHIHNWDWR
RVWDYLORQDQMLKRYHOLþQHLSURIHVLRQDOQHåLYRWH
,QWHUYMXLVXLVSUHSOHWDQLVDSULYDWQLPVQLPFLPDLVHþFLPD
L] QRYLQD L IRWRJUD¿MDPD VWRWLQD OMXGL NRML VX VH ERULOL
SURWLYEROHVWLþDNLSUHQHJRãWRMH+,9GRELRLPHLSUH
QHJRãWRMHRWNULYHQDWHUDSLMD
9DåQRMHDOLLWHãNRGDVHVHüDPRNDNRQDVMH$,'6WRP
VLOLQRPSRJRGLRVDPRMHGQRPNDGDMHELORSRWUHEQRUD
]XPHWLUDãLUHQXHSLGHPLMXSUHQHJRãWRVPRXRSãWH]QDOL
R þHPX VH UDGL 'R JRGLQH YHURYDWQR MH EDUHP
JHMPXãNDUDFDX6DQ)UDQFLVNXELOR+,9SR]LWLYQR
D NDGD VX VH JRGLQH SRMDYLOL SUYL WHVWRYL QD +,9
QMLKRYEURMMHYHURYDWQRSUHPDãLR
7RNRPVHGDPGHVHWLKJRGLQDOMXGLVXVHVHOLOLX6DQ)UDQ
FLVNRNDNRELSREHJOLRGPUåQMHLL]RODFLMHRGQRVQRKR
PRIRELMH.DNRMHGDQRGSHWRURL]¿OPDNDåHÄ$NRVWH
YHüLPDOL]DDXWREXVNXNDUWX]DYDVELELOREROMHGDMHWR
NDUWD]D6DQ)UDQFLVNR³LÄNDGELVWHVWLJOLRYGH]QDOLVWH
GDVWHGRãOLNXüL³9LGHWLRYDM¿OP]QDþLGRåLYHWLRVHüDM
RSWLPL]PDNRMLVXOMXGLGHOLOLWDGDNUR]RWNULYDQMHåLYRWD
SULMDWHOMDLVHNVXDOQRVWL
3ULþHX¿OPXSULND]XMXãLULQXKXPDQLWDUQRJLGUXãWYHQRJ
RGJRYRUD X DWPRVIHUL QH VDPR SROLWLþNH UDYQRGXãQRVWL
YHü DNWLYQRJ SURJRQD L PUåQMH 6Uå ¿OPD þLQH VWRWLQH
SULPHUD 3OHVDþ L FYHüDU *DM NRML MH V EODJLP GRVWRM
DQVWYRPSRNODQMDRFYHüHOMXGLPDNRMLVDKUDQMLYDOLVYRMH
SULMDWHOMH L OMXEDYQLNH ,OL VHVWUD SDFLMHQWD NRMD QLMH ELOD
VYHVQDNROLNRMHSRPRJODPHGLFLQVNRMVHVWULVDPRWLPH
ãWRMRMMHND]DODÄMDVHRVHüDPPQRJREROMHNDG]QDPGD
VWHYLVDQMLPQMHQLPEUDWRPLGDJDSRãWXMHWHLQHJXMHWH
VOMXEDYOMX³
7HåLQX PHGLFLQVNH UHDOQRVWL ]ERJ WRJD ãWR OMXGL XPLUX
XPHVWRGDVHRSRUDYOMDMXSULND]XMHVHVWUD(MOLQJRYRUHüL
NDNR QLNDGD SUH WRJD QLMH ELOD X VREL SXQRM OHNDUD NRML
ULGDMXMHUVXLPVYLSDFLMHQWLXPUOLÄ=DWRVPRVHVYLEDYLOL
LVWUDåLYDQMHPQLVPRPRJOLGDUDGLPRQLãWDGUXJR³
-HGLQL þRYHN NRML MH SUHåLYHR NOLQLþNR LVWUDåLYDQMH OHND
]YDQRJ VXULQLQ 'DQLMHO JRYRUL NDNR MH UDQR SUHNLQXR
WHUDSLMXMHUQLMHPRJDRGDMHSRGQHVHDOLLNDNRMHQMHJRY
OMXEDYQLNNRMLMHUDGLRNDRLVWUDåLYDþXJODYQRMODERUDWR
ZZZKLYELOWHQLQIR
ULML]D+,9XPURRGNRPSOLNDFLMDQDMHWULWULPHVHFDSUH
]DYUãHWNDVYRJLVWUDåLYDQMD
6YHRYHSULþHVXYH]DQH]DRGUHÿHQRPHVWRLYUHPH.RG
JHMPXãNDUDFDX6DQ)UDQFLVNXVHGHVLODMHGQDRGQDMYLãLK
SUHYDOHQFLMD NRMX VX XEU]R SUHYD]LãOL KHPR¿OLþDUL NRML
]DYLVHRGGRQLUDQHNUYLXGREDSUHQHJRãWRMHRWNULYH
QDXVSHãQDWHUDSLMD3ULþHX¿OPXVXYH]DQH]DGUXãWYR
GUXãWYHQHLSROLWLþNHRGJRYRUHXERUELSURWLY$,'6D
6XQFHSRODNRL]OD]LÄNDNRVXOMXGLSRþHOLGDSUHåLYOMDYDMX³
L NDGD MH QDSRNRQ HIHNWLYQD WHUDSLMD SRVWDOD GRVWXSQD
ÄQDãOLVXSXWNUR]ROXMX³2YDM¿OPMHSRWUHVDQLWXåDQ
DOL QLMH GHSUHVLYDQ 6YL X ¿OPX JRYRUH EODJR GRN QDP
SULND]XMXVYRMSXWWDNRGDPRåHPRGDQDVOXWLPRNDNRMH
WRNRGQMLKGRYHORQDQHNLQDþLQGREROMHJUD]XPHYDQMD
åLYRWD L ]EOLåDYDQMD VD OMXGLPD NRMH X QHNRM GUXJDþLMRM
VLWXDFLMLQLNDGQHELXSR]QDOL
$,'6 MH KLOMDGDPD SXWD SRJRGLR VYDNX ]HPOMX UHJLRQ
LOLJUDGLPQRJHUD]OLþLWHSRSXODFLMHRGNRMLKVYDNDLPD
VYRMXSULþXLVRSVWYHQXERUEXVDRNUXåHQMHP2YDM¿OP
EL WUHEDOR GD RKUDEUL RVWDOH GD LVSULþDMX VYRMH SULþH$
PLOLRQLOMXGLLPDMXGUXJDþLMXSULþXRWRPHNDNRLKMH+,9
SRJRGLR L NDNR MRã XYHN XWLþH QD QMLKRYH åLYRWH L NRML
XSUNRV VYLP UD]OLNDPD PRJX GD VDRVHüDMX VD RVWDOLP
SULþDPD
.DRFHOLQD¿OPD¿UPLãHLRMDþDYDVYDþLMXOLþQXLVWRULMX
VD+,9RP2QLPDNRMLVHWHNXSR]QDMXVD+,9RPGDMH
LVWRULMVNX SHUVSHNWLYX L] XJOD NRML MH GDQDV MDNR WHãNR
]DPLVOLWL+XPDQLWDUQLDVSHNW¿OPDELWUHEDORGDSRNUHQH
SRWUHEX]DSUHSR]QDYDQMHPYDåQRVWLSUHYHQFLMHRYHLQ
IHNFLMHNRGQRYLKJHQHUDFLMDLREH]EHÿLYDQMHHIHNWLYQHL
SULXãWLYHWHUDSLMH]DVYHXVYHWX
Ä0LVPRELOLWX³MHSULND]DQX%HRJUDGXQDPHÿXQDURGQRP
IHVWLYDOX 4XHHU ¿OPD Ä0HUOLQND³ JRGLQH VYHJD
ãHVWPHVHFLQDNRQSUHPLMHUHX6$'L9HOLNRM%ULWDQLML$
QHGXJR]DWLPVHSRMDYLORL'9'L]GDQMH
0LVPRELOLWXWe Were Here, SAD, 2011. 90 minuta
5HåLMD'HMYLG9DMVPDQ'DYLG:HLVVPDQ
1D'9'XRGXL]GDQMX3HFFDGLOOR3LFWXUHV
KWWSZHZHUHKHUH¿OPFRP
KWWSSHFFDSLFVFRP9LHZLG
*RGLQD,EURM
+,9%,/7(1+7%H
1$-$9('2*$Ĉ$-$
'DMHPR VSLVDN PHÿXQDURGQLK NRQIHUHQFLMD QD WHPX
+,9$,'6D NRMH üH VH RGUåDYDWL X QDUHGQRP SHriodu. Detaljnije informacije o konferencijama,
PRJXüQRVWLPD XþHVWYRYDQMD L SULMDYH GDWH VX QD
]YDQLþQLPSUH]HQWDFLMDPDRYLKGHãDYDQMD
*RGLãQML VNXS R UH]LVWHQWQRVWL L DQWLUHWURYLUXVQRM
terapiji
/RQGRQ9HOLND%ULWDQLMD
KWWSZZZPHGLVFULSWOWGXN5HVLVWDQFHKWP
*RGLãQMDNRQIHUHQFLMDR$,'6XX6$'
±/DV9HJDV6$'
KWWSZZZQPDFRUJWHFKQLFDODVVLVWDQFHFED
SURJUDPVXVFRQIHUHQFHRQDLGVKWPO
-HVHQMD%+,9$NRQIHUHQFLMD]D
±/RQGRQ9HOLND%ULWDQLMD
KWWSZZZEKLYDRUJ
+,9$,'6NRQIHUHQFLMD]D$XVWUDOLMX
0HOEXUQ$XVWUDOLMD
KWWSKLYDLGVFRQIHUHQFHFRPDX
0HÿXQDURGQD NRQIHUHQFLMD R NOLQLþNRM L üHOLMVNRM LPX
QRORJLML
ýLNDJR6$'
KWWSZZZRPLFVRQOLQHRUJLPPXQRORJ\
'UXJL JOREDOQL VLPSR]LMXP R LVWUDåLYDQMLPD X VLVWHPD
]GUDYVWYHQH]DãWLWH
±3HNLQJ.LQD
KWWSZZZKVUV\PSRVLXPRUJ
0HÿXQDURGQDUDGLRQLFDR+,9XLVWDUHQMX
±%DOWLPRU6$'
KWWSZZZYLURORJ\HGXFDWLRQFRP
*RGLQD,EURM
'UXJLNRQJHUVRDQWLUHWURYLUXVQLPOHNRYLPD
1RYHPEDU.HPEULGå%RVWRQ6$'
KWWSZZZDQWLYLUDOVHOVHYLHUFRP
0HÿXQDURGQLNRQJUHVRNRULãüHQMXOHNRYDXWHUDSLML
+,9LQIHNFLMH
±*OD]JRY9HOLND%ULWDQLMD
KWWSZZZKLYFRP
.RQIHUHQFLMDR+,9WHVWLUDQMX
$WODQWD6$'
KWWSZZZKLYWHVWLQJFRQIHUHQFHRUJ
.RQIHUHQFLMD R UHWURYLUXVLPD L RSRUWXQLVWLþNLP LQ
IHNFLMDPD
± $OWDQWD 6$' WUHED GD EXGH
SRWYUÿHQD
KWWSUHWURFRQIHUHQFHRUJ
*RGLãQMD%+,9$NRQIHUHQFLMD
±0DQþHVWHU9HOLND%ULWDQLMD
KWWSZZZEKLYDRUJ
.RQIHUHQFLMD0HÿXQDURGQRJGUXãWYD]D$,'6,$6R
SDWRJHQH]LWUHWPDQXLSUHYHQFLML+,9D
±.XDOD/XPSXU0DOH]LMD
KWWSZZZLDVRUJ
0HÿXQDURGQL NRQJUHV R$,'6X ]D$]LMX L 3DFL¿N
,&$$3
%DQJNRN7DMODQG
KWWSZZZLFDDSRUJ
6YHWVND$,'6NRQIHUHQFLMD$,'6
0HOEXUQ$XVWUDOLMD
KWWSZZZDLGVRUJ
ZZZKLYELOWHQLQIR
+,9%,/7(1+7%H
ƒ”—«‹–‡•˜‘Œ
,ƒ•‘’‹•Œ‡„‡•’Žƒ–ƒǤ‘’”‹Œ‡—ƒ”—†ā„‡‹…‡«ƒ•‘’‹•©‡ƒ•‡”‡†‘˜‘•Žƒ–‹ƒ†ƒ–—ƒ†”‡•—Ǥƒ”—†ā„‹—
–ƒ‘¯‡‘ā‡–‡‹œ˜”æ‹–‹‘Ž‹‡ƒƒ†”‡•‹™™™ǤŠ‹˜Ǧ„‹Ž–‡Ǥ‹ˆ‘
‹–—Žƒǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴‡ǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴”‡œ‹‡ǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
•–ƒ‘˜ƒǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
†”‡•ƒ—•–ƒ‘˜‡ǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴‘æ–ƒ•‹„”‘Œǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
‡•–‘ǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
ƒ‹Žǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̷̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
”‘Œ–‡Ž‡ˆ‘ƒǣ̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴̴
~‡Ž‹†ƒ†‘„‹Œƒǣ
†‹‰‹–ƒŽ‘‹œ†ƒŒ‡’—–‡‡Ž‡–”‘•‡’‘æ–‡
斃’ƒ‘‹œ†ƒŒ‡ƒƒ†”‡•——•–ƒ‘˜‡
ƒ”—†ā„‡‹…—’‘惎Œ‹–‡ƒƒ†”‡•—ǣǦŽ—„ǡeƒˆƒ”‹‘˜ƒ͸ǡͳͳͲͲͲ‡‘‰”ƒ†ǡ”„‹Œƒǡ‹Ž‹ƒˆƒ•ǣ
Ϊ͵ͺͳȋͲȌͳͳ͵͵Ͷͷͺͷʹ
˜ƒŽƒæ–‘•–‡’‘•–ƒŽ‹ƒæ’”‡–’Žƒ–‹Ǥ
‘Ž‹‘ā‡Ž‹–‡†ƒ’‘‘‰‡–‡‹œ†ƒ˜ƒŒ‡„‹Ž–‡«ƒ•‘’‹•ƒǡ–‘‘ā‡–‡—”ƒ†‹–‹—’Žƒ–‘†‘ƒ…‹Œ‡Ǥ
'RQDFLMHL]6UELMH
3ULPDODF4NOXE
âDIDULNRYD%HRJUDG
6YUKD
'RQDFLMD]D+7%þDVRSLV
5DþXQ
Donacije iz ostalih zemalja:
&RUUHVSRGHQWLV$*5,)533&UHGLW$JULFROH3DULV
0(%$56
&5(',7$*5,&2/(65%,-$$'1RYL6DG
,%$156
4&OXE
'MXUGMHYGDQVND$%HRJUDG
5HSXEOLFRI6HUELD
‘‹ƒ–‡‡‹Š’‹–ƒŒƒ‹Ž‹ƒŒ‡’‘–”‡„ƒ’‘‘©—˜‡œ‹•ƒ—’Žƒ–‘‘–ƒ–‹”ƒŒ–‡ƒ•Ǥ
‡ŽǣΪ͵ͺͳȋͲȌͳͳ͵͵Ͷͷͺͷʹ
Ǧƒ‹Žǣ‘ˆϐ‹…‡̷“Ǧ…Ž—„Ǥ‘”‰Ǥ”•
†”‡•ƒǣeƒˆƒ”‹‘˜ƒ͸ǡ‡‘‰”ƒ†
ZZZKLYELOWHQLQIR
*RGLQD,EURM
‹Ǧƒ•‡ «‹‹ ‰”—’ƒ ƒ–‹˜‹•–ƒǡ —‰Žƒ˜‘ ’‘œ‹Ǧ
–‹˜‹Šǡ‘Œ‹•‡„ƒ˜‡–‡”ƒ’‹Œ‘‹ˆ‡…‹Œ‡‹’‘•˜‡©‡‹
•—‘„‡œ„‡¯‹˜ƒŒ—’”ƒ˜‘˜”‡‡‹Š‹ˆ‘”ƒ…‹Œƒ‘–‡”ƒ’‹Œ‹
‘•‘„ƒƒ‘Œ‡ā‹˜‡•ƒǦ‘‹’”—āƒ‘…‹ƒœ†”ƒ˜•–˜‡‡
‡‰‡Ǥ
‹Ǧƒ•‡Œ‡‘•‘˜ƒʹͲͲͲǤ‰‘†‹‡‘†•–”ƒ‡ƒ–‹˜‹•–ƒ’”‡Ǧ
–Š‘†‘ƒ‰ƒā‘˜ƒ‹Šƒ—”‡¯‹˜ƒŒ—‹‹œ†ƒ˜ƒæ–˜——•Ž‘’—
”‡ƒ–‡–”‘Œ‡…–‹œ‘†‘ƒǤ
˜‹Œ‹Š‘˜‹ƒ–‡”‹ŒƒŽ‹•—’”‘‹œ˜‡†‡‹—œ—«‡æ©‡’‘œ‹Ǧ
–‹˜‹Š‘•‘„ƒ‹’”‡‰Ž‡†ƒ‹‘†•–”ƒ‡Ž‡ƒ”ƒ‹•–”—«‹Š
•ƒ”ƒ†‹ƒǤ‡†‹…‹•‹•ƒ˜‡–‹…‹•—’‘•‡„‘ƒ˜‡†‡‹œƒ
•˜ƒ—’—„Ž‹ƒ…‹Œ—Ǥ˜‡ƒ–‡”‹ŒƒŽ‡ǡ—ŽŒ—«—Œ—©‹‹•ƒ†”āƒŒ
™‡„•ƒŒ–ƒǡ•—’”‡‰Ž‡†ƒŽ‹‡†‹…‹•‹•ƒ˜‡–‹…‹‹‘•‘„‡
‘Œ‡ā‹˜‡•ƒǦ‘Ǥ
HIV Treatment Bulletin – HTBŒ‡‡’”‘ϐ‹–‹ā—”ƒŽ
‘Œ‹‹œ˜‡æ–ƒ˜ƒ‘ƒŒ˜ƒā‹Œ‹ƒ’”‡†…‹ƒ—‡†‹…‹‹
‹’”‹•–—’—–‡”ƒ’‹Œ‹Ǥ
”‡†‹ǣ‹‘‘ŽŽ‹•
‡Š‹«‹—”‡†‹ǣ‘ŽŽ›Žƒ›†‡
‡†‹…‹•‹•ƒ˜‡–‹…‹ǣ
”ƒ”‡‡…‡”ƒǡAlbert Einstein College of Medi-­‐
cine, NYC.
”ƒŒƒ›Šƒ‰ƒ‹ǡRoyal Free Hospital, London.
ƒ—ŽŽƒ…Šƒ”†ǡBritish School of Osteopathy, London.
”ƒ”–‹‹•Š‡”ǡBrighton & Sussex University Hospi-­‐
tals.
”‘ˆǤ‹ƒƒ
‹„„ǡMedical Research Council, London.
”‡‰‰
‘•ƒŽ˜‡•ǡAIntl Treatment Preparedess Coali-­‐
tion (ITPC).
”
ƒ”‡–Šƒ”†›ǡCase Western Reserve Univ. Cleve-­‐
land.
”ƒ›‡Š‘‘ǡUniversity of Liverpool Hospital.
”‘ˆǤŽ‹˜‡‘˜‡†ƒ›ǡInternational Laboratory Virology Centre.
”‘ˆǤƒ‡•…–›”‡ǡChris Hani Baragwanath Hosp. South Africa
”
”ƒ‡‡‘›Ž‡ǡChelsea & Westminster Hosp, Lon-­‐
don. ”–‡ˆƒƒ—••ǡDüsseldorf.
”‘ˆƒ”‘Ž‹‡ƒ„‹ǡUCL Medical School, London.
”
”ƒŠƒƒ›Ž‘”ǡImperial College, London.
”–‡’Š‡ƒ›Ž‘”ǡBirmingham Heartlands Hospital.
”
ƒ”‡–Š—†‘”Ǧ‹ŽŽ‹ƒ•ǡImperial College, London.
”†—†‹Ž‹•ǡManchester General Hospital, Manchester.
‹Ǧƒ•‡Ȉ͘–ŠŽ‘‘”ǡ͙͛
”‡ƒ–—ơ‘Ž–”‡‡–ǡ‘†‘ǡ͕‘Ǥ
ǣΪ͘͘ȋ͔Ȍ͖͔͔͛͛͘͘͜͜͜ȈǣΪ͘͘ȋ͔Ȍ͖͔͔͛͛͘͘͜͜͝
Š––’ǣȀȀ™™™Ǥ‹Ǧƒ•‡Ǥ‹ˆ‘
Download

HIV bilten HTB - HIV i-Base