BÜYÜME FAKTÖRLERİ
Büyüme faktörleri
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Polipeptid yapıda, endojen solubl faktörler
Farklı nöronlar, farklı büyüme faktörleri
için reseptör ekspresse ederler
Hücrenin yaşamasını,gelişmesini,
farklılaşmasını ve sinapsların
stabilizasyonunu sağlarlar
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A growth factor is a naturally occurring
substance capable of stimulating
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cellular growth
proliferation
cellular differentiation.
Stimulates cell cycle from G0 phase to G1
phase
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Adrenomedullin (AM)
Angiopoietin (Ang)
Autocrine motility factor
Bone morphogenetic proteins (BMPs)
Brain-derived neurotrophic factor (BDNF)
Epidermal growth factor (EGF)
Erythropoietin (EPO)
Fibroblast growth factor (FGF)
Glial cell line-derived neurotrophic factor (GDNF)
Granulocyte colony-stimulating factor (G-CSF)
Granulocyte macrophage colony-stimulating factor (GMCSF)
Growth differentiation factor-9 (GDF9)
Hepatocyte growth factor (HGF)
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Hepatoma-derived growth factor (HDGF)
Insulin-like growth factor (IGF)
Migration-stimulating factor
Myostatin (GDF-8)
Nerve growth factor (NGF) and other neurotrophins
Platelet-derived growth factor (PDGF)
Thrombopoietin (TPO)
Transforming growth factor alpha(TGF-α)
Transforming growth factor beta(TGF-β)
Tumor_necrosis_factor-alpha(TNF-α)
Vascular endothelial growth factor (VEGF)
Wnt Signaling Pathway
placental growth factor (PlGF)
[(Foetal Bovine Somatotrophin)] (FBS)
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IL-1- Cofactor for IL-3 and IL-6. Activates T cells.
IL-2- T-cell growth factor. Stimulates IL-1 synthesis.
Activates B-cells and NK cells.
IL-3- Stimulates production of all non-lymphoid cells.
IL-4- Growth factor for activated B cells, resting T cells,
and mast cells.
IL-5- Induces differentiation of activated B cells and
eosinophils.
IL-6- Stimulates Ig synthesis. Growth factor for plasma
cells.
IL-7- Growth factor for pre-B cells.
Factor
Principal
Source
PDGF
platelets,
endothelial cells,
placenta
promotes proliferation of
connective tissue, glial and
smooth muscle cells
submaxillary gland,
Brunners gland
promotes proliferation of
mesenchymal, glial and
epithelial cells
common in
transformed cells
may be important for
normal wound healing
EGF
TGF-α
FGF
NGF
Primary Activity
promotes proliferation of
wide range of cells;
many cells; inhibits some
protein is
stem cells; induces
associated with the
mesoderm to form in early
ECM
embryos
mast cells,
eosinophils, bone
marrow stromal
cells, keratinocytes
Comments
two different protein chains form 3
distinct dimer forms; AA, AB and
BB
related to EGF
at least 18 family members, 5
distinct receptors
member of a family of proteins
termed neurotrophins that promote
proliferation and survival of
promotes neurite outgrowth
neurons; neurotrophin receptors
and neural cell survival
are a class of related proteins first
identified as proto-oncogenes: TrkA
Factor
Principal
Source
Erythrop
oietin
kidney
TGF-β
IGF-1
IGF-2
Primary Activity
Comments
promotes proliferation and
differentiation of erythrocytes
anti-inflammatory (suppresses
cytokine production and class II
activated Th1 cells (TMHC expression), promotes
helper) and natural
wound healing, inhibits
killer (NK) cells
macrophage and lymphocyte
proliferation
at least 100 different
family members
primarily liver
promotes proliferation of many
cell types
related to IGF-2 and
proinsulin, also called
somatomedin C
variety of cells
promotes proliferation of many
cell types primarily of fetal
origin
related to IGF-1 and
proinsulin
Neurotrophins
Nerve growth factor (NGF)
Brain-derived neurotrophic factor (BDNF)
Neurotrophin 3 (NT3)
Neurotrophin 4/5 (NT4/5)
Neurokines
Ciliary neurotrophic factor (CNTF)
Leukemia inhibitory factor (LIF)
Interleukin 6 (IL-6)
Cardiotrophin 1 (CT-1)
Fibroblast growth
factors
FGF-1
FGF-2
Transforming growth
factor  superfamily
Transforming growth factors  (TGF)
Bone morphogenetic factors (BMPs)
Glial-derived neurotrophic factor (GDNF)
Neurturin
Epidermal growth
factor superfamily
Epidermal growth factor (EGF)
Transforming growth factor  (TGF)
Neuregilins
Other growth factors
Platelet-derived growth factor (PDGF)
Insulin-like growth factor I (IGF-I)
Nörotrofinler
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Nöron yaşamı ve ölümü
Sinaps stabilizasyonu ve eliminasyonu
Büyüme ve küçülme süreçleri
Nörotrofik Faktörler
Sinir büyüme faktörü (Nerve growth factor= NGF)
Beyin kökenli nörotrofik faktör (Brain-derived neurotrophic factor= BDNF)
Nörotrofin-3 (NT-3)
Nörotrofin-4/5 (NT-4/5)
Nörotrofin-6 (NT-6)
Değiştirici büyüme faktörü-3 (Transforming growth factor-3= TGF-3)
Temel fibroblast büyüme faktörü (Basic fibroblast growth factor=bFGF)
Asidik fibroblast büyüme faktörü (aFGF)
Glia kökenli nörotrofik faktör (Glial-derived neurotrophic factor= GDNF)
Siliar nörotrofik faktör (CNTF)
Kolinerjik gelişme faktörü (Cholinergic development factor= CDF)
Platelet kökenli nörotrofik faktör (Platelet-derived neurotrophic factor= PDNF)
Insüline bağımlı büyüme faktörü (Insulin-dependent growth factor= IDGF)
Epidermal büyüme faktörü (Epidermal growth factor= EGF)
Proaptotik reseptörler (P75)
Antiaptotik reseptörler (TrkA)
Carvey, 1998: Stahl, 2000; Sah ve diğ., 2003
Nörotrofin reseptörleri
Yaşamı sürdürme
Hücre farklılaşması
TRK sinyali
P75
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growth factor