ÖZGEÇMİŞ
1.
Adı Soyadı:
Ülkan Kılıç
2.
Doğum Tarihi: 10.10.1971
3.
Unvanı:
4.
Öğrenim Durumu:
Doç. Dr.
Derece
Üniversite
Alan
Yıl
Lisans
Veteriner
Ankara Üniversitesi
1994
Doktora
Veteriner DVM, PhD
LMU, Münih, Almanya
2000
Veteriner DVM, PhD
Graduate School Bern,
2009
Hücresel ve Biyomedikal
Tıp Fakültesi, Bilim
Bilimler
Akademisi, Diş Hekimliği
Moleküler Biyoloji ve
Mikrobiyoloji
Doktora
Fakültesi, Vetsuisse, Bern
İsviçre
1. Doktora tezi: (D.V.M.-PhD)
Ribotyping of Clostridium perfringens from industrially produced minced meat with regard to a
plant bound contamination study
2. Doktora Tezi (D.V.M.-PhD)
Effects of human erythropoietin (Epo) on brain plasticity and functional recovery following stroke
5.
Akademik Ünvanlar:
Yardımcı Doçentlik Tarihi :
30.12.2008
Doçentlik Tarihi
01.04.2010
:
1
Profesörlük Tarihi
Görev Ünvanı
Postdoc
:
Görev Yeri
Brain Research Laboratory, Department of
Yıl
2000 Nov-2001 July
Neurology, Medical School, University of
Tübingen, Germany
Senior Researcher
Senior Researcher
Senior Researcher
Yard. Doç. Dr.
Doç. Dr.
6.
Brain Research Laboratory, Department of 2001 Aug-2002-Dec
Neurology, Medical School, University of
Göttingen, Germany
Brain Research Laboratory, Department of 2003 Jan-2007-Oct
Neurology, Medical School, University of
Zürich, Switzerland
Cardiovascular
Research,
Institute
of 2007 Oct-2008- Jun
Physiology, University of Zürich, Switzerland
Yeditepe Üniversitesi Tıp Fakültesi Tıbbi Biyoloji 2008 Ağustos- 2010
A.D.
Haziran
Bezmialem Vakıf Ünversitesi Tıp Fakültesi Tıbbi Temmuz 2010Biyoloji A. D. Bşk.
Yönetilen Yüksek Lisans ve Doktora Tezleri
6.1. Yüksek Lisans Tezleri
Yüksek Lisans Öğrencisi Eş Danışman İstanbul Teknik Üniversitesi Fen Bilimleri Enstitüsü
Yüksek Lisans Öğrencisi Danışman Bezmialem Vakıf Üniversitesi Sağlık Bilimleri Enstitüsü
Biyoteknoloji
6.2. Doktora Tezleri
Doktora öğrencisi Eş Danışman İstanbul Üniversitesi Sağlık Bilimleri Enstitüsü Tıbbi Genetik
7.
Yayınlar
7.1. Uluslararası hakemli dergilerde yayınlanan makaleler (SCI & SSCI & Arts and
Humanities)
1. Ertugrul Kilic, Raluca Reitmeir, Ulkan Kilic, Ahmet Caglayan, Mustafa Beker, Taha
Kelestemur, Sinem Ethemoglu, Gurkan Ozturk, and Dirk Hermann Stroke: HMG-CoA
2
reductase inhibition promotes stroke recovery perilesional tissue remodeling and
contralesional tract plasticity. Submitted to Stroke 2014.
2. Fatma B. Seker, Ulkan Kilic, Nur Ekimci, Signem Ethemoglu, Berrak Caglayan, Selami
Demirci, Aysegül Dogan, Serdar Öztezcan, Fikrettin Sahin, Bayram Yilmaz, Ertugrul Kilic.
HMG-CoA reductase inhibition ameleriotes brain epileptiform activity: Role of eNOS
submitted to Neuroscience 2014.
3. Kilic U., Gok O., Elibol-Can B., Ozgen IT., Erenberk U., Uysal O., Dundaroz MR. “SIRT1
gene variants are related to risk of childhood obesity” submitted to European Journal of
Pediatrics. 2014
4. Kilic U., Sahin K., Tuzcu M., Basak N., Orhan C., Elibol-Can B., Kilic E., Sahin F., Kucuk
O. “Epigallocatechin-3-gallate promotes cisplatin sensitization in HeLa human cervical
cancer cells” submitted to International Journal of Gynecological Cancer. 2014
5. Kilic U., Gok O., Elibol-Can B., Uysal O., Bacaksiz A. “Efficacy of statins on SIRT1 and
eNOS expression: SIRT1 gene variants and coronary atherosclerosis in human” submitted to
Clinical and Experimental Pharmacology and Physiology. 2014
6. Kilic U., Gok O., Erenberk U., Dundaroz MR., Torun E., Kucukardali Y., Elibol-Can B.,
Uysal O., “A remarkable age-related increase in SIRT1 protein expression: SIRT1 gene
variants and longevity in human” submitted to Age. 2014
7. Müzeyyen İzmirli, Ömer Göktekin, Ahmet Bacaksız, Ömer Uysal, Ülkan Kılıç.
The
effect of the SIRT1 2827 A>G polymorphism, resveratrol, exercise, age and occupation in
Turkish population with cardiovascular disease. The Anatolian Journal of Cardiology 2014
accepted. DOI: 10.5152/akd.2014.5214 ( IF:0.715)
8. Kilic U, Gok O, Bacaksiz A, Izmirli M, Elibol-Can B, Uysal O. SIRT1 gene polymorphisms
affect the protein expression in cardiovascular diseases. PLoS One. 2014 Feb
28;9(2):e90428. doi: 10.1371( IF:3.7)
9. Erenberk U, Dundaroz R, Gok O, Uysal O, Agus S, Yuksel A, Yilmaz B, Kilic U.
Melatonin attenuates phenytoin sodium-induced DNA damage. Drug Chem Toxicol. 2014
Apr;37(2):233-9. doi: 10.3109/01480545.2013.838777. ( IF:1.3)
3
10. Kilic U, Yilmaz B, Reiter RJ, Yüksel A, Kilic E. Effects of memantine and melatonin on
signal transduction pathways vascular leakage and brain injury after focal cerebral ischemia
in mice. Neuroscience. 2013 May 1;237:268-76. doi: 10.1016/j ( IF:3.458)
11. Kilic U, Kilic E, Tuzcu Z, Tuzcu M, Ozercan IH, Yilmaz O, Sahin F, Sahin K. Melatonin
suppresses cisplatin-induced nephrotoxicity via activation of Nrf-2/HO-1 pathway. Nutr
Metab (Lond). 2013 Jan 12;10(1):7. doi: 10.1186/1743-7075-10-7. ( IF:2.89)
12. Sahin K, Tuzcu M, Basak N, Caglayan B, Kilic U, Sahin F, Kucuk O. Sensitization of
Cervical Cancer Cells to Cisplatin by Genistein: The Role of NFκB and Akt/mTOR
Signaling Pathways. J. Oncol. 2012;2012:461562. doi: 10.1155/2012/461562. Epub 2012
Sep 27.
13. Kilic U, Yilmaz B, Ugur M, Yüksel A, Reiter RJ, Hermann DM, Kilic E. Evidence that
membrane-bound G protein-coupled melatonin receptors MT1 and MT2 are not involved in
the neuroprotective effects of melatonin in focal cerebral ischemia. J Pineal Res. 2012
Mar;52(2):228-35. ( IF:5.855)
14. Herz J, Reitmeir R, Hagen SI, Reinboth BS, Guo Z, Zechariah A, ElAli A, Doeppner TR,
Bacigaluppi M, Pluchino S, Kilic U, Kilic E, Hermann DM. Intracerebroventricularly
delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral
ischemia via mechanisms involving anti-inflammatory actions. Neurobiol Dis. 2012
Mar;45(3):1077-85. ( IF:5.121)
15. Reitmeir R, Kilic E, Reinboth BS, Guo Z, ElAli A, Zechariah A, Kilic U, Hermann DM.
Vascular endothelial growth factor induces contralesional corticobulbar plasticity and
functional neurological recovery in the ischemic brain. Acta Neuropathol. 2012
Feb;123(2):273-84. ( IF:7.695)
16. Reitmeir R, Kilic E, Kilic U, Bacigaluppi M, ElAli A, Salani G, Pluchino S , Max
Gassmann M Hermann DM. Post-acute delivery of erythropoietin induces stroke recovery
by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity.
Brain 134(1): 84-99 2011 (I.F.:9.490)
17. Kilic U, Tug N, Karateke A, Yılmaz B, Uğur M, Kilic E. Erytropoietin receptor-like
immunostaining on human spermatozoa. Reprod Biomed Online. Jun 19 2010 (I.F.: 2.380)
(All of the authors equally contributed to this work.)
4
18. Kilic E, Elali A, Kilic U, Guo Z, Ugur M, Uslu U, Bassetti CL, Schwab ME, Hermann DM.
Role of Nogo-A in neuronal survival in the reperfused ischemic brain. J Cereb Blood Flow
Metab. Jan 20 2010 (I.F.: 5.741)
19. Tug N, Altunkaynak ME, Aktas RG, Kilic U, Yilmaz B, Cam C, Karateke A. Does
erythropoietin affect motility of spermatozoa? Arch Gynecol Obstet. 2010 May;
281(5):933-8 (I.F.: 1.072)
20. Bacigaluppi M, Pluchino S, Jametti LP, Kilic E, Kilic U, Salani G, Brambilla E, West MJ,
Comi G, Martino G, Hermann DM.
Delayed post-ischemic neuroprotection following
systemic neural stem cell transplantation involves multiple mechanisms. Brain. Aug;132(Pt
8):2239-51, 2009 (I.F.: 9.603)
21. Osto E, Matter CM, Kouroedov A, Malinski T, Bachschmid M, Camici GG, Kilic U,
Stallmach T, Boren J, Iliceto S, Lüscher TF, Cosentino F .c-Jun N-Terminal Kinase 2
Deficiency Protects Against Hypercholesterolemia-Induced Endothelial Dysfunction and
Oxidative Stress. Circulation. Nov 11;118 (20):2073-80. Oct 27. 2008 (I.F.: 14.595)
22. Kilic E, Spudich A, Kilic U, Rentsch KM, Vig R, Matter CM, Wunderli-Allenspach H,
Fritschy JM, Bassetti CL, Hermann DM. ABCC1: a gateway for pharmacological
compounds to the ischaemic brain. Brain. Oct;131 (Pt 10):2679-89. 2008 (I.F.: 9.603)
23. Kilic U, Kilic E, Bassetti CL, Hermann DM. TLR-4 deficiency protects against focal
cerebral ischemia and axotomy-induced neurodegeneration. Neurobiology Dis. Jul;
31(1):33-40. 2008 (I.F.: 4.852)
24. Hédou GF, Koshibu K, Farinelli M, Kilic E, Gee CE, Kilic U, Baumgartel K. Hermann DM,
Mansuy IM.. PP1-dependent bidirectional synaptic plasticity controls ischemic recovery in
the adult brain, Journal of Neuroscience Jan 2; 28(1):154-62. 2008 (I.F.: 7.452)
25. Kilic E, Kilic U, Bacigallupi M. Guo Z, Ben Abdallah N, Reiter RJ, Wolfer DP. Hermann
DM, Bassetti CL. Delayed melatonin administration promotes neuronal survival,
neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal
cerebral ischemia in mice. J Pin Res Sep;45(2):142-8. 2008 (I.F.: 5.056)
26. Kilic E, Kilic U, Vogel P, Böttiger B, Hermann DM. Poxvirus-derived cytokine response
modifier a (crma) does not protect against focal cerebral ischemia in mice. Brain Res. 1185:
293-300. 2007 (I.F.: 2.494)
5
27. Kilic U, Kilic E, Järve A, Guo Z, Spudich A, Bieber K, Barzena U, Bassetti CL, Marti HH,
Hermann DM. Human VEGF protects axotomized retinal ganglion cells in vivo by
activating ERK-1/-2 and Akt pathways Journal of Neuroscience 26 (48):12439-46 2006
(I.F.: 7.452)
28. Kilic E, Kilic U, Wang Y, Bassetti CL, Marti HH, Hermann DM. The phosphatidylinositol3 kinase/ Akt pathway mediates VEGF's neuroprotective activity and induces blood brain
barrier permeability after focal cerebral ischemia. FASEB J. Jun 20: 81185-7 2006 (I.F.:
7.049)
29. Matter CM, Ma L, von Lukowicz T, Meier P, Lohmann C, Zhang D, Kilic U, Hofmann E,
Ha SW, Hersberger M, Hermann DM, Lüscher TF. Increased balloon-induced
inflammation, proliferation, and neointima formation in apolipoprotein E (ApoE) knockout
mice. Stroke. Oct; 37(10):2625-32. 2006 (I.F.: 6.499)
30. Spudich A, Kilic E, Xing H, Kilic U, Wunderli-Allenspach H, Bassetti CL, Hermann DM.
Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after
focal cerebral ischemia. Nature Neuroscience 9: 487-488 2006 (I.F.: 14.164)
31. Kilic E, Kilic U, and Hermann DM TAT fusion proteins against ischemic stroke: Current
status and future perspectives. Frontiers in Bioscience 11:1716-1721. 2006 (I.F.: 3.308)
32. Kilic, E, Kilic U, Bähr M and Hermann, D.M.´´NMDA Antagonist MK-801 Reverses
detrimental Effects of Tissue-Plasminogen Activator Following Intraluminal Thread
Occlusion in Mice. Neurodegenerative diseases 2: 49-55 2005 (I.F.: 2.989)
33. Kilic E, Kilic U, Soliz U, Gassmann M, Bassetti CL, Hermann DM. Brain-derived
erythropoietin protects from focal cerebral ischemia by dual activation of ERK-1/-2 and Akt
pathways. FASEB J 19:2026-2028. 2005 (I.F.: 7.049)
34. Kilic U, Kilic E, Soliz J, Gassmann M, Bassetti CL, Hermann DM. Erythropoietin-induced
neuroprotection following retinal ganglion cell axotomy is mediated by ERK-1/-2 signaling
in vivo FASEB J 19: 249-251. 2005 (I.F.: 7.049)
35. Kilic U, Kilic E, Reiter RJ, Bassetti CL, Hermann DM. Signal transduction pathways
mediating melatonin-induced neuroprotection after focal cerebral ischemia in mice. Journal
of Pineal Research Jan; 38(1):67-71. 2005 (I.F.: 5.056)
6
36. Kilic E, Kilic U, Reiter RJ, Bassetti CL, Hermann DM. Tissue-plasminogen activatorinduced ischemic brain injury is reversed by melatonin: role of iNOS and Akt. Journal of
Pineal Research 39; 151-156. 2005 (I.F.: 5.056)
37. Wang Y, Kilic E, Kilic U, Weber B, Bassetti CL, Marti HH and Hermann DM. Brainselective VEGF overexpression induces post-ischemic neuroprotection, but also facilitates
hemodynamic steal phenomena. Brain. Jan; 128(1) 52-63. 2005 (I.F.: 9.603)
38. Kilic U, Kilic E, Bassetti CL and Hermann DM. Post-ischemic delivery of rosuvastatin
induces neuroprotection after intraluminal thread occlusion in mice via Erk-1/-2, Bcl-XL and
caspases-9/ -3, but not endothelial NO synthetase (eNOS) pathways. Neuroscience.
134:901-906. 2005 (I.F.: 3.556)
39. Kilic E, Kilic U, Matter C, Lüscher TF, Bassetti CL and Hermann DM. Inhibition of
endothelial NO synthase by tissue-plasminogen activator after focal cerebral ischemia:
Signaling mechanisms and reversal by statin. Stroke Feb;36(2):332-6. 2005 (I.F.: 6.499)
40. Spudich A, Frigg R, Kilic E, Kilic U, Bassetti CL, Hermann DM. Aggravation of brain
injury by prion protein deficiency, but lack of neuroprotection by enhanced prion protein
expression following focal cerebral ischemia in mice: Role of STAT-1 and JNK-1/-2
Neurobiology of Disease Nov; 20(2): 442-9. 2005 (I.F.: 4.852)
41. Kilic E, Kilic U, and Hermann DM. TAT-GDNF in neurodegeneration and ischemic stroke.
CNS Drug Reviews 11:353-362. 2005 (I.F.: 4.432)
42. Reiter RJ, Tan DX, Leon J, Kilic U, Kilic E. When melatonin gets on your nerves: Its
benefical actions in experimental models of stroke. Experimental Biology and Medicine
Feb; 230(2):104-17. 2005 (I.F.: 2.202)
43. Grimm, C., Hermann, D.M., Bogdanova, A., Hotop, S., Kilic, Ü., Wenzel, A., Kilic, E., and
Gassmann, M. Neuroprotection by hypoxic preconditioning: HIF-1 and erythropoietin
protect from retinal degeneration. Sem. Cell Dev. Biol. 16: 531-538. 2005 (I.F.: 4.528)
44. Kilic U, Kilic E, Dietz GPH and Bähr M. The TAT protein transduction domain enhances
the neuroprotective effect of Glial Cell Line-Derived Neurotrophic Factor after Optic Nerve
Transection in Mice. Neurodegenerative Diseases 1, 144-49. 2004 (I.F.: 2.989)
45. Kilic U, Yulug B, Kilic E and Bähr M. Rifampicin attenuates brain damage in focal
ischemia. (Equal contribution), Brain Research 996: 76-80. 2004 (I.F.: 2.494)
7
46. Kilic U, Kilic E, Lingor P, Yulug B and Bähr M. Rifampicin inhibits neurodegeneration in
the optic nerve transection model in vivo and after MPP+-intoxication in vitro Acta
Neuropathologica 108, 65-68. 2004 (I.F.: 5.310)
47. Kilic E, Kilic U, Reiter RJ, Bassetti CL, Hermann DM. Prophylactic use of melatonin
protects against focal cerebral ischemia in mice: role of endothelin converting enzyme-1.
Journal of Pineal Research. Nov; 37(4):247-51. 2004 (I.F.: 5.056)
48. Kilic E, Weishaupt JH, Kilic U, Rohde G, Yulug B, Peters K, Hermann DM and, Bahr M.
The superoxid dismutase 1 (sod1) G93A mutation does not promote neuronal injury after
focal brain ischemia and optic nerve transection in mice. Neuroscience 128 (2), 359-364.
2004 (I.F.: 3.556)
49. Kilic E, Kilic U, Hermann DM, Yulug B and Reiter RJ Melatonin reduces disseminate
neuronal death after mild focal ischemia in mice via inhibition of caspase-3 and is suitable
as an add-on treatment to tissue-plasminogen activator Journal of Pineal Research 36,
171-176. 2004 (I.F.: 5.056)
50. Kilic E, Kilic U, Bassetti CL, and Hermann DM. Intravenously administrated recombinant
tissue-plasminogen activator attenuates neuronal injury after mild focal ischemia.
Neuroreport 15:687-689. 2004
51. Reiter RJ, Tan DX, Gitto E, Sainz RM, Mayo JC, Leon J, Manchester LC, Vijayalaxmi,
Kilic E, Kilic U. Pharmacological utility of melatonin in reducing oxidative cellular and
molecular damage. Polish Journal of Pharmacology Mar-Apr; 56 (2): 159-70. 2004 (I.F.:
2.167, The Pharmacological Reports)
52. Kilic, U, Kilic E, Dietz GPH and Bähr M. Intravenous TAT-GDNF is protective after focal
cerebral ischemia in mice´´. Stroke 34, 1304-1310. 2003 (I.F.: 1.64)
53. Kilic U, Schalch B, Stolle A. Ribotyping of Clostridium perfringens from industrially
produced ground meat. Letters of Applied Microbiology 34(4) 238-243. 2002
54. Kilic E, DM Hermann, S Kügler, H., Kilic U, Schmeer, C., Holzmüller and M. Bähr.
`Adenovirus-mediated neuron-specific Bcl-XL expression protects against disseminated
neuronal injury and brain infarction following transient middle cerebral artery occlusion in
mice. Neurobiology of Disease 11:275-284. 2002 (I.F.: 4.852)
8
55. Kilic U, Schalch B, Solle A. Zur Feintypisierung von Clostridium perfringens aus rohem
Fleisch. Archiv für Lebensmittelhygiene 52:13-15. 2001
7.2. Uluslararası diğer hakemli dergilerde yayınlanan makaleler
7.3. Uluslararası bilimsel toplantılarda sunulan ve bildiri kitabında (Proceedings) basılan
bildiriler
1. Ülkan Kilic, Ahmet Burak Caglayan, Mustafa C. Beker, Ertugrul Kilic. The
phosphatidylinositol-3 kinase/Akt pathway mediates melatonin’s neuroprotective activity
after focal cerebral ischemia. EMBO, 2014, Amsterdam
2. Ertugrul Kilic, Ülkan Kilic, Raluca Reitmeier, Ahmet Burak Caglayan,Muhsine Sinem
Ethemoglu, Dirk M. Hermann. Post-acute delivery of the 3-hydroxy-3-methylglutaryl
coenzyme A reductase inhibitor rosuvastatin promotes perilesional tissue remodelling and
behavioural outcome after middle cerebral artery occlusion. EMBO, 2014, Amsterdam
3. Ahmet Burak Caglayan, Mustafa C. Beker, Ülkan Kilic, Berrak Caglayan, Taha
Kelestemur, Reyhan Z. Gündogdu, Ertugrul Kilic. Roles of P2X7 receptors in neuronal
injury after optic nerve transaction and focal cerebral ischemia in mice. EMBO, 2014,
Amsterdam
4. U. Kilic, A. Yüksel, B. Yilmaz, S. Eyüboglu, E. Kilic. Are membrane-bound G-proteincoupled Receptors MT1 and MT2 really necessary for the neuroprotective effect of
melatonin in focal cerebral ischemia? 3-7 September 2011 Federation of European
Physiological Societies, Turkish-FEPS Physiology Congress, İstanbul
Poster Award
5. Endocrine modulatory effects of bisphenol A and ostradiol on the brain kisspeptin/GPR54
system immature rat uterotrophic assay model. S. Eyuboglu, T. Kelestemur, E.Kilic, U.
Kilic and B. Yilmaz. 3-7 September 2011, Federation of European Physiological
Societies, Turkish-FEPS Physiology Congress, İstanbul
Oral Presentation Price
6. Eyuboglu S, Kilic U, Ugur M, Seker B, Can B, Findik S, Yilmaz B and Kilic E, "Effects of
melatonin and memantine on brain injury and intracellular signaling: roles of AKT p38 p21
and ERK1/2 phosphorylation." 3-5 July 2011 Annual BSN Conference, Downing
College, Cambridge, UK.
Oral Presentation Price
9
7. F. Mete, E.Kilic, S. Eyuboglu, A. Vitrinel, U.Kilic and B. Yilmaz, "Effects of Hyperthermia
on neurogenesis and neurobehavior in the young male rat." 11-14 July 2011 Physiology
2011, University of Oxford, UK.
8. U. Kilic, M. Ugur, S. Eyuboglu, B. Cevreli, A. Cumbul, B. Seker, B. Yilmaz, E. Kilic
Neuroprotective effect of melatonin combined with memantine in Ischemic-brain injury
BRAIN 2011, Barcelona, Spain
9. E. Kilic, B. Yılmaz, M. Ugur, B. Cevreli, B. Yulug, D.M. Hermann, U. Kilic. The roles of
melatonin receptor 1 and 2 in the treatment of stroke. BRAIN 2011, Barcelona, Spain
10. U. Kilic (Invited Speaker). Molecular Biology Techniques in Post Genomic Era: Blotting
Analysis. 1st Inter University Certificate Program of Predictive & Personalized
Medicine in Daily Modern Medical and Pharmacy Practice, Yeditepe University Faculty
of Medicine & Faculty of Pharmacy, April 15-17, 2011 İstanbul, Turkey
11. U. Kilic, B. Yilmaz, E. Cam, H. Sarikaya, Burak Yulug, E. Kilic. Restorative effects of
melatonin after stroke in mice. Meeting of the European Neuroendocrine Association,
ENEA October 17-20, 2008. Antalya, Turkey
12. U. Kilic, A. Ayar, E. Cam, H. Sarikaya B. Yilmaz, E. Kilic. TLR-4 deficiency protects
against focal cerebral ischemia and axotomy-induced neurodegeneration. Meeting of the
European Neuroendocrine Association, ENEA, October 17-20, 2008. Antalya, Turkey
13. E. Kilic, U. Kilic, ME. Schwab, CL. Bassetti, DM. Hermann. Pre-ischemic, but not postischemic Nogo-A deactivation aggravates neuronal injury after middle cerebral artery
occlusion in mice. FENS Forum 2008 in Geneva. July 12 - 16, 2008
14. E. Kilic, U. Kilic, DM. Hermann, CL. Bassetti. Delayed melatonin administration promotes
neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and
anxiety after mild focal cerebral ischemia in mice. XVII. European Stroke Conference
Nice, France 13 - 16 May 2008
15. E. Kilic, U. Kilic, ME. Schwab, CL. Bassetti, DM. Hermann.Pre-ischemic, but not postischemic Nogo-A deactivation aggravates neuronal injury after middle cerebral artery
occlusion in mice. XVII. European Stroke Conference Nice, France 13 - 16 May 2008
16. E. Kilic, U. Kilic, DM. Hermann, CL. Bassetti. Delayed melatonin administration promotes
neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and
10
anxiety after mild focal cerebral ischemia in mice 12. Jahrestagung Zerebrovaskuläre
Arbeitsgruppe der Schweiz (ZAS) vom 24. Januar 2008 Aarau Switzerland
17. Pre-ischemic, but not post-ischemic Nogo-A deactivation aggravates neuronal injury after
middle cerebral artery occlusion in mice E. Kilic, U. Kilic, ME. Schwab, CL. Bassetti, DM.
Hermann. 12. Jahrestagung Zerebrovaskuläre Arbeitsgruppe der Schweiz (ZAS) vom
24. Januar 2008. Aarau. Switzerland
18. Ü. Kilic, E. Kilic, C. L. Bassetti, D. M. Hermann TLR-4 deficiency protects against focal
cerebral ischemia and delayed neuronal degeneration: ZNZ Symposium 2007 Neuroscience Center Zurich, 14 Sep. 2007
19. E. Kilic, Ü. Kilic, M. Bacigaluppi, Z. Guo, N. Bin Abdallah, D. P. Wolfer, C. L. Bassetti, D.
M. Hermann Delayed melatonin promotes neuronal survival, neurogenesis and motor
recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in
mice: ZNZ Symposium 2007 - Neuroscience Center Zurich, 14 Sep. 2007
20. Kilic E, Kilic U, Hermann DM, Bassetti CL. Restorative effects of melatonin in
experimental stroke model. 59th American Academy of Neurology (AAN) Meeting Boston,
MA. April 28-May-5, 2007
21. U. Kilic, E. Kilic, J. Soliz, C.L. Bassetti, M. Gassmann, D.M. Hermann,Transgenic
erythropoietin (Epo) protects from focal cerebral ischemia by a dual pathway involving both
ERK-1/-2 and Akt. Schweizerische Neurologische Gesellschaft (178. Tagung), Palazzo dei
Congressi, Lugano, 31. 5. - 2. 6. 2007
22. U. Kilic, E. Kilic, A. Spudich, C.L. Bassetti, H.H. Marti, D.M. Hermann, Human Vascular
Endothelial Growth Factor Protects Axotomized Retinal Ganglion Cells In Vivo by
Activating ERK-1/2 and Akt Pathways. Schweizerische Neurologische Gesellschaft (178.
Tagung), Palazzo dei Congressi, Lugano, 31. 5. - 2. 6. 2007
23. U. Kilic, E. Kilic, Z. Guo, C.L. Bassetti, M.E. Schwab, D.M. Hermann, NogoA deficiency
aggravates brain injury after transient focal cerebral ischemia in mice Schweizerische
Neurologische Gesellschaft (178. Tagung), Palazzo dei Congressi, Lugano, 31. 5. - 2. 6.
2007
11
24. U. Kilic, E Kilic, CL Bassetti, HH Marti, DM Hermann. Human VEGF protects axotomized
retinal ganglion cells in vivo by activating ERK-1/-2 and Akt pathways. Society for
Neuroscience, 30 th Annual Meeting. Atlanta, Georgia, from October 14-18 , 2006
25. Ü. Kilic, E. Kilic, A. Spudich, A. Järve, K. Bieber, C.L. Bassetti, H.H. Marti and D.M.
Hermann. Human VEGF protects axotomized retinal ganglion cells in vivo by activating
ERK-1/-2 and Akt pathways. ZNZ Symposium 20 Oct. Zürich 2006
26. E. Kilic, Ü. Kilic, D. Wolfer, C.L. Bassetti and D.M. Hermann. Restorative effects of
melatonin after focal cerebral ischemia ZNZ Symposium 20 Oct. Zürich 2006
27. E Kilic, DM. Hermann, A Spudich, M Bacigaluppi, U Kilic and CL Bassetti. Restorative
effect of melatonin after focal cerebral ischemia in mice. Swiss Society for Neuroscience,
2006
28. E. Kilic, U. Kilic, C.L. Bassetti, D.M. Hermann Melatonin reverses tissue-plasminogen
activator (t-PA)-induced brain injury after focal cerebral ischaemia in mice: role of inducible
NO synthase and phosphatidyl inositol-3 kinase/ Akt.
15th Meeting of the European
Neurological Society which will take place in Vienna, 18 - 22 June, 2005.
29. E. Kilic, U. Kilic, J. Soliz, C.L. Bassetti, M. Gassmann, D.M. Hermann Erythropoietin
protects from focal cerebral ischaemia by a dual pathway involving both ERK-1/-2 and Akt.
15th Meeting of the European Neurological Society which will take place in Vienna, 18 - 22
June, 2005.
30. E. Kilic, Ü. Kilic, C.L. Bassetti and D.M. Hermann Melatonin reverses tissue-plasminogen
activator (t-PA)-induced brain injury after intraluminal middle cerebral artery occlusion:
Role of inducible NO synthase and phosphatidyl inositol-3 kinase/ Akt. Brain 05,
Amsterdam, 2005
31. Ü. Kilic, E. Kilic, J. Soliz, C.L. Bassetti, M. Gassmann and D.M. Hermann Transgenic
erythropoietin protects from focal cerebral ischemia by a dual pathway involving both ERK1/-2 and Akt Brain 05, Amsterdam, 2005
32. HH Marti, Y Wang, E Kilic, Ü Kilic, CL Bassetti, DM Hermann. Transgenic VEGF induces
post-ischemic neuroprotection, but facilitates hemodynamic steal phenomena Brain 05,
Amsterdam, 2005
12
33. Spudich, E. Kilic, Ü. Kilic, H. Wunderli-Allenspach, C.L. Bassetti and D.M. Hermann.
Inhibition of multiple drug resistance (Mdr) transporter-1 potentiates neuroprotective drug
action after focal cerebral ischemia in mice 9th EFNS Congress, Athen, Greece, Sep. 17-20
2005
34. Spudich, R. Frigg, E. Kilic, Ü. Kilic, B. Oesch, A. Raeber, C.L. Bassetti and D.M.
Hermann. Aggravation of ischemic brain injury by prion protein deficiency, but lack of
neuroprotection by elevated prion protein levels: Role of tyrosine kinases Brain 05,
Amsterdam, 2005
35. E. Kilic, Ü. Kilic, C.L. Bassetti and D.M. Hermann Melatonin reverses tissue-plasminogen
activator (t-PA)-induced brain injury after intraluminal middle cerebral artery occlusion:
Role of inducible NO synthase and phosphatidyl inositol-3 kinase/ Akt. 9th EFNS Congress,
Athen, Greece, Sep. 17-20 2005
36. E. Kilic, Ü. Kilic, , J. Soliz, C.L. Bassetti, M. Gassmann and D.M. Hermann Transgenic
erythropoietin protects from focal cerebral ischemia by a dual pathway involving both ERK1/-2 and Akt 9th EFNS Congress, Athen, Greece, Sep. 17-20 2005
37. Kilic E, Kilic Ü, Soliz J, Gassmann M, Bassetti CL, Hermann DM, Neuroprotection by
neuron-specific erythropoietin (epo) overexpression in transient focal ischemia and retinal
ganglion cell axotomy in mice involves multiple signaling pathways,``9th International
Symposium on Pharmacology of Cerebral Ischemia, Marburg, Germany, 2004
38. Kilic E, Kilic Ü, Matter C, Lüscher T, Bassetti CL, Hermann DM, Aggravation of focal
cerebral ischemia by tissue-plasminogen activator is reversed by rosuvastatin - role of
endothelial no synthase,``9th International Symposium on Pharmacology of Cerebral
Ischemia, Marburg, Germany, 2004
39. Wang Y, Kilic E, Kilic Ü, Bassetti CL, Marti HH, Hermann DM, Brain-selective vegf
overexpression induces post-ischemic neuroprotection, but also facilitates hemodynamic
steal phenomena. ``9th International Symposium on Pharmacology of Cerebral Ischemia,
Marburg, Germany, 2004
40. Ü. Kilic, E. Kilic, J. Soliz, M. Gassmann, C. Bassetti, D. Hermann (Zürich, CH) Neuronselective erythropoietin (Epo) overexpression protects against transient focal ischemia and
retinal ganglion cell axotomy in mice via multiple signaling pathways. DGN Kongress
Düsseldorf, 2004
13
41. E. Kilic, Ü. Kilic, C. Matter, T. Lüscher, C. Bassetti, D. Hermann (Zürich, CH) Aggravation
of focal cerebral ischemia by tissue-plasminogen activator is reversed by rosuvastatin - Role
of endothelial NO synthase. DGN Kongress Düsseldorf, 2004
42. Y. Wang, E. Kilic, Ü. Kilic, C. Bassetti, H. Marti, D. Hermann (Zürich, CH; Heidelberg)
Brain-selective VEGF overexpression induces post-ischemic neuroprotection, but also
facilitates hemodynamic steal phenomena. DGN Kongress Düsseldorf, 2004
43. E. Kilic, U. Kilic, C.L. Bassetti und D.M. Hermann. I.v. TAT-Bcl-XL is protective after
focal brain ischemia in mice. Vortrag am 2. Tag der Klinischen Forschung am
UniversitätsSpital Zürich, Schweiz, 10.5.2003
44. Kilic E, Kilic Ü,1 Soliz J, Gassmann M, Bassetti CL, Hermann DM, Injury reduction after
transient focal ischemia in transgenic mice overexpressing erythropoietin (epo) in the brain.
Society for Neuroscience, 2003
45. E. Kilic, U. Kilic, C.L. Bassetti und D.M. Hermann. Neuroprotection strategies in acute
ischemic stroke: TAT-fusion proteins as innovative treatment options. Vortrag / Poster an
der Frühjahrstagung der Schweizerischen Neurologischen Gesellschaft in Solothurn,
Schweiz, 9.5.2003
46. Kilic, E., Ü. Kilic, G. Dietz ve M. Bähr, ``Tat-fusion protein mediated neuroprotective
protein delivery after transient focal cerebral ischemia,``9th International Symposium on
Pharmacology of Cerebral Ischemia, Marburg, Germany, 2002
47. Kilic, E., D.M. Hermann, Ü. Kilic, S. Kügler and M. Bähr; Adenovirally administered BclXL is protective against striatal injury following intraluminar thread occlusion in mice. 4th
Meeting of the German Neuroscience Society 28 th Göttingen Neurobiology Conference
Göttingen Germany, 2001
48. Çelik, Ü, B. Schalch, H. Eisgruber, A. Stolle (1998): Ribotyping of Clostridium perfringens
isolated from minced meat. 44th International Congress of Meat Science and Technology
(ICOMST), Barcelona, Spain31.08-05.09.1998
49. Çelik, Ü, B. Schalch, H. Eisgruber (1998) Ribotypisierung von Clostridium perfringens
Isolaten aus Hackfleisch 39. Arbeitstagung des Arbeitsgebietes Lebensmittelhygiene, Dreiländertagung-Garmisch-Partenkirchen, Deutschland 22-25.09.1998
14
7.4. Yazılan uluslararası kitaplar veya kitaplarda bölümler
Handbook of Genitourinary Medicine
Chapter 9: Epigenetic Mechanisms (M. İzmirli, D. Alptekin, U Kilic)
7.5. Ulusal hakemli dergilerde yayınlanan makaleler
7.6. Ulusal bilimsel toplantılarda sunulan ve bildiri kitabında basılan bildiriler
1. Ülkan Kılıç (Davetli Konuşmacı). 3-hiroksi-3-metilglutaril koenzim A redüktaz inhibitörü
rosuvastatin’in beyin felci sonrası beyin plastisitesi üzerine olan etkileri. XIII. Ulusal Tıbbi
Biyoloji ve Genetik Kongresi 27-30 Ekim 2013, Kuşadası, Aydın, Turkey
2. Ülkan Kılıç, Ahmet Burak Çağlayan, Mustafa Çağlar Beker, Ertuğrul Kılıç. Fosfatidil
inozitol-3 kinaz/AKT sinyal yolağının melatoninin iskemi sonrası nöroprotektif etkisindeki
rolü. XIII. Ulusal Tıbbi Biyoloji ve Genetik Kongresi 27-30 Ekim 2013, Kuşadası,
Aydın, Turkey
3. Birsen Elibol Can, Ülkan Kılıç, Ertuğrul Kılıç, Siğnem Eyüboğlu Dinç, Ewa Jakubowska
Doğru. Fötal dönemde alkole maruz kalmış ve kontrol sıçanlarında doğumdan sonraki
hipokampus gelişimi sırasında sinaptik proteinlerde, sinaptofizin ve PSD-95, ve dendritik
diken yoğunluğundaki değişimler. XIII. Ulusal Tıbbi Biyoloji ve Genetik Kongresi 27-30
Ekim 2013, Kuşadası, Aydın, Turkey
4. Özlem Gök, Merve Karakaş, Çilem Ercan, Ömer Uysal, Ülkan Kılıç. Melatonin’in
phenytoin sodium’un oluşturduğu DNA hasarı üzerine etkisi. XIII. Ulusal Tıbbi Biyoloji
ve Genetik Kongresi 27-30 Ekim 2013, Kuşadası, Aydın, Turkey
5. U. Kilic, M. Ugur, Ü. Uslu, A. Cumbul, B. Yilmaz, E. Kilic. Role of NogoA in neuronal
survival in the reperfused ischemic brain. 9th National Neuroscience Kongres, Yeditepe
University Istanbul, Turkey, Apr 13-17, 2010. Turkish Journal of Neurology 16 Suppl1:
144, March 2010
6. U. Kilic, M. Ugur, M. Yücel, S. Eyüboglu, G. Büyükgüclü, B. Yilmaz, E. Kilic. Restorative
effects of VEGF on brain plastiity and funtional reovery after stroke. 9th National
Neuroscience Kongres, Yeditepe University Istanbul, Turkey, Apr 13-17, 2010 Turkish
Journal of Neurology 16 Suppl1: 143, March 2010
15
7. S. Eyüboglu, G. Büyükgüclü, M. Ugur, T. Gencol, Elisa Piranen, U. Kilic, B. Yilmaz, E.
Kilic. Effects of NMDA antagonist memantine on brain injury and rt-PA Toxicity after
cerebral ischemia. 9th National Neuroscience Kongres, Yeditepe University Istanbul,
Turkey, Apr 13-17, 2010 Turkish Journal of Neurology 16 Suppl1: 145, March 2010
8. M. Ugur, U. Kilic, B. Yilmaz, G. Büyükgüclü, Elisa Piranen, S. Eyüboglu, E. Kilic. The
roles of melatonin receptor 1 and 2 in stroke treatment. 9th National Neuroscience
Kongres, Yeditepe University Istanbul,Turkey, Apr 13-17,
2010 Turkish Journal of
Neurology 16 Suppl1: 146, March 2010
9. Ulkan Kilic (Invited speaker). Neuroprotective and neurorestoreative effects of
erytropoietin after brain injury. XI. National Medical Biology and Genetic Congres Oct
28-31 Bodrum, Turkey
10. E. Kilic, Ü. Kılıç, M. Uğur, B. Yılmaz, D. Hermann Nogo-A İnhibisyonunun Beyin Hasarı
Sonrası Hücre Yaşamına Olan Etki Ve Mekanizmaları. 35. ulusal Fizyoloji Kongresi, Gazi
Universitesi, Ankara, 30 Eylül- 3 Ekim 2009
11. Ü. Kılıç, M. Uğur, M. Gassmann, E. Kilic. Beyin Felci Sonrası Subakut Eritropoetin
Uygulamasının Hücre Yaşamı Aksonal Plastisite Ve Fonksiyonel İyileşmeye Olan Etkileri.
35. ulusal Fizyoloji Kongresi, Gazi Universitesi, Ankara, 30 Eylül- 3 Ekim 2009
7.7. Diğer yayınlar
8.
Projeler
9.
İdari Görevler
1. Tıbbi Biyoloji Anabilim Dalı Başkanı
07/2010-
2. Mezuniyet Öncesi Eğitim Komisyonu Tıp Fakültesi 1. Sınıf Koordinatörü
07/2010- 02/2014
3. Mezuniyet Öncesi Eğitim Komisyonu Tıp Fakültesi Baş Koordinatör Yardımcısı
07/2010- 02/2014
4. Akademik Değerlendirme ve Eğitim Komisyonu Üyeliği
01/2011-2012
5. Bologna Eğitim Komisyonu Üyeliği
01/2011-2013
6. Bilimsel Araştırma Projeleri (BAP) Komisyonu Üyeliği
01/2011-
7.Üniversite Tanıtım Komisyonu Üyeliği
01/2011-2013
16
8. Araştırma Merkezi Başkan Yardımcısı
06/2011-04/2012
9. Deney Hayvanları Etik Kurul Üyeliği
11/2011-
10. Araştırma Merkezi Başkanı
04/2012-
11. Deney Hayvanları Etik Kurul Başkanı
04/2012-
.
10. Bilimsel ve Mesleki Kuruluşlara Üyelikler
Schweizerische Geselschaft für Lebensmittel- und UmweltChemie
2004-
Society for Neuroscience
2006-
Turkish Neuroendocrinology Society
2008-
Tıbbi Biyoloji ve Genetik Derneği
2009-
Tıbbi Genetik Derneği
2010-
İstanbul Veteriner Hekimler Odası
05/2014
11. Burs ve Ödüller
2011 Eylül
Poster Award
3-7 September 2011 Federation of European Physiological Societies,
Turkish-FEPS Physiology Congress, İstanbul
2011 Eylül
Oral Presentation Price
3-7 September 2011 Federation of European Physiological Societies,
Turkish-FEPS Physiology Congress, İstanbul
2011 Temmuz
Oral Presentation Price 3-5 July 2011 Annual BSN Conference, Downing
College, Cambridge, UK.
2010 Nisan
Poster Birincilik Ödülü. 9. Ulusal Sinir Bilimleri Kongresi 13-17 Nisan 2010,
TÜBAS/Yeditepe Üniversitesi, İstanbul, Turkey
2010 Nisan
Poster Mansiyon Ödülü 9. Ulusal Sinir Bilimleri Kongresi 13-17 Nisan 2010,
TÜBAS/Yeditepe Üniversitesi, İstanbul, Turkey
2005 Mart
Poster and oral presentation price. Clinical Research, University Hospital
Zurich, March, 2005 Zurich, Switzerland
1996-2000
Yurt Dışı Doktora Bursu (MEB)
17
12. Son iki yılda verdiğiniz lisans ve lisansüstü düzeydeki dersler için aşağıdaki tabloyu
doldurunuz.
Akademik
Yıl
Dönem
Dersin Adı
Haftalık Saati
Teorik
Güz
2008-2009
Uygulama
Öğrenci
Sayısı
Medical Biology (Medical School)
3
83
Molecular Biology and Genetic
3
60
Basic Medical Biology (Dentistry)
3
73
Molecular Biology and Genetic
3
24
3
12
Basic Medical Biology (Dentistry)
3
51
Medical Biology (Medical School)
2
72
Molecular Biology and Genetic
3
51
(Pharmacy)
(Pharmacy)
İlkbahar
Molecular Biology and Genetic
(Health Sciences)
Güz
(Pharmacy)
2009-2010
İlkbahar
Not: Açılmışsa, yaz döneminde verilen dersler de tabloya ilave edilecektir.
Dönem
Dersin Adı
Haftalık Saati
Teorik
Akademik
Yıl
2010-2011
Genetik
Bilgi Üniversitesi (Sağlık Bilimleri
İlkbahar Yüksek Okulu)
2
Uygulama
Öğrenci
Sayısı
2
18
Akademik
Yıl
Dönem
Haftalık Saati
Dersin Adı
Teorik
BVÜ
Medical
Biology
(Medical
Sayısı
3
50
3
40
3
99
School)
Molecular Biology and Genetic
Güz
Uygulama
Öğrenci
(Dentistry)
BVÜ
2011-2012
Bilgi
Molecular Biology and Genetic
Üniversitesi
Nursery
Spring
Health Sciences
Nutrition and Dietetics
Akademik
Yıl
Dönem
Dersin Adı
Haftalık Saati
Teorik
BVÜ
2012-2013
Güz
Tıbbi Biyoloji (Tıp Fakültesi)
3
Moleküler Biyoloji ve Genetik
2
Uygulama
2
Öğrenci
Sayısı
111
64
(Diş Hekimliği Fakültesi)
BVÜ
Akademik
Yıl
2013-2014
Dönem
Dersin Adı
Haftalık Saati
Teorik
BVÜ
Tıbbi Biyoloji
3
Uygulama
2
Öğrenci
Sayısı
160
19
Akademik
Yıl
Dönem
Haftalık Saati
Dersin Adı
Teorik
Tıbbi Biyoloji
2013-2014
Güz
Uygulama
3
Öğrenci
Sayısı
3
Yüksek Lisans Bezmialem Vakıf
Üniversitesi
Sağlık
Bilimleri
Enstitüsü Biyoteknoloji
Akademik
Yıl
Dönem
Haftalık Saati
Dersin Adı
Teorik
Gen
tedavisi
Ürünleri
ve
Uygulama
3
Öğrenci
Sayısı
3
Biyoteknolojik Uygulamalar
2013-2014
Bahar
Yüksek Lisans
Bezmialem Vakıf Üniversitesi
Sağlık
Bilimleri
Enstitüsü
Biyoteknoloji
Akademik
Yıl
Dönem
Haftalık Saati
Dersin Adı
Teorik
Deneysel Sinir Bilimi
2
Uygulama
2
Öğrenci
Sayısı
4
Yüksek Lisans
2013-2014
Bahar
Bezmialem Vakıf Üniversitesi
Sağlık
Bilimleri
Enstitüsü
Biyoteknoloji
12. Toplam Atıf Sayısı: 2637
h index: 27
13. Yabancı Diller: Almanca, İngilizce, İtalyanca (Basic)
20
14. Projeler:
111S418 TÜBİTAK 15/04/2012-15/04/2015
Melatoninin İskemi Sonrası Beyin Plastisitesi ve Onarımı Üzerine Olan Etkileri
BVÜ-BAP 9.2011/6: Fosfatidil İnositol-3 Kinaz (PI-3 Kinaz) /AKT Sinyal İletim Yolağının Beyin
Felci Sonrası Melatoninin Nöroprotektif Etkisindeki Önemi (Tamamlandı).
BVÜ-BAP 9.2012/15: SIRT1’in Obezite Üzerine Etkisi (Submitted).
BVÜ-BAP 6.2013/21: Sirtuin1 Gen polimorfizmlerinin ve İlgili Proteinlerin Kardiyovasküler
Hastalıklar ile İlişkisinin Araştırılması (PLOS ONE 2014)
BVÜ-BAP 6.2013/22 Sirtuin1 Gen polimorfizmlerinin Yaşlanma ile İlişkisinin Araştırılması
(Submitted).
21
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