Slov. Antropol., 15(1):45-52, 2012
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1iEUHåLHPOiGHåH 949 01 Nitra; email: [email protected]
Abstract: Anthropopathogenic effect of the phtalates on human health. Phthalates are group of
synthetic chemicals, which is used in chemical industry as a plasticizers or solvents in widespread
sort of materials and consumer products. Based on animal studies, there are several concerns about
their toxic effect on human health. It is proved that phthalates modulate hormonal levels in animal
studies; they have a lot of adverse effects on reproductive tract, especially in males and can also
affect respiratory and digestive system. In this paper, we want to summarize most important studies
about sources and routes of exposure and potential health endpoints in human population.
Key words: phthalate, exposure assessment, toxicology
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ADIBI, J. J., WHYATT, R. M., WILLIAMS, P. L., CALAFAT, A. M., CAMANN, D.,
HERRICK, R., NELSON, H., BHAT, H. K., PERERA, P. P., SILVA, M. J., HAUSER, R., 2008:
Characterization of phthalate exposure among pregnant women assesed by repeat air and urine
samples. Environ. Health. Persp., 116:467-473.
AKINGBEMI, B. T., RE, G., KLINEFELTER G. R., ZIRKIN, B. R., HARDY, M. P., 2004:
Phthalate-induced Leydig cell hyperplasia is associated with multiple endocrine disturbances.
Proceeding of National Academy of Sciences, 101:775-780.
ATSDR, 1995: Toxicological profile for diethyl phthalate (DEP). Agency for Toxic Substances
and Disease Registry.
ATSDR, 2001: Toxicological profile for di-n-butyl phthalate (DBP). Agency for Toxic
Substances and Disease Registry.
BECKER, K., SEIWERT, M., ANGERER, J., HEGER, W., KOCH, H. M., NAGORKA, R.,
ROSSKAMP, E., SEIFERT, B., 2004 : DEHP metabolites in urine of children and DEHP in house
dust. Int. J. Hyg. Envir. Heal., 207:409-417
BISCARDI, D., MONARCA, S., DE FUSCO, R., 2003: Evaluation of the migration of
mutagens/carcinogens from PET bottles into mineral water by Tradescantia/micronuclei test,
Comet assay on leucocytes and GM/MS. Sci. Total. Environ., 302:101-108
BORCH, J., DALGAARD, M., LADEFOGED, O., 2005: Early testicular effects in rats
perinatally exposed to DEHP in combination with DEHA ± apoptosis assessment and
imunohistochemical studies. Reprod. Toxicol., 19:517-525
BORNEHAG, C. G., LUNDGREN, B., WECHLER, C. J, SIGSGAARD, T., HAGERHEDENGMAN, L., SUNDELL, J., 2005: Phthalates in indoor dust and their association with building
characteristics. Environ. Health. Persp., 113:1399-1404.
BORNEHAG, C. G., SUNDELL, J., HAGERHED-ENGMAN, L., SIGSGAARD T., JANSON
6$%(5*1'DPSQHVV¶DWKRPHDQGLWVDVVRFLDWLRQZLWKDLUZD\QRVHDQGVNLQV\PSWRPV
among 10,851 preschool children in Sweden: a cross-sectional study. Indoor. Air. 15(10):48-55.
CASAUJANA, N., LACORTE, S., 2003: Presence and release of phthalic esters and other
endocrine disrupting compuonds in drinking water. Chromatographia., 57:649-655.
COLON, I., CARO, D., BOURDNOY, C. J., ROSARIO, O., 2000: Identification of
phthalate esters in the serum of young Puerto Rican girls with premature breast development.
Environ. Health. Persp., 108:895-900.
49
DAVID, R. M., MCKEE, R .H., BUTALA, J. H., 2001: Esters of aromatic mono-, di-, and
tricarboxylic acids, aromatic diacids and di-, tri- or polyalcohols. In: Bingham E, Cohrssen B,
3RZHOO&+HG3DWW\¶VWR[LFRORJ\1HZ<RUN-RKQ:LOH\DQG6RQVV±932.
FALK H., PORTNOY B., 1976: Respiratory tract illness in meat wrappers. JAMA., 235:915917.
FOSTER, P. M. D., 2006: Disruption of reproductive development in male rat offspring
following in utero exposure to phthalate esters. Int. J. Androl., 29:140-147.
GRAY, L. E., WILSON, V. S., STOKER, T., LAMBRIGHT, C., FURR, J., NORIEGA, N.,
HOWDESHELL, K., ANKLEY, G.T., GUILLETTE, L., 2006: Adverse effects of environmental
antiandrogens and androgens on reproductive development in mammals. Int. J. Androl., 29:96-104.
HATCH, E. E., NELSON, J. W., QURESHI, M. M., WEINBERG, J., MOORE, L. L.,
SINGER, M., WEBSTER, T. F., 2008: Association of urinary phthalate metabolite concentrations
with body mass index and waist circumference: a cross-sectional study of NHANES data, 1999±
2002. Environ. Health. Perspect., 7:27.
HAUSER R., WILLIAMS, P., ALSTHUL, L., CALAFAT, A. M., 2005: Evidence of
Interaction between Polychlorinated Biphenyls and Phthalates in Relation to Human Sperm
Motility. Environ. Health. Perspect., 113:425-430.
HOPPIN, J. A., ULMER, R., LONDON, S .J., 2004 : Phthalate exposure and pulmonary
function. Environ. health. persp., 112:571-574.
JAAKKOLA, J. J. K., OIE, L., NAFSTAD, P., BOTTEN, G., SAMUELSEN, S. O., MAGNUS,
P., 1999: Surface materials in the home and development of bronchial obstruction in young children
in Oslo, Norway. Am. J. Public. Health., 84:188-192.
JAAKKOLA, J. J. K., PARISE, H., LEBEDEVA, N. I., SPENGLER, J. D., 2004: Asthma,
wheezing and allergies in Russian schoolchildren in relation to new surface materials in the home.
Am. J. Public. Health., 94:560-562.
JAAKKOLA, J. J. K., VERKASALO, P. A., JAAKKOLA, N., 2000: Plastic wall materials in
the home and respiratory health in young children. Am. J. Public. Health., 90:560-562.
KAVLOCK, R., BARR, D., BOEKELHEIDE, K., BRESLIN, W., BREYSSE, P., CHAPIN, R.,
GAIDO, K., HODGSON, E., MARCUS, M., SHEA, K., WILLIAMS, P., 2006: NTP-CERHR
Expert Panel update on the reproductive and developmental toxicity of di(2-ethylhexyl) phthalate.
Reprod. Toxicol., 22:291-399.
KOCH, H. M., ANGERER, J., 2007: Di-iso-nonylphthalate (DINP) metabolites in human urine
after a single oral dose of deuterium-labelled DINP. Int. J. Hyg. Envir. Heal., 210:9-19.
KOCH, H. M., BECKER, K., WITTASSEK, M., SEIWERT, M., ANGERER, J,, KOLOSSAGEHRING, M., 2007: Di-n-butylphthalate and butylbenzylphthalate: urinary metabolite levels and
estimated daily intakes²pilot study for the German Environmental Survey on children. J. Exp. Sci.
Environ. Ecol.17:378 ±387.
KOLARIK, B., NAYDENOV, K., LARSSON, M., BORNEHAG, C. G., SUNDELL, J., 2008:
The association between phthalates in dust and allergic diseases among bulgarian children. Environ.
Health. Persp., 116:98-103.
KOLENA, B., PILKA, T., BAR7(.29È $ 921'5È.29È 0 3(7529,ý29È ,
2012: $QDOê]DG\QDPLFNêFKSĐ~FQ\FKSDUDPHWURYY VNXSLQHSUREDQGRYSUDFXM~FLFKYãSHFLILFNRP
W\SHSUDFRYQpKRSURVWUHGLDýHVNiDQWURSRORJLH, 62(1):20-23.
LATINI, G., DE FELICE, C., DEL VECCHIO, A., 2003a: Lactational exposure to di-(2ethylhexyl)-phthalate. Pediatr. Res., 54:84-88.
LATINI, G., DEFELICE, C., PRESTA, G., 2003: In utero exposure to di-(2ethylhexyl)phthalate and duration of human pregnancy. Environ. Health. Perspect., 111:1783±5.
LEE, B. M., KOO, H. J., 2007: Hershberger assay for antiandrogenic effects of phthalates. J.
Tox. Environ. Health., Part A, 70:1365-1370.
50
MAIN, K. M., 2006: Human breast milk contamination with phthalates and alterations of
endogenous reproductive hormones in infants three months of age. Environ. Health.
Persp.,114:270-276.
MOUNTURI, P., JOVER, E., MORGANTINI, M., BAYONA, J. M., TRIASSI, M., 2008:
Assessing human exposure to phthalic acid and phthalate esters from mineral water stored in
polyethylene terephthalate and glass bottles. Food. Addit. Contam., 25:511-518.
NIELSEN, J., FAHRAEUS, C., BENSRYD, I., AKESSON, B., WELINDER, H., LINDEN, K.,
1989: Small airways function in workers processing polyvinylchloride. Int. Arch. Occup. Environ.
Health., 61(7):427-430.
NORBACK, D., WIESLANDER, G, NORDSTROM, K., WALINDER, R., 2000: Asthma
symptoms in relation to measured building dampness in upper concrete floor construction, and 2ethyl-1-hexanol in indoor air. Int. J. Tuberc. Lung. Dis. 4(11):1016-1025.
‘,(/1AFSTAD, P., BOTTEN, G., JAAKKOLA, J. J. K., 1999: Ventilation in the homes
and bronchial obstruction in young children. Epidemiol., 110:294-299.
PAGE, B. D., LACROIX, G. M., 1995: The occurrence of phthalate ester and di-2-ethylhexyl
adipate plasticizers in Canadian packaging and food sampled in 1985±1989: a survey. Food. Addit.
Contam. 12,:129-151.
PANT, N., SHUKLA, M., PATEL, K. D., SHUKLA, Y., MATHUR, N., GUPTA, Y. K., 2008:
Correlation of phthalate exposures with semen quality. Toxicol. Appl. Pharm., 231:112-6.
PETERSEN, J. H., BRENDAHL, T., 2000: Plasticizers in total diet samples, baby food and
infant formulae. Food. Addit. Contam., 17:133-141.
POLAKOFF, P. L., LAPP, N. L., REGER, R., 1975: Polyvinyl chloride pyrolysis products. A
potential cause for respiratory impairment. Arch. Environ. Health., 30(6):269-271.
REDDY, U. M., KO, C. W., WILLINGER, M., 2006: Maternal age and the risk of stillbirth
throughout pregnancy in the United States. Am. J.Obstent. Gynecol., 195(3):764-770.
SATHYANARAYANA, S., KARR, C. J., LOZANO, P., BROWN, E., CALAFAT,A. M., LIU,
F., SWAN, S. H., 2008: Baby Care Products: Possible Sources of Infant Phthalate Exposure.
Pediatrics., 121:206-268.
SCHETTLER, T., 2006: Human exposure to phthalates via consumer products. Int. J. Androl.,
29:134-139
SCHMIDT, P., KOHLER, M., MEIERHOFER, R., LUZI, S., WEGELIN, M., 2008: Does the
reuse of PET bottles during solar water disinfection pose a health risk due to the migration of
plasticizers and another chemicals into the water? Water. Res., 42:5054-5060.
SILVA, M. J., BARR, D. B., REIDY, J. A., 2003: Glucuronidation patterns of common urinary
and serum monoester phthalate metabolites. Arch. Toxicol., 77:561-567.
STALHNUT, R. W, WIJNGAARDEN, E., DYE, T. D., COOK, S., SWAN, S. H. 2007:
Concentration of urinary phthalate metabolites are asociated with increased waist circumference
and insuline resistance in adult U.S. males. Environ. Health. Perspect., 115:6.
STANLEY, M. K., ROBILLARD, K. A., STAPLES, CH. A. 2003: Introduction. In:
Handbook of Enviromental Chemistry, 3Q:1-7.
SWAN, S. H., 2008: Enviromental phthalate exposure in relation to reproductive outcomes
and another health endpoints in humans. Environ. Res., 105:177-184.
TSUMURA, Y., ISHIMITSU, S., SAITO, I., SAKAI, H., TSUCHIDA, Y., TONGAI, Y., 2003:
Estimated daily intake of plasticizers in 1-week duplicate diet samples following regulation of
DEHP-containing PVC gloves in Japan. Food Additives and Contaminants. 20:317-334.
TUOMAINEN, A., MARKKU, S., SIEPPI, A., 2004. Indoor air quality and health problems
associated with damp floor coverings. Int. Arch. Occup. Environ. Health., 77:22-226.
US FDA (US Food and Drug Administration), Indirect food additives: adhesives and
components of coatings adhesives. 2000. http://www.accessdata.fda.gov/scripts/cdrh/cfdocs/
cfCFR/CFRSearch.cfm?CFRPart=175&showFR=1 Online. Available: 21 July 2012.
51
US FDA (US Food and Drug Administration): Safety Assessment of Di(2-ethylhexyl) Phthalate
(DEHP)Release from Medical Devices. 2002. Online. Available: http://www.fda.gov/cdrh/ost/dehppvc.pdf. 21 July 2012.
WORMUTH, M., SCHERINGER, M., VOLLENWEIDER M., HUNGERBUHLER, K., 2006:
What are the sources of exposure to eight frequently used phthalic acid esters in Europeans? Risk.
Anal. 26:803-824.
52
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