CURRICULUM VITAE
Assoc. Prof. Dr. Özlem Darcansoy İşeri
Date of Birth
09/03/1980
Martial status
Married (1 child)
e-mail
[email protected], [email protected]
EDUCATION/TITLE
Year
Degree/Title
University/High School
Major
September 2013
Associate Professor
-
Biology
February 2009*
PhD
Middle East Technical University
Biotechnology
(METU)
November
2004*
M.Sc.
METU
June 2002
B.Sc. (High honors) METU
Biology
June 1998
High school
-
Biotechnology
TED Ankara College
* M.Sc. and PhD programs are integrated.
ADMINISTRATIVE DUTIES
Year
Duty
Institute/Institution
January 2014-Ongoing
Vice Director
BU Institute of Transplantation and
Gene Sciences
January 2014-Ongoing
Executive Council
Member
BU Institute of Transplantation and
Gene Sciences
January 2013-Ongoing
Science and
Advisory Council
Member
BU Ayseabla Schools
ACADEMIC EXPERIENCE
Year
November 2013Ongoing
Status
University/Institute
BU Faculty of Engineering, Department of
Biomedical Engineering
(Assistant Professor) (Designated at the Institute of Transplantation
and Gene Sciences)
Faculty member
February 2012-
Faculty staff
November 2013
(Instructor)
BU Faculty of Engineering, Department of
Biomedical Engineering
(Designated at the Institute of Transplantation
1
and Gene Sciences)
April 2009-February
2012
October 2002January 2009
2001
(July-September)
Specialist researcher BU Institute of Transplantation and Gene
Sciences
Research assistant
METU Department of Biological Sciences
Summer practice
TÜBİTAK DNA/Cell Bank & Gene Research
Laboratory
TEACHING EXPERIENCE
1. Baskent University, Faculty of Engineering, Department of Biomedical Engineering;
Genetic Technology (BME430)
2. Baskent University, Department of Psychiology; General Biology (PSK 106)
3. Graduate School of Health Sciences, Medical Biology Graduate Program; Applied
Biology (TIB518)
4. Graduate School of Health Sciences, Nursing Graduate Program; Physiological
Processes and Nursing Evaluation I (HEM501)
5. Middle East Technical University, Department of Biological Sciences, Molecular
and Transmission Genetics Laboratory
6. Middle East Technical University, Department of Biological Sciences, Microbiology
Laboratory
7. Middle East Technical University, Department of Biological Sciences, General
Biology Laboratory
8. Middle East Technical University, Department of Biological Sciences, Cell Biology
Laboratory
RESEARCH INTERESTS
Molecular biology and genetics of cancer, chemotherapy resistance, biotechnology
applications in cancer chemotherapy, use of biotechnology in plant and crop science,
anticarcinogenic and antimicrobial activities of natural products
2
TECHNICAL EXPERIENCE
Animal cell culture (monolayer and suspension), cell viability assays (XTT, MTT),
DNA, RNA and protein isolation from cell culture and tissue samples, vertical and
horizontal gel electrophoresis systems (agarose, PAGE, SDS-PAGE), RT-PCR,
western blot, immunocytochemistry and immunohistochemistry, use of gene databases
and primer design for RT-PCR, real-time PCR and cDNA microarray (including data
analysis), determination of lipid peroxidation in animal cell culture and plants,
COMET assay (cell culture and plant), enzyme activity assays in plants, telomerase
activity assay, prokaryotic and eukaryotic cloning
THESIS
“Investigation of Docetaxel and Doxorubicin Resistance in MCF-7 Breast Carcinoma
Cell Line”
February 2009, METU Graduate School of Applied Sciences, Department of
Biotechnology
Advisor: Prof.Dr. Ufuk Gündüz (METU Department of Biological Sciences)
Co-advisor: Prof.Dr. Fikret Arpacı (Gülhane Military School of Medicine, Department
of Oncology)
SCHOLARSHIPS
1. TÜBİTAK, Doktorate Scholar in Turkey (2005-2006)
2. Multidisciplinar Cancer Research Symposium, Young Researcher Scholar (March
2006, Bursa-TURKEY)
3. 9th FEBS Young Scientist Forum Scholar (June 2009, Prague-CZECH REPUBLIC)
4. 1st Multidisciplinar Cancer Research Congress, Young Researcher Scholar (May
2009, Antalya-TURKEY)
5. FEBS Scholar (32nd FEBS Congress, 2007, Vienn-AUSTURIA)
6. Türkish Society of Biochemistry, FEBS Scholar (31st FEBS Congress, 2006,
İstanbul-TURKEY)
AWARDS
1. Turkish Society of Hematology 32nd National Hematology Congress, November 812, 2006, Antalya-TURKEY, Industry Award
2. Turkish Society of Clinical Biochemists 1st National Congress, October 1-4, 2003,
Kapadocia-TURKEY, Poster Special Award
3
MEMBERSHIPS
1. Turkish Society of Biochemistry
2. Turkish Society of Biotechnology
3. Turkish Society of Molecular Cancer Research
4. European Association of Cancer Research
LANGUAGE SKILLS
English (Very good; under graduate and graduate degrees in English)
BOOK CHAPTER
1. Alkım C, Çakar ZP, İşeri ÖD. Molecular Biology Chapter 19: Transcriptomes and
Microarrays [Moleküler Biyoloji. Bölüm 19: Transkriptom ve Mikroarraylar]. Editör
Mehmet Karataş. NOBEL Academic Publishing, Ankara, Turkey, 2012, pg. 382-403.
PUBLICATIONS
1. Işeri OD, Sahin FI, Haberal M. Sodium Chloride Priming Improves Salinity
Response of Tomato (Lycopersium esculentum Mill.) at Seedling Stage. Journal of
Plant Nutrition, DOI:10.1080/01904167.2013.859699, In press. (SCI)
2. Işeri OD, Körpe DA, Sahin FI, Haberal M. Screening of Nasturtium officinale
extracts for biological activities: Implications for plant pathogens. Journal of
Biologically Active Products From Nature, 2014 (In press).
3. Yurtcu E, İşeri ÖD, Sahin FI. Genotoxic and Cytotoxic Effects of Doxorubicin and
Slymarin on Human Hepatocellular Carcinoma Cells. Human and Experimental
Toxicology, 2014 (In press). (SCI)
4. Işeri OD, Yutcu E, Sahin FI, Haberal M. Corchorus olitorius (jute) extract induced
cytotoxicity and genotoxicity on human multiple myeloma cells (ARH-77).
Pharmaceutical Biology, 51(6): 766-70, 2013. (SCI)
5. İşeri ÖD, Körpe DA, Şahin Fİ, Haberal M. Hydrogen Peroxide Pretreatment of
Roots Enhanced Oxidative Stress Response of Tomato under Cold Stress. Acta
Physiologiae Plantarum, 35(6): 1905-1913, 2013. (SCI)
6. Işeri OD, Körpe DA, Sahin FI, Haberal M. High Salt Induced Oxidative Damage
and Antioxidant Response Differs in Nicotiana tabacum L. and Nicotiana rustica L.
Cultivars. Journal of Applied Biological Sciences, 7 (1): 15-23, 2013.
7. Körpe DA, Işeri OD, Sahin FI, Cabi E, Haberal M. High-antibacterial activity of
4
Urtica spp. seed extracts on food and plant pathogenic bacteria. International Journal
of Food Science and Nutrition, 64(3): 355-62, 2012. (SCI)
8. Körpe DA, Işeri OD, Sahin FI, Haberal M. Determination of Genetic Stability of
Tomato (Lycopersicon esculentum Mill.) Grafted on Tobacco (Nicotiana tabacum
L.) by Random Amplified Polymorphic DNA Analysis. Harran University Journal of
the Faculty of Agriculture 16(2): 37-44, 2012.
9. Işeri OD, Kars MD, Gündüz U. Two different docetaxel resistant MCF-7 sublines
exhibited different gene expression pattern. Molecular Biology Reports, 39: 3505–
3516, 2012. (SCI)
10. Işeri OD, Körpe DA, Yurtcu E, Sahin FI, Haberal M. Copper-induced oxidative
damage, antioxidant response and genotoxicity in Lycopersicum esculentum Mill.
and Cucumis sativus L. Plant Cell Reports, 30(9):1713-21, 2011. (SCI)
11. İşeri ÖD, Kars MD, Arpacı F, Atalay C, Pak I, Gündüz U. Drug resistant MCF-7
cells exhibit epithelial-mesenchymal related gene expression pattern. Biomedicine
and Pharmacotherapy 65(1): 40-45, 2011. (SCI)
12. İşeri ÖD, Mutlu PK, Kars MD, Avcu F, Ural AU, Gündüz U. Expression of
multidrug resistance 1, lung resistance protein and breast cancer resistance protein
genes in chronic leukemias. International Journal of Hematology and Oncology
1(19): 1-8, 2009. (SCI)
13. Kars MD, Iseri OD, Gunduz U. A Microarray Based Expression Profiling of
Paclitaxel and Vincristine Resistant MCF-7 Cells. European Journal of
Pharmacology 657(1-3): 4-9, 2011. (SCI)
14. Dönmez Y, Akhmetova L, Işeri OD, Kars MD, Gündüz U. Effect of MDR
modulators verapamil and promethazine on gene expression levels of MDR1 and
MRP1
in
doxorubicin-resistant
MCF-7
cells.
Cancer
Chemotherapy
and
Pharmacology 67(4): 823-828, 2011. (SCI)
15. Yurtcu E, İşeri ÖD, Sahin FI. Effects of ascorbic acid and b-carotene on HepG2
human hepatocellular carcinoma cell line. Molecular Biology Reports (2010) DOI
10.1007/s11033-010-0549-5. (SCI)
16. İşeri ÖD, Kars MD, Arpaci F and Gündüz U. Gene Expression Analysis of Drug
Resistant MCF-7 Cells: Implications for Relation to Extracellular Matrix Proteins.
Cancer Chemotherapy and Pharmacology 65 (3): 447-55, 2010. (SCI)
17. İşeri ÖD, Kars MD, Gündüz U. Drug Resistant MCF-7 Cells Have Altered
5
Expression Levels of β-Tubulin Isotypes and Mutations in TUBB Gene. International
Journal of Hematology and Oncology 2 (20): 75-83, 2010. (SCI)
18. Kars MD, İşeri ÖD, Gündüz U. Drug resistant breast cancer cells overexpress ETS1
gene. Biomedicine and Pharmacotherapy 64(7): 458-62, 2010. (SCI)
19. Kars MD, Iseri ÖD, Ural AU, Avcu F, Beyzadeoglu M, Dirican B, Gündüz U.
Development of Radioresistance in Drug Resistant Human MCF-7 Breast Cancer
Cells. Journal of Radiotherapy in Practice, 8:207-213, 2009.
20. [Kars MD, İşeri ÖD, Arpacı F, Gündüz U. Meme Kanseri MCF-7 Hücre Hattında
Paklitaksel ve Vinkristine Karşı Gelişmiş Çoklu İlaç Direnci Mekanizmalarının
Mikrodizin Analizi ile Belirlenmesi. Türk Onkoloji Dergisi 24(4):153-158, 2009.]
21. İşeri ÖD, Kars MD, Eroğlu S, Gündüz U. Cross-resistance Development and
Combined Applications of Anticancer Agents in Drug Resistant MCF-7 Cell Lines.
International Journal of Hematology and Oncology 1 (19): 1-8, 2009. (SCI)
22. Eskiocak U, İşeri ÖD, Kars MD, Biçer A, Gündüz U. Effect of Doxorubicin on
Telomerase Activity and Apoptotic Gene Expression in Doxorubicin Resistant and
Sensitive MCF-7 Cells. Chemotherapy 54: 209-216, 2008. (SCI)
23. Kars MD, Iseri OD, Gunduz U, Molnar J. Reversal of MDR by Synthetic and
Natural Compounds in Drug Resistant MCF-7 Cell Lines. Chemotherapy 54: 194200, 2008. (SCI)
24. Sakin V, Eskiocak U, Kars MD, İşeri ÖD, Gündüz U. hTERT Gene Expression
Levels and Telomerase Activity in Drug Resistant MCF-7 Cells. Experimental
Oncology 30(3): 1-4, 2008.
25. Kars MD, İşeri ÖD, Ural AU, Gündüz U. In Vitro Evaluation of Zoledronic Acid
Resistance Developed in MCF-7 Cells. Anticancer Research 27: 4031-4038, 2007.
(SCI)
26. Kars MD, Iseri OD, Gunduz U, Ural AU, Arpaci F, Molnar J. Development of
rational in vitro models for drug resistance in breast cancer and modulation of MDR
by selected compounds. Anticancer Research 26: 4559-4568, 2006. (SCI)
6
PROJECTS INVOLVED
Involved as project coordinator:
1. Experimental Research Foundation of Baskent University (BUERF): Determination
of Chemical Constitutents of Leaf, Root, and Seed Extracts Obtained with Solvents
of Different Polrity, DA13/28, Temmuz 2013- Ongoing..
2. BUERF: Evaluation of Plant Extracts of High Antibacterial Activity against
Bacterial Canker Disease of Tomato for Allelopathic Effect on Tomato Seed
Germination, DA12/22, August 2012-Ongoing.
3. BUERF: Impact Assessment of Different Tomato Rootstocks on Tomacco Graft
Success, Vegetative Development and Crop Yield, and Nicotine Content, DA12/20,
August 2012-Ongoing.
4. BUERF: Evaluation of Cytotoxic and Genotoxic Effects of Corchorus olitorius L.
(Jüte) Extrcats on Human Multiple Miyeloma Cells, DA11/29, December 2011December 2012.
5. BUERF: Investigation of Antimicrobial Efficacy of Corchorus olitorius L. (Jüte)
Extracts on Food and Plant Borne Pathogens, DA11/07, May 2011-Ongoing.
6. BUERF: Impact Assessment of Hydrogen Peroxide Pretreatments on Cold Tolerance
of Tomato Seedlings, DA11/06, February 2011-April 2011.
7. BUERF: Investigation of Antimicrobial Efficacy of Plant Extracts on Food and Plant
Borne Pathogens, DA10/17, June 2010-September 2011.
8. BUERF: Impact Assessment of Different Tomato Cultivars and Grafting Techniques
on “Tomacco” Vegetative Development and Crop Yield, and Nicotine Content;
DA10/16, June 2010-Ongoing.
9. BUERF: Grafting of Cultivated Varieties of Tomato on Tobacco Rootstocks,
Determination of Vegetative Development and Crop Yield, and Analysis Nicotine
Content; DA09/37, October 2009-March 2013.
10. BUERF: Determination of Effect of Seed Priming and Early Seedling Treatments on
Salinity Tolerance of Tomato, DA10/09, March 2010-September 2010.
11. BUERF: Impact Assessment of Copper on Seed Development; DA09/31, September
2009-June 2010.
12. BUERF: Investigation of Effect of Salinity Stress on Tomato Grafted on Tobacco;
DA09/22, June 2009-June 2010.
7
Involved as researcher:
1. BUERF: Impact Assessment of Silymarin on Tankyrase, Axin, and β-catenin
Expression Levels in Different Cell Lines, DA13/30, June 2013-Ongoing.
2. BUERF: Development of Escherichia coli Biosensörs for Legionella pneumophila,
DA12/05, February 2013-May 2013.
3. BUERF: Investigation of Antibacterial Activity of Calendula officinalis Extracts,
DA12/28, August 2012- December 2012.
4. BUERF: Expression of β-Andrenergic Receptors on Human Carcinoma Cell Lines
and Determination of Cytotoxicity of Different Andrenergic Ligands on These Cell
Lines, DA10/20, August 2010-June 2013.
5. BUERF: Cloninig of Legionella pneumophila “lqs” Gene Cluster into an
Expresssion Vector and Transformation to Escherichia coli, DA12/05, February
2012-May 2012.
6. BUERF: Investigation of Slymarin on Telomerase Activity of Liver Carcinoma
Cells, DA09/36, December 2009-Ongoing.
7. BUERF: Effect of Doxorubicin and Some Antioxidant Diet Supplements on Human
Hepatocellular Cell Line; DA10/01, February 2010-April 2010.
8. METU-Gülhane Military School of Medicine Partner Project: Investigation of
Multidrug Resistance Mechanisms in Multiple Myeloma Cell Lines by Microarray
Analysis; BAP2008-R-08-11-11, September 2008-June 2010.
13. TÜBİTAK: ‘Synthesis of Dendritic Polymers for Anticancer Drug Release and
Applications in Cell Cultures’ 107T179, July 2007-January 2009
14. TÜBİTAK: ‘Investigation of Mechanisms of Drug Resistance and Reversal In
Different Model Cancer Cell Lines By Molecular Biology Techniques’ 106S019,
June 2006-June 2008.
15. DPT: ‘Investigation of Anticancer Drug Resistance Mechanisms and Drug Targeting
in Mammary Carcinoma’ BAP 07-02-DPT.02K120540-14, June 2002-June 2005.
16. METU Research Foundation Project: Investigation of MRP1 and BCRP Gene
Expression Levels in Anticancer Drug Applied Resistant MCF-7 Cell Line; BAP2003-07-0200-64, June 2003-April 2006.
8
INVITED SPEECHS
1. Baskent University, Faculty of Medicine, Department of Medical Genetics, 15
March 2013; ‘Çoklu İlaç Dirençliliğinde Yeni Perspektifler: microRNA ve
Epigenetik’.
2. METU Synthetic Biology Day, Ankara, 23 February 2013; ‘Sentetik Biyoloji ve
Tıptaki Uygulamaları’.
3. Eurobiotech 2012 Agriculture Symposium, 12-14 April 2012, Kayseri, Turkey;
Journal of Biotechnology 161S (2012) p9. ‘Genotoxicity Studies in Plant Cellls’.
4. Baskent University, Faculty of Medicine, Department of Medical Genetics and
Medical Biology, 21 October 2011; ‘Gen Transferinin Tıptaki Uygulamaları’.
5. Baskent University, Faculty of Medicine, Department of Medical Genetics and
Medical Biology, 6 November 2009; ‘Antikanser İlaç Dirençlilik Mekanizmaları ve
İlaç Dirençliliğinin Geri Çevrilmesi’.
6. Baskent University, Faculty of Engineering, 6 May 2009; ‘Antikanser İlaç
Dirençlilik Mekanizmaları ve İlaç Dirençliliğinin Geri Çevrilmesi’.
INTERNATIONAL CONFERENCE PRESENTATIONS (FULL MANUSCRIPT)
1. Körpe DA, İşeri ÖD, Duman M, Denkbaş EB, Sahin FI, Haberal M. Biological
synthesis of metallic nanoparticles using Urtica pilulifera L. Leaf extract. 8th
Nanoscience and Nanotechnology Congress, 25-29 June 2012, Ankara, Turkey,
0836, PP-118.
2. Güç E, Gündüz G, Şen P, İşeri ÖD, Kars MD, Gündüz U: Synthesis and
Characterization of Dendritic Polymers and PLGA Microcapsules for Anti-Cancer
Drug Release. 13th International Pharmaceutical Technology Symposium, 10-13
September 2006 Antalya-TURKEY, p73.
INTERNATIONAL CONFERENCE PRESENTATIONS
1. Darcansoy İşeri Ö, Sahin FI, Terzi YK, Yurtcu E, Erdem R, Sarialioglu F. βadrenoreceptor antagonists reduces cancer cell proliferation, invasion, and migration
in vitro. European Human Genetics Conference 2013, June 8-11, Paris, France;
European Journal of Human Genetics, 21(S2): 528.
2. Ozer O, Terzi YK, Darcansoy İşeri Ö, Yılmaz Çelik Z, Sahin FI. EGCG
applications on HT-29 and MCF-7 cell lines and evaluation of tumor supressor gene
9
methylation. American Society of Human Genetics, 62nd Annual Meeting, 6-10
November, 2012, San Fransisco, USA: S885. Poster.
3. İşeri ÖD, Yurtcu E, Sahin FI, Haberal M. Corchorus olitorius L. (Jute) Extracts
Prevented Proliferation of Human Multiple Myeloma Cells (ARH-77) and Induced
DNA Damage. New Biotechnology (Abstracts of the 15th European Congress on
Biotechnology, 23-26 September 2012, İstanbul, Turkey) 29(2): S114. Poster.
4. İşeri ÖD, Körpe DA, Sahin FI, Haberal M. Evaluation of Plant Extracts of High
Antibacterial Activity against Clavibacter michiganensis subsp. michiganensis for
Allelopathic Effect on Tomato Seed Germination. New Biotechnology (Abstracts of
the 15th European Congress on Biotechnology, 23-26 September 2012, İstanbul,
Turkey) 29(2): S186. Poster.
5. Haberal M, Körpe DA, İşeri ÖD, Sahin FI. Evalution of Fruit and Leaf Nicotine
Content of New ‘Tomacco’ Unions. Eurobiotech 2012 Agriculture Symposium, 1214 April 2012, Kayseri, Turkey; Journal of Biotechnology 161S (2012) p32. Poster.
6. İşeri ÖD, Körpe DA, Sahin FI, Haberal M. Cucumber (Cucumis sativus L.) Growth
Under Normal and Drought Irrigation. Eurobiotech 2012 Agriculture Symposium,
12-14 April 2012, Kayseri, Turkey; Journal of Biotechnology 161S (2012) p32.
Poster.
7. Sahin FI, İşeri ÖD, Haberal M. NaCl priming improves salinity response of tomato
(Lycopersium esculentum Mill.) at seedling stage. European Biotechnology Congress
2011, September 28-October 1, İstanbul, Turkey (Current Opinion in Biotechnology
2011, 22(Supp 1): S46-S47). Oral.
8. İşeri ÖD, Körpe DA, Sahin FI, Cabi E, Haberal M. Screening of Corchorus olitorius
L. extracts for antioxidant and antibacterial activities. European Biotechnology
Congress 2011, September 28-October 1, İstanbul, Turkey (Current Opinion in
Biotechnology 2011, 22(Supp 1): S46). Oral.
9. İşeri ÖD, Körpe DA, Sahin FI, Haberal M. Hydrogen Peroxide Pretreatment of
Roots Enhanced Oxidative Stress Response of Tomato under Cold Stress. 1st
International Symposium of Secondary Metabolites: Chemical, Biological and
Biotechnological Properties, September 12-15, Pamukkale-Denizli, Turkey. Oral.
10. İşeri ÖD, Körpe DA, Sain FI, Kartal T, Haberal M. Characterization of Nasturtium
officinale L. (Watercress) Leaf and Root Extractsfor Antioxidant and Antibacterial
Activities” 1st International Symposium of Secondary Metabolites: Chemical,
10
Biological and Biotechnological Properties, September 12-15, Pamukkale-Denizli,
Turkey. Oral.
11. Körpe DA, İşeri ÖD, Sahin FI, SAHIN, Cabi E, Haberal M. Investigation of Urtica
spp. Extracts for Antioxidant and Antibacterial Activities: Implications for Plant
Pathogens. 1st International Symposium of Secondary Metabolites: Chemical,
Biological and Biotechnological Properties, September 12-15, Pamukkale-Denizli,
Turkey. Oral.
12. İşeri ÖD, Körpe DA, Sahin FI, Haberal M. Organic and Inorganic Chemical Pretreatments Enhanced Cucumber (Cucumis sativus L.) Seed Germination. 1st
International Symposium of Secondary Metabolites: Chemical, Biological and
Biotechnological Properties, September 12-15, Pamukkale-Denizli, Turkey. Oral.
13. Akhmetova L, Dönmez Y, İşeri ÖD, Kars MD, Gündüz U. Modulation of Multidrug
Resistance in Doxorubicin Resistant MCF-7 Cells. Turkish Journal of Biocehemistry
(34) 21st National Biochemistry Congress (28-31 October, 2009, İstanbul, Turkey)
Special Issue S81. Poster.
14. Nil Z, Urfalı Ç, Şenyılmaz D, Kars MD, İşeri ÖD, Gündüz U. Investigation of Cross
Resistance Development in Zoledronic Acid Resistant MCF-7 Cells. Turkish Journal
of Biocehemistry (34) 21st National Biochemistry Congress (28-31 October, 2009,
İstanbul, Turkey) Special Issue S118. Poster.
15. İşeri ÖD, Kars MD, Arpacı F, Atalay C, Pak I, Gündüz U. Drug resistant MCF-7
cells possessed epithelial-mesenchymal related gene expression pattern. 34th FEBS
Congress, Life’s Molecular Interactions, 4-9 July 2009, The FEBS Journal
276(Supp1): 101, Prag-Çek Cumhuriyeti. Poster.
16. İşeri ÖD, Kars MD, Arpacı F, Gündüz U. Role of ETS1 in paclitaxel and vincristine
resistance development in MCF-7 cells. 34th FEBS Congress, Life’s Molecular
Interactions, 4-9 July 2009, The FEBS Journal 276(Supp1): 363, Prag-Çek
Cumhuriyeti. Poster. (Young Scientist Forum).
17. Iseri ÖD, Kars MD, Ural AU, Avcu F, Beyzadeoglu M, Dirican B, Gündüz U.
Development of Radioresistance in Drug Resistant Human MCF-7 Breast Cancer
Cells. 1st International Multidisciplinary Cancer Research Congress, 22-24 May
2009, Antalya-Türkiye. Oral.
18. İşeri ÖD, Kars MD, Arpacı F, Gündüz U. Two Docetaxel Resistant MCF-7 Sublines
Selected in Different Drug Concentrations Exhibited Differential Gene Expression
11
Pattern. 1st International Multidisciplinary Cancer Research Congress, 22-24 May
2009, Antalya-Türkiye. Oral.
19. Akar AR, Akçalı KC, Durdu S, Deniz GÇ, Cingöz B, İşeri ÖD, Kaya B, Özyurda Ü.
Involvement Of Bcl-2 Family Of Proteins In Vascular Smooth Muscle Cell
Apoptosis In Patients With Ascending Aortic Aneurysm And Dissection. 1st
International Multidisciplinary Cancer Research Congress, 22-24 May 2009,
Antalya-Türkiye. Poster.
20. Nil Z, Dönmez Y, İşeri ÖD, Kars MD, Gündüz U. Expression of the Ceramide
Metabolizing Enzymes In Drug Resistant MCF-7 Cells. 1st International
Multidisciplinary Cancer Research Congress, 22-24 May 2009, Antalya-Türkiye.
Poster.
21. İşeri ÖD, Kars MD, Arpacı F, Gündüz U. Drug Resistant MCF-7 Cells Have Altered
mRNA Levels for ECM Related Proteins. 33rd FEBS Congress Biochemistry of Cell
Regulation, June 28-July 7 2008, Athens-GREECE, FEBS Journal. Poster.
22. İşeri ÖD, Kars MD, Arpacı F, Gündüz U. Alterations in β-tubulin Isotypes and
AntiMicrotubule Drug Resistance in MCF-7 Cells. 33rd FEBS Congress
Biochemmistry of Cell Regulation, June 28-July 7 2008, Athens-GREECE, FEBS
Journal. Poster.
23. Dönmez Y, İşeri ÖD, Kars MD, Gündüz U. Analysis of β-tubulin isotypes and
apoptotic gene expression in response to paclitaxel treatment in MCF-7 breast
carcinoma cell lines. EMBO Young Scientists Forum, February 20-22 2008,
İstanbul-TURKEY, p 47. Poster.
24. İşeri ÖD, Kars MD, Arpacı F, Gündüz U. Analysis of Expression of β-tubulin
Isotypes and Mutations of Class I β-tubulin Gene In Docetaxel Resistant MCF-7
Cells. 32nd FEBS Congress Molecular Machines, July 7-12 2007, Vienna-AUSTRIA,
FEBS Journal, Vol 274 p 234. Poster.
25. Kars MD, İşeri ÖD, Gündüz U, Molnár J. Reversal of MDR by Synthetic and
Natural Compounds in Drug Resistant MCF-7 Cell Lines. 32nd FEBS Congress
Molecular Machines, July 7-12 2007, Vienna-AUSTRIA, FEBS Journal, Vol 274 p
233. Poster.
26. Eskiocak U, İşeri ÖD, Kars MD, Biçer A, Gündüz U. Effect of Doxorubicin on
Telomerase Activity and Apoptotic Gene Expression in Doxorubicin Resistant and
Sensitive MCF-7 Cells. 32nd FEBS Congress Molecular Machines, July 7-12 2007,
12
Vienna-AUSTRIA, FEBS Journal, Vol 274 p 156. Poster.
27. İşeri ÖD, Kars MD, Gündüz U. Promethazine inhibits MDR1 gene expression in
drug resistant MCF-7 cell lines. 2nd Congress of Molecular Medicine 24-26 March
2007, İstanbul-TURKEY, p308. Poster.
28. Kars MD, İşeri ÖD, Ural AU, Gündüz U. In-vitro evaluation of zoledronic acid
resistance developed in MCF-7 cells. 2nd Congress of Molecular Medicine, 24-26
March 2007, İstanbul-TURKEY, p304. Poster.
29. Sakin V, Eskiocak U, Kars MD, İşeri ÖD, Gündüz U. Investigation of hTERT
mRNA levels and telomarase activity in drug resistant MCF-7 cells. II. Congress of
Molecular Medicine 24-26 March 2007, İstanbul-TURKEY, p310. Poster.
30. Eroğlu S, Kars MD, İşeri ÖD, Gündüz U. Cross-resistance Development and
Combined Applications of Anticancer Agents in Drug Resistant MCF-7 Cell Lines.
3rd International Meeting on Medicinal and Pharmaceutical Chemistry, 16-21
October 2007, Antalya- TÜRKİYE, p 136. Poster.
31. Ural AU, Iseri OD, Mutlu PK, Kars MD, Avcu F, Gunduz U. Expression of
multidrug resistace 1, lung resistance protein and breast cancer resistance protein
genes in chronic lymphocytic and chronic myelogeneous leukemia. American
Society of Hematology 48th Annual Meeting, 9-12 December 2006 Orlando-FloridaUSA, Blood Journal of American Society of Hematology Vol. 108 No: 11 Part 2
p169b. Poster. (Industry Award).
32. Güç E, Gündüz G, Şen P, İşeri ÖD, Kars MD, Gündüz U. Synthesis and
Characterization of Dendritic Polymers and PLGA Microcapsules for Anti-Cancer
Drug Release. 13th International Pharmaceutical Technology Symposium, 10-13
September 2006 Antalya-TURKEY, p73. Poster.
33. Kars MD, Iseri ÖD, Gündüz U, Doleschall Z, Csuka O, Bak M, Molnár J. Analysis
of Multidrug Resistance (MDR) Related Gene Expression Profiles in MCF-7 Cell
Lines: 19th Meeting of the European Association For Cancer Research, 1-4 July
2006, Budapest–HUNGARY, p86. Poster.
34. Kars MD, Iseri ÖD, Gündüz U, Ural AU, Molnár J. Modulation of Multidrug
Resistance in Paclitaxel and Vincristine Resistant MCF-7 Cell Lines. 31st FEBS
Congress, 24-29 June 2006, Istanbul-Turkey, FEBS Journal, Vol 273 p278. Oral.
35. Iseri ÖD, Kars MD, Gündüz U, Arpacı F. Investigation of Multidrug Resistance in
Docetaxel and Doxorubicin Resistant MCF-7 Cell Lines. 31st FEBS Congress, 24-29
13
June 2006, Istanbul-Turkey, FEBS Journal Vol 273, p43. Oral.
36. Iseri ÖD, Kars MD, Gündüz U. Investigation of Apoptotic Gene Expression Levels
in Multidrug Resistant MCF-7 Cell Lines. 31st FEBS Congress, 24-29 June 2006,
Istanbul-Turkey, FEBS Journal, Vol 273 p80. Oral.
37. Kars MD, Iseri ÖD, Kücük B, Sen P, Gündüz U. An Improved Technique for
Preparation of Doxorubicin Loaded PLGA Microspheres for Drug Release Studies.
31st FEBS Congress, 24-29 June 2006, Istanbul-TURKEY, FEBS Journal, Vol 273
p281. Oral.
38. Kars MD, Iseri ÖD, Gündüz U, Engi H, Molnár J. Investigation of Molecular
Mechanisms of Multiple Drug Resistance in MCF-7 Cell Line and Reversal of MDR.
17th International Congress on Anticancer Treatment, 30 January- 02 February 2006,
Paris-FRANCE, p328. Oral.
39. Kars MD, Iseri ÖD, Gündüz U, Molnár J. Reversal of Multiple Drug Resistance in
Anticancer Drug Selected Resistant MCF-7 Cell Lines. International Seminar on
Drug Resistance in Cancer, 5 December 2005, Szeged-HUNGARY, page 23. Oral.
40. Demirel M, İşeri ÖD, Atalay C, Baran Y, Kaya P, Gündüz U. Investigation of
molecular mechanisms of multiple drug resistance. European 11th COST ACTION
B16 Symposium on Multi-drug Resistance Reversal, Belek-TURKEY, 2005. Poster.
41. İşeri ÖD, Demirel M, Arpacı F, Gündüz U. Investigation of multidrug resistance
gene expression in mammary carcinoma tissue samples. Hellenic Association of
Medical Geneticists and Aristotle University of Thessaloniki, 6th Balkan Meeting on
Human Genetics, GREECE, 2004, p13. Poster.
42. Demirel M, İşeri ÖD, Ural AU, Gündüz U. Cytotoxicity and multidrug resistance
gene expression analysis in MCF-7 breast carcinoma cell. Hellenic Association of
Medical Geneticists and Aristotle University of Thessaloniki, 6th Balkan Meeting on
Human Genetics, GREECE, 2004, p76. Oral.
NATIONAL CONFERENCE PRESENTATIONS (FULL MANUSCRIPT)
1. İşeri ÖD, Yurtcu E, Sahin FI, Haberal M. Corchorus olitorius L. (Jüt) Özütlernin
İnsan Multipl Myelom Hücreleri (ARH-77) Üzerindeki Sitotoksik ve Genotoksik
Etkilerinin Değerlendirilmesi. 17. Ulusal Biyoteknoloji Kongresi, 23-26 Eylül 2012,
İstanbul, Türkiye, sf. 18-22. Oral.
2. Darcansoy İşeri Ö, Aksoy D, Şahin Fİ, Haberal M. Tuz Stresinin Tütün Üzerine
Aşılanmış Domates Bitkisine Etkilerinin İncelenmesi. 16. Ulusal Biyoteknoloji
14
Kongresi, 13-15 Aralık 2009, Antalya-TÜRKİYE. Oral.
3. Darcansoy İşeri Ö, Aksoy D, Yurtçu E, Şahin Fİ, Haberal M. Bakır Ağır Metalinin
Domates Tohum Gelişimine Genotoksik ve Sitotoksik Etkilerinin İncelenmesi. 16.
Ulusal Biyoteknoloji Kongresi, 13-15 Aralık 2009, Antalya-TÜRKİYE. Oral.
NATIONAL CONFERENCE PRESENTATIONS
1. İşeri ÖD, Körpe DA, Yurtcu E, Şahin Fİ, Haberal M. Bakır Ağır Metalinin
Lycopersicum esculentum Mill. Ve Cucumis sativus L. Tohum Gelişimi Üzerine
Genotoksik ve Sitotoksik Etkilerinin İncelenmesi. Türkiye VI. Ulusal Bahçe Bitkileri
Kongresi, 4-8 Ekim 2011, Şanlıurfa, Türkiye, sf. 29-30. Oral.
2. Körpe DA, Haberal M, Kartal T, İşeri ÖD, Şahin Fİ. Farklı Tütün Anaçları Üzerine
Aşılanan Ticari Domates Çeşitlerinin Aşılama Yöntemlerinin Aşı Verimi Üzerine
Etkilerinin Belirlenmesi. Türkiye VI. Ulusal Bahçe Bitkileri Kongresi, 4-8 Ekim
2011, Şanlıurfa, Türkiye, sf. 85. Poster.
3. Haberal M, Körpe DA, İşeri ÖD, Şahin Fİ. Farklı Tütün Anaçları Üzerine Domates
Aşılanması ile Elde Edilen “Tomacco” Bitkisinin Örtü Altı Koşullarda Gelişiminin
İncelenmesi. Türkiye VI. Ulusal Bahçe Bitkileri Kongresi, 4-8 Ekim 2011, Şanlıurfa,
Türkiye, sf. 85. Poster.
4. Yurtcu E, Darcansoy İşeri Ö, Şahin Fİ. Beta Karoten ve Askorbik Asidin İnsan
Hepatosellüler Karsinoma Hücreleri Üzerindeki Etkilerinin Değerlendirilmesi. 3.
Multidisipliner Kanser Sempozyumu, 14-17 Mart 2010, Bursa-TÜRKİYE. Oral.
5. Yurtcu E, Darcansoy İşeri Ö, Şahin Fİ. İnsan Hepatosellüler Karsinoma Hücreleri
Üzerinde
Doksorubisin
ve
Silimarinin
Etkilerinin
Değerlendirilmesi.
3.
Multidisipliner Kanser Sempozyumu, 14-17 Mart 2010, Bursa-TÜRKİYE. Oral.
6. Aksoy D, Darcansoy İşeri Ö, Şahin Fİ, Haberal M. Tütün Üzerine Aşılanmış
Domates Bitkisinin Rastgele Çoğaltılmış Polimorfik DNA (RAPD) Yöntemi ile
Moleküler Analizi. 16. Ulusal Biyoteknoloji Kongresi, 13-15 Aralık 2009, AntalyaTÜRKİYE. Poster.
7. Akhmetova L, Dönmez Y, İşeri ÖD, Kars MD, Gündüz U. Modulation of Multidrug
Resistance in Doxorubicin Resistant MCF-7 Cells. 21. Ulusal Biyokimya Kongresi
28-31 Ekim 2009, İstanbul-Türkiye. Oral.
8.
Nil Z, Urfalı Ç, Şenyılmaz D, Kars MD, İşeri ÖD, Gündüz U. Investigation of
Cross Resistance Development in Zoledronic Acid Resistant MCF-7 Cells. 21.
Ulusal Biyokimya Kongresi 28-31 Ekim 2009, İstanbul-Türkiye. Oral.
15
9. Kars MD, İşeri ÖD, Arpacı F, Gündüz U. Meme Kanseri MCF-7 Hücre Hattında
Paklitaksel ve Vinkristine Karşı Gelişmiş Çoklu İlaç Direnci Mekanizmalarının
Mikrodizin Analizi ile Belirlenmesi. Ulusal Kanser Kongresi, 22-26 Nisan 2009,
Antalya-Türkiye. Oral.
10. Dönmez Y, İşeri ÖD, Kars MD, Gündüz U. Paklitaksel Uygulanan MCF-7
Hücrelerinde
Apoptotik
Gen
Ekspresyonu
Düzeylerinin
İncelenmesi.
15.
Biyoteknoloji Kongresi, 28-31 Ekim 2007, Antalya-TÜRKİYE, p 63. Poster.
11. Dönmez Y, Akçay İM, İşeri ÖD, Kars MD, Gündüz U. Paklitaksel ve Vinkristin
Uygulanan MCF-7 Hücrelerinde β-tubulin İzotip Ekspresyonlarının İncelenmesi. 15.
Biyoteknoloji Kongresi, 28-31 Ekim 2007, Antalya- TÜRKİYE, p 64. Poster.
12. Ural AU, Iseri OD, Mutlu PK, Kars MD, Avcu F, Gunduz U. Kronik lenfositik
lösemi ve kronik miyelositer lösemi vakalarında çoklu ilaç direnç 1, akciğer direnç
protein ve meme kanseri direnç protein genlerinin tanımlanması. Türk Hematoloji
Derneği 32. Hematoloji Kongresi, 8-12 Kasım 2006, Antalya-TÜRKİYE, Turkish
Journal of Hematology Vol. 23 No:3 p131. Poster.
13. Iseri ÖD, Kars MD, Gündüz U. ATP Bağımlı Taşıyıcı Poteinlerinin Gen Ekspresyon
Düzeylerinin MCF-7 Meme Kanseri Hücre Hatlarında İncelenmesi. Multidisipliner
Kanser Araştırma Sempozyumu 12-15 Mart 2006, Uludağ-TÜRKİYE, p200. Poster.
14. Iseri ÖD, Kars MD, Gündüz U. Dosetaksel ve Doksorubisine Dirençli MCF-7
Meme Kanseri Hücre Hatlarında Bcl-2 ve Bax Gen Ekspresyonlarının İncelenmesi.
Sözlü sunum. Multidisipliner Kanser Araştırma Sempozyumu 12-15 Mart 2006,
Uludağ-TÜRKİYE, p115. Oral.
15. Eskiocak U, İşeri ÖD, Kars MD, Gündüz U. Telomeraz aktivitesinin TRAP
yöntemiyle incelenmesi. 14. Ulusal Biyoteknoloji Kongresi, 31 Ağustos-2 Eylül
2005 Eskişehir-TÜRKİYE, p 545. Poster.
16. İşeri ÖD, Demirel M, Arpacı F, Gündüz U. Meme kanseri doku örneklerinde ve
MCF-7 model hücre hattında ilaç dirençliliği genlerinin ekspresyon analizi. Türk
Biyokimya Derneği Moleküler Kanser Sempozyumu, 6-7 Nisan 2004, İzmirTÜRKİYE, p 26. Oral and poster.
17. Demirel M, İşeri ÖD, Ünal N, Ural AU, Gündüz U. Taksoid grubu ilaçların MCF-7
meme kanseri hücre hattında sitotoksisite ve gen ekspresyonu analizleri. Klinik
Biyokimya Uzmanları Derneği 1. Ulusal Kongresi, 1-4 Ekim 2003, KapadokyaTÜRKİYE, p173. Poster. (Poster Special Award)
16
COURSES PARTICIPATED
1. Biochrom Spectrophotometric Analysis and Applications, 20 September, 2012,
Ankara, Turkey.
2. American Type Culture Collection; Cell Culture Seminars, 18 January 2012, Ankara,
Turkey.
3. Oncology 2008 (Onkoloji 2008), 20-22 November 2008, Oncology Institute,
Onkoloji Institüsü, Hacettepe University, Ankara-TURKEY.
4. Principles in Cell Culture Technology and Artificial Organs, 24-26, November 2004,
Ege University Applied Science-Technology Research Institute, İzmir-TURKEY.
TECHNICAL COMPUTER SKILLS
Microarray data analysis software (GeneSpring), gene databank search and use of
various softwares for primer design, image analysis software (Scion Image), statistical
analysis software (SPSS)
CITATIONS
Citations in SCI Journals (Excluding Self Citations) (98 citations)
Cited: Kars et al. Anticancer Research 26: 4559-4568, 2006.
Citations: 13
Cited: Kars et al. Anticancer Research 27: 4031-4038, 2007.
Citations: 6
Cited: Kars et al. Chemotherapy 54: 194-200, 2008.
Citations: 17
Cited: Eskiocak et al. Chemotherapy 54: 209-216, 2008.
Citations: 13
Cited: Sakin et al. Experimental Oncology 30(3): 1-4, 2008.
Citations: 1
Cited: İşeri et al. Cancer Chemotherapy and Pharmacology 65 (3): 447-55, 2010.
Citations: 4
Cited: İşeri et al. International Journal of Hematology and Oncology 2 (20): 75-83,
2010.
Citations: 1
Cited: Kars et al. Biomedicine and Pharmacotherapy 64(7): 458-62, 2010.
17
Citations: 2
Cited: Yurtcu et al. Molecular Biology Reports, 38(7): 4265-4272, 2010.
Citations: 3
Cited: İşeri et al. Biomedicine and Pharmacotherapy 65(1): 40-45, 2011.
Citations: 12
Cited: Donmez et al. Cancer Chemother Pharmacol 67(4):823-8, 2011.
Citations: 18
Cited: Işeri et al. Plant Cell Reports, 30(9):1713-21, 2011.
Citations: 1
Cited: Kars et al. European Journal of Pharmacology 657: 4-9, 2011.
Citations: 2
Citations Published in Journals That are not Indexed in SCI (Excluding Self Citations)
(12 citations)
Cited: Kars et al. Anticancer Research 26: 4559-4568, 2006.
Citations: 2
Cited: Kars et al. Anticancer Research 27: 4031-4038, 2007.
Citations: 2
Cited: Kars et al. Chemotherapy 54: 194-200, 2008.
Citations: 2
Cited: Eskiocak et al. Chemotherapy 54: 209-216, 2008.
Citations: 1
Cited: İşeri et al. Cancer Chemotherapy and Pharmacology 65 (3): 447-55, 2010.
Citations: 1
Cited: Kars et al. Biomedicine and Pharmacotherapy 64(7): 458-62, 2010.
Citations: 1
Cited: İşeri et al. Biomedicine and Pharmacotherapy 65(1): 40-45, 2011.
Citations: 2
Cited: Yurtcu et al. Molecular Biology Reports, 38(7): 4265-4272, 2010.
Citations: 1
18
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